LOCUS       NM_001079712            2357 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysine demethylase 4D (Kdm4d), mRNA.
ACCESSION   NM_001079712 XM_001072078
VERSION     NM_001079712.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2357)
  AUTHORS   Zuryn,S., Ahier,A., Portoso,M., White,E.R., Morin,M.C.,
            Margueron,R. and Jarriault,S.
  TITLE     Transdifferentiation. Sequential histone-modifying activities
            determine the robustness of transdifferentiation
  JOURNAL   Science 345 (6198), 826-829 (2014)
   PUBMED   25124442
REFERENCE   2  (bases 1 to 2357)
  AUTHORS   Khoury-Haddad,H., Guttmann-Raviv,N., Ipenberg,I., Huggins,D.,
            Jeyasekharan,A.D. and Ayoub,N.
  TITLE     PARP1-dependent recruitment of KDM4D histone demethylase to DNA
            damage sites promotes double-strand break repair
  JOURNAL   Proc Natl Acad Sci U S A 111 (7), E728-E737 (2014)
   PUBMED   24550317
REFERENCE   3  (bases 1 to 2357)
  AUTHORS   Young,L.C. and Hendzel,M.J.
  TITLE     The oncogenic potential of Jumonji D2 (JMJD2/KDM4) histone
            demethylase overexpression
  JOURNAL   Biochem Cell Biol 91 (6), 369-377 (2013)
   PUBMED   24219278
  REMARK    Review article
REFERENCE   4  (bases 1 to 2357)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   5  (bases 1 to 2357)
  AUTHORS   Hillringhaus,L., Yue,W.W., Rose,N.R., Ng,S.S., Gileadi,C.,
            Loenarz,C., Bello,S.H., Bray,J.E., Schofield,C.J. and Oppermann,U.
  TITLE     Structural and evolutionary basis for the dual substrate
            selectivity of human KDM4 histone demethylase family
  JOURNAL   J Biol Chem 286 (48), 41616-41625 (2011)
   PUBMED   21914792
REFERENCE   6  (bases 1 to 2357)
  AUTHORS   Iwamori,N., Zhao,M., Meistrich,M.L. and Matzuk,M.M.
  TITLE     The testis-enriched histone demethylase, KDM4D, regulates
            methylation of histone H3 lysine 9 during spermatogenesis in the
            mouse but is dispensable for fertility
  JOURNAL   Biol Reprod 84 (6), 1225-1234 (2011)
   PUBMED   21293030
REFERENCE   7  (bases 1 to 2357)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 2357)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 2357)
  AUTHORS   Nudel,U., Katcoff,D., Zakut,R., Shani,M., Carmon,Y., Finer,M.,
            Czosnek,H., Ginsburg,I. and Yaffe,D.
  TITLE     Isolation and characterization of rat skeletal muscle and
            cytoplasmic actin genes
  JOURNAL   Proc Natl Acad Sci U S A 79 (9), 2763-2767 (1982)
   PUBMED   6953429
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128760.1.
            
            On Dec 11, 2006 this sequence version replaced XM_001072078.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128760.1, CK470820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2357
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q12"
     gene            1..2357
                     /gene="Kdm4d"
                     /note="lysine demethylase 4D"
                     /db_xref="GeneID:689582"
                     /db_xref="RGD:1591045"
     exon            1..44
                     /gene="Kdm4d"
                     /inference="alignment:Splign:2.1.0"
     exon            45..2329
                     /gene="Kdm4d"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1876
                     /gene="Kdm4d"
                     /EC_number="1.14.11.66"
                     /note="jumonji domain-containing protein 2D; jmjC
                     domain-containing histone demethylation protein 3D; lysine
                     (K)-specific demethylase 4D; [histone
                     H3]-trimethyl-L-lysine(9) demethylase 4D"
                     /codon_start=1
                     /product="lysine-specific demethylase 4D"
                     /protein_id="NP_001073180.1"
                     /db_xref="GeneID:689582"
