LOCUS       NM_001044236            5337 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lysine demethylase 4B (Kdm4b), transcript variant
            1, mRNA.
ACCESSION   NM_001044236 XM_001057877 XM_001057929 XM_001057990 XM_001058044
            XM_006244316 XR_005737
VERSION     NM_001044236.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5337)
  AUTHORS   Zhang,Y., Wang,Y., Zhou,X., Wang,J., Shi,M., Wang,J., Li,F. and
            Chen,Q.
  TITLE     Osmolarity controls the differentiation of adipose-derived stem
            cells into nucleus pulposus cells via histone demethylase KDM4B
  JOURNAL   Mol Cell Biochem 472 (1-2), 157-171 (2020)
   PUBMED   32594337
  REMARK    GeneRIF: Osmolarity controls the differentiation of adipose-derived
            stem cells into nucleus pulposus cells via histone demethylase
            KDM4B.
REFERENCE   2  (bases 1 to 5337)
  AUTHORS   Tumber,A., Nuzzi,A., Hookway,E.S., Hatch,S.B., Velupillai,S.,
            Johansson,C., Kawamura,A., Savitsky,P., Yapp,C., Szykowska,A.,
            Wu,N., Bountra,C., Strain-Damerell,C., Burgess-Brown,N.A.,
            Ruda,G.F., Fedorov,O., Munro,S., England,K.S., Nowak,R.P.,
            Schofield,C.J., La Thangue,N.B., Pawlyn,C., Davies,F., Morgan,G.,
            Athanasou,N., Muller,S., Oppermann,U. and Brennan,P.E.
  TITLE     Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of
            H3K4me3 at Transcription Start Sites and Proliferation of MM1S
            Myeloma Cells
  JOURNAL   Cell Chem Biol 24 (3), 371-380 (2017)
   PUBMED   28262558
REFERENCE   3  (bases 1 to 5337)
  AUTHORS   Chen,L., Fu,L., Kong,X., Xu,J., Wang,Z., Ma,X., Akiyama,Y., Chen,Y.
            and Fang,J.
  TITLE     Jumonji domain-containing protein 2B silencing induces DNA damage
            response via STAT3 pathway in colorectal cancer
  JOURNAL   Br J Cancer 110 (4), 1014-1026 (2014)
   PUBMED   24473398
REFERENCE   4  (bases 1 to 5337)
  AUTHORS   Zhao,L., Li,W., Zang,W., Liu,Z., Xu,X., Yu,H., Yang,Q. and Jia,J.
  TITLE     JMJD2B promotes epithelial-mesenchymal transition by cooperating
            with beta-catenin and enhances gastric cancer metastasis
  JOURNAL   Clin Cancer Res 19 (23), 6419-6429 (2013)
   PUBMED   24077348
REFERENCE   5  (bases 1 to 5337)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   6  (bases 1 to 5337)
  AUTHORS   Kawazu,M., Saso,K., Tong,K.I., McQuire,T., Goto,K., Son,D.O.,
            Wakeham,A., Miyagishi,M., Mak,T.W. and Okada,H.
  TITLE     Histone demethylase JMJD2B functions as a co-factor of estrogen
            receptor in breast cancer proliferation and mammary gland
            development
  JOURNAL   PLoS One 6 (3), e17830 (2011)
   PUBMED   21445275
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5337)
  AUTHORS   Northcott,P.A., Nakahara,Y., Wu,X., Feuk,L., Ellison,D.W.,
            Croul,S., Mack,S., Kongkham,P.N., Peacock,J., Dubuc,A., Ra,Y.S.,
            Zilberberg,K., McLeod,J., Scherer,S.W., Sunil Rao,J.,
            Eberhart,C.G., Grajkowska,W., Gillespie,Y., Lach,B., Grundy,R.,
            Pollack,I.F., Hamilton,R.L., Van Meter,T., Carlotti,C.G., Boop,F.,
            Bigner,D., Gilbertson,R.J., Rutka,J.T. and Taylor,M.D.
