LOCUS       NM_001389240            4759 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus lysine demethylase 3A (Kdm3a), transcript variant
            1, mRNA.
ACCESSION   NM_001389240 XM_006236639
VERSION     NM_001389240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4759)
  AUTHORS   Yang,M., Chen,Y., Huang,X., Shen,F. and Meng,Y.
  TITLE     Lysine demethylase KDM3A alleviates hyperoxia-induced
            bronchopulmonary dysplasia in mice by promoting ETS1 expression
  JOURNAL   Exp Cell Res 435 (2), 113945 (2024)
   PUBMED   38286256
  REMARK    GeneRIF: Lysine demethylase KDM3A alleviates hyperoxia-induced
            bronchopulmonary dysplasia in mice by promoting ETS1 expression.
REFERENCE   2  (bases 1 to 4759)
  AUTHORS   Guo,X., Zhang,B.F., Zhang,J., Liu,G., Hu,Q. and Chen,J.
  TITLE     The histone demthylase KDM3A protects the myocardium from
            ischemia/reperfusion injury via promotion of ETS1 expression
  JOURNAL   Commun Biol 5 (1), 270 (2022)
   PUBMED   35338235
  REMARK    GeneRIF: The histone demthylase KDM3A protects the myocardium from
            ischemia/reperfusion injury via promotion of ETS1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4759)
  AUTHORS   Wu,J.C., Sun,J., Xu,J.C., Zhou,Z.Y. and Zhang,Y.F.
  TITLE     Down-regulated microRNA-199a-3p enhances osteogenic differentiation
            of bone marrow mesenchymal stem cells by targeting Kdm3a in
            ovariectomized rats
  JOURNAL   Biochem J 478 (4), 721-734 (2021)
   PUBMED   33410908
  REMARK    GeneRIF: Down-regulated microRNA-199a-3p enhances osteogenic
            differentiation of bone marrow mesenchymal stem cells by targeting
            Kdm3a in ovariectomized rats.
REFERENCE   4  (bases 1 to 4759)
  AUTHORS   Liu,X., Chen,J., Zhang,B., Liu,G., Zhao,H. and Hu,Q.
  TITLE     KDM3A inhibition modulates macrophage polarization to aggravate
            post-MI injuries and accelerates adverse ventricular remodeling via
            an IRF4 signaling pathway
  JOURNAL   Cell Signal 64, 109415 (2019)
   PUBMED   31513837
  REMARK    GeneRIF: KDM3A inhibition modulates macrophage polarization to
            aggravate post-MI injuries and accelerates adverse ventricular
            remodeling via an IRF4 signaling pathway.
REFERENCE   5  (bases 1 to 4759)
  AUTHORS   Zhang,B.F., Jiang,H., Chen,J., Guo,X., Hu,Q. and Yang,S.
  TITLE     KDM3A inhibition attenuates high concentration insulin-induced
            vascular smooth muscle cell injury by suppressing MAPK/NF-kappaB
            pathways
  JOURNAL   Int J Mol Med 41 (3), 1265-1274 (2018)
   PUBMED   29286083
  REMARK    GeneRIF: KDM3A inhibition may exert numerous protective effects on
            high insulinstimulated vascular smooth muscle cell.
REFERENCE   6  (bases 1 to 4759)
  AUTHORS   Okada,Y., Scott,G., Ray,M.K., Mishina,Y. and Zhang,Y.
  TITLE     Histone demethylase JHDM2A is critical for Tnp1 and Prm1
            transcription and spermatogenesis
  JOURNAL   Nature 450 (7166), 119-123 (2007)
   PUBMED   17943087
REFERENCE   7  (bases 1 to 4759)
  AUTHORS   Loh,Y.H., Zhang,W., Chen,X., George,J. and Ng,H.H.
