LOCUS       NM_001277177           10937 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus lysine demethylase 5A (Kdm5a), transcript variant
            1, mRNA.
ACCESSION   NM_001277177 XM_002726483 XM_002729425
VERSION     NM_001277177.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10937)
  AUTHORS   Zhou,Z., Zhang,X., Yi,G., Zhang,Y., Zhang,J., Tan,C., Wan,B.,
            Li,Y., Lu,H. and Lu,W.
  TITLE     LINC00092 derived from follicular fluid alleviated the symptoms of
            PCOS through inactivation of phosphatase and tensin homolog by
            recruiting KDM5A
  JOURNAL   Reprod Biol 23 (2), 100764 (2023)
   PUBMED   37084543
  REMARK    GeneRIF: LINC00092 derived from follicular fluid alleviated the
            symptoms of PCOS through inactivation of phosphatase and tensin
            homolog by recruiting KDM5A.
REFERENCE   2  (bases 1 to 10937)
  AUTHORS   Kong,S.Y., Kim,W., Lee,H.R. and Kim,H.J.
  TITLE     The histone demethylase KDM5A is required for the repression of
            astrocytogenesis and regulated by the translational machinery in
            neural progenitor cells
  JOURNAL   FASEB J 32 (2), 1108-1119 (2018)
   PUBMED   29212818
  REMARK    GeneRIF: These data suggest that KDM5A is a key regulator that
            maintains neural progenitor cells in an undifferentiated state by
            repressing astrocytogenesis and that its expression is
            translationally controlled during astrocyte differentiation.
REFERENCE   3  (bases 1 to 10937)
  AUTHORS   Labadie,S.S., Dragovich,P.S., Cummings,R.T., Deshmukh,G.,
            Gustafson,A., Han,N., Harmange,J.C., Kiefer,J.R., Li,Y., Liang,J.,
            Liederer,B.M., Liu,Y., Manieri,W., Mao,W., Murray,L., Ortwine,D.F.,
            Trojer,P., VanderPorten,E., Vinogradova,M. and Wen,L.
  TITLE     Design and evaluation of 1,7-naphthyridones as novel KDM5
            inhibitors
  JOURNAL   Bioorg Med Chem Lett 26 (18), 4492-4496 (2016)
   PUBMED   27499454
REFERENCE   4  (bases 1 to 10937)
  AUTHORS   Qi,L., Zhu,F., Li,S.H., Si,L.B., Hu,L.K. and Tian,H.
  TITLE     Retinoblastoma binding protein 2 (RBP2) promotes
            HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer
            via the Akt pathway
  JOURNAL   PLoS One 9 (8), e106032 (2014)
   PUBMED   25162518
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10937)
  AUTHORS   Nishio,H., Hayashi,Y., Moritoki,Y., Kamisawa,H., Mizuno,K.,
            Kojima,Y. and Kohri,K.
  TITLE     Distinctive changes in histone H3K4 modification mediated via Kdm5a
            expression in spermatogonial stem cells of cryptorchid testes
  JOURNAL   J Urol 191 (5 Suppl), 1564-1572 (2014)
   PUBMED   24679876
  REMARK    GeneRIF: Kdm5a expression was significantly higher in undescended
            testes.
REFERENCE   6  (bases 1 to 10937)
  AUTHORS   Tu,S., Teng,Y.C., Yuan,C., Wu,Y.T., Chan,M.Y., Cheng,A.N.,
            Lin,P.H., Juan,L.J. and Tsai,M.D.
  TITLE     The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC
            motif
  JOURNAL   Nat Struct Mol Biol 15 (4), 419-421 (2008)
   PUBMED   18270511
REFERENCE   7  (bases 1 to 10937)
  AUTHORS   Patsialou,A., Wilsker,D. and Moran,E.
  TITLE     DNA-binding properties of ARID family proteins
  JOURNAL   Nucleic Acids Res 33 (1), 66-80 (2005)
   PUBMED   15640446
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 10937)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   9  (bases 1 to 10937)
  AUTHORS   Sandrock,B. and Egly,J.M.
  TITLE     A yeast four-hybrid system identifies Cdk-activating kinase as a
            regulator of the XPD helicase, a subunit of transcription factor
            IIH
  JOURNAL   J Biol Chem 276 (38), 35328-35333 (2001)
   PUBMED   11445587
REFERENCE   10 (bases 1 to 10937)
  AUTHORS   Chan,S.W. and Hong,W.
