LOCUS       NM_001106663            4132 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lysine demethylase 4C (Kdm4c), mRNA.
ACCESSION   NM_001106663 XM_001067369 XM_216426
VERSION     NM_001106663.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4132)
  AUTHORS   Hu,J., Wu,W., Yu,M., Xia,Z. and Gao,C.
  TITLE     MicroRNA-340-5p inhibits endothelial apoptosis, inflammatory
            response, and pro-coagulation by targeting KDM4C in anti-neutrophil
            cytoplasmic antibody (ANCA)-mediated glomerulonephritis through
            activation of B cells
  JOURNAL   Autoimmunity 54 (6), 343-352 (2021)
   PUBMED   34121556
  REMARK    GeneRIF: MicroRNA-340-5p inhibits endothelial apoptosis,
            inflammatory response, and pro-coagulation by targeting KDM4C in
            anti-neutrophil cytoplasmic antibody (ANCA)-mediated
            glomerulonephritis through activation of B cells.
REFERENCE   2  (bases 1 to 4132)
  AUTHORS   Tumber,A., Nuzzi,A., Hookway,E.S., Hatch,S.B., Velupillai,S.,
            Johansson,C., Kawamura,A., Savitsky,P., Yapp,C., Szykowska,A.,
            Wu,N., Bountra,C., Strain-Damerell,C., Burgess-Brown,N.A.,
            Ruda,G.F., Fedorov,O., Munro,S., England,K.S., Nowak,R.P.,
            Schofield,C.J., La Thangue,N.B., Pawlyn,C., Davies,F., Morgan,G.,
            Athanasou,N., Muller,S., Oppermann,U. and Brennan,P.E.
  TITLE     Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of
            H3K4me3 at Transcription Start Sites and Proliferation of MM1S
            Myeloma Cells
  JOURNAL   Cell Chem Biol 24 (3), 371-380 (2017)
   PUBMED   28262558
REFERENCE   3  (bases 1 to 4132)
  AUTHORS   Cascante,A., Klum,S., Biswas,M., Antolin-Fontes,B.,
            Barnabe-Heider,F. and Hermanson,O.
  TITLE     Gene-specific methylation control of H3K9 and H3K36 on neurotrophic
            BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem
            cell differentiation
  JOURNAL   J Mol Biol 426 (20), 3467-3477 (2014)
   PUBMED   24747049
  REMARK    GeneRIF: Data indicate that histone demethylases KDM4A/C regulate
            H3K9 and H3K36 methylation on brain-derived neurotrophic factor
            (BDNF) versus astroglial glial fibrillary acidic protein (GFAP)
            genes in neural stem cells.
REFERENCE   4  (bases 1 to 4132)
  AUTHORS   Hong,Q., Yu,S., Yang,Y., Liu,G. and Shao,Z.
  TITLE     A polymorphism in JMJD2C alters the cleavage by caspase-3 and the
            prognosis of human breast cancer
  JOURNAL   Oncotarget 5 (13), 4779-4787 (2014)
   PUBMED   24952432
REFERENCE   5  (bases 1 to 4132)
  AUTHORS   Xu,Y., Yao,H.B., Jin,Y., Ma,Y.Y., Wang,H.J. and Shao,Q.S.
  TITLE     [Expressions of Jumonji domain containing protein 2C and
            hypoxia-inducible factor-1alpha in gastric carcinoma and their
            clinical significance]
  JOURNAL   Zhonghua Yi Xue Za Zhi 93 (42), 3375-3378 (2013)
   PUBMED   24418035
REFERENCE   6  (bases 1 to 4132)
  AUTHORS   Metzger,E., Yin,N., Wissmann,M., Kunowska,N., Fischer,K.,
            Friedrichs,N., Patnaik,D., Higgins,J.M., Potier,N.,
            Scheidtmann,K.H., Buettner,R. and Schule,R.
  TITLE     Phosphorylation of histone H3 at threonine 11 establishes a novel
            chromatin mark for transcriptional regulation
  JOURNAL   Nat Cell Biol 10 (1), 53-60 (2008)
   PUBMED   18066052
  REMARK    Erratum:[Nat Cell Biol. 2008 Feb;10(2):245]
REFERENCE   7  (bases 1 to 4132)
  AUTHORS   Loh,Y.H., Zhang,W., Chen,X., George,J. and Ng,H.H.