  TITLE     Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate
            self-renewal in embryonic stem cells
  JOURNAL   Genes Dev 21 (20), 2545-2557 (2007)
   PUBMED   17938240
REFERENCE   8  (bases 1 to 4759)
  AUTHORS   Tachibana,M., Nozaki,M., Takeda,N. and Shinkai,Y.
  TITLE     Functional dynamics of H3K9 methylation during meiotic prophase
            progression
  JOURNAL   EMBO J 26 (14), 3346-3359 (2007)
   PUBMED   17599069
REFERENCE   9  (bases 1 to 4759)
  AUTHORS   Yamane,K., Toumazou,C., Tsukada,Y., Erdjument-Bromage,H.,
            Tempst,P., Wong,J. and Zhang,Y.
  TITLE     JHDM2A, a JmjC-containing H3K9 demethylase, facilitates
            transcription activation by androgen receptor
  JOURNAL   Cell 125 (3), 483-495 (2006)
   PUBMED   16603237
REFERENCE   10 (bases 1 to 4759)
  AUTHORS   Hoog,C., Schalling,M., Grunder-Brundell,E. and Daneholt,B.
  TITLE     Analysis of a murine male germ cell-specific transcript that
            encodes a putative zinc finger protein
  JOURNAL   Mol Reprod Dev 30 (3), 173-181 (1991)
   PUBMED   1793593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced XM_006236639.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222223.1, SRR26643284.6190.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JAXUCZ010000004.1  105233216-105233370 c
            156-371             JAXUCZ010000004.1  105232437-105232652 c
            372-527             JAXUCZ010000004.1  105225490-105225645 c
            528-638             JAXUCZ010000004.1  105224463-105224573 c
            639-741             JAXUCZ010000004.1  105221706-105221808 c
            742-866             JAXUCZ010000004.1  105220796-105220920 c
            867-939             JAXUCZ010000004.1  105220483-105220555 c
            940-1028            JAXUCZ010000004.1  105220300-105220388 c
            1029-1192           JAXUCZ010000004.1  105214181-105214344 c
            1193-1704           JAXUCZ010000004.1  105211887-105212398 c
            1705-1909           JAXUCZ010000004.1  105208172-105208376 c
            1910-2124           JAXUCZ010000004.1  105205599-105205813 c
            2125-2277           JAXUCZ010000004.1  105201982-105202134 c
            2278-2373           JAXUCZ010000004.1  105201758-105201853 c
            2374-2501           JAXUCZ010000004.1  105201355-105201482 c
            2502-2697           JAXUCZ010000004.1  105199803-105199998 c
            2698-2870           JAXUCZ010000004.1  105197639-105197811 c
            2871-3107           JAXUCZ010000004.1  105196977-105197213 c
            3108-3279           JAXUCZ010000004.1  105195815-105195986 c
            3280-3373           JAXUCZ010000004.1  105195054-105195147 c
            3374-3504           JAXUCZ010000004.1  105194396-105194526 c
            3505-3624           JAXUCZ010000004.1  105192372-105192491 c
            3625-3764           JAXUCZ010000004.1  105192152-105192291 c
            3765-3941           JAXUCZ010000004.1  105190977-105191153 c
            3942-4076           JAXUCZ010000004.1  105190757-105190891 c
            4077-4759           JAXUCZ010000004.1  105189208-105189890 c
FEATURES             Location/Qualifiers
     source          1..4759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..4759
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /note="lysine demethylase 3A"
                     /db_xref="GeneID:312440"
                     /db_xref="RGD:708351"
     exon            1..155
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            156..371
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..4157
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /EC_number="1.14.11.65"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lysine-specific demethylase 3A; zinc finger protein TSGA;
                     testis-specific gene A protein; jumonji domain-containing
