LOCUS       NM_001107177            6276 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lysine demethylase 5B (Kdm5b), mRNA.
ACCESSION   NM_001107177 XM_001062221 XM_001062340 XM_239761
VERSION     NM_001107177.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6276)
  AUTHORS   Wang,B., Tan,Y., Zhang,Y., Zhang,S., Duan,X., Jiang,Y., Li,T.,
            Zhou,Q., Liu,X. and Zhan,Z.
  TITLE     Loss of KDM5B ameliorates pathological cardiac fibrosis and
            dysfunction by epigenetically enhancing ATF3 expression
  JOURNAL   Exp Mol Med 54 (12), 2175-2187 (2022)
   PUBMED   36481938
REFERENCE   2  (bases 1 to 6276)
  AUTHORS   Liu,S.X., Barks,A.K., Lunos,S., Gewirtz,J.C., Georgieff,M.K. and
            Tran,P.V.
  TITLE     Prenatal Iron Deficiency and Choline Supplementation Interact to
            Epigenetically Regulate Jarid1b and Bdnf in the Rat Hippocampus
            into Adulthood
  JOURNAL   Nutrients 13 (12), 4527 (2021)
   PUBMED   34960080
  REMARK    GeneRIF: Prenatal Iron Deficiency and Choline Supplementation
            Interact to Epigenetically Regulate Jarid1b and Bdnf in the Rat
            Hippocampus into Adulthood.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6276)
  AUTHORS   Li,Y., Liu,S., Zhang,Y., Gao,Q., Sun,W., Fu,L. and Cao,J.
  TITLE     Histone demethylase JARID1B regulates proliferation and migration
            of pulmonary arterial smooth muscle cells in mice with chronic
            hypoxia-induced pulmonary hypertension via nuclear factor-kappa B
            (NFkB)
  JOURNAL   Cardiovasc Pathol 37, 8-14 (2018)
   PUBMED   30172777
REFERENCE   4  (bases 1 to 6276)
  AUTHORS   Tumber,A., Nuzzi,A., Hookway,E.S., Hatch,S.B., Velupillai,S.,
            Johansson,C., Kawamura,A., Savitsky,P., Yapp,C., Szykowska,A.,
            Wu,N., Bountra,C., Strain-Damerell,C., Burgess-Brown,N.A.,
            Ruda,G.F., Fedorov,O., Munro,S., England,K.S., Nowak,R.P.,
            Schofield,C.J., La Thangue,N.B., Pawlyn,C., Davies,F., Morgan,G.,
            Athanasou,N., Muller,S., Oppermann,U. and Brennan,P.E.
  TITLE     Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of
            H3K4me3 at Transcription Start Sites and Proliferation of MM1S
            Myeloma Cells
  JOURNAL   Cell Chem Biol 24 (3), 371-380 (2017)
   PUBMED   28262558
REFERENCE   5  (bases 1 to 6276)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 6276)
  AUTHORS   Xiang,Y., Zhu,Z., Han,G., Ye,X., Xu,B., Peng,Z., Ma,Y., Yu,Y.,
            Lin,H., Chen,A.P. and Chen,C.D.
  TITLE     JARID1B is a histone H3 lysine 4 demethylase up-regulated in
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 104 (49), 19226-19231 (2007)
   PUBMED   18048344
REFERENCE   7  (bases 1 to 6276)
  AUTHORS   Iwase,S., Lan,F., Bayliss,P., de la Torre-Ubieta,L., Huarte,M.,
            Qi,H.H., Whetstine,J.R., Bonni,A., Roberts,T.M. and Shi,Y.
  TITLE     The X-linked mental retardation gene SMCX/JARID1C defines a family
            of histone H3 lysine 4 demethylases
  JOURNAL   Cell 128 (6), 1077-1088 (2007)
   PUBMED   17320160
REFERENCE   8  (bases 1 to 6276)
  AUTHORS   Patsialou,A., Wilsker,D. and Moran,E.