  TITLE     Multiple recurrent genetic events converge on control of histone
            lysine methylation in medulloblastoma
  JOURNAL   Nat Genet 41 (4), 465-472 (2009)
   PUBMED   19270706
REFERENCE   8  (bases 1 to 5337)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   9  (bases 1 to 5337)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   10 (bases 1 to 5337)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On or before Jul 26, 2021 this sequence version replaced
            XM_006244316.4, NM_001044236.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643289.24873.1,
                                           SRR26643298.47499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000009.1  1245903-1246077
            176-340             JAXUCZ010000009.1  1269081-1269245
            341-516             JAXUCZ010000009.1  1272048-1272223
            517-631             JAXUCZ010000009.1  1272601-1272715
            632-825             JAXUCZ010000009.1  1274931-1275124
            826-875             JAXUCZ010000009.1  1289253-1289302
            876-979             JAXUCZ010000009.1  1292423-1292526
            980-1117            JAXUCZ010000009.1  1295771-1295908
            1118-1314           JAXUCZ010000009.1  1305773-1305969
            1315-1416           JAXUCZ010000009.1  1310585-1310686
            1417-1604           JAXUCZ010000009.1  1310829-1311016
            1605-1993           JAXUCZ010000009.1  1314987-1315375
            1994-2114           JAXUCZ010000009.1  1315671-1315791
            2115-2293           JAXUCZ010000009.1  1317138-1317316
            2294-2510           JAXUCZ010000009.1  1317426-1317642
            2511-2587           JAXUCZ010000009.1  1317864-1317940
            2588-2643           JAXUCZ010000009.1  1318087-1318142
            2644-2752           JAXUCZ010000009.1  1318247-1318355
            2753-2938           JAXUCZ010000009.1  1320350-1320535
            2939-3103           JAXUCZ010000009.1  1320665-1320829
            3104-3223           JAXUCZ010000009.1  1320912-1321031
            3224-3316           JAXUCZ010000009.1  1322060-1322152
            3317-5337           JAXUCZ010000009.1  1322364-1324384
FEATURES             Location/Qualifiers
     source          1..5337
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..5337
                     /gene="Kdm4b"
                     /note="lysine demethylase 4B"
                     /db_xref="GeneID:301128"
                     /db_xref="RGD:1588576"
     exon            1..175
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            176..340
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..3499
                     /gene="Kdm4b"
                     /EC_number="1.14.11.66"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific demethylase 4B; lysine (K)-specific
                     demethylase 4B"
                     /codon_start=1
                     /product="lysine-specific demethylase 4B isoform 1"
                     /protein_id="NP_001037701.2"
                     /db_xref="GeneID:301128"
                     /db_xref="RGD:1588576"
                     /translation="MGSEDHSAQNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAG
                     LAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLA
                     NSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGNLRSILDM
                     VERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGK
                     RLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGY
                     HAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYEQWK
                     QGRDLTVLDHTRPTALSSPELSSWSASRTSLKAKLLRRQISVKESRPWRKAEEERRPS
                     LERRREPTRRPGPASHRRRSQPKKSKPEDSRSPGEATAGVAGLDEARGCSRRETMPEE
                     EEEEELSPSQGHEAEGVEEDGRGKPRPTKARSKKKTPSLLSPPLLSAPPALFPAEEVL
                     RLPPQPKSPGPAMGPMAAEGGPPPTALNVVPPGVPGEETEVRPRPIIPMLYVLPRANS
                     SDGDREHAAHPQLAPMELGPEEEDQAQAGDSQGTTSFSKLKVEIKKSRRHPLGRPPTR
                     SPLSVVKQEASSDEEAFPFSGEDDGSDPEALRSLLSLQWKSKAASFQAERKLNAAAAL
                     SEPYCAVCTLFYPYSQSVQTEREVLATPGDSAVQPPSKSGQRTRPLIPEMCFTSSGEN
                     TEPLPANSYVGEDGTSPLISCAHCCLQVHASCYGVRPELAKEGWTCSRCAAHAWTAEC
