LOCUS       NM_001419772           10824 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lysine demethylase 5C (Kdm5c), mRNA.
ACCESSION   NM_001419772 XM_039100480
VERSION     NM_001419772.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10824)
  AUTHORS   Lin,H., Ma,N., Zhao,L., Yang,G. and Cao,B.
  TITLE     KDM5c Promotes Colon Cancer Cell Proliferation Through the
            FBXW7-c-Jun Regulatory Axis
  JOURNAL   Front Oncol 10, 535449 (2020)
   PUBMED   33042830
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10824)
  AUTHORS   Chen,X., Xu,M., Xu,X., Zeng,K., Liu,X., Pan,B., Li,C., Sun,L.,
            Qin,J., Xu,T., He,B., Pan,Y., Sun,H. and Wang,S.
  TITLE     METTL14-mediated N6-methyladenosine modification of SOX4 mRNA
            inhibits tumor metastasis in colorectal cancer
  JOURNAL   Mol Cancer 19 (1), 106 (2020)
   PUBMED   32552762
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10824)
  AUTHORS   Puccini,A., Lenz,H.J., Marshall,J.L., Arguello,D., Raghavan,D.,
            Korn,W.M., Weinberg,B.A., Poorman,K., Heeke,A.L., Philip,P.A.,
            Shields,A.F., Goldberg,R.M. and Salem,M.E.
  TITLE     Impact of Patient Age on Molecular Alterations of Left-Sided
            Colorectal Tumors
  JOURNAL   Oncologist 24 (3), 319-326 (2019)
   PUBMED   30018131
REFERENCE   4  (bases 1 to 10824)
  AUTHORS   Tumber,A., Nuzzi,A., Hookway,E.S., Hatch,S.B., Velupillai,S.,
            Johansson,C., Kawamura,A., Savitsky,P., Yapp,C., Szykowska,A.,
            Wu,N., Bountra,C., Strain-Damerell,C., Burgess-Brown,N.A.,
            Ruda,G.F., Fedorov,O., Munro,S., England,K.S., Nowak,R.P.,
            Schofield,C.J., La Thangue,N.B., Pawlyn,C., Davies,F., Morgan,G.,
            Athanasou,N., Muller,S., Oppermann,U. and Brennan,P.E.
  TITLE     Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of
            H3K4me3 at Transcription Start Sites and Proliferation of MM1S
            Myeloma Cells
  JOURNAL   Cell Chem Biol 24 (3), 371-380 (2017)
   PUBMED   28262558
REFERENCE   5  (bases 1 to 10824)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 10824)
  AUTHORS   Audenet,F., Yates,D.R., Cancel-Tassin,G., Cussenot,O. and
            Roupret,M.
  TITLE     Genetic pathways involved in carcinogenesis of clear cell renal
            cell carcinoma: genomics towards personalized medicine
  JOURNAL   BJU Int 109 (12), 1864-1870 (2012)
   PUBMED   22035299
  REMARK    Review article
REFERENCE   7  (bases 1 to 10824)
  AUTHORS   DiTacchio,L., Le,H.D., Vollmers,C., Hatori,M., Witcher,M.,
            Secombe,J. and Panda,S.
  TITLE     Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and
            influences the circadian clock
  JOURNAL   Science 333 (6051), 1881-1885 (2011)
   PUBMED   21960634
REFERENCE   8  (bases 1 to 10824)
  AUTHORS   Abidi,F.E., Holloway,L., Moore,C.A., Weaver,D.D., Simensen,R.J.,
            Stevenson,R.E., Rogers,R.C. and Schwartz,C.E.
  TITLE     Mutations in JARID1C are associated with X-linked mental
            retardation, short stature and hyperreflexia
  JOURNAL   J Med Genet 45 (12), 787-793 (2008)
   PUBMED   18697827
REFERENCE   9  (bases 1 to 10824)
  AUTHORS   Kim,T.D., Shin,S. and Janknecht,R.
  TITLE     Repression of Smad3 activity by histone demethylase SMCX/JARID1C
  JOURNAL   Biochem Biophys Res Commun 366 (2), 563-567 (2008)
   PUBMED   18078810
REFERENCE   10 (bases 1 to 10824)
  AUTHORS   Iwase,S., Lan,F., Bayliss,P., de la Torre-Ubieta,L., Huarte,M.,
            Qi,H.H., Whetstine,J.R., Bonni,A., Roberts,T.M. and Shi,Y.