  TITLE     Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone
            receptor-mediated transcription
  JOURNAL   J Biol Chem 276 (30), 28402-28412 (2001)
   PUBMED   11358960
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Mar 17, 2013 this sequence version replaced
            XM_002729425.2, XM_002726483.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. There are no full-length
            transcripts supporting this RefSeq in rat and it is unknown if this
            exon combination exists in rat; however, it is predicted based on
            partial transcript alignments and on full-length transcript support
            from the human homolog (GeneID 5927, AB209999.1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               JAXUCZ010000004.1  155238124-155238696
            574-651             JAXUCZ010000004.1  155240263-155240340
            652-774             JAXUCZ010000004.1  155242370-155242492
            775-945             JAXUCZ010000004.1  155247213-155247383
            946-1080            JAXUCZ010000004.1  155257271-155257405
            1081-1186           JAXUCZ010000004.1  155258263-155258368
            1187-1278           JAXUCZ010000004.1  155260134-155260225
            1279-1437           JAXUCZ010000004.1  155262018-155262176
            1438-1557           JAXUCZ010000004.1  155265289-155265408
            1558-1716           JAXUCZ010000004.1  155265920-155266078
            1717-1898           JAXUCZ010000004.1  155267330-155267511
            1899-2061           JAXUCZ010000004.1  155270928-155271090
            2062-2181           JAXUCZ010000004.1  155275739-155275858
            2182-2376           JAXUCZ010000004.1  155279148-155279342
            2377-2558           JAXUCZ010000004.1  155283398-155283579
            2559-2683           JAXUCZ010000004.1  155284140-155284264
            2684-2834           JAXUCZ010000004.1  155285162-155285312
            2835-2949           JAXUCZ010000004.1  155287042-155287156
            2950-3305           JAXUCZ010000004.1  155291084-155291439
            3306-3444           JAXUCZ010000004.1  155292558-155292696
            3445-3624           JAXUCZ010000004.1  155295541-155295720
            3625-3786           JAXUCZ010000004.1  155296500-155296661
            3787-4338           JAXUCZ010000004.1  155298706-155299257
            4339-4482           JAXUCZ010000004.1  155299610-155299753
            4483-4642           JAXUCZ010000004.1  155300098-155300257
            4643-4863           JAXUCZ010000004.1  155301974-155302194
            4864-5274           JAXUCZ010000004.1  155304166-155304576
            5275-10937          JAXUCZ010000004.1  155310459-155316121
FEATURES             Location/Qualifiers
     source          1..10937
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..10937
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /note="lysine demethylase 5A"
                     /db_xref="GeneID:312678"
                     /db_xref="RGD:1305429"
     exon            1..573
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             409..5481
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /EC_number="1.14.11.67"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific demethylase 5A; jumonji, AT rich
                     interactive domain 1A (Rbp2 like); lysine (K)-specific
                     demethylase 5A"
                     /codon_start=1
                     /product="lysine-specific demethylase 5A isoform 1"
                     /protein_id="NP_001264106.1"
                     /db_xref="GeneID:312678"