  TITLE     DNA-binding properties of ARID family proteins
  JOURNAL   Nucleic Acids Res 33 (1), 66-80 (2005)
   PUBMED   15640446
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 6276)
  AUTHORS   Tan,K., Shaw,A.L., Madsen,B., Jensen,K., Taylor-Papadimitriou,J.
            and Freemont,P.S.
  TITLE     Human PLU-1 Has transcriptional repression properties and interacts
            with the developmental transcription factors BF-1 and PAX9
  JOURNAL   J Biol Chem 278 (23), 20507-20513 (2003)
   PUBMED   12657635
REFERENCE   10 (bases 1 to 6276)
  AUTHORS   Lu,P.J., Sundquist,K., Baeckstrom,D., Poulsom,R., Hanby,A.,
            Meier-Ewert,S., Jones,T., Mitchell,M., Pitha-Rowe,P., Freemont,P.
            and Taylor-Papadimitriou,J.
  TITLE     A novel gene (PLU-1) containing highly conserved putative
            DNA/chromatin binding motifs is specifically up-regulated in breast
            cancer
  JOURNAL   J Biol Chem 274 (22), 15633-15645 (1999)
   PUBMED   10336460
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473958.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_239761.4, XM_001062340.1, XM_001062221.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132270,
                              SAMD00132271 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..6276
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..6276
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /note="lysine demethylase 5B"
                     /db_xref="GeneID:304809"
                     /db_xref="RGD:1565602"
     exon            1..370
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..4801
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /EC_number="1.14.11.67"
                     /note="Jumonji, AT rich interactive domain 1B (RBP2-like);
                     jumonji, AT rich interactive domain 1B (Rbp2 like); lysine
                     (K)-specific demethylase 5B"
                     /codon_start=1
                     /product="lysine-specific demethylase 5B"
                     /protein_id="NP_001100647.1"
                     /db_xref="GeneID:304809"
                     /db_xref="RGD:1565602"
                     /translation="MEPATALPPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFAD
                     PFAFIHKIRPIAEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLN
                     FLDQIAKYWELQGSTLKIPHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMG
                     FAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKPNLTSDTKDKEYKPHDIPQRQS
                     VQPSETCPPARRAKRMRAEAMNIKIEPEEATEARTHNLRRRMGCATPKRENEKEVKST
                     IKQEPTEKKDCVLESEKDKPKSRAKKTATAVDLYVCLLCGSGNDEDRLLLCDGCDDSY
                     HTFCLLPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMADAFKSD
                     YFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKISPE
                     EEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSI
                     NYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEV
                     PVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRY
                     CVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDF
                     ELLPDDERQCIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDD
                     LYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLR
                     HLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQSQLTVNELRQFVTQLCALPCVL
                     SQTPLLKDLLNRVEDFQQQSQRLLSEERPRASELQQLLDVSFTFDVELPQLAEMRIRL