  TITLE     The X-linked mental retardation gene SMCX/JARID1C defines a family
            of histone H3 lysine 4 demethylases
  JOURNAL   Cell 128 (6), 1077-1088 (2007)
   PUBMED   17320160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Apr 18, 2023 this sequence version replaced XM_039100480.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.65156.1,
                                           SRR26643299.67725.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               JAXUCZ010000021.1  24824874-24825337
            465-542             JAXUCZ010000021.1  24828808-24828885
            543-665             JAXUCZ010000021.1  24830902-24831024
            666-836             JAXUCZ010000021.1  24831301-24831471
            837-971             JAXUCZ010000021.1  24832666-24832800
            972-1095            JAXUCZ010000021.1  24835191-24835314
            1096-1277           JAXUCZ010000021.1  24835420-24835601
            1278-1436           JAXUCZ010000021.1  24836571-24836729
            1437-1556           JAXUCZ010000021.1  24838521-24838640
            1557-1715           JAXUCZ010000021.1  24838751-24838909
            1716-1897           JAXUCZ010000021.1  24842936-24843117
            1898-2060           JAXUCZ010000021.1  24843213-24843375
            2061-2180           JAXUCZ010000021.1  24850238-24850357
            2181-2375           JAXUCZ010000021.1  24850464-24850658
            2376-2557           JAXUCZ010000021.1  24854701-24854882
            2558-2682           JAXUCZ010000021.1  24854961-24855085
            2683-2830           JAXUCZ010000021.1  24855223-24855370
            2831-2936           JAXUCZ010000021.1  24855810-24855915
            2937-3295           JAXUCZ010000021.1  24856499-24856857
            3296-3434           JAXUCZ010000021.1  24857443-24857581
            3435-3614           JAXUCZ010000021.1  24858029-24858208
            3615-3752           JAXUCZ010000021.1  24858368-24858505
            3753-4334           JAXUCZ010000021.1  24858684-24859265
            4335-4413           JAXUCZ010000021.1  24859551-24859629
            4414-4613           JAXUCZ010000021.1  24859766-24859965
            4614-10824          JAXUCZ010000021.1  24860213-24866423
FEATURES             Location/Qualifiers
     source          1..10824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq13"
     gene            1..10824
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /note="lysine demethylase 5C"
                     /db_xref="GeneID:317432"
                     /db_xref="RGD:1560601"
     exon            1..464
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..4979
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /EC_number="1.14.11.67"
                     /note="lysine (K)-specific demethylase 5C"
                     /codon_start=1
                     /product="lysine-specific demethylase 5C"
                     /protein_id="NP_001406701.1"
                     /db_xref="GeneID:317432"
                     /db_xref="RGD:1560601"
                     /translation="MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGIC
                     KIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKI
                     PNVERRILDLYSLSKIVVEEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERI
                     VYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQP
                     DPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKNLRKKDKEGPECPPTVVVKEE
                     LGGDVKMESASPKTFLEGKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGD
                     EDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREY
                     TLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFG
                     SGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVF
                     SAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQ
                     LVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLP
                     AGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRK
                     ALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKC
                     SSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALE
                     SEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAGPDRVAGVQMTLAELQDF
                     LGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVE
                     VPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLVAGASVAPSPAVDKAQAE
                     LQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIPVHLPNIQSLKEALAKAR
                     AWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKT
                     FLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSV
                     IVAFKEGEQKEKEGILQLRRTNSAKPSPLASLTTNSSTASICVCGQVPAGVGALQCDL
                     CQDWFHGRCVTVPRLLSSQRSSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALL
                     VALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESK
                     PEESLAYSSDGGDGTGNMPKVQGLLENGDSVTSPEKVATEEGSGKRDLELLSSLLPQL
                     TGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLKRVQTLLELEK
                     AERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEE
                     ETGGEVPPVPFPNNGSPSTQEDQDGLEPVLDAGSDTSAPFSTLTSRLLMSCPQQPSLQ
                     QL"
     exon            465..542
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            543..665
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            666..836
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            837..971
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1095
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1277
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1436
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1556
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1715
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1897
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2060
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2180
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..2375
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2557
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2682
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2830
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2936
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3295
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            3296..3434
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3614
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3752
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            3753..4334
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4413
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            4414..4613
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
     exon            4614..10824