                     CLCNLRGGALQRTTEHRWIHVICAIAVPEVRFLNVIERNPVDVSAIPEQRWKLKCVYC
                     RKRMKRVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHRASGAGG
                     QLLRTVSLGQIVITKNRNGLYYRCRVIGTTAQTFYEVNFDDGSYSDNLYPESITSRDC
                     LRLGPPPEGELVELRWTDGNLYRARFISMATSLIYQVEFEDGSQLTVKRADIFTLEEE
                     LPKRVRSRLSLSTGTPQEPSFSGDGVKAAKRPRVATVLATTTEDTGRSPEYLAFMESL
                     LQAQGQPGAPF"
     exon            341..516
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            517..631
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            632..825
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            826..875
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            876..979
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1117
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1314
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1416
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1604
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1993
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2114
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2293
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2510
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2587
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2643
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..2752
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2938
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3103
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3223
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3316
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..5337
                     /gene="Kdm4b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagggct cggccgcgag cgagagaacc aacggaggag cgtagagacc aggcgaagat
       61 aggagctgag tggcccgggc gggcaagcga gcgagggccg gcagtggcga cgcgagacgg
      121 ctgggcacgc gcagctcaac ctgctgtcca cgctccgggc cgcgcgttgc gccaggtgta
      181 gctccacttt gctgcaacga tggggtctga ggaccacagt gcccagaatc ccagctgcaa
      241 aatcatgacc ttccgcccca ccatggatga attcagggac ttcaacagat atgtggccta
      301 cattgagtcg cagggtgccc accgtgccgg cctggccaag atcatcccac ccaaggagtg
      361 gaagccacgg cagacatatg atgacattga tgacgtggtc atcccagcac ctatccaaca
      421 ggtggtgaca ggccagtcgg ggcttttcac acagtacaac atccagaaga aggccatgac
      481 tgtgggggag taccgccgcc tagccaacag tgagaagtac tgtaccccac gccatcagga
      541 cttcgatgac ctggaacgca agtactggaa gaacctgacc tttgtctcac ccatctatgg
      601 ggctgacatc agtggctccc tgtatgatga tgacgtggcc cagtggaaca tcggcaatct
      661 gaggtccatc ctagacatgg tggagcgcga atgcgggacc atcattgagg gtgtgaacac
      721 accctacttg tactttggca tgtggaaaac cacgtttgcc tggcacacag aggacatgga
      781 cctctacagc atcaactacc tgcactttgg cgagcccaag tcctggtacg ccataccacc
      841 agagcacggc aagcgcctgg agcgcctggc cataggcttc ttccctggga gctcacaggg
      901 ctgcgatgcc ttcctaaggc acaagatgac gctcatctcg cccatcatcc tgaagaagta
      961 tggcatcccc ttcagccgga ttacacagga agctggggag ttcatgatca cattccccta
     1021 tggttaccat gcgggcttca accatggctt taactgcgct gagtccacta actttgccac
     1081 gctgcgctgg atcgactatg gcaaagtggc cacacagtgt acatgtcgaa aggacatggt
     1141 caagatctcc atggatgtgt ttgtacgcat actgcagccc gaacgctatg agcagtggaa
     1201 gcaagggcgt gacctcacag tgctggacca cacgaggccc acagccctga gcagtcccga
     1261 gctcagctct tggagtgcct cacgaacttc actcaaggcc aagctcctgc gaagacaaat
     1321 tagtgtgaag gagagcagac cctggagaaa ggctgaggag gagaggaggc cgagtctaga
     1381 gaggaggcgg gagccgacca ggaggccagg gccggcgtca caccggagac ggagccagcc
     1441 caagaagtcc aaacctgaag actccaggtc tccaggggaa gccacagctg gggtagctgg
     1501 tctggacgag gccaggggct gttcccggag ggagaccatg cctgaggagg aggaggaaga
     1561 ggagctgtca ccttcacagg gccatgaggc cgagggcgtg gaagaggatg gcagaggcaa
     1621 gcctcggcca actaaggcca ggagcaagaa gaagactccc agcctactgt cacccccatt
     1681 gctgtctgcc ccaccagccc tattccccgc cgaggaggtc ctgaggcttc caccccaacc
     1741 taagtctcca gggccagcca tgggccccat ggctgcagag gggggtcctc caccaacagc
     1801 cctcaatgtc gtgcctcctg gggtgccagg tgaggaaaca gaggtgcggc cccggcccat
     1861 tatcccaatg ctgtacgtgt tgccccgtgc caacagctct gatggggaca gggagcatgc
     1921 tgcccatcca cagttggcac ccatggagct ggggccagaa gaggaagacc aggcccaggc
