LOCUS       NM_001037196            2460 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus lysine demethylase 8 (Kdm8), mRNA.
ACCESSION   NM_001037196 XM_219312
VERSION     NM_001037196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2460)
  AUTHORS   Saran,A.R., Kalinowska,D., Oh,S., Janknecht,R. and DiTacchio,L.
  TITLE     JMJD5 links CRY1 function and proteasomal degradation
  JOURNAL   PLoS Biol 16 (11), e2006145 (2018)
   PUBMED   30500822
  REMARK    Erratum:[PLoS Biol. 2019 Aug 21;17(8):e3000454. doi:
            10.1371/journal.pbio.3000454.. PMID: 31433800]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2460)
  AUTHORS   Liu,H., Wang,C., Lee,S., Deng,Y., Wither,M., Oh,S., Ning,F.,
            Dege,C., Zhang,Q., Liu,X., Johnson,A.M., Zang,J., Chen,Z.,
            Janknecht,R., Hansen,K., Marrack,P., Li,C.Y., Kappler,J.W.,
            Hagman,J. and Zhang,G.
  TITLE     Clipping of arginine-methylated histone tails by JMJD5 and JMJD7
  JOURNAL   Proc Natl Acad Sci U S A 114 (37), E7717-E7726 (2017)
   PUBMED   28847961
REFERENCE   3  (bases 1 to 2460)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (bases 1 to 2460)
  AUTHORS   Wang,Z., Wang,C., Huang,X., Shen,Y., Shen,J. and Ying,K.
  TITLE     Differential proteome profiling of pleural effusions from lung
            cancer and benign inflammatory disease patients
  JOURNAL   Biochim Biophys Acta 1824 (4), 692-700 (2012)
   PUBMED   22326748
REFERENCE   5  (bases 1 to 2460)
  AUTHORS   Hsia,D.A., Tepper,C.G., Pochampalli,M.R., Hsia,E.Y., Izumiya,C.,
            Huerta,S.B., Wright,M.E., Chen,H.W., Kung,H.J. and Izumiya,Y.
  TITLE     KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1
            coding region to regulate cancer cell proliferation
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9671-9676 (2010)
   PUBMED   20457893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC100627.1.
            
            On Nov 18, 2005 this sequence version replaced XM_219312.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100627.1, SRR8487227.244427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2460
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..2460
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /note="lysine demethylase 8"
                     /db_xref="GeneID:308976"
                     /db_xref="RGD:1304823"
     exon            1..264
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            265..765
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..1518
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /EC_number="1.14.11.73"
                     /note="jmjC domain-containing protein 5; lysine
                     (K)-specific demethylase 8; lysine-specific demethylase 8;
                     jumonji domain-containing protein 5; jumonji domain
                     containing 5; arginyl C3-hydroxylase KDM8; jumonji C
                     domain-containing protein 5; L-arginine (3R)-hydroxylase
                     KDM8"
                     /codon_start=1
                     /product="bifunctional peptidase and arginyl-hydroxylase
                     JMJD5"
                     /protein_id="NP_001032273.1"
                     /db_xref="GeneID:308976"
                     /db_xref="RGD:1304823"
                     /translation="MSEDTTEPLVGPSTLWKDLRALLPDTEEELKLDLSEKVDRSMAT
                     LLRQALGLFYEGRWQKCLQASEAVLDYSWEKLNTGPWRDVDKEWRRVYSFGCLLKTLC
                     LCQAPQKATAVAEALRVCDMGLLMGAAILGDILLKVATVLQTHLLPRKQPACGPHQDQ
                     PATKKAKHDASSTPDVVLDREVPRLRCPPLQHFKKHFLVPGRPVILEGVADHWPCMKK
                     WSLQYIQEIAGCRTVPVEVGSRYTDEDWSQTLMTVNEFIHKYILSEAKDVGYLAQHQL
                     FDQIPELKQDISIPDYCCLGNGEEEEITINAWFGPQGTISPLHQDPQQNFLVQVLGRK