                     /db_xref="RGD:1305429"
                     /translation="MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAE
                     KTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQG
                     STLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKS
                     HYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRT
                     RRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFN
                     MQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGD
                     WRCPKCVAEECNKPREAFGFEQAIREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEK
                     EFWRLVSSIEEDVIVEYGADISSKDFGSGFPIKDGQRKMLPEEEEYALSGWNLNNMPV
                     LEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPS
                     HAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTF
                     PRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADP
                     ECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTT
                     CFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYD
                     TWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVA
                     QLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEF
                     HERAQEAMMDETPDSSKLQVLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDP
                     QQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMA
                     NLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKG
                     RPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKN
                     RRKKVKEIIEKEKEKDLDLEPLSDLEEGLEETRDAAMVVAVFKEREQKEIEAMHSLRA
                     ANLAKMTIVDRIEEVKFCICRKTASGFMLQCELCKDWFHNGCVPLPKSGSQKKGSSWQ
                     AKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQ
                     ALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSA
                     FNRVVSSVSSSPHQAMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEE
                     IPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLE
                     LSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSVEEKPL
                     KMKGKDSSEKKRKRKLEKVEQFFGEGKQKTKELKKIDKPKKKKLKLNVDKSKELNKLA
                     KKLAKEEERKKKKEKAAAAKVELAKESTEKKRERKVLDIPSKYDWSGAEESDDENAVC
                     AAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPDSPG
                     HAPPPPFIMSYKLPMEDLKETS"
     exon            574..651
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            652..774
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            775..945
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1080
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1186
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1278
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1437
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1557
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1716
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1898
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2061
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2181
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2376
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2558
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2683
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2834
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..2949
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3305
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3444
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3624
