LOCUS       NM_001401950            6744 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lysine demethylase 6B (Kdm6b), transcript variant
            2, mRNA.
ACCESSION   NM_001401950 XM_039086482
VERSION     NM_001401950.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6744)
  AUTHORS   Park,C.S., Lee,J.Y., Seo,K.J., Kim,I.Y., Ju,B.G. and Yune,T.Y.
  TITLE     TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by
            Regulating the mTOR/JMJD3 Axis in Rats
  JOURNAL   Mol Neurobiol 61 (2), 662-677 (2024)
   PUBMED   37653221
  REMARK    GeneRIF: TRPM7 Mediates BSCB Disruption After Spinal Cord Injury by
            Regulating the mTOR/JMJD3 Axis in Rats.
REFERENCE   2  (bases 1 to 6744)
  AUTHORS   Qiao,Y., Li,L., Bai,L., Gao,Y., Yang,Y., Wang,L., Wang,X., Liang,Z.
            and Xu,J.T.
  TITLE     Upregulation of lysine-specific demethylase 6B aggravates
            inflammatory pain through H3K27me3 demethylation-dependent
            production of TNF-alpha in the dorsal root ganglia and spinal
            dorsal horn in rats
  JOURNAL   CNS Neurosci Ther 29 (11), 3479-3492 (2023)
   PUBMED   37287407
  REMARK    GeneRIF: Upregulation of lysine-specific demethylase 6B aggravates
            inflammatory pain through H3K27me3 demethylation-dependent
            production of TNF-alpha in the dorsal root ganglia and spinal
            dorsal horn in rats.
REFERENCE   3  (bases 1 to 6744)
  AUTHORS   Zhang,C., Ye,W., Zhao,M., Long,L., Xia,D. and Fan,Z.
  TITLE     KDM6B Negatively Regulates the Neurogenesis Potential of Apical
            Papilla Stem Cells via HES1
  JOURNAL   Int J Mol Sci 24 (13), 10608 (2023)
   PUBMED   37445785
  REMARK    GeneRIF: KDM6B Negatively Regulates the Neurogenesis Potential of
            Apical Papilla Stem Cells via HES1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6744)
  AUTHORS   Lee,J., Choi,H., Park,C., Jeon,S. and Yune,T.
  TITLE     Jmjd3 Mediates Neuropathic Pain by Inducing Macrophage Infiltration
            and Activation in Lumbar Spinal Stenosis Animal Model
  JOURNAL   Int J Mol Sci 22 (24), 13426 (2021)
   PUBMED   34948220
  REMARK    GeneRIF: Jmjd3 Mediates Neuropathic Pain by Inducing Macrophage
            Infiltration and Activation in Lumbar Spinal Stenosis Animal Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6744)
  AUTHORS   Nanduri,J., Wang,N., Wang,B.L. and Prabhakar,N.R.
  TITLE     Lysine demethylase KDM6B regulates HIF-1alpha-mediated systemic and
            cellular responses to intermittent hypoxia
  JOURNAL   Physiol Genomics 53 (9), 385-394 (2021)
   PUBMED   34297635
  REMARK    GeneRIF: Lysine demethylase KDM6B regulates HIF-1alpha-mediated
            systemic and cellular responses to intermittent hypoxia.
REFERENCE   6  (bases 1 to 6744)
  AUTHORS   Negishi,M., Saraya,A., Mochizuki,S., Helin,K., Koseki,H. and
            Iwama,A.
  TITLE     A novel zinc finger protein Zfp277 mediates transcriptional
            repression of the Ink4a/arf locus through polycomb repressive
            complex 1
  JOURNAL   PLoS One 5 (8), e12373 (2010)
   PUBMED   20808772
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6744)
  AUTHORS   Liska,F., Gosele,C., Rivkin,E., Tres,L., Cardoso,M.C., Domaing,P.,
            Krejci,E., Snajdr,P., Lee-Kirsch,M.A., de Rooij,D.G., Kren,V.,
            Krenova,D., Kierszenbaum,A.L. and Hubner,N.