                     /gene="Kdm5c"
                     /gene_synonym="RGD1560601"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaaaccaa gatggcggtg gcagcgatga aacctgcggc gactggcact tacctgtagt
       61 agtgaaggct tcaatagttg ggaggcagcg gtagggtttg gaagaaacgg aacaagacta
      121 agaaccggta atcggaatct cagcctgaga cttttagagc acggcacccg ccccccaagc
      181 ccttgacggg cggtggccgt cctgcttagg gcctagactc tgagaagtgc atcggtttca
      241 gacagcggcg gcgccatgag tccttaaggg cggcctgagc cctccggatc tctggcccag
      301 ccctcgggcc caccatggag ctggggtccg acgatttcct accgccgccg gagtgtccgg
      361 tgttcgagcc tagctgggcc gagttccgag accctctagg ctacatcgcg aaaatcagac
      421 ccatcgccga gaagtccggc atttgcaaga tccgcccacc cgcggactgg cagccaccct
      481 ttgctgtgga agtggacaac ttcaggttta ccccccgaat ccagaggttg aatgagctgg
      541 aggcccagac aagagtgaaa ctgaactatt tggaccagat tgccaaattc tgggagatcc
      601 agggctcatc cttaaagatt cccaatgtag aacggcggat cttggacctc tatagcctca
      661 gcaaaattgt ggtggaagaa ggtggttatg aaactatctg caaggaccgt cgatgggccc
      721 gtgtggccca gcgcctcaac tatccacctg gcaaaaacat tggttccttg ctacgctctc
      781 actatgaacg tattgtttat ccctatgaaa tgtaccagtc tggagccaac cttgtgcagt
      841 gtaacacacg cccatttgat aatgaggaaa aggacaagga atataaaccc cacagcatcc
      901 cccttcgaca gtctgtgcag ccttccaagt tcaacagtta tggacgacgg gcaaagagac
      961 tacagccaga tccggaaccc acagaggaag acattgaaaa gaatccagaa ttgaagaagc
     1021 tacagatata tggagcaggt cccaagatga tgggactggg cctgatggcc aaggataaga
     1081 atctgcggaa aaaagataaa gaagggcctg agtgtccccc cactgtggtg gtaaaggagg
     1141 aattaggtgg ggatgtcaag atggaatcag cctcacccaa gactttccta gaaggcaagg
     1201 aggaactgag tcacagccct gagccctgca ccaagatgac catgagacta cgaaggaacc
     1261 acagcaatgc ccagtttatt gagtcatatg tatgccgaat gtgttcccga ggagatgaag
     1321 atgacaaact cttactgtgt gatggctgtg atgacaatta ccacatcttt tgcctgctgc
     1381 ctcctttgcc tgaaatcccg aaaggtgtct ggaggtgtcc aaagtgtgtc atggcggagt
     1441 gtaagcggcc ccctgaagcc tttggctttg agcaagctac ccgggaatat actcttcaga
     1501 gctttggaga gatggctgac tcctttaaag cagactactt caacatgcct gtgcatatgg
     1561 tacccacaga acttgtagag aaggagttct ggcggctggt gaatagcatc gaggaagacg
     1621 taactgtgga gtatggggct gacatccatt ccaaagaatt tggcagcggt ttccctgtca
     1681 gtgacagtaa gcggcaccta accccagagg aggaggagta tgccacaagt ggctggaacc
     1741 tgaatgtgat gcctgtgttg gagcagtctg tactgtgcca catcaatgca gatatatctg
     1801 gcatgaaggt accatggctg tatgtgggaa tggtcttctc agccttttgc tggcatatcg
     1861 aggatcattg gagttactct attaactacc tccactgggg tgagccaaaa acctggtatg
     1921 gagtcccatc gcttgcagca gaacacttgg aagaagtgat gaagaagctg acaccagagc
     1981 tttttgatag ccagcctgat ctccttcacc aacttgttac tctcatgaat cctaacacac
     2041 tcatgtccca tggtgtgccg gttgttcgca caaaccagtg tgcaggagaa tttgtcatca
     2101 cttttcctcg tgcttaccac agtggtttca accaaggcta caactttgct gaagcagtca
     2161 acttttgcac tgctgactgg ctgcctgctg gacgccagtg cattgagcac taccgacgac
     2221 tacgaagata ctgtgtcttt tctcatgagg agctcatttg caagatggct gcctgccctg
     2281 agaagctgga cctgaacctg gcagcagctg tacataagga gatgttcatt atggtgcagg
     2341 aggagcggcg tctacgaaag gctctgttgg aaaagggtat caccgaggct gagcgagagg
     2401 cttttgagct gcttccagat gatgaacgtc agtgcataaa gtgcaagacc acatgtttcc
     2461 tatctgccct ggcttgctat gactgcccag atggccttgt ctgcctttct cacatcaatg
     2521 acctctgcaa gtgctccagt agccgccagt accttcggta ccggtacacc ttggatgagc
     2581 tccctgctat gctgcataaa ctcaaagttc gagctgagtc ctttgacacc tgggctaaca
