LOCUS       NM_001107966            4421 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus lysine demethylase 4A (Kdm4a), mRNA.
ACCESSION   NM_001107966 XM_001072204 XM_233441
VERSION     NM_001107966.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4421)
  AUTHORS   Li,L., Ding,Z., Ma,F., Zhang,K., Lu,D., Wang,H. and Yang,K.
  TITLE     Spinal nerve transection-induced upregulation of KDM4A in the
            dorsal root ganglia contributes to the development and maintenance
            of neuropathic pain via promoting CCL2 expression in rats
  JOURNAL   Eur J Neurosci 60 (6), 5169-5188 (2024)
   PUBMED   39136140
  REMARK    GeneRIF: Spinal nerve transection-induced upregulation of KDM4A in
            the dorsal root ganglia contributes to the development and
            maintenance of neuropathic pain via promoting CCL2 expression in
            rats.
REFERENCE   2  (bases 1 to 4421)
  AUTHORS   Li,W., Zhang,Y., Lv,J., Zhang,Y., Bai,J., Zhen,L. and He,X.
  TITLE     MicroRNA-137-mediated lysine demethylase 4A regulates the recovery
            of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis
  JOURNAL   Int J Neurosci 133 (1), 37-50 (2023)
   PUBMED   33499717
  REMARK    GeneRIF: MicroRNA-137-mediated lysine demethylase 4A regulates the
            recovery of spinal cord injury via the SFRP4-Wnt/beta-Catenin axis.
REFERENCE   3  (bases 1 to 4421)
  AUTHORS   Liu,Y., Zhao,L., Zhang,J., Lv,L., Han,K., Huang,C. and Xu,Z.
  TITLE     Histone Demethylase KDM4A Inhibition Represses Neuroinflammation
            and Improves Functional Recovery in Ischemic Stroke
  JOURNAL   Curr Pharm Des 27 (21), 2528-2536 (2021)
   PUBMED   33402077
  REMARK    GeneRIF: Histone Demethylase KDM4A Inhibition Represses
            Neuroinflammation and Improves Functional Recovery in Ischemic
            Stroke.
REFERENCE   4  (bases 1 to 4421)
  AUTHORS   Qin,G., Li,Y., Wang,H., Yang,J., Chen,Q., Tang,H., Wang,Y.,
            Zhang,M., Jiang,T., Lin,S. and Huo,S.
  TITLE     Lysine-Specific Demethylase 4A Regulates Osteogenic Differentiation
            via Regulating the Binding Ability of H3K9me3 with the Promoters of
            Runx2, Osterix and Osteocalcin
  JOURNAL   J Biomed Nanotechnol 16 (6), 899-909 (2020)
   PUBMED   33187585
  REMARK    GeneRIF: Lysine-Specific Demethylase 4A Regulates Osteogenic
            Differentiation via Regulating the Binding Ability of H3K9me3 with
            the Promoters of Runx2, Osterix and Osteocalcin.
REFERENCE   5  (bases 1 to 4421)
  AUTHORS   Johansson,C., Velupillai,S., Tumber,A., Szykowska,A., Hookway,E.S.,
            Nowak,R.P., Strain-Damerell,C., Gileadi,C., Philpott,M.,
            Burgess-Brown,N., Wu,N., Kopec,J., Nuzzi,A., Steuber,H., Egner,U.,
            Badock,V., Munro,S., LaThangue,N.B., Westaway,S., Brown,J.,
            Athanasou,N., Prinjha,R., Brennan,P.E. and Oppermann,U.
  TITLE     Structural analysis of human KDM5B guides histone demethylase
            inhibitor development
  JOURNAL   Nat Chem Biol 12 (7), 539-545 (2016)
   PUBMED   27214403
REFERENCE   6  (bases 1 to 4421)
  AUTHORS   Sohi,G., Marchand,K., Revesz,A., Arany,E. and Hardy,D.B.