                     EQARWLEEVQQACLDSSSLSLDDMRRLIDLGVGLAPYSAVEKAMARLQELLTVSEHWD
                     DKAKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTVLKDSVQKARDWVQDVDALQAG
                     GRVPVLETLIELVARGRSIPVHLNSLPRLEMLVSEVHAWKESAAKTFLLENSPYSLLE
                     VLCPRCDIGLLGLKRKQRKLKDPLPSGKKRSTKLESLSDLERALTESKETASAMATLG
                     EARLREMEALQSLRFANEEKLLSPAQDVETKVCLCQKTPATPMIQCELCRDAFHTSCV
                     AVSSISQSSRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNW
                     QHRAQQLLSSGNLKLVQDQAGSGLLFSRWPASAGTASAADKVSQPPGTTSFSLPEDWD
                     NRTSYLHSPFSTGQSCIPLHGLSPEVNELLMEAQLLQVSLPEVQELYQTLLTKPSSAQ
                     QADRSSPVRPSSEKNDCLRGKRDAINSLERKLKRRPEREGLPSERWDRVKKMRTPQKK
                     KIKLSHPKDMNNFKLERERSYDLVRNAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQ
                     PEGDEVDWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTGKDAPSRK"
     exon            371..448
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            449..571
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            572..742
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            743..877
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            878..974
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1084
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1243
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1363
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1522
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1704
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1867
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1987
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2182
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2364
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2489
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2640
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2755
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..3111
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3250
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3430
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3589
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..4075
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4187
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            4188..4342
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4663
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..6276
                     /gene="Kdm5b"
                     /gene_synonym="Jarid1b; RGD1565602"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caagacgtcg tcggaggaag gctgaaaaag ccctaggtgt tgccgttgct agtagaagtc
       61 ggacttgtcg cccgagctgt gcgtgtgcac aggtttcgga cggagcggag ctcgctgccg
      121 cggttgcgga gcttgccctg tgctcgcccc tgcccacgtc gcggtgatgg agccggccac
      181 cgcgctgccc ccaggcccgc gcccggcgct gccccttggg ggccccggcc cgctgggaga
      241 gttcctgcct ccccccgagt gtccggtctt cgagcccagc tgggaagagt tcgcggaccc
      301 cttcgctttc atccacaaga tccggcccat agccgagcag actgggatct gtaaggtgcg
      361 gccgccgccg gattggcagc caccattcgc ttgtgatgtt gataaacttc attttacccc
      421 gcgtatccag aggcttaatg agctggaggc ccaaacacgt gtaaaattga acttcctgga
      481 ccagattgcc aagtattggg agctacaggg aagtactctg aagattcctc atgtggagag
      541 aaagatctta gacttgttcc agctaaataa gttagttgca gaggaaggtg ggtttgcagt
      601 tgtttgcaag gacagaaaat ggaccaaaat tgccaccaag atgggttttg ctcctggtaa
      661 agcagtgggc tcacatatca ggggacatta tgagcgaatc ctcaatccgt acaatttgtt