  TITLE     Rat hd mutation reveals an essential role of centrobin in spermatid
            head shaping and assembly of the head-tail coupling apparatus
  JOURNAL   Biol Reprod 81 (6), 1196-1205 (2009)
   PUBMED   19710508
  REMARK    Erratum:[Biol Reprod. 2010 Apr;82(4):804. Rooij, Dirk G de
            [corrected to de Rooij, Dirk G]]
REFERENCE   8  (bases 1 to 6744)
  AUTHORS   Burgold,T., Spreafico,F., De Santa,F., Totaro,M.G., Prosperini,E.,
            Natoli,G. and Testa,G.
  TITLE     The histone H3 lysine 27-specific demethylase Jmjd3 is required for
            neural commitment
  JOURNAL   PLoS One 3 (8), e3034 (2008)
   PUBMED   18716661
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6744)
  AUTHORS   Jepsen,K., Solum,D., Zhou,T., McEvilly,R.J., Kim,H.J., Glass,C.K.,
            Hermanson,O. and Rosenfeld,M.G.
  TITLE     SMRT-mediated repression of an H3K27 demethylase in progression
            from neural stem cell to neuron
  JOURNAL   Nature 450 (7168), 415-419 (2007)
   PUBMED   17928865
REFERENCE   10 (bases 1 to 6744)
  AUTHORS   De Santa,F., Totaro,M.G., Prosperini,E., Notarbartolo,S., Testa,G.
            and Natoli,G.
  TITLE     The histone H3 lysine-27 demethylase Jmjd3 links inflammation to
            inhibition of polycomb-mediated gene silencing
  JOURNAL   Cell 130 (6), 1083-1094 (2007)
   PUBMED   17825402
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 3, 2022 this sequence version replaced XM_039086482.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.43330.1,
                                           SRR26643284.13438.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               JAXUCZ010000010.1  54640861-54641014   c
            155-266             JAXUCZ010000010.1  54634305-54634416   c
            267-384             JAXUCZ010000010.1  54629493-54629610   c
            385-528             JAXUCZ010000010.1  54629091-54629234   c
            529-670             JAXUCZ010000010.1  54628860-54629001   c
            671-769             JAXUCZ010000010.1  54628571-54628669   c
            770-989             JAXUCZ010000010.1  54628255-54628474   c
            990-1082            JAXUCZ010000010.1  54628074-54628166   c
            1083-1244           JAXUCZ010000010.1  54627831-54627992   c
            1245-1442           JAXUCZ010000010.1  54627547-54627744   c
            1443-1784           JAXUCZ010000010.1  54627002-54627343   c
            1785-3949           JAXUCZ010000010.1  54624751-54626915   c
            3950-4076           JAXUCZ010000010.1  54624542-54624668   c
            4077-4182           JAXUCZ010000010.1  54624330-54624435   c
            4183-4388           JAXUCZ010000010.1  54623043-54623248   c
            4389-4453           JAXUCZ010000010.1  54622878-54622942   c
            4454-4525           JAXUCZ010000010.1  54622724-54622795   c
            4526-4674           JAXUCZ010000010.1  54622481-54622629   c
            4675-4789           JAXUCZ010000010.1  54622248-54622362   c
            4790-4977           JAXUCZ010000010.1  54621978-54622165   c
            4978-5119           JAXUCZ010000010.1  54621688-54621829   c
            5120-5246           JAXUCZ010000010.1  54621188-54621314   c
            5247-5417           JAXUCZ010000010.1  54620933-54621103   c
            5418-6744           JAXUCZ010000010.1  54619520-54620846   c