     2641 aagtacgagt agccctggag gtggaagatg ggcggaagcg cagcctggaa gaactgagag
     2701 cactagaatc tgaggctcgt gagcgaaggt ttcctaacag tgagcttcta cagcgactga
     2761 agaactgcct gagtgaggca gaggcttgtg tgtcccgggc tctgggattg gtcagtggcc
     2821 aggaagctgg ccctgacagg gtggctggtg tacagatgac tctggccgag ctacaggatt
     2881 ttctgggcca gatgaacaac ctaccctgtg ccatgcacca gattggggat gtcaagggta
     2941 ttctggaaca ggtggaagcc taccagactg aggcccgtga ggccctggtc tcacagccct
     3001 ccagtccagg gctgctgcaa tccctattgg agagagggca gcagctgggt gtggaggtac
     3061 ctgaagccca gcagctccaa aggcaggtgg aacaggctcg gtggctggat gaggtaaaac
     3121 gcacgctggc tccctctgcc cgaaggggta ccctggccat catgcgggga ctgttggttg
     3181 cgggcgccag tgtagcccct agccctgctg tggataaggc ccaggcagag cttcaggagc
     3241 tgctgaccat cgctgaacgc tgggaagaga aagcccacct ctgcttagag gccaggcaga
     3301 agcatccacc agccacactt gaggccataa tccatgaagc agaaaacatc ccggttcatc
     3361 tgcccaatat ccagtctctc aaggaggctc ttgctaaggc ccgagcatgg attgctgatg
     3421 tggatgagat ccaaaatggt gaccactacc cttgtttgga tgacttggag ggccttgtgg
     3481 ctgtgggtcg ggacctccct gtggggctgg aggaactgag acagctagag ctgcaggtac
     3541 tgacagcaca ctcctggaga gaaaaggcct ccaagacctt cctcaagaag aactcctgct
     3601 acactttatt ggaggtgctc tgcccgtgtg cagacgccgg ctcagacagc accaaacgca
     3661 gccggtggat ggagaaggag ctggggttgt acaaatctga cacagagctg ttggggctgt
     3721 ctgcgcagga cctcagggac ccaggctctg tgatcgtggc cttcaaagag ggggagcaga
     3781 aggagaagga agggatccta cagcttcgtc gtaccaactc agccaagcca agtccactgg
     3841 catcgttgac aacaaactcg tctacagctt ctatctgcgt gtgtgggcaa gtgccagctg
     3901 gggtgggagc tctgcagtgt gacctgtgtc aggactggtt ccatgggcgc tgtgtgacag
     3961 taccccgcct cctcagctcc cagaggtcca gtcttacctc atccccactg ctggcctggt
     4021 gggaatggga caccaaattc ttgtgccctc tgtgtatgcg ctcacggcgc ccacgcttgg
     4081 aaaccatcct ggcactgctg gtagccctac agagactgcc tgtacggctg cctgagggtg
     4141 aggctctaca gtgcctcaca gagagagcca tcagctggca aggccgtgcc aggcaggttt
     4201 tggcctctga ggaagtgact gctctgttgg gacggctggc tgaactccgc caacggctac
     4261 aggctgaatc caagcctgag gaatccctgg cctactcttc agatggtgga gatggcactg
     4321 gcaatatgcc taaggtccag gggctgttgg agaatgggga cagtgtgacc agtcctgaaa
     4381 aggtagccac agaggagggc tcaggtaaga gagatctgga gctgctatcc tcgctattac
     4441 cacagttgac tggccctgtg ttggaactgc ctgaggcaac ccgagcccca ctagaggaac
     4501 ttatgatgga aggggatctg cttgaggtga ccttagatga gaatcatagc atctggcagc
     4561 tgctgcaggc tgggcagcct ccagacttga agagggtcca gacacttctg gagctggaga
     4621 aggcagagcg ccatgggagt cggacacgag gccgagccct agagaggaga cggcggagga
     4681 aggtggatcg gggtggggag cccgatgatc cggcacgaga ggagctagag ccaaagaggg
     4741 tacggagctc aggaccagaa gccgaggaag tccaggagga agaggagctg gaggaggaga
     4801 ctgggggtga ggtccctcct gtacccttcc ccaacaatgg cagtcccagc acccaggagg
     4861 accaggatgg cttagaacca gtgttagacg ctggttctga cacctcagcc cctttctcta
     4921 ctctgacttc ccggctgttg atgtcctgcc cacagcagcc atctctgcaa caattgtgac
     4981 aatggctgag cctagcacag accccaacaa agatccttcc ttggcctcaa ggatcctttc
     5041 tgaccatcaa gcctgcttct tggaggtggg cgggtaggtg gagagactcc cccctcacca
     5101 ccatccccaa gaccgtgact tttatattct gactccaagg tattgttcag acctcagctc
     5161 ctgggggccg gcccctggag tcctgcgtcc ctggtaacct ctaaccagca ttcccagaca
     5221 ccagaggcag atagacaggt gggcagggga tctactgggg ctgggccagc accattccag
     5281 agacaaatcc agggcacatg caaactgggg gacctctccc ttatccccag ttctgaccct