      721 cctatctggg gacagcctga ggtgtcttca gaagcctaac ctgacctcgg acacaaagga
      781 caaggagtac aaaccccatg atattcccca gaggcagtct gtgcagccct cagaaacctg
      841 ccctccggcc cgccgagcaa agcgcatgag agcagaggct atgaatatta aaattgagcc
      901 agaagaggca acagaagcca ggactcataa cctgaggcgc cgaatgggct gtgccactcc
      961 aaaacgggaa aacgagaaag aagtgaaaag taccatcaag caagaaccca ccgagaagaa
     1021 agactgtgtg ttagaaagtg agaaggacaa gcccaagagc cgtgccaaga aaaccgccac
     1081 tgctgtggac ctgtatgtgt gcctcttatg tggcagcggc aatgacgagg accggctgct
     1141 cctgtgtgac ggctgtgacg acagttacca caccttctgc ctgcttcccc ctctccatga
     1201 tgttcccaag ggagactgga ggtgtcctaa gtgtttggct caagagtgta gtaagccaca
     1261 agaagctttc ggctttgaac aggctgcaag ggactataca ctccgtacgt ttggggaaat
     1321 ggcagatgca ttcaaatctg attacttcaa catgccggtc catatggttc ccacagagct
     1381 ggtggagaag gagttttggc ggctggtaag cactattgaa gaagacgtca ccgtggagta
     1441 tggagctgat attgcttcaa aagagtttgg cagtggcttt cctgttcgag atggcaaaat
     1501 caagatttct cctgaggaag aggagtatct tgatagtggc tggaatttga ataacatgcc
     1561 agtgatggag cagtctgtcc ttgctcacat tactgctgat atatgcggca tgaaactgcc
     1621 ttggttgtat gtgggcatgt gcttttcttc cttctgttgg catatcgaag accactggag
     1681 ctattcaatc aactacctgc actggggtga gccgaaaacc tggtatggag ttccaggata
     1741 tgctgctgag cagcttgaaa acgtaatgaa gaagctggct ccagagctct ttgtgtccca
     1801 gccagacctc ctccaccagc ttgtgacgat catgaacccc aatacgctga tgactcacga
     1861 agtgcctgtg tatcgaacga atcagtgtgc tggggagttt gtcattacgt tcccgagagc
     1921 ctaccacagt ggcttcaatc aaggctttaa ttttgctgag gcagttaact tctgcactgt
     1981 tgattggctg ccgttgggcc gccagtgcgt ggagcattat cgcctgctgc accgctactg
     2041 cgtcttttcc catgatgaga tgatatgcaa gatggcttcc aaggctgatg tgttagacgt
     2101 ggtagtggca tccactgttc agaaggacat ggccatcatg attgaggatg aaaaggcttt
     2161 aagggaaact gtccgtaaac tgggagtgat tgattctgag agaatggact ttgagctgtt
     2221 gcccgatgat gagcggcagt gtataaagtg caaaactacg tgcttcatgt ctgccatctc
     2281 ctgctcctgt aaacctggcc tgcttgtttg cctgcatcat gtcaaagagc tgtgctcctg
     2341 tcccccttac aagtataacc tgcggtatag atacactctg gatgatctct atccgatgat
     2401 gaatgcgttg aagcttcgag cagagtcgta caatgaatgg gccttaaatg tgaatgaagc
     2461 cttggaagca aagattaata agaagaaaag tctcgtcagc tttaaagctt tgattgaaga
     2521 atcagaaatg aagaaattcc cagacaatga tcttttgcgt caccttcgcc tagttacgca
     2581 ggatgcagaa aagtgtgcct ctgttgccca gcagttgctt aatggcaaaa ggcaaacgag
     2641 gtatcgatct ggtggaggga agtctcagag tcagctgaca gtgaatgagc ttcggcagtt
     2701 cgtgactcag ctgtgcgctc ttccctgcgt ccttagtcag acaccactgc taaaggatct
     2761 cttgaatcgt gtggaagatt tccagcagca aagccagaga ctgctgtctg aggagaggcc
     2821 ccgtgcttct gagcttcagc agttgctgga tgtcagcttc acttttgatg ttgaacttcc
     2881 acagctagct gagatgcgta tccgcttaga acaggcccgt tggctagaag aggttcagca
     2941 ggcttgcctg gactccagct ccctttcttt ggatgatatg agacgactca tagacttagg
     3001 ggtggggcta gctccatatt ctgccgtgga gaaagctatg gcccgcctgc aggaactgct
     3061 aacagtgtca gagcactggg acgacaaagc caagagtctc ctcagagcaa gacctcggca
     3121 ttccttgagt agccttgcta cagcagtaaa agagatggag gagatccccg cctatctgcc
     3181 caatggtaca gtcctgaagg attctgtgca gaaagccaga gactgggttc aggatgtaga
     3241 tgcattgcag gcaggaggac gcgtgccagt gttagaaaca ctcattgaac ttgtcgcaag
     3301 aggccgatcc atcccggtac atctgaattc tttacccaga ttggaaatgc tagtatccga
     3361 ggttcatgct tggaaagaaa gcgctgctaa aacattcctg cttgagaatt cgccatactc
     3421 tctgttagag gttctttgtc ctcggtgtga cattggcctt ttgggattga aaaggaagca