  TITLE     Maternal protein restriction elevates cholesterol in adult rat
            offspring due to repressive changes in histone modifications at the
            cholesterol 7alpha-hydroxylase promoter
  JOURNAL   Mol Endocrinol 25 (5), 785-798 (2011)
   PUBMED   21372147
REFERENCE   7  (bases 1 to 4421)
  AUTHORS   Trojer,P., Zhang,J., Yonezawa,M., Schmidt,A., Zheng,H., Jenuwein,T.
            and Reinberg,D.
  TITLE     Dynamic Histone H1 Isotype 4 Methylation and Demethylation by
            Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji
            Domain-containing JMJD2/KDM4 Proteins
  JOURNAL   J Biol Chem 284 (13), 8395-8405 (2009)
   PUBMED   19144645
REFERENCE   8  (bases 1 to 4421)
  AUTHORS   Fodor,B.D., Kubicek,S., Yonezawa,M., O'Sullivan,R.J., Sengupta,R.,
            Perez-Burgos,L., Opravil,S., Mechtler,K., Schotta,G. and
            Jenuwein,T.
  TITLE     Jmjd2b antagonizes H3K9 trimethylation at pericentric
            heterochromatin in mammalian cells
  JOURNAL   Genes Dev 20 (12), 1557-1562 (2006)
   PUBMED   16738407
REFERENCE   9  (bases 1 to 4421)
  AUTHORS   Gray,S.G., Iglesias,A.H., Lizcano,F., Villanueva,R., Camelo,S.,
            Jingu,H., Teh,B.T., Koibuchi,N., Chin,W.W., Kokkotou,E. and
            Dangond,F.
  TITLE     Functional characterization of JMJD2A, a histone deacetylase- and
            retinoblastoma-binding protein
  JOURNAL   J Biol Chem 280 (31), 28507-28518 (2005)
   PUBMED   15927959
REFERENCE   10 (bases 1 to 4421)
  AUTHORS   Zhang,D., Yoon,H.G. and Wong,J.
  TITLE     JMJD2A is a novel N-CoR-interacting protein and is involved in
            repression of the human transcription factor achaete scute-like
            homologue 2 (ASCL2/Hash2)
  JOURNAL   Mol Cell Biol 25 (15), 6404-6414 (2005)
   PUBMED   16024779
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474008.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233441.4, XM_001072204.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4421
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4421
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /note="lysine demethylase 4A"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
     exon            1..116
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            117..292
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..3167
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /EC_number="1.14.11.-"
                     /note="jumonji domain containing 2A; lysine (K)-specific
                     demethylase 4A"
                     /codon_start=1
                     /product="lysine-specific demethylase 4A"
                     /protein_id="NP_001101436.1"
                     /db_xref="GeneID:313539"
                     /db_xref="RGD:1306378"
                     /translation="MTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGAD
                     VNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMD
                     LYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLK
                     KYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCR
                     KDMVKISMDVFVRRFQPERYKLWKAGKDSTVIDHTLPTPEAAEFLKDSGLTPRAGNEE
                     CPEEDSEAAEQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYE
                     MTECQATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAA
                     ALDLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETTESVSCQGQEKTVLT
                     VHSYSRGDGKAAPGEPSVKRQRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLS
                     KLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNE
                     LMAQQAPHCAVCMIFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCS
                     TDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDC
                     CLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFC
                     KKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLER
                     AKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQ
                     DCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLD
                     EELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME"
     exon            293..407
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            408..601
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            602..651
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            652..755
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            756..893
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1138
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1338
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1706
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1827
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2009
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2214
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2291
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2347
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2456
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2642
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2813
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2933
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3026
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..4421
                     /gene="Kdm4a"
                     /gene_synonym="Jmjd2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgact ttaaaggagg cggagctttg tctttcgccc tcaagaaaga cagtgggatc
       61 ggcgagtggc gacagcagga atcgagcctg agccctgcta gggctttagg ctccaggttg
      121 ttcctcccaa agaatggaag cctcgaacct cctatgatga catcgacgat ctggtcatcc
      181 ctgcacccat ccagcagctg gtgactggcc agtccggcct cttcactcag tacaatatac
      241 agaagaaagc catgactgtt cgtgagttcc gcaagatcgc caatagtgac aagtactgta
      301 ctccacggta tagtgaattt gaagaacttg agcgtaaata ctggaaaaac ctcacattca
      361 atcctcccat ctatggagca gatgtgaatg gtactctcta tgaacagcac gttgatgagt
      421 ggaacatcgg ccggctgaag accatcctgg acctggtgga gaaggagagt gggatcacca
      481 tcgagggcgt gaacaccccc tacctgtact ttggcatgtg gaagacgtcc tttgcctggc
      541 acacggaaga catggatctg tacagcatca actacctgca ctttggagag ccaaagtctt
      601 ggtactctgt tccacctgag catgggaaac gcctggagcg gctcgccaaa ggctttttcc
      661 caggaagtgc tcaaagctgt gaggcttttc tccgccacaa gatgaccctg atctccccat
      721 taatgctgaa gaagtatggc attccctttg acaaggtgac ccaagaagcc ggggagttta
      781 tgatcacttt tccatatggg taccatgctg gtttcaacca tggcttcaac tgtgcagagt
      841 ctaccaattt tgctacccgt cggtggattg aatatggcaa gcaggctgta ctgtgttcct
      901 gcagaaaaga tatggtgaag atctctatgg acgtgtttgt caggaggttc cagccggaac
      961 gctacaaact ttggaaagct gggaaagaca gcactgttat tgaccacact ctgcccacac
     1021 cggaagcagc tgagtttctg aaggacagtg gactaacccc aagagctggg aatgaggagt
     1081 gcccagagga ggactcggaa gcggcggagc agggagagga gggggatgtg aagagaagcc
     1141 tggctaagca ccgaataggg acaaagagac accgagtctg tctggaaata ccacaggagg
     1201 tcagtcagag cgagctcttc cccaaggaag agctgagttc tggacagtat gagatgacag
     1261 agtgccaggc caccctcgcc ccagtgaggc ccacccacag ctccgtgcgg caagttgagg
     1321 acagccttcc cttcccagat tactccgacc ccactgaggt caaattcgaa gagctgaaga
     1381 acgtcaaact agaagaggag gatgaggatg aggagccgga agcagctgca ctggaccttt
     1441 ctgtgaatcc cgagtctgta gaaggacgcc tcgtcttctc gggctccaaa aagaaagcct