  TITLE     Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate
            self-renewal in embryonic stem cells
  JOURNAL   Genes Dev 21 (20), 2545-2557 (2007)
   PUBMED   17938240
REFERENCE   8  (bases 1 to 4132)
  AUTHORS   Wissmann,M., Yin,N., Muller,J.M., Greschik,H., Fodor,B.D.,
            Jenuwein,T., Vogler,C., Schneider,R., Gunther,T., Buettner,R.,
            Metzger,E. and Schule,R.
  TITLE     Cooperative demethylation by JMJD2C and LSD1 promotes androgen
            receptor-dependent gene expression
  JOURNAL   Nat Cell Biol 9 (3), 347-353 (2007)
   PUBMED   17277772
REFERENCE   9  (bases 1 to 4132)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   10 (bases 1 to 4132)
  AUTHORS   Hu,N., Wang,C., Hu,Y., Yang,H.H., Giffen,C., Tang,Z.Z., Han,X.Y.,
            Goldstein,A.M., Emmert-Buck,M.R., Buetow,K.H., Taylor,P.R. and
            Lee,M.P.
  TITLE     Genome-wide association study in esophageal cancer using GeneChip
            mapping 10K array
  JOURNAL   Cancer Res 65 (7), 2542-2546 (2005)
   PUBMED   15805246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001106663.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2473211.1,
                                           SRR26643298.27632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                JAXUCZ010000005.1  93147037-93147117
            82-242              JAXUCZ010000005.1  93159985-93160145
            243-418             JAXUCZ010000005.1  93167966-93168141
            419-533             JAXUCZ010000005.1  93210078-93210192
            534-727             JAXUCZ010000005.1  93225623-93225816
            728-777             JAXUCZ010000005.1  93235346-93235395
            778-881             JAXUCZ010000005.1  93240119-93240222
            882-1019            JAXUCZ010000005.1  93248166-93248303
            1020-1213           JAXUCZ010000005.1  93271377-93271570
            1214-1446           JAXUCZ010000005.1  93274607-93274839
            1447-1766           JAXUCZ010000005.1  93277831-93278150
            1767-1875           JAXUCZ010000005.1  93280388-93280496
            1876-2057           JAXUCZ010000005.1  93284063-93284244
            2058-2271           JAXUCZ010000005.1  93285734-93285947
            2272-2348           JAXUCZ010000005.1  93287780-93287856
            2349-2404           JAXUCZ010000005.1  93301752-93301807
            2405-2513           JAXUCZ010000005.1  93304930-93305038
            2514-2699           JAXUCZ010000005.1  93319309-93319494
            2700-2870           JAXUCZ010000005.1  93323340-93323510
            2871-2990           JAXUCZ010000005.1  93339178-93339297
            2991-3083           JAXUCZ010000005.1  93347160-93347252
            3084-4132           JAXUCZ010000005.1  93351992-93353040
FEATURES             Location/Qualifiers
     source          1..4132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..4132
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /note="lysine demethylase 4C"
                     /db_xref="GeneID:298144"
                     /db_xref="RGD:1307528"
     exon            1..81
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            82..242
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..3260
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /EC_number="1.14.11.-"
                     /note="jumonji domain containing 2C; lysine (K)-specific
                     demethylase 4C; lysine-specific demethylase 4C-like"
                     /codon_start=1
                     /product="lysine-specific demethylase 4C"
                     /protein_id="NP_001100133.3"
                     /db_xref="GeneID:298144"
                     /db_xref="RGD:1307528"
                     /translation="MEVVEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRA
                     GLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQKKPMTVKEFRQL
                     ANSSKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLD
                     VVEEECGISIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHG
                     KRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMITFPYG
                     YHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRNDMVKISMDIFVKKFQPDRYQIW
                     KQGKDIYTIDHTKPTPESTPEVKTWLQRRKKLRKAPKSLQGNKSLSKRPKAEEDEEFA
                     EFIGEEVSSPAVCPRHLKVTEKPEKFKLANIGASSEKEASDTRIQVDQSLTNDTKLSG
                     KSCINSSVIDEIQPENDTANAVTSPSTLKKASDLIPFSHGHITGKESRLLKILQLESP
                     KIPSSLAESNRVLTEGEENDEEGHASNLEPGEVPDALSEERNGLNVPKIIEGQPKTTK
                     SWRHPLGKPPARSPMTLVKQQVASDEELPEVLSIDEEVEETESWAKPLIHLWQTKSPN
                     FMAEQEYNATVAKMEPNCAICTLLMPYYKPDNSKEENDSRWETAVNEVVQSGRKTKPI
                     IPEMCFIYSEENVEYSPPNAFLEEDGTSLLISCSKCFVRVHASCYGVPSHEVCDGWLC
                     ARCKRNAWTAECCLCNLRGGALKQTKNNQWAHVICAVAVPEVRFTNVPERTQIDVDRI
                     PLQRLKLKCIFCRQRVKRVSGACIQCSYGRCPASFHVTCAHAAGVLMEPDDWPYVVNI
                     TCFRHRVNSNVKSKTCEKAISVGQTVITKHRNTRYYSCRVIDVTSQIFYEVMFDDGSF
                     SRDTFPEDIVSRNCVKLGPPAEGEVIQVKWPDGKLYGAKYLGSNVAYMYQVEFEDGSQ
                     IAMKREDIYTLDEELPKRVKARFSTASDMRFEDTFYGADVIQGERKRQRVLSSRLKNE
                     YVDDPVYRTFLKSSFQKKCQKRQ"
     exon            243..418
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            419..533
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            534..727
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            728..777
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            778..881
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1019
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1213
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1446
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1766
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1875
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2057
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2271
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2348
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2404
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2513
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2699
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2870
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..2990
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3083
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..4132
                     /gene="Kdm4c"
                     /gene_synonym="Jmjd2c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagattccca aaaccctcag gggaggccgc actttcatcc ctttcattcg ggtggcgtct
       61 ggacctcctc cagcggcgca gagacatctg tagccatcat ggaggtggtg gaggtggaga
      121 gtcccctaaa tcccagctgt aagataatga cattcagacc ttcaatggag gagtttcggg
      181 agttcaacaa atatctcgca tacatggaat ctaaaggagc ccatcgagca ggtcttgcca
      241 aggtgattcc tcctaaggag tggaagccaa gacaatgcta tgatgatatt gataatttgc
      301 ttattccagc accaattcag cagatggtca caggacagtc gggactgttt actcaataca
      361 acatccagaa aaagcccatg actgtgaagg agttcaggca gctggctaac agtagcaaat
      421 actgtactcc aagatacttg gattatgaag atttggaacg caaatactgg aaaaacttaa
      481 cttttgtggc acctatttat ggagcggata ttaatgggag catatatgat gagggtgtgg
      541 atgaatggaa tatagctcgc ctaaatacag tcttggatgt ggttgaagaa gagtgcggca
      601 tttctattga gggtgtaaat accccttatc tctattttgg aatgtggaaa acgacgttcg
      661 catggcacac tgaggatatg gatctctaca gtattaatta tctccacttt ggggagccca
      721 agtcttggta tgctatacct ccagagcatg gaaagcgact tgaaagacta gcccaaggct
      781 ttttccccag cagctcccaa ggctgtgatg cattcctccg ccacaagatg acactgattt
      841 ccccctcagt gctgaagaag tatggcattc cctttgacaa gattacccag gaggctggag
      901 agttcatgat tacttttcct tatgggtatc atgctggttt taatcatggt ttcaattgtg
      961 ctgagtctac aaactttgct acagtcagat ggattgacta tggaaaagtt gctaaattgt