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3786
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..4338
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..4482
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4642
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4643..4863
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4864..5274
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
     exon            5275..10937
                     /gene="Kdm5a"
                     /gene_synonym="Jarid1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcctctc gaggagaggt cgcggagcca tcaggggcca cgcacccaga gtggacggag
       61 agtgcagaac cttgaccggc aagctgagaa aaaaaggcac gccggctgtc atggaaggga
      121 ggaaggcgag aagacccgac tagacgtggc ggcggtggga ttttgtttcc tgcggtggcg
      181 gactgattta gcagtacgtt aacttccgga agcgtcctgt ccctgagagg aaaagccctg
      241 aaggaaacaa taacaaacga caggaggaag cgcttctggg tcttctgtga ggaatagttc
      301 tctcctaaga agatgcgctg cggcccctgt gaggagacgt gagagggctt ggcggccgtc
      361 acccagcctt tcccggcttg tgcacctcag ggccccctgg cttttaccat ggcgggcgtg
      421 ggcccggggg gctacgcggc ggagttcgtg ccgccgcccg agtgcccggt ctttgagccc
      481 agttgggagg agttcacaga cccgctaagt tttatcggtc gcatccggcc tctggctgag
      541 aaaactggca tctgcaaaat ccgtccaccc aaggattggc aacctccatt tgcttgtgaa
      601 gtaaaaacct tccgattcac tcccagagtc cagcgcctga atgaacttga ggcaatgact
      661 agagtaagat tggacttctt ggatcaactg gcaaaatttt gggaacttca aggatctaca
      721 ttgaagattc ccgtggtgga gagaaaaatc ctggatttgt atgctttaag caagattgtt
      781 gccagcaaag gaggttttga aatagtcacc aaagagaaga aatggtctaa agtgggtagc
      841 cgtttgggat atctgccagg aaaaggaact gggtctcttt tgaagtcaca ctatgaaaga
      901 attctctacc catatgagct tttccaatct ggtgtcagcc ttatgggtgt acaaatgcct
      961 gatttagatc ttaaggaaaa agttgaagct gaggttctca gtactgacat ccagccttcc
     1021 ccagagcggg gaacaagaat gaatatccca ccaaagagaa caagacgagt taaatcccag
     1081 tcagactctg gagaagtaaa tagaaataca gaactgaaga aacttcagat ttttggggct
     1141 ggacccaaag tagtaggcct ggcagtagga gcaaaagata aagaagatga ggtcacccga
     1201 agacggaaag ttaccaacag gtcagatgca tttaacatgc agatgagaca acggaaagga
     1261 actctctctg ttaactttgt cgatctctat gtttgcatgt tttgtggtcg aggaaacaat
     1321 gaggataaac tgcttttgtg tgacgggtgt gatgacagct accatacatt ttgtctgctt
     1381 ccaccacttc ctgatgtgcc caaaggagac tggaggtgtc ctaaatgtgt tgctgaggaa
     1441 tgtaacaaac ctcgagaagc ctttggattt gagcaagcta taagagaata tacacttcaa
     1501 agcttcggag agatggcaga taattttaag tctgattatt tcaatatgcc agtgcatatg
     1561 gttcctacag agctagtaga aaaggagttc tggcggctag taagtagtat tgaagaagac
     1621 gtcattgtag agtatggagc tgatatctct tcaaaagatt ttggaagtgg atttcctata
     1681 aaggatggtc agagaaagat gttaccagaa gaggaggagt atgcactttc tggttggaat
     1741 ttgaataaca tgcctgttct ggagcagtct gttcttgctc atattaatgt ggacatttct
     1801 ggtatgaagg tgccgtggct ctatgtggga atgtgctttt cttctttttg ctggcatatt
     1861 gaagatcact ggagttattc aattaactac ttgcattggg gcgagccaaa gacatggtat
     1921 ggtgtaccat ctcatgctgc agaacaactg gaggaggtga tgagggagct ggcccctgag
     1981 ttatttgaat cacagcctga cctcctacat cagttagtaa ccatcatgaa cccaaatgtg
     2041 ctcatggagc atggtgtgcc tgtgtacaga actaatcagt gtgctggaga gtttgtggtg
     2101 acgtttcctc gtgcctatca ctctggattt aaccagggat acaactttgc tgaagccgtg
     2161 aacttctgta ctgctgactg gttgcccatt ggacgtcagt gtgtaaatca ctatcgacgg
     2221 ctgaggcgcc attgtgtctt ttcacatgag gaactcattt tcaagatggc agcagatcca
     2281 gaatgcttag atgtggggct ggctgccatg gtatgcaaag agttgactct catgactgaa
     2341 gaagaaacac gattgaggga atcggttgtt caaatgggtg tcgtgatgtc agaagaagaa