                     /db_xref="RGD:1591045"
                     /translation="MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAG
                     LAKVIPPKEWRARQSYDNISNILIATPLQQVVSGQAGVFTQYHKKKKAMTVGQYRHLA
                     NSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDL
                     LEQECGIVIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGR
                     RLELLAKELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGY
                     HAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYEMWK
                     RGQDQAVVDHTEAMGPTSQELTTWRVIQAPRKTWGLKHLRLRQVSRCLLPVATDSNIA
                     NNTQMCHTSRQAADSKGDEVQESDPAIAPPYPLGLSSPGHMSTGKRGLGRRPCELGVQ
                     ESTNGAPVKRRLPEGRDDRSPSPELQSQSVTGDLIVNSDLVNPGPQHPVTASEGGLTS
                     DP"
ORIGIN      
        1 agaaggcgca aataagtacg ggggcagcca cgagctttcc aaagattata ttttagtcac
       61 atccctgaag agattctgct gcacccgtct ctgcaatcca gtagacaacg agaggaaaga
      121 accaggttcc aactgaacat gtgagagtct ggggctccct gactgagctg atgcccagag
      181 tgctggatct gggttagtca gcaacctaac aaaagctagt cccatcacac gcacagaagc
      241 cgtcaggaca ctcggctaca tcacacacac agcaattctt tttgtaaaat cctgcttcct
      301 caatcctgtg tatatattgg attttggtgt ttaagttgaa gctatgaaga ctaagtccac
      361 ctgtgctcag aatccaaatt gcagcataat gatatttcgt ccaaccaaag aagagtttaa
      421 cgactttgac aaatacatcg cctacatgga gtcccaaggg gcacacagag ctggactggc
      481 caaggtcatc ccgccaaaag aatggagggc caggcagtct tatgacaata tcagtaacat
      541 cttaatagca actcccctgc agcaagtagt ctccgggcag gcaggtgtgt tcactcaata
      601 ccataagaag aagaaagcca tgacagttgg gcagtaccgg cacctggcca acagtaaaaa
      661 ataccaaacc ccaccacacc tggattttga agatttggag agaaaatact ggaagaatcg
      721 cctgtatgag tcaccaattt atggtgctga cgtcagtggc tccctgtttg atgggaagac
      781 tcaacagtgg aatgtgggcc acctgggaac aattcaagac ctattggaac aggaatgcgg
      841 catagtgatt gagggcgtca acacgcccta cctgtacttt ggcatgtgga agacctcctt
      901 tgcgtggcac acggaggaca tggacctgta cagtatcaac tacctgcact ttggacagcc
      961 caagacctgg tatgctgtac cccctgagca tggcaggcgc ctggagctcc tagccaagga
     1021 actcttccca ggcagctccc agggctgcca ggccttcctg aggcacaagg tggcgctcat
     1081 ctcacccact gtgctcaagg agaatggcat cccctttggt cgaatcaccc aggaggctgg
     1141 ggagttcatg gtcacctttc cctatggcta ccacgcgggc ttcaaccatg gcttcaactg
     1201 tgcagaagcc atcaatttcg ccacgccgag gtggattgac tatggcaagg tggcatctca
     1261 gtgcagctgt ggggaggcca gggtgagctt ctccatggat gcctttgtga ggatcctgca
     1321 gcctgagcga tatgagatgt ggaaacgagg tcaagatcag gcagttgtgg accacacaga
     1381 ggctatgggg cctaccagtc aggagctcac cacctggcgg gtgatccagg caccaagaaa
     1441 aacttggggc ctgaagcatc tccggcttcg ccaggtttca cgctgtcttc tgcctgtagc
     1501 cactgacagt aacattgcca acaacaccca gatgtgccac acctccaggc aagcagcaga
     1561 ttcgaaaggt gatgaggtcc aggagtctga cccagccata gccccaccat atcctctggg
     1621 tctatcttct cctggccaca tgtcaactgg aaaacgtggt cttggtcgtc gcccttgtga
     1681 actaggagtt caggagtcca ccaatggagc tccagtcaag aggcgacttc cagaaggcag
     1741 agatgacaga agtcccagcc cagagcttca gtcccagtcc gtgactggag acttaatagt
     1801 caactcagac cttgtaaatc ctgggccaca gcatcctgtg acagcttctg aagggggatt
     1861 gacctctgac ccctaaacct atgtcctgac ttacagctca ttgccccgca ctcaggatgc
     1921 tctctaaggc cattacctca gttttgactg agtttgcagg gcactggcta cacctgagag
     1981 agttccttgt cagttctaac tcctaaacac accctgcccc ttcctccttc cggaactcgg
     2041 ccagctctgg atactgctaa ctcctgctct tccaggagat atttcattgg ctgctccttt
     2101 tgagtttctg agagccaagt tcagctgaga ctgctcagtg ctcatcttcc ctccctctgc
     2161 catttcttgc aaatgtctaa ctgttgacac tagatgacta ctcacaaagg aagtagtcac
     2221 aaaaaaggtc aaaagtcatt tgagagtcac agatgatctc tcaaacttga tgtattaaaa
     2281 tgtgtctcac ccggctttca caaataaagg caaagcagtc aaaagcttaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaa
//