     1021 gcacgtgtag gaatgacatg gtgaagatat caatggatat ctttgtgaag aaatttcagc
     1081 cagatagata ccagatttgg aaacaaggaa aggatatata tactattgac catacaaagc
     1141 caaccccaga atctacccca gaagtaaaaa catggctaca gaggaggaaa aagttaagaa
     1201 aagctcccaa gagtttgcag ggcaataagt cactttctaa aaggcctaaa gctgaggaag
     1261 atgaggaatt tgctgaattc attggggaag aggtctcaag ccctgctgtg tgccctcggc
     1321 acctcaaggt cacagaaaag ccagaaaaat tcaagctggc aaacatagga gcatcttcag
     1381 aaaaagaagc ttctgatact aggatacaag tagatcaaag cttaacgaat gacaccaagc
     1441 tctcaggaaa aagttgcata aattcatctg taatagatga aatacaacca gagaatgaca
     1501 ccgccaatgc tgtaacttcg ccatctacgc tgaagaaggc ttctgaccta ataccatttt
     1561 ctcatggcca tataacaggc aaggagtcac gtttacttaa gattctccag cttgaatctc
     1621 ccaagatacc ttcttcgctg gcagaaagta atagagtatt gacagaggga gaagaaaatg
     1681 atgaagaggg ccatgcaagt aaccttgaac ctggggaagt cccagatgct ctcagtgaag
     1741 agagaaatgg gctcaatgtt cctaagataa tagaaggaca gccaaaaact actaagagtt
     1801 ggcgacatcc acttgggaag cctccggcca gatccccaat gactcttgta aagcagcagg
     1861 tagcaagtga tgaagaattg cctgaggtcc taagcattga cgaagaagtt gaagaaacag
     1921 agtcttgggc aaagcctctg atccaccttt ggcagacaaa gtcgcccaac tttatggctg
     1981 aacaggagta caatgcaact gtggcaaaaa tggagccaaa ttgtgcaatc tgcactctgc
     2041 tcatgccata ctacaagcct gataacagca aagaagaaaa tgattctaga tgggagacag
     2101 cagtaaatga agtggttcaa tctggaagaa agactaaacc cattattcca gagatgtgtt
     2161 ttatttatag tgaagaaaat gttgaatatt ccccccctaa tgcctttctt gaagaagatg
     2221 gaacaagtct tctgatttcc tgttccaagt gcttcgtgcg ggttcatgca agttgttatg
     2281 gtgtcccttc tcatgaggtc tgtgatggat ggctgtgtgc ccgatgcaaa agaaatgcat
     2341 ggactgcaga atgctgtctc tgcaatttga gaggaggtgc acttaaacag actaagaaca
     2401 atcagtgggc tcatgtcata tgtgctgttg cagttccaga agttcgattc actaatgtcc
     2461 cagaaaggac acaaatagat gtagacagaa tacctttaca gaggttaaaa ttgaaatgca
     2521 tattctgtag acagcgggtt aaaagggttt ctggagcctg catccagtgt tcctatggcc
     2581 gctgcccagc ctctttccat gttacatgtg cccatgctgc tggagtactc atggagcctg
     2641 atgactggcc ttatgtggta aacatcactt gcttccgaca tagagtcaat tcaaacgtga
     2701 agtccaaaac ttgtgagaaa gccatttctg tgggtcagac agtcatcaca aaacatcgaa
     2761 atactcggta ctacagctgc agagtgatag atgtgacatc tcaaatcttc tatgaggtca
     2821 tgtttgatga tggttccttc agcagagaca catttcctga ggatattgtg agccgaaact
     2881 gtgtgaagct gggccctcct gcagaaggag aagtcatcca agtcaaatgg cctgatggta
     2941 aactctatgg agcaaagtat cttggatcaa atgttgcgta catgtatcag gttgaatttg
     3001 aagatggatc ccagatagca atgaagagag aagacatata caccttagat gaagagttac
     3061 ccaagagagt aaaggctcgt ttttccacag cctccgatat gcgatttgaa gacacatttt
     3121 atggagcaga tgtaatccaa ggggagagga agaggcaaag agtgctgagc tccaggctca
     3181 agaatgagta tgtggatgat cctgtgtatc gtactttcct gaagagttct ttccagaaga
     3241 aatgtcagaa gagacagtag ttgctaacat gcaacagcca cagtgcagct cagaccagaa
     3301 gagggaagac aaagggacag ccttggggta tgcactggga cccgtggatg ggtgcttctg
     3361 tggtactggt aataaatcag gcttctagga tttgattacc aagcaaccaa gaagagacct
     3421 attacttgct tctgtcatct gatcatccct cagtcatttg tttgacccca aagaatatta
     3481 ctacgtgaag ggaaatagca gtgaatggcc cactagataa aactcctgcc agaaaagagg
     3541 ttgttccctc tctttggctc aggtccctcc tcagggaaca tatatggagg ctcctttgcc
     3601 ccagctcatt tagtggaagc ctcatcaccc tagaggtagg gtgataattt atatattttc
     3661 cacagccagg gaaagattct cactcatatt tgttttaagt ggcagttttt ataaaacatt
     3721 tttaaaacac aaatggcatg tatggtaatg ggatttacct gtgtgctatc tctatcccct
     3781 tgtacagaac ttttccattt ttttatatta ttgcttttga ttgtgtctga aaactgagtt
     3841 gacctttata agaggaaatt ttttgctctt gaagaggaat tcatatgaag tatatgggaa
     3901 ttttatatat ttacagagga aaaatcttgg cctgatattt tgaacacttc ataattcctg
     3961 ttcagaatag atatttataa aatatatatt tctttcatta tgtgtttgta aaaattagag
     4021 tttaaagaaa tatacttaat gcatactttt aaactaatgt aacatgattt ttctttccaa
     4081 aagcctggaa atgtattagt atttaaaaat taaaatctgt tttctcctgt gc
//