     2401 gtcttcgaac ttgttcctga tgatgagcgg cagtgttcag catgcagaac cacatgtttt
     2461 ctctcagctc tcacatgctc ctgtaatcca gagcgacttg tatgtttgta tcatccaact
     2521 gatttgtgct cctgccccat gcagaacaaa tgtcttaggt accgataccc acttgaagac
     2581 ctcccatctc tgctttatgg tgtcaaagtg agagcacagt cctatgacac ttgggtcaat
     2641 cgtgtcacag aagcattatc agctagcttc aaccataaga aagatttgat tgaattgaga
     2701 gtaatgctgg aagatgctga ggataggaaa tacccagaga atgatctctt tcgaaagctc
     2761 agggatgcgg taaaagaagc tgagacctgt ggttctgtgg ctcagctgct tctgagcaaa
     2821 aaacaaaaac acaggcagag ctcagatagt gggaagactc ggaccaaact gacagtagaa
     2881 gaattgaagg cctttgtcca acaacttgtt agtcttccgt gtgtcatcag ccaaactcga
     2941 caagtaaaga atctgctgga tgatgtagaa gaatttcatg aacgtgccca ggaggccatg
     3001 atggatgaaa ctccagattc ttccaaactc caagtgttaa tagacatggg ctctagtctc
     3061 tatgtggaac tacctgaatt gccccgacta aagcaagagc tacagcaggc tcggtggctg
     3121 gatgaagtaa gactgactct atcagaccca caacaagtca ctttggatgt catgaagaaa
     3181 ttgattgact ctggggtagg cttggcacct caccatgctg tggaaaaggc aatggctgaa
     3241 ctacaggaac ttcttacagt ctctgaacga tgggaagaga aggcgaaggt ctgcctgcag
     3301 gcaagaccac ggcacagtat ggcaaattta gaaaatattg taaatgaagc caagaacatt
     3361 ccagcctttc tacccaatgt gttgtcctta aaagaagcct tacaaaaggc tcgtgaatgg
     3421 acagctaaag tggaagctat tcagagcggc agcaactatg cttacttgga acagcttgag
     3481 agcttgtctg ctaaaggacg ccctatccct gtgcgcctcg atgccttgcc tcaagtggag
     3541 tcacaagtag cagcagcgcg agcctggagg gagcggacgg ggcggacctt ccttaagaag
     3601 aattccagcc atacattgtt acaggtgcta agtccacgaa cagacattgg tgtatatggc
     3661 agtggcaaaa acagaaggaa aaaagtaaaa gaaataatag aaaaagaaaa ggagaaggac
     3721 ctagaccttg aacctttgag tgacttagaa gaaggactgg aggagacgag ggacgcagcc
     3781 atggtggtgg cagttttcaa agaacgagaa caaaaggaga ttgaagccat gcattccctc
     3841 agagcagcca acctagccaa gatgaccatt gtggaccgca tagaagaagt aaagttttgt
     3901 atttgccgca agacagcgag tgggtttatg ctacagtgtg agctctgcaa agactggttc
     3961 cataatggct gtgttcccct tcctaagtca ggttcccaga aaaagggatc cagctggcaa
     4021 gccaaagacg taaaattcct ttgccctctc tgcatgagat cccggaggcc gaggctagag
     4081 actattctgt cactcctggt atcccttcag aagttgcctg tacgattgcc tgaaggagaa
     4141 gcactgcagt gtttgacaga gcgtgctatg agttggcaag atagagcacg acaagcttta
     4201 gccacagatg aactgtcttc tgccctggcc aaactctctg tgttaagcca gcgtatggta
     4261 gaacaagcag cccgagaaaa aactgaaaag attatcagtg cagaactcca gaaagcagcc
     4321 gccaatccag acttacaggg acacttacct agtttccagc agtctgcttt taaccgggtg
     4381 gtgagcagtg tatcctcttc cccccaccaa gcgatggact atgatgatga agaaacagac
     4441 tctgatgaag atattcgaga gacatatggc tatgacatga aggatacagc cagtgtaaag
     4501 tcctctagca gtctggaacc caatctcttt tgcgatgaag agattcctat caaatcggag
     4561 gaagtggtga cccacatgtg gacagcacct tcattctgtg cagagcatgc atattcttct
     4621 gcttctaaga gttgttctca aggttctagc actccaagaa agcagcctcg gaagagccct
     4681 ttggttccca gaagtttgga gcctccagta ttagaattgt ctcctggagc aaaagcccag
     4741 ttggaagaac tcatgatggt tggagacctc ctagaagtgt ctctggatga gacacaacac
     4801 atatggcgga ttttgcaggc cacacatcca ccctcagagg acagattctt acatatcatg
     4861 gaggatgata gcgtagaaga gaaaccatta aaaatgaaag gaaaggattc ttcagagaag
     4921 aaacggaagc ggaaattaga aaaggtagaa cagttttttg gagaaggaaa acagaagacc
     4981 aaggagctaa agaaaataga taaacctaaa aagaagaaat taaaattaaa tgtggacaaa
     5041 tcaaaagagc tgaataaatt ggctaagaag ttagcaaaag aagaagagcg aaagaaaaag
     5101 aaagaaaagg ctgctgcagc caaagtggag cttgcgaaag agagcaccga gaagaaaaga
     5161 gagagaaagg tgctggatat cccttcaaag tatgactggt cgggcgcaga ggagtctgat