                     YIRLYSPQESEAVYPHETHILHNTSQVDVENPDLEKFPKFTEAPFLSCILSPGDTLFI
                     PAKYWHYVRSLDLSFSVSFWWS"
     exon            766..932
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1065
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1110
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1260
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1353
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..2449
                     /gene="Kdm8"
                     /gene_synonym="Jmjd5; RGD1304823"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgtgcta aggccagccg aagaatcttc gccccgacag aaccagtcgt cgccagcgac
       61 gagagacaca agcccgtcca agtgccagag aggttagttg gagcaccgcg gcgctcaggc
      121 tgcgggagtt gcttagattc aaagcgctgg ccgtgaagga cggattgctc aggcgagcag
      181 gaacggtttc gcgcaggcgc cgtgggaggc ctgggagccg ctcgagaagc cgcatgcgta
      241 gcagctgtcc gctcggcaca aacggggctg atcatgtcag aggacactac agagccccta
      301 gtggggccca gcaccctctg gaaggacctc agggcgctcc tgccagacac agaggaggag
      361 ctgaagctgg atctcagtga gaaggtggac aggagcatgg ctacgctgct acggcaggct
      421 ttgggtctgt tctatgaagg ccgttggcag aagtgcctgc aggccagtga ggctgtcctg
      481 gactactcct gggaaaagct caacactggt ccctggcgag atgtagacaa ggaatggcgc
      541 cgggtatatt ccttcggctg cctcctgaag accctgtgcc tgtgccaggc accacagaag
      601 gccactgctg tggctgaagc actgcgggtg tgtgacatgg gcctgttgat gggggcagcc
      661 atccttgggg acattcttct caaagttgct acagtcctcc agacacatct gctccctaga
      721 aagcagcctg cctgtggccc tcaccaggat cagcctgcta ccaagaaggc aaagcatgat
      781 gccagctcaa ctcctgatgt ggtattagat cgggaagtgc ccaggcttcg ctgcccacct
      841 ctgcagcact tcaagaagca ttttctagtt cctgggagac ctgtgatctt ggaaggtgtg
      901 gctgaccact ggccgtgcat gaagaagtgg agtctacagt acatccagga gattgctggc
      961 tgccgcactg tccccgtgga agtgggttca agatacacag atgaagactg gtcccagact
     1021 ctcatgacag tcaatgagtt catccacaaa tacattctga gcgaggcaaa ggatgtcggg
     1081 taccttgctc aacaccagct gttcgaccag atcccagagt tgaagcagga catcagcatc
     1141 cccgattact gttgcctggg caatggagaa gaggaagaga tcactatcaa tgcctggttt
     1201 ggtcctcaag gaaccatctc cccattgcat caggaccccc agcagaactt cctggtccag
     1261 gtgttaggaa ggaagtacat ccggctgtat tctccgcaag agtctgaggc agtgtaccct
     1321 catgagacac acattcttca taacaccagc caggttgatg tggaaaaccc cgacctagag
     1381 aagttcccca agttcaccga ggccccgttt ctgtcctgca ttctgtcccc aggagacacc
     1441 ctctttatac ctgctaagta ctggcattac gtgcgctccc tggacctgag cttctctgtc
     1501 agcttctggt ggtcatagca aaggcggagt ggaaaggacc ctccaggaag acaccttatc
     1561 caaaagcagt gaacccagtg acagtgttag actccagcag tcctgctcca caatcagtat
     1621 ctgttaggat gtcacagagc tgctgtgtaa ccacgtgaca tgtgtgtggc ccagctgctg
     1681 tgtgtaccca tgtgatgtgt gtgtgcctag gcgatccaga ttatggatgc ttcttttccc
     1741 tgtaactgct gggctgagta tctgccttgc tgctggggtg cctgagtgcc actggcaagc
     1801 tgctcagagg agacagagca cagtccgtaa taggggtcct cagtccatgg ttccttgggt
     1861 gtgttttctc aggtgggaaa aagcaaggtc tgggacggct gctattgttc ccagtcttct
     1921 gtgtactcag gtgtcaccag gcccgatggc ttactactag gagttggaga tccttgggtc
     1981 catgtttccc ctcggggcat ttatgcacca ggctggaagg ggaaggcaga gcctgggatg
     2041 gtgacagaac tggtttggtt ctgagtgagt ggcaggaata aggaggggct gggagcaaag
     2101 tcttctctag gagatacagg ccagcccttt aggaggaagc ccctcccctc aggcagtcct
     2161 tgatgaagag atggtccttg ctcggtccaa ctgctttatt agatggtggg tttgaataca
     2221 cacaccttac tcagggtgaa ccggggattg catacttgtg ggaaggaatg caagggaacc
     2281 tcatttggct gaacacttgg ggcctagcta gatactttat tagcatgaga actccagagt
     2341 ctgagcctat tcaaccttac cagttcttct gtctggtggc acagtcactt ggtccatatg
     2401 taatttaaaa tttcttcaat aacaataaaa tatattttct taagtaaaaa aaaaaaaaaa
//