     3481 gagaaagttg aaggatccct tgccaagtgg gaagaagaga agcaccaagt tagagagtct
     3541 gagtgatctg gaaagggctc tgactgagag caaagagacg gcgtcagcta tggcaactct
     3601 tggggaagct cgcctacgag agatggaagc tttgcagtct ctcagatttg ccaatgaaga
     3661 gaaattgctg tcacctgccc aagatgtgga gacgaaggtt tgcttgtgtc agaagactcc
     3721 agccactccc atgattcagt gtgaactctg cagggatgct ttccatacta gttgtgtggc
     3781 ggtgtccagt atttcacaaa gctcccgaat ctggctttgt cctcactgtc gaaggtcaga
     3841 gaagcctcca ttagagaaaa ttctgcctct gctggcctcc ctacagcgta taagagttcg
     3901 tcttcctgaa ggggatgcac tccgatacat gattgaaaga accgtgaact ggcaacatag
     3961 agcccagcaa ctgctttctt cagggaatct aaaacttgtg caggaccaag cgggttctgg
     4021 actgttgttt agcagatggc cagcctcagc aggaacggcg tcagcagcag acaaggtgtc
     4081 tcaacctcct ggcacaacat ccttttcatt gccggaagac tgggacaaca gaacctcata
     4141 tttacactct cccttctcta ccggtcagag ttgtatcccc cttcatggtt tgagtccaga
     4201 ggtgaatgaa ttgctgatgg aagcccagtt gctccaggtg tccctccctg aagtccagga
     4261 gctttatcag actttactta cgaagccaag ctctgctcag caagccgacc gaagctcacc
     4321 agtcagaccc agcagtgaga agaacgattg tcttcgaggg aaacgagatg caatcaacag
     4381 tcttgagaga aaactgaaaa gacgcccaga aagagaaggc cttcccagtg aacggtggga
     4441 tcgagttaaa aaaatgcgga cccctcaaaa gaagaaaatc aaactgagtc accccaagga
     4501 catgaacaat ttcaaattag aaagagagcg tagctatgac ttagtccgga atgctgaaac
     4561 tcattccctg ccctcagaca catcctactc cgagcaggag gactctgagg atgaagatgc
     4621 catctgtcca gctgtgagct gcctgcagcc agaaggagat gaggtggact gggtccagtg
     4681 tgatggcagc tgcaatcagt ggtttcatca ggtctgtgtt ggtgtctctc cagagatggc
     4741 agagaaagaa gactacatct gtgtgcgctg tactggaaag gacgcaccaa gccgaaagta
     4801 aaaacaaaac acacactcac ttcatgtaat tcaggactcc aataaagaag atttcctcaa
     4861 tctcagcaaa gctacaggac tgggatcgag ccagcctgta cacggtgcta tttctattcc
     4921 ttatgggatc atttttccag aactctttga aaaaaagaaa aaacaactaa aaaatttttg
     4981 acactttttt gtaatttttt ccttaaaagc tgtttgtggt tgttgaagtt taaaatgctg
     5041 actgtttttt gcaggggtct ctactgattt cgaaggtctt ggagtttgca cctttttgtg
     5101 tacagcatta acattgtact tgtgcctggg atacaccggc ctaagagtct aactcagtgt
     5161 cagggcccag gacgggcacc agaattccag tagccctcgc tgagcagccg ctctcctttc
     5221 tctgtcacca cattggggga cttttaagtt ttcactttgg ggtttttgtt cctttctttc
     5281 tctccttttc ctttctggta ggctaggttt atttatctga gcaataactt ctatgttggt
     5341 ttcagtggct ggaattaaaa caaaacaaac ttctaaacag tgtgttggtt tagcatttgg
     5401 ttaatgtaca gaaagcaaac gtctagtttc tggtgtcact gaactagtga tgtaggaaga
     5461 gacttcgctg taagtaatcg ccacggctgt attttggctt tctccctact cagttcttcc
     5521 ccacccccat ctcacacccc accttttttt ttttttttgg tagaatgtat caaatgttgc
     5581 agtttttatt gtggaataat aaatccttgg tcctcttata acactagact acagagcttc
     5641 ttctgccctc ccccctgtgg gcctgcacaa ccagaggggt tgtttgcatt tgctccttcc
     5701 caggcagcct gcagcaggag tgtgtgtgct ggaggagtct ctgtagcctg attctttgtg
     5761 ggtctgggcc ctcttgtccc actaatagag agtccctgtc ttcaaagacc acagccagtt
     5821 cttcaagccg tgttcttttt ccataatctc tcagaatgtt ggagctgtcc ctccatcact
     5881 ccagactgta agacagcact cccgtggaat gcttgacagg gaagtttggc cgagagttaa
     5941 gttgctgtgg cccatcatct tagagggttg gttctcttgt atcatttttg gagaaccttg
     6001 ggcctgcctg ggattcctct gccttctatg taattccatc agtctttctg gttgtggacg
     6061 gcccatacct gtttgcccct gttctgtaga gaggaggact tcctggtgaa cagaaggaca
     6121 agctctcgct cactcgtctt cctcactgtc tatagccata cgcctgatgg tgggcagagc
     6181 tagcagacct ttactaaaac atcaaaaagc ggtttgtaaa gtagcgagaa tttaaatgta
     6241 ctgtccccta tgcaatccag ataattaaat ctgttt
//