                     protein 1A; jmjC domain-containing histone demethylation
                     protein 2A; jumonji domain containing 1A; probable zinc
                     finger protein; lysine (K)-specific demethylase 3A;
                     [histone H3]-dimethyl-L-lysine(9) demethylase 3A"
                     /codon_start=1
                     /product="lysine-specific demethylase 3A isoform 1"
                     /protein_id="NP_001376169.1"
                     /db_xref="GeneID:312440"
                     /db_xref="RGD:708351"
                     /translation="MVLTLGESWPVLVGKRFLSLSAAEGSDGGHDNWDLERVAEWPWL
                     SGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIDVYSLLRRAFLVEHNLVLAERKSP
                     EIPEQVIQWPAIMYKSLLDKAGLGSITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSL
                     TDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVRIYSLDPSTQWFSATVVHGNPSS
                     KTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRIGAVKRKSSENNGSSVSKQA
                     KSCSEVSPSMCPVQSVPTTVCKEILLGCTAATPSSKGPRQQNTPQAANSPPNIGAKLP
                     QGCHKQSLPEEISSCLNTKSEVLRTKPDVCKAGLLSSKSSQVGAGDLKILSEPKGSCI
                     QPKTNTDQESRLESTPQPVTGLTKECLVTKTSSKAELDNATAPELQKRLEHTASTPDG
                     LSDKPEVEAGVTRLNSCSEKKVGPSDLGSQSQNLKETSVKVDHDSCCTRSSNKTQTPP
                     ARKSVLTDPDKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPV
                     FCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILAN
                     IGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFG
                     VCVDCYRMKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHS
                     VRAKWGIKANCPCSNRQFKLFSKPALKEDLKQASLSGEKPSLGTMVQQSSPVLEPAAV
                     CGEAPSKPASNVKPICPANTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPL
                     PPLNKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASL
                     VQNKTSSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQ
                     GQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDV
                     PNRLKNEKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASR
                     LPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEE
                     EVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPA
                     DHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKV
                     AEDFVSPEHVKHCFWLTQEFRHLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSL
                     GKS"
     exon            372..527
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            528..638
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            639..741
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            742..866
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            867..939
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1028
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1192
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1704
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1909
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2124
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2277
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2373
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2501
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2697
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2870
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3107
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3279
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3373
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3504
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3624
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3625..3764
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3765..3941