FEATURES             Location/Qualifiers
     source          1..6744
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..6744
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /note="lysine demethylase 6B"
                     /db_xref="GeneID:363630"
                     /db_xref="RGD:1307629"
     exon            1..154
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            155..266
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            267..384
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..528
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..670
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..5441
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /EC_number="1.14.11.68"
                     /note="isoform 2 is encoded by transcript variant 2;
                     jumonji domain-containing 3; lysine-specific demethylase
                     6B; lysine (K)-specific demethylase 6B"
                     /codon_start=1
                     /product="lysine-specific demethylase 6B isoform 2"
                     /protein_id="NP_001388879.1"
                     /db_xref="GeneID:363630"
                     /db_xref="RGD:1307629"
                     /translation="MHRAVDPPGARSAREAFALGGLSCAGAWSSCPPHPPPRNSWLPG
                     GRCSASIGQPPLSAPLPPSHGNSSGHPNKPYYASGTPTPRPLHGKLESLHGCVQALLR
                     EPAQPVLWEQLGQLYESEHDSEEAICCYHRALRYGGSFAELGPRIGRLQQAQLWNLHA
                     GSCQHRAKVLPPLEQVWNLLHLEHKRNYGAKRGGPPVKRSAEPPVVQPMPPAALSGPS
                     GEEGLSPGGKRRRGCSSEQAGLPPGLPLPPPPPPPPPPPPPPPPPPLPGLAISPPFQL
                     TKPGLWNTLHGDAWGPERKGSAPPERQEQRHSLPHPHPYPAPAYTAHPPSHRLGPATP
                     LGPGPRPPGAESHGCLPATRPPGSDLRESRVQRSRMDSSVSPAASTACVPYAPSRPPG
                     LPGTSSSSSSSNNTGLRGVEPSPGIPGADHYQNPALEIAPHQARLGPSAHSSRKPFLT
                     APAAAPHLSLPSGTPSSPPPPCPRLLRPPPPPAWMKGSACRSAREDGEILGELFFGAE
                     GPPRPPPPPLPHRDGFLGPPNPRFSVGTQDSHTPPTPPTTTSSSSSSSSSNSHSSSPT
                     GPVPFPPPPYLARSIDPLPRPSSPTLSSQDPPLPPLTLALPPAPPSSCHQNTSGSFRR
                     SESPRPRVSFPKTPEVGQGPPPGSLSKAPQPVPPGVGELPARGPRLFDFPPTPLEDQF
                     EEPAEFKILPDGLANIMKMLDESIRKEEEQQQQEAGAVPPPPLKEPFASLRSSLPSDT
                     APAATTAAATPTTTTTTTTQEEEKKPPPALPPPPPLAKFPPPPQPPPPPPASPASLLK
                     SLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPKP
                     SVSSSSQFSTSGGPWVRERRAGEEPAPGPVTPAQLPPPLPLPPARSESEVLEEISRAC
                     ETLVERVGRSAINPADPVDIADPVDSGTEPQPPPAQAKEESGGVAVAAAGPGSGKRRQ
                     KEHRRHRRTCRDSVGRRPREGRAKAKAKAPKEKSRRVLGNLDLQSEEIQGREKARPDV
                     GGASKVKTPTTPAPPPAPAPSAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLS
                     EGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASKNAKVKGK
                     FRESYLSPAQSVKPKINTEEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPRNPI
                     TVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDLTGTRQIWPCES
                     SRSHTTIAKYAQYQASSFQESLQEEKESEDEESEEPDSTTGTSPSSAPDPKNHHIIKF
                     GTNIDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMKVPGSR
                     TPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDL
                     YASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEW
                     NEVKNVKSIVPMIHVSWNVARTVKISDPDLFKMIKFCLLQSMKHCQVQRESLVRAGKK
                     IAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSRNTYLVHCEGCARRRSAGLQGVVV
                     LEQYRTEELAQAYDAFTLAPASTSR"
     exon            671..769
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            770..989
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1082
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1244
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1442
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1784
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..3949
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4076
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4182
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4388
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4453
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4454..4525
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4674
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..4789
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4790..4977
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            4978..5119
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5246
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5247..5417
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
     exon            5418..6744
                     /gene="Kdm6b"
                     /gene_synonym="Jmjd3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgtggaagg ggggcgggtg cgggtgtttg tgttggaaaa tcaaactgcg ccacggggta
       61 gagtggcccc cccaacccct ctctgggaga gggggggccg ctcgaccccc aagaggcctt
      121 gaagatcttg aatatctggg acccccagaa ccaggttccc ccaggcacca tgtcagcctc
      181 atagtaggac ccaccccacg acttctgttg tgccccattg ctggagtgct tgttccaatg
      241 aggcagtcca cttccaactc catctggctg ttactgaggc ggagacaagg gtgatgattg
      301 gctttctggg gatagagaag tcttgtgatt ggctaaattt ctgaagctct tgaagctgtg
      361 agaggacgct cccacggagg ctggaattgg ttgcagaagg ccagagaccg tcacctggaa
      421 acagtgggca ctcttgttaa gggcagttgg agctggacca tcgggccaga gagctggggc
      481 agggggctgt gccccatctc cagggctcct ggggccactg ctgacctggc tggatgcatc
      541 gggcagtgga ccctccaggg gcccgctctg cacgggaagc ctttgccctt gggggcttga
      601 gctgtgctgg ggcttggagc tcctgcccac cccatcctcc tccccgaaac tcatggctgc
      661 ctggaggcag atgctctgcc agcattgggc agcccccact ctctgctcct ttacccccct
      721 ctcatggcaa cagctccggg caccctaaca agccctatta tgcttctggg actcctaccc
      781 caagacccct ccatgggaag ttggagtctc tacatggctg tgtacaggca ttgctccggg
      841 agccagccca gccggtctta tgggaacagc ttggacagtt gtatgagtcg gagcacgaca
      901 gcgaggaggc catatgctgc taccacaggg cccttcgcta cggaggaagc ttcgctgaac
      961 tggggccccg aattggccga ttgcagcagg cccagctctg gaaccttcat gctggttcct
     1021 gtcagcacag agccaaggtc ctgcctcccc tggagcaagt atggaatttg ctgcaccttg
     1081 agcacaaacg gaactatggg gctaagcgag ggggccctcc agtgaagaga tctgctgaac
     1141 ccccagtggt ccagcctatg cctcctgccg cactctcagg cccctcagga gaggaaggcc
     1201 tcagccctgg aggcaagcgc aggagaggct gcagctctga acaggctggc cttcccccgg
     1261 gtctgccact ccctccacca ccaccacccc cacctccacc cccgccaccc ccacccccac
     1321 caccgctgcc tggcctggct attagccccc catttcagct gactaaacca gggctgtgga
     1381 ataccctgca tggagatgct tggggccctg agcgcaaggg ttcagcaccc ccagagcgcc