     5341 gggttaggcc atgctacact aaccttccct ctccacctca cacttttgcc tccctctcca
     5401 ttttacttct ttcctctccc cttcatcttt tcccttaccc ttactgttcc acccaggagg
     5461 aggaaacttc acatagctgt cctcaccttt tattttaaat gaattttgtt ggggttgagc
     5521 ggggctgcct atggtctgaa ggcttttggt gcttgtccac acacccacct caacccttcc
     5581 tgcccatcct cctctatctc ctttcctcct cctgggttca tgctgtaata aagaagattg
     5641 ttggtgtgta attaatttgt tcaaaaggag aagaaaaagc aaaacaaaaa actttgtttc
     5701 aactaaagcc tattttaatt ttattttatt attttcctca ttagaaataa aacccttagg
     5761 aatgtttttt tttggaaaca tgtttctgaa gtgcatttct cttcaaaaag agcagcccct
     5821 tcctcgcctg ttaatggagc agttgcaatg ctagttagtg gtagtgccag ggccagggaa
     5881 gcagggctct gaatttaaat cttaccaact tctctctaac cttggaaaag atatccagtt
     5941 cctcccccca agccattccc ttgtcttcag actggtgggt actggtccct tttgataatt
     6001 tgcacagcag cttctgctag ctgtgtgctc ttaattttct gttctctggg ggacttttct
     6061 tcatggcttt attgaggtag agtttccatg ctataaaatt cagctgtttt aaatatgtaa
     6121 tttggtgagt cagaccatcc ttgatgtttc tccattagtt ctttctgccc ttaatgaatg
     6181 tgtggttaat ttgtaatttc tgtgtcactg ttaactgctc tattgagatg aaatttgcat
     6241 agcatccagt ttatccactt aaagtataca attcagtgac ttttagttta tttcagtcat
     6301 tgaatgaatc atcactgcaa aaaaaatttt agaatgtttt tacaaccctc agaagaaacc
     6361 ccacattgcc taggtattcc ctccctactc ccatttgtct cttctggaca ttttatataa
     6421 atgaaattat acaatatgtg atccttttgt gtctggcttc tttgacttgg catagtagct
     6481 tcaagcctat tagtagtcct acagtagtta tattttcatc cttctgagcc tgaaagatga
     6541 agggactatg cttgaccagg gactgacctc ctgaaatacg tttatacatg tttttgtggg
     6601 tatcttatgt gcatctttct cagattaaga cccaccagat tgcatcgtat ttataaagga
     6661 accataaccc tctaaagact aagaaacatt tttatggttc tgagagttct ctgtctggag
     6721 tttacctagg aggtagagga aaaagcaaaa gcttggaggc cctgcttcac tggctaactt
     6781 ccaggcatcc ctggcttttc ctaagttttt cctcttctca aggttgtata aggtgttaca
     6841 gactaaagtc aaatcttgat ccctagctca ggaactcagc acaccagcac tcttactttg
     6901 cccttcctca tttatatctt cagaggatta ttttgctcca tttctcccct ttcccaggat
     6961 ttccagttgc tagaaatcta gtgatatatc tcaccctctt ggggtggctt tcaggggtgg
     7021 gagcatggct ttagacctac ctgccttatg cagtcttttt agtctatgtt gaaaggtaaa
     7081 caccagtaaa cagtgaatat ccctgccctg ggatattccc ctgggtccat tttgatacta
     7141 agtttcaatc aagggtcttt tgcccagcca ttggaattaa tcatggtttc caataagagt
     7201 tggagatagc agaagagaca cccaaaggaa cttgatcttg acattttact accactctac
     7261 tccaggaagc caggcacagc acaggaagaa gtggccaaag gaaaggtaaa gatggtgcct
     7321 acaacctaca gcaactccta ggctagtgaa ctgctcaggc caaggtaggg gtcctttgtg
     7381 gtatgggcct gccccttacc aagttccaga cagccttttt cagttagccc ttccttccct
     7441 gccatatccc ttatacactt tccgccctct tcacagtgta catgtagcca ttagtgaagc
     7501 aaaactgtct taattaggtt tctgttgctg tgataaaacc gaaagaactt gggggagaaa
     7561 gtgtttattt catcttacac cttgtagtcc atccagagaa gaaagcagga acctggaggc
     7621 aggagctgct gcagaggcca tggaggggtg ctgcttactg gcttgctcat catgacttgc
     7681 tcagcctaca tatggtaccc aggaccacca gcccagggat ggcacggccc acagtgagct
     7741 aggtcctact atatcagtca tcaatcaaaa aaaatgtacc ctgggctgtc caatctgatg
     7801 ggggcatttt ctcaattggg ttttccctct ttgtccaaga aagcaccaaa tgagtgggca
     7861 agttttacct cagagtcatt tagtttacag attccatctt gctgctacat cctaccagac
     7921 agttccactc ctgtcaggat agcacctgag tatgcaggga tggaaagaga taactgcttc
     7981 tattaaggac aaatctccct cctcccctga cccccattct cctcttactg agacagaacc
     8041 tgtatccctg gctgtcctgg aactcactgt gtagaccagg ctagcctcaa actcataggg