     1501 cctccagcct aggctccagt tcctctcagg attcagtttc ttcagattcc gaaaccaccg
     1561 agtctgtctc ttgccagggc caagagaaaa cagttctcac ggtgcacagc tactccagag
     1621 gagatggcaa ggctgcccca ggcgagccga gtgtgaagag gcagcgcagc gccccccgca
     1681 gcatcagcga gcaggagctg gcagaggttg cagatgagta catgctctcc ctggaggaga
     1741 ataagaagac caagggtcgc cgccagccct tgagcaagct cccacgccat cacccgctgg
     1801 tgttgcagga gtgcggcagc gatgacgaga cttctgaaca gctgacaccc gaggaagagg
     1861 ctgaggagac cgaggcttgg gctaagcctc tgagccagct gtggcagaac cgacctccaa
     1921 actttgaggc tgaaaaggaa ttcaatgagc tcatggccca gcaggcccct cactgtgctg
     1981 tgtgtatgat cttccagacc taccatcagg tggaatttgg aggcttcagt cagagctgtg
     2041 ggaatgcttc agaaccagct gcccaacctc agaggactaa gccattgatc cccgaaatgt
     2101 gctttaccac aactggctgc agcacagaca tcaatctgtc caccccttac ctagaggagg
     2161 atggcaccag catgctggtg tcttgtaaga agtgcagtgt ccgggtccac gccagttgct
     2221 atggcgtccc ccctgcaaag gcttctgaag aatggatgtg ctctcgatgt tcagccaatg
     2281 ccctggagga agactgctgt ttatgctcac tgcgtggagg ggccctgcag agagcaaacg
     2341 acgacagatg ggttcatgtt tcatgtgctg tggcaattct agaagcaagg tttgtcaaca
     2401 ttgctgaaag aagtccagtg gatgtgagca aaatccctct gccccgcttc aaactgaagt
     2461 gtgtcttttg taagaagcga agaaaacgga atgctggctg ttgtgtgcag tgctctcacg
     2521 gccgctgccc cactgccttc catgtgagct gtgcccaggc tgccggggtg atgatgcaac
     2581 ccgatgactg gccttttgtt gtcttcatca cgtgcttccg ccacaagatt cccaatttgg
     2641 agcgagctaa gggagccttg ctgagcatca cggccggcca gaaggtcatc agcaagcaca
     2701 agaacggccg cttctaccag tgcgaggtgg tcagactcac caccgaaacc ttctacgaag
     2761 tcaactttga tgacggctcc ttcagcgaca acctttatcc tgaggacata gtgagtcagg
     2821 actgtctcca actggggcct cctgctgaag gcgaagtggt tcaagtcaga tggacagatg
     2881 gtcaagtcta tggggctaag tttgtggcct cccaccccat ccagatgtac caggtggagt
     2941 tcgaggatgg ctcgcagctg gtggttaaga gagatgatgt atacacactg gatgaagagc
     3001 ttcccaagag agtcaagtct agactgtcag tagcttcaga catgcggttc aatgagattt
     3061 tcacagagaa ggaagtaaag caagaaaaga aaaggcaacg ggtcatcaac tcaaggtacc
     3121 gggaggatta catcgagcca gcactgtatc gggccatcat ggagtagacg tttcccgggt
     3181 ctgagaggtc ccagccatca aggcgagaac actctcgggt tccacagcac agcagacact
     3241 tggaactcag aagtcttaga aagagaagct gtacaaagaa aaggaatgac atgtctgacc
     3301 catcaccttc tcactcctcc ttcaatgaat tctgccgtga aaagacaagc cgggcgcttg
     3361 gcagcagctg acgctgacac tgggatgctg tgactccatc agcgcccagt ccaaaccggt
     3421 cagctgttcc tgctgggcgg attgttgttt cttagcctag gactagcttc ctaccaccca
     3481 cctgcaccag caaggcagag aggtgctggt gctcaaccca atcccctttt gtatttatgt
     3541 atgagtgtgt gagtgcacgc atgtacaggt gtgtacctgt gtgagagcgc tcgagtgtgc
     3601 acctgtgtgc ttgagaatgt gtgggtgtgc aagcacgtgt gtgtgtgtgt gcgcgagtgc
     3661 ctgtgtgcat gagtgcatga gtgtgtgtgt gggagtgtgc ttgatctgga ctagcttcag
     3721 ccagcccctg ggcttcactt tctcctttgc ctctgcaggg caaacaaaat gtgaaattct
     3781 gccctcagct aagctgagta agggccctgg gggatggcta gaggttggtt gccatctgtc
     3841 ccttcctgga ccgatttcaa gagagtgctg gcaaagctgc agtattggga tgctaaggag
     3901 ctgactgcca cctctgtcca cccttggagt agaactcaga ggttctgtac tatgagccca
     3961 caaacttcag gcacggaagc ccctgtggca gtgttagagg gtgtgggtgg ggcctacctt
     4021 gaagggagaa ttttaatgat ggaaacaggc agagcctggt gggtaatttt tgtgcagggg
     4081 aaaaaattgc agttatgcag gggctatctg tgggttagga tgaactgggg ccactggagg
     4141 ccaagggcag gtgtagccac gcccttggtc aggggtgggg tggggctgat tgagggtggg
     4201 ggggtgggac tggagggcaa cattgaaggg gttaaacagg tttttgctcc tcttgaattt
     4261 gtttgcctgg gcccaatatt ggagggcttc ataccttgct ctgtatacag gagtcagatt
     4321 tataatactt cccctttttt gttacgtatg aactctataa accaaattat tttgaaaact
     4381 ggtgcattac cttgtcctta gcaataaaat gtattgagca g
//