     1441 aggagcagcg gcactcgctg cctcaccctc atccataccc agctcctgcc tacactgctc
     1501 atccgcccag ccaccggctg ggcccggcca caccccttgg tccaggtccc cgacccccag
     1561 gagcagagag ccatggctgc ctgcctgcca cccgtccccc cggaagtgac cttagagaga
     1621 gcagagttca gaggtcgcgg atggactcca gcgtttcacc agcagcatct accgcctgcg
     1681 tgccttacgc cccttcccgg ccccctggcc tccccggcac cagcagcagc agcagtagca
     1741 gtaacaacac tggtcttcgg ggtgtggagc cgagcccagg cattcctggc gctgaccatt
     1801 accaaaaccc tgcgttggag atagcccctc accaggcccg cctgggtccc tccgcacaca
     1861 gcagtcggaa accatttttg acagcccctg ctgccgctcc ccacttatcc ctaccatccg
     1921 ggaccccttc atcccctcca cccccatgtc ctcgcctctt gcgccctcca ccaccccctg
     1981 cttggatgaa gggctcagcc tgccgctcag ctcgagagga tggagagatc ttaggggagc
     2041 tcttctttgg tgctgaggga cctccccgtc ctcctccccc accccttccc caccgtgatg
     2101 gcttcttggg gcctccaaac ccccgctttt ctgtgggcac tcaggattcg catacccctc
     2161 ccactccccc aaccaccacc agcagcagca gcagcagcag cagcagcaac agccacagca
     2221 gtagtcctac tgggcctgtg cccttcccac cacctcccta tctggccaga agtatagacc
     2281 cccttcccag gccatctagc ccaacactga gctcccagga cccacctctt ccaccactga
     2341 ctcttgccct gcctccagcc cctccctcct cctgccacca aaatacctca ggaagcttca
     2401 ggcgctcgga gagcccccgg cccagggtct ccttcccaaa gacccccgag gtggggcagg
     2461 ggccacctcc aggctctctg agtaaagccc cccagcctgt gccacctggg gttggagagc
     2521 tgcctgcccg aggcccgagg ctctttgatt ttccaccaac tccactggag gaccagtttg
     2581 aagagccagc tgaattcaag atcctccctg atgggctagc taacatcatg aagatgctgg
     2641 atgaatccat tagaaaggag gaagagcagc agcagcaaga ggcaggcgcg gttcccccac
     2701 ccccactcaa agagcccttt gcatctctac ggtcttcact tcccagtgac acagccccag
     2761 ctgccaccac tgctgctgca actcccacca ccaccaccac caccaccacc caagaagagg
     2821 agaagaagcc accaccagcc ctgccaccac caccgcctct agccaagttt cctccaccac
     2881 cccagccccc accacctcca ccagccagcc cagccagcct gctcaaatca ttggcctctg
     2941 ttcttgaggg gcaaaagtac tgttatcggg ggactggagc agccgtttca accaggcccg
     3001 ggtccgtgcc cgccactcag tattccccta gtcctgcatc aggtgctacc gccccaccac
     3061 ccacttcagt ggcccctagc gcccagggct cccccaagcc ctctgtttcc tcgtcatctc
     3121 agttctctac ctcaggtggg ccttgggtcc gagagcgcag ggcaggtgaa gagccagcac
     3181 caggccccgt gacccctgcc cagttgcccc cacctctgcc gctgccccct gctcgttctg
     3241 agtctgaggt gctagaagaa atcagtcggg cttgtgagac ccttgtagag cgggtgggcc
     3301 ggagtgccat caacccagca gacccagtgg acatagcaga cccagtggac agtgggactg
     3361 agccacagcc gcctcctgca caggccaagg aggagagtgg gggagtggca gtggcggcag
     3421 caggtccagg tagtggtaag cgtcgtcaga aggagcatcg gaggcacaga cggacctgta
     3481 gggacagtgt gggtcgtagg ccccgtgagg ggagggccaa ggccaaggcc aaggctccca
     3541 aagaaaaaag ccgaagggtg ctggggaact tggacttgca gagtgaagag atccagggcc
     3601 gggagaaggc ccggcctgat gtaggtgggg cttccaaagt caagacgccc acaactccag
     3661 cgcccccacc tgctcctgcc ccctctgctc agccaacacc cccatcagct cctgtccctg
     3721 ggaagaagac tcgagaggaa gctccagggc ctccaggtgt gagccgtgca gatatgctga
     3781 agcttcggtc gcttagtgag gggccaccta aggagctgaa gatcaggctc atcaaggtgg
     3841 agagtgggga caaggagacc ttcatcgcct ctgaggtaga agagcggcgg ctgcgcatgg
     3901 cagacctcac catcagccac tgcgctgctg atgtcatgcg tgccagcaag aatgccaagg
     3961 tgaaagggaa attccgagag tcctaccttt cccctgccca gtctgtgaaa ccgaagatca
     4021 acactgagga gaagctgccc cgggaaaaac tcaaccctcc tacacccagc atttatttgg