     5221 gatgagaatg ctgtatgtgc agcacagaac tgccaaaggc cgtgtaagga caaggtagac
     5281 tgggtacaat gtgatggtgg ctgtgatgag tggtttcatc aagtttgtgt tggtgtatcc
     5341 ccagaaatgg ctgaaaatga agattacatc tgtataaact gtgcaaagaa gcaggggcca
     5401 gatagcccag gccacgcacc acctcctccc ttcataatga gctacaaact accaatggag
     5461 gatcttaaag agaccagtta gcagatgttt ggttagcttg caacatgggg ggaagtggac
     5521 cacactgaga ccttactcat caagcagagt ggttctcacc actcagaatg ttgtttccac
     5581 agatgaatgg acttcagaag aagtcctctt agtgctggct gcctgtctgc atggactgtg
     5641 tgggctccat tgccttatct gtgcagagga tggcttccca ggtgcagcag ccaagtatct
     5701 caactcctga ctcctttggg tgtggtttgc tgagttaagg tcaggttcta atggagctct
     5761 caggaggctg ttcggcacta acacattgat gtacttagtg gggcatatga gaagtggctt
     5821 tcaaccagct ggtgttagct gtagaaggtt acaacttaac ggtggtgcca tgggaaggcc
     5881 tgattatttg aatctcctta gggtaattgg ataggagtca gagtacaact ctgtccgtaa
     5941 ttactgacac acatgccctg ctgatccagt taggagaagc aggccagagt tatcccttct
     6001 agaagtcttg gggtggcagt gcagtctacg gacctcagct gcttgtgctt atttaccaat
     6061 aagaaaattc tccagaagag cccctcactt tcctcaggaa ggttcaaaat ctgactagac
     6121 tggattctgg aaggaaggga ggggtttttt tgttttgttt tattttgttt gttttttttc
     6181 ttacttcaag gcaagtagcc cattggtttg agaagtccgt ctgggtctgt gttttagcga
     6241 agaaaggtag gtgcacggat ccaggtttct ggagggagta gggatgacaa gtgagaacat
     6301 tctactgagc ctcagtgatg catgcttatc tgggaaaccc tcattcacaa gtattccaga
     6361 ctccaccatg cttcacgcat ggccatgagc aagactggca aataacagct tttgccttgc
     6421 agccctaacc ctagtgcttg tagtttccaa catggtccca gcagatgttg atgaataaca
     6481 ccatggcttc atcagaggat gtggggctgt aggtcctctg ggtgtgaagc tgttctagta
     6541 aatccgtttt taaaaagaaa gacttgtttt tacttttttc taaatgtctc tgactactga
     6601 ctgttctata gattattttt ccttttttga tatacatata taaatataga tatatatata
     6661 tatatttact gttaccagca gcgtatgata gagtttgagc atcaaaaatc catttgggaa
     6721 cttgtatttt ctttcgcttt ttgataaaga aatcccattc cttccttgta gtacaaggag
     6781 ctagcacttc gttcttcatt ctcgcctaag catatcctcc atttttcttc tattctattc
     6841 aagaagataa tatatttctt ccatgttggg acttggtccc tgtctgttgg gcagcttggt
     6901 cttattctag tcagtgctga atgttttgta tgtttgaaac tatggtgctg tgcccccctc
     6961 ccagcccacc cccattgggt tctgtgttct tatgaaggtc ttagttgtag tctataaact
     7021 ccacaacaag gggactaata tattttaaag gacaaaaagg ttttctaaaa atagtgttta
     7081 tcttcactat cctttgttct ttattttagt ttaagaatct gcagtttgac ttaaactcat
     7141 catttgtcct attaaagggg gcattgagca aacctagaaa gtttgtagcc tctgttcccc
     7201 tttgccccag tctcttaaag aaatgtcttc tagtaactag aagtgagatg tactgtccag
     7261 ttacagactg tgtgggtatg agggttacct caaaaggcat cttaggaaaa gaaaaaggtt
     7321 tcttacaaaa cccctatccc aagtgctaac caggcttgac cctgcttagc ttccaaggtc
     7381 agatgagaca catacaggtg gtacggctgt aggtacaaca tccagtttct gaaaaatgct
     7441 ttctctggtt tatactacct actttttggt ctctttactt aatgttaagt aatatagctt
     7501 gacaagttac gttgtttgaa tgtgttgcta tgcttgtgtc ttgaatttcc atctcaatgt
     7561 gagtatgagt taagatttca gtagtgttta caaggttaat taagtaaaca gttaacttca
     7621 cacattttca ttttgccaaa catgaagatt atcacttcag aattttattt ggttattgtt
     7681 ataatgaaaa aagcacaatg taagaaatat ttttagtctt tgtaaaagac ttactcttag
     7741 taagaaacct tttagtcttt gtaaaagact tgaaatacct gtggtttaaa aattgagtgt
     7801 acaccaaccc ttcagaaatt tacagtgtaa gtgatagaat cccagaatac attttacact
     7861 tttgattttt ccttccaatt aactactttc cattaactgt gttatcaata gtaaagttgg
     7921 ggatactgaa aggtgactgt ttgagtaata atttgtgttc tttgtacagt gtttgtctgt
     7981 tggagacctc agagataggc agtctgtacc tgtgaatagc tgcctgtcat cttctgatgt
     8041 tttgaaactt ttaaatatat aatttaattg attcatttga ctcttctgta cttatttgaa