     8101 atctgcctgt ctctgcctcc tgagtgcttg gattaaagct gtgccaccac atccagcatc
     8161 taagttcctc ctttggccca actgtgcatt tcttcctgtc tctagctttt ccatgcctcc
     8221 actgtgcctt aaatcatgtc caaaacacta ggtttaatgg ttctttaacc cacttaccta
     8281 ttctgagagt tcctggagga gaaaaacaag aaccaggtct gagtcctctg ctaattcaag
     8341 gctgagagtt gggaggtggg aatgaattgt gtatggtcag ttcagatcaa gcagcatttc
     8401 caactctaca gtgcatgtga attctgttcg ttatgcactg tatgaagtct gatgatccaa
     8461 gatgactgaa tctggaccat gatcaccaga gccctgaaag agaaacatta accatctgtc
     8521 ctagaagacc taaatttagg gggtgcttaa atcctgggtg ccacactcca tgtaagatac
     8581 ttggcaaagt tcttagtaca caaggaatag gcccctagta taataggctg ggcccagcca
     8641 aaactcacca aagttgtgac tcccaatttc catgcaaaaa tacaataaag ccctacttat
     8701 atcagaaggg gtctaagtaa ttggcatgtt catggtagaa atttactgtt agtaaactgg
     8761 ggcatcagca atactggtta ggtgggtaga agccagtatt gctattgttc tgtggaatca
     8821 ttcccatgcc tgtctgtgtt aggtatgtat tgccaaaaga cagtaatatg gctgacatat
     8881 ttatctaatc tctaaaacaa aactatggag gtaaatgcag gaagattgca aatttgaagc
     8941 tagttgagtt gtagagtggg accctgtctc aaacaaaagc caaaactgcc ataaagcaac
     9001 atttagctga cttcaaggtc attcacaggc atcaatcaag gtgtcagcca gcacagctga
     9061 catctccagg cttactgggc taggatgtgt tggctctttg caggagtcag tttctcactg
     9121 gctgttgaac aggttcagtc agtttcttga atgtggggtg gaccttttca caggggagct
     9181 cacaatatgg ctgcttgttt catgagatca agatgggcaa gagtcagaaa tgacatttca
     9241 tcatttttac aattgacgat attcattaga agccattagg aggaagaaag gagggaagat
     9301 ctagaccata ttcagaagga aggaattaag aggatggggt ttgttgaggg tcatcttgga
     9361 gatgaactat tatgatttac tctgataatt attcatgtcc cttccatgta caaaatatat
     9421 ttactcctta agttctttta agtcacatcc cattacaaca tatcctcaaa ggtgctaaat
     9481 atgaatgaat tgccttgtgc ataatcccta catatggctc aagtactgtt ttctctctat
     9541 ggctagagct gtgaaactta aaaacacgag ttgtccatcc ctaccacttc ctaatataca
     9601 atggagggaa ggcatataca aacattccag ttcaaaaagg gcaaaggata tgtgtatgcc
     9661 tctggcaatt gaagctacta atctgttaca agttaaatcc agctgggcaa atgaagttcc
     9721 ttgaattggt tccaaggtgg gacgattttt catactgttt tctgggctct tgctgttacc
     9781 tgtgcttttt caggagaagt agcacatgtt tgcgatggga aatttttttc tctactgttt
     9841 actgccagaa ttttggagga ccagtgactt cttgcagagc atgtgtcatc agttaccatc
     9901 aagacaaagg gctttgactt cttttgggca tgttgatcat tcagcagtaa actagaatga
     9961 gattggcctt cagggcaacc ctgacttaga gtccgccatc atggccactt tgttcagaag
    10021 ccaacaggca gataaaagtg acaggataga gattagccac acccatagaa tgggatatca
    10081 cgtttgcgat cttccatagt ggtgcttctt tatttgggtc atgaaaattc tcacattctg
    10141 ctcattccaa gatggccagc tatacacata ggccttttcc ctcagatgtc tcttcaacat
    10201 ttcagtcttg ttcttcccta atccttgact gcagacatga atccgtaagc tatctatgct
    10261 tttgactgtt tctgtgatag taattttaat caacccaaag tggatctgta attctgaaat
    10321 tagccacttg tagccgacac cagcatgtcc cgcagaacat ctataagcga aggttgaata
    10381 ttgtatccct tagttgtctg gtctcaagga accccctatg gggtctcaga ggacaggaaa
    10441 aaaagggtga caatgtagca agtgtgcatt tccagacctt cacataattg ggcagacctg
    10501 ataaaatagt taatgcaaat tactatttga tgtcatgtgc tcagatgttc atgagaaaat
    10561 aagtctactt ttctattttt atctttcttt gcttctgaga tcttgctgct tgcagtctta
    10621 ctctccattt ttgtttgttt tgtcttatac atatgttgta tcttgggcca gtgaggtggc
    10681 ccagtgggta aaagcacttg ctacacaagc ctggtggcct gaattcaatc ccagggatcc
    10741 acataagaga gaatcgattc atgcaagttg tcttgtgtgt acgctcgcac acataaatag
    10801 atgtaataaa aatacttttt aaaa
//