     4081 agagcaaacg agacgccttc tcgccggtcc tgctgcagtt ctgtacagat ccccggaacc
     4141 ccatcactgt catcaggggc ctggcaggtt cacttcggct caacttaggc cttttttcca
     4201 ccaagactct ggtggaggcg agcggtgaac acacagtgga ggtccgtacc caagtgcagc
     4261 agccctcaga cgagaactgg gatctgacag gtaccagaca gatctggccc tgtgagagct
     4321 cccgttcaca caccaccatc gctaaatatg cacagtacca ggcttcgtcc ttccaggagt
     4381 cactgcagga ggagaaagag agtgaggatg aggaatccga ggaaccagac agcactacag
     4441 gaacctctcc cagcagtgca ccagacccca agaaccatca catcatcaag tttggcacaa
     4501 acatcgacct gtctgatgcc aagaggtgga agccacaact acaggagctg ctgaaactgc
     4561 ctgccttcat gcgagtaaca tccacaggca acatgcttag ccatgtggga cacaccatcc
     4621 tgggcatgaa caccgtgcag ctatacatga aggttcctgg cagtcgaacg ccaggccacc
     4681 aggagaataa caatttttgc tctgtcaata tcaacattgg ccccggggac tgcgagtggt
     4741 tcgcggtaca tgagcactat tgggagacca tcagcgcctt ctgcgatcgg catggtgtgg
     4801 attacttgac tggttcctgg tggccaatct tggatgacct ctatgcgtcc aatattcctg
     4861 tttaccgctt cgtgcagcgc cctggagacc ttgtgtggat taatgcaggg actgtgcatt
     4921 gggtgcaggc tactggctgg tgcaacaaca ttgcctggaa cgtggggccc ctcaccgcct
     4981 atcaatacca gctggccctg gagcgatatg agtggaacga ggtgaagaac gtcaagtcca
     5041 ttgtacccat gattcatgtg tcctggaacg tagctcgaac ggtcaagatc agtgatcctg
     5101 acttgttcaa aatgatcaag ttctgcctcc tgcagtcaat gaagcactgc caggtgcagc
     5161 gggagagcct ggtgcgggca gggaagaaaa tcgcttacca aggccgcgtc aaggacgagc
     5221 ctgcctacta ctgcaacgaa tgcgatgtgg aggtgttcaa catcctgttc gttacaagtg
     5281 agaatggcag ccgaaacacg tacctggtgc actgcgaggg ctgtgcgcgc cgtcgcagtg
     5341 cgggcctaca gggcgtggtg gtgctagagc agtaccgcac agaggagctg gcacaggcct
     5401 atgatgcctt cacactggct cctgccagca cgtcgcgatg aggccggacg ccccgctcgc
     5461 ccgcccacgc gggcggggcc accagcacac gcctgggctg gacctaggtc ccgcctctgg
     5521 ccgggaaggg ggttgggccc agcccttcca ccctattggc agctcccctc acttaattta
     5581 ttaagaaaaa aaaatttttt taacaaatac gaggaaaaaa aggaaaaaaa atgggagacg
     5641 gggagggggc tggcagcccc tcgcccacca gcgcctcccc tcaccgactt tggcctttct
     5701 agcaacagac acaaggacca ggctccggcg gcggcggggg tcacatacgg gttccctcaa
     5761 gcctgcccgc cgcgcgcccg cctgccgccc gccggcgcag acgttcgcgg ctcgttgtgt
     5821 acatagacat tcggcagccg aggtttttaa tgagattctt tctatgggct ttacccctcc
     5881 ccaggacctc ctttttttac ttccaatgct agctgtgatc cctgtatatg tctcttgttt
     5941 attcactcgg ttatgattcg tatttttgtt ctttttgttt ttggttttta atttataaca
     6001 gtcccactca cctctattta ttcatttttt gggttttttt gttttgtttt ttcttttttt
     6061 cttttttttt ttgggaaaac ccgacctcct acaccccaag ctatccctcc tgcctctttg
     6121 ggaggcccat tcctgggccc tccctacgcc ccagtatatg tccgggcttg gcccgtccgt
     6181 ctccgcccgc ccgcggctcc agccgggttc tcatggtgct caaacctgct cccctcccct
     6241 acgtcctgca ctttcttgga ccagtacccc cactcccgac ccgaccccaa ccccacctga
     6301 gggtgagcga ctcctgtact gtaggggaag aagtgggaac tgaaatggta ttttgtaaaa
     6361 aaaataaata aataaaataa aaaaatgttt taaagaaata actatgagga aaaggaaccc
     6421 tgtcctcccc agcctcggcc attttaaaaa cagtggacac ctacacacac acataccccc
     6481 cttttttaag gcgtgaaaca tcccagggca gggcctcttt ggggcaggga caccctgggg
     6541 tgatttttct ctggggcttt attttcattt tcttagttcg ttttctcccg ctggggctgc
     6601 ggaggggtgg ggggatttac agtcccgccc cctcgcactg cactgtctct ctgccccagg
     6661 ggcagagggg gcttcccatc cctaccctat tttcggtgat ttttgtgtga gaatattatt
     6721 aaaaataaaa acaggaaaaa aaaa
//