     1981 tggtgactca cagggaacaa cctccttctc taagctgaag gtggagatca aaaagagtcg
     2041 gcgtcacccc ttgggtcggc cacccacacg gtccccgcta tctgtggtca agcaggaggc
     2101 ctcaagtgat gaagaggcct tcccattctc aggagaggat gatggcagtg accctgaggc
     2161 cttgaggtcc ctgctgtccc tgcagtggaa gagcaaggca gccagcttcc aagctgagag
     2221 gaagctgaat gcggcagccg ccctcagcga gccctactgt gccgtctgta ccctcttcta
     2281 cccctacagc cagtcagtac agacagagcg ggaggtcctg gccactccag gggacagtgc
     2341 tgtccagccg ccctccaaaa gtggccagag gacacggcca ctgatccctg agatgtgctt
     2401 cacttcaagt ggggagaaca cagaaccgct gcctgccaac tcctacgtcg gtgaggacgg
     2461 caccagtcca ctcatctcct gtgcccactg ctgtctgcag gtccatgcca gttgctatgg
     2521 tgtccggcct gagctggcca aagagggctg gacatgttcc cggtgtgcgg cccacgcctg
     2581 gactgcggaa tgctgtttgt gcaaccttcg gggaggagca ctacagagga ccacagagca
     2641 caggtggatt catgtgatct gcgccattgc agtccccgag gtacgattcc tcaatgtgat
     2701 cgaacgcaac ccagtggacg tcagtgccat ccctgagcag cgatggaaac tgaaatgtgt
     2761 gtactgccgc aagcgtatga agagggtgtc gggtgcctgc atccagtgct cctacgagca
     2821 ctgctccacg tccttccatg tgacctgcgc acatgctgct ggcgtcctca tggagccaga
     2881 tgactggccc tatgtagtgt ccatcacctg cctcaagcac agggccagtg gagcaggggg
     2941 ccagctgttg cgcacggtgt ccctgggcca gatcgtcatc accaagaatc gcaatgggct
     3001 ctactaccgc tgccgtgtca ttggcaccac tgctcagaca ttctatgagg tcaacttcga
     3061 tgatggctcc tacagcgaca acctgtatcc agagagcatc acaagcagag actgtctgcg
     3121 gctagggccg cctcctgagg gcgagctggt ggagctgcgg tggacagacg gtaatctgta
     3181 cagagccagg ttcatctcca tggccaccag cctcatctac caggtagagt ttgaggatgg
     3241 atctcagctg actgtgaagc gtgcggacat cttcacactt gaagaggaat tgcccaagag
     3301 ggtacggtcc cggctgtcac tgagcaccgg cacaccacag gagcccagct tctccggaga
     3361 tggcgtgaag gccgccaagc gcccacgggt ggccaccgtg ctggccacca ccactgagga
     3421 cacagggcgc agcccagaat acctggcctt catggagagc ctgctgcagg cgcagggcca
     3481 gcctggagca cccttctaga tactgcccac tcctgtccca ctgtaggtaa ctgggtaaca
     3541 ggacccgcag gatccaactt ggccagactc agggagcgag accggcatcc ctggactaca
     3601 gtgactccac gggacctggc ctggctctgc tcttctccta aaggtgctaa ggggcgtccc
     3661 agagtctcct gtgacagatg ctagccaagg acactggggc acagccccaa cctgttttct
     3721 agatttgtgg ctttaaaaat tgacaacagg cacattcttt ttcctctcca ccaagatgcg
     3781 aggagataaa agtttcatct gtgtttgaca cctgaggatg tttgtctact gagcaggtgg
     3841 gaaggcactt ttgtacaggt gttccctgga gggggcagca gcccagtgtg cagtgacttg
     3901 tgtgatggcc gcttgagatg ctccctgctt cctgctcggg gaggtgggcc ctgcaggagt
     3961 gggccctgcc ctgcctcctc catgccctgc cctgtgcaga gtatgcctca ctctgccttt
     4021 gctgcctggg ctcccatgag ccttcacctt tggactaggg cctctgtgtg gctgagggca
     4081 ggagaaagca gattccacct tcacttgaag ccctgatcga gtgacacagg gcacagactt
     4141 cacaggccct gtccgcacta gccgccacta cccatgggtt ggctataggt tctgtctctt
     4201 tagaagccac tgccgccata gggcctcagg ccccaggaga gacagctgac cttaaatgac
     4261 aaaggactgg acagagggac ctggccctgc ggacctgctg gggacttagg gactgggcct
     4321 ctgctgagtg cccaatggct gccatgccca tgtgtacatt gaaattctat ttatattgta
     4381 aagagaataa aaaaggaccc aacctgggcc tggaaggaga ggccaaaccg caggagtctc
     4441 aggctgtgcc ccttgtgggc tctgcagtgg ctgcaggtgg ccctgcttgt gcccccaccc
     4501 cccaccctcc agagaggccc tgatttttgt gcaaaaacaa aagctcactc cccgccagat
     4561 gaaggactcc atatttttgc ctcattctct ggcctctggt tcagtatcaa ttaaagccct
     4621 tgagctgagc gcttcctatt cccacctggt catggctgtg ttgtcatttt gtgccaggac
     4681 aagatgggct caggatggag gtgtccttgg caggcataat gggtacagtg tgtcctggtc
     4741 tgggcgtagg ggtcgccagg aggtgggacg ccatcctcag gacatctagt atctccacag
     4801 tgacgtggag ctgaggccgt gtgtccctcg tgtccctcct gaatgtctgt gctctctctg
     4861 actctcctgc ctgctcctac actgtggggc cacagaggag caaaggccct gggattgggc
     4921 agaccatggc ctggtgaagc agagggagga gtggaggaag ggtggcctcc aaagggtaga
     4981 cttggatttg acttggaggg aggaggagga gggtagaagc tgccaaaggc tctggacaga
     5041 agagggggag cctccctggt gctttcagca agagctcagc agcagacagc cccggtgccg
     5101 caggggcctt ggtttctctt tgaaactgtc ccatatgact ctaggaagga aagggaaggt
     5161 ggccctgcca gtgatagggc ctgggccctg tgggagtgaa gcgatgtcct aggaggggac
     5221 atctaactag ctgtcacctc gcctggtaca tcgggccaag ctcacatgta cagcccccag
     5281 tcctgggcca aatctagccc tggacctgtt tgttaataaa gttttccttg cacatgg
//