     8101 gaatttgatt tgtcttaagt atagatttag acaaaaactc aaaagaccat aagagagagg
     8161 ctggttaaga atactggctc ctcttctaga ggtttataca ggttcagttc tcaacactac
     8221 atggtgactc acagccatct gtgtcgtcct cttctggatt ccaagagctc tgtacacatg
     8281 tggtacacag atacattcta gaaatactca caaatataag taatgaaaat cttgtttaaa
     8341 attttctttt aaggatataa gagaagctag cactccaccc acaaattaaa aaccctatag
     8401 tttgtgagtt aatgaaataa gactcatcta tttaaggaga agtagatgtt ctaatgtaaa
     8461 actttgtttc acgagaatta caagtaactc cattcttctg tatcatttgt ttacattttg
     8521 tattaaaact tgatttatgt ttctctttct gcctcctcaa agttgcagtt cttcattatt
     8581 agcattttaa cttaagcatt taatattttt taaactattt ctcattgcct tcattacaaa
     8641 tagtttgaca aaggtaacat ggaatgaaaa aaaagttgaa gtatgcctgc tgttttggca
     8701 cactcagtaa actagccagg gctacataat gagaccctgt ctcaaaaaaa aaaaaatagg
     8761 agttaagtct ttgataattg ttcacaggga aggccaatta gaactgtgca gtccccatgt
     8821 tcagaagtac aagggagcag tagttactgg tccttaattg gaggagaaga ggtggcatca
     8881 tcatcctctc acagacgttt gtttcacctc ctggcgttcc tgcaaaagcc atgcgcagtg
     8941 gctgctatga gccaactctg cccatctgac tctgacttga gccgcagtga gagaatgaat
     9001 tactgtgtca tacttggaag agctgaaagg cagacagaca ttcagtctgt gatggcccat
     9061 gacctgacag gaacatggca gacactgcca ggtcctggag tcagcatgat ttcacaaatg
     9121 cttcccttcc cttccagctc ggctttgtgt cctcaactgg gcctgagaaa tgtccatttg
     9181 ttcttcttag tttgctggac agagttcagt gcacgtaaag aaactgcttg tcagctgggc
     9241 atggtggtat acacttttaa tcctgacact tgggagacag gcagactggt ttatacagtg
     9301 tgttccacaa cagccagagc tgcataataa tagaacttgt caccaaaaaa aaaaaaaaga
     9361 aagaaaagaa actgcttgtc agtgtgttaa gtgtgtcagc cagtaaagta gaaatgatgg
     9421 aaaaataaag cctgcctttg ccaagcagtt taggtgcacg cttttatttc cagcactcag
     9481 gaggcagcag caggaagatc tctttgagtt tgaggccaac ctggtctaca gaacaagttc
     9541 aaggacagcc aaggctacag agaccctgcg tcaaaaacac aaagccttcc tttcaaaagg
     9601 ttaaaactgt ctgcctttgg gataaaacag caatttggag tagatgttgg aaactgcaaa
     9661 gtgtgaagat tctaagctgt tgacgtccca aataacccag aacccaagtc ccacgaagtt
     9721 tcacatgtga attagcttta tgtgtgcaga gtgttgcttt catagtaggt ccttaagcac
     9781 actatctttc aggttgctgt ccctttaaat caaaccacac cattactttg agtatgactt
     9841 tgccacgtgg tattttcaac acacggggaa agagtggaca ttgatgtctt tgagattgga
     9901 gtattccctt ggcctggatc cactcaccac tgtacaacat aggatataca ctgggaaagg
     9961 atagcgttgc tctcctacag taatgtgtct gtctaaacag tatattttaa gaacttcagc
    10021 ctcccccagt tgatgatccc tttacattaa gttgtgccag ggttgttgat tgtgtagaag
    10081 agtgatgtga cttatttgcc tgagtaaatt gttctcagac ttacaacctt ccttcgccag
    10141 cccaggccta caatgttttc agcctctgag acttaaactg ctgaatagct caccccttct
    10201 agctctttgt gagctctggc ttttctctct gctctgcttg aattgctctg attagcctca
    10261 aactaactct agcaatctgt tccaatcttc tggctccttc tcattctgtc tttaccagta
    10321 tccttgtgtc tagcttgttt tctcttcaac ctgtcactgt aaaactctcc tagtacaact
    10381 gtctctgaat tccacaaact ccgcctgcct ttgaactgat tgactcaaac gaactgaaca
    10441 gaactgacta gcactcgatc tgcatgcctc tttctcctga gagctggcgt taaaggtgtg
    10501 tacccccaca tctggacttc ttgttacctg aaatttgctt tatacagact ggccttgaat
    10561 tcagagatct tacctaggtc tcctgggatc tgtattccag gcagatccca caaacctagg
    10621 ttttggaagg tgatctctta ccagaacagc catgttctga attaaggaat attccttatg
    10681 gaaattataa cttgatttca tgatgtttaa gcatgttttt tgtttgttct ttgtttttgt
    10741 ctgaactgtg gttaatttta ttacgtcgtt tgttttccat gatgtttgtg ctcaaaattc
    10801 cccatcccaa ctctcagtca gtctcatcat ttctattggt ggtgatctca aatggttatg
    10861 taaatgtaaa tcctgagaat aagtactgaa aatcctgagg gaattagcca ataaaaagga
    10921 gccgttttta acctgga
//