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            3942..4076
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4759
                     /gene="Kdm3a"
                     /gene_synonym="Jmjd1; Jmjd1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaatcatcg gtggcagcgg ctccgagggg gcgggcccgg gaggctgtgc gtgtcttgtg
       61 tgagagagct cttgaaccaa gtcagagcta gagtcggctg ggcggctggg ctctcttgcc
      121 gccgtcgcgg gtgactcagg gaggcgggag gcgggggagg agcccttcct gctggcgtgg
      181 aaaccatggt gctcacgctc ggagaaagtt ggccagtatt ggtggggaag cgattcctca
      241 gtctgtccgc agctgaaggc agcgacggcg gccacgacaa ctgggacttg gagcgcgttg
      301 cagagtggcc ctggctgtcc gggaccattc gagctgtttc tcacactgac gttaccaaga
      361 aagatttgaa ggtttgtgtg gagtttgatg gagagtcttg gagaaagaga agatggatag
      421 atgtctacag ccttctaaga agagcatttt tagtagaaca taacctggtt ctggcagaac
      481 gaaaatcacc tgagattcct gagcaagtta ttcagtggcc tgcaataatg tacaaatctc
      541 tactagacaa agctggcttg ggatccataa cttctgttcg cttccttgga gatcagcaaa
      601 gtgtatttgt ttccaaagac cttttgaaac ctatacagga tgtaaacagt cttcggcttt
      661 cccttactga taatcagacg gtcagtaaag agtttcaagc tttgattgta aaacatttgg
      721 atgaaagcca tcttttacaa ggtgacaaga accttgttgg ttcagaagta agaatttata
      781 gcttggatcc atctactcag tggttttcag caactgttgt acatggaaac ccctcatcca
      841 aaactcttca agtcaactgt gaggagattc cagcgctgaa aattgttgat ccagcactga
      901 ttcacgttga agttgtacac gataattttg taacgtgtgg taattctaca agaattggag
      961 ctgtgaaacg caagtcttct gagaataatg gaagttcagt ttctaaacaa gcaaaatctt
     1021 gctctgaggt ctctcccagt atgtgtcctg tacagtctgt tcccacaaca gtgtgtaagg
     1081 agatcctgct tggctgtact gcagcaaccc catctagcaa gggcccaaga cagcagaaca
     1141 ctccccaggc agccaattct ccacctaaca ttggagcaaa acttcctcaa ggatgtcaca
     1201 agcagagttt accagaagaa atttcttcct gtctaaatac aaaatctgaa gtactgagaa
     1261 caaaaccaga tgtttgcaaa gcaggattac tttcttcaaa atcttctcag gttggagctg
     1321 gagacttgaa aattctgagt gagcccaaag gtagctgtat ccagcctaaa acaaacactg
     1381 atcaggagag cagactggag tctactccac aaccagtcac tggccttaca aaggagtgct
     1441 tggttacaaa gacttcctct aaggcagaac tggacaatgc cactgctcct gaactgcaga
     1501 agcgtctaga gcacacagct tccacacccg atggtctttc agacaagcca gaagtggaag
     1561 caggtgtcac taggcttaat agctgttcag aaaagaaggt tggaccttca gatttaggtt
     1621 cgcagtcaca gaatttaaag gaaacttcag taaaagtcga tcatgacagc tgttgtacaa
     1681 gaagcagtaa taaaacccag actcccccag cccggaagtc agttttgaca gacccagata
     1741 aactcaagaa gctacagcag agtggagagg cctttgttca ggatgactcc tgtgttaaca
     1801 tcgtggcaca gctgcccaag tgtcgggagt gtcgattaga cagcctgcgc aaggataagg
     1861 accagcagaa agactcgcca gtgttctgtc gcttttttca cttcaggagg ttacaattca
     1921 acaaacatgg tgttctgcgg gtagaaggct tcttaacacc aaacaagtac gacagtgaag
     1981 cgattggctt gtggctgcct ttgaccaaaa atgttgtggg gactgatttg gacacagcaa
     2041 agtatatcct ggccaatatt ggagaccact tctgtcaaat ggtgatttct gagaaggagg
     2101 ctatgtcaac tattgagcca cacaggcagg ttgcttggaa acgagctgtc aaaggagtta
     2161 gagaaatgtg tgatgtgtgt gacacaacca ttttcaacct gcactgggtg tgccctcggt
     2221 gtgggtttgg agtgtgtgta gattgctacc ggatgaagag gaagaattgc caacaggggg
     2281 ctgcctacaa gactttctct tggataaggt gtgtgaagag tcaaatacat gagcctgaga
     2341 acctgatgcc cacgcagatt attcctggca aagccctcta cgatgttgga gacattgtgc
     2401 attctgtcag agcaaaatgg ggtataaagg ccaattgtcc ctgctccaac aggcagttca
     2461 agctcttctc gaagccagcc ttaaaggaag acctgaagca ggcatccttg tctggagaaa
     2521 aaccaagtct cggcaccatg gtacagcaaa gctcccctgt gttggagcca gcagccgtgt
     2581 gtggggaagc accctccaag ccagccagca atgtgaagcc catctgtcca gccaacacat
     2641 cccctttaaa ctggctagct gacctgacca gtggcaatgt caacaaggaa aacaaggaaa
     2701 aacagctgac tatgccaatt ttaaagaacg aaatcaaatg ccttccaccc ttgcctcctc
     2761 tgaacaagtc cagcactgtc ctccatactt ttaacagcac aattttgaca cccgtgagca
     2821 acaataattc tggttttctt cgaaatcttt tgaattcatc cacaggaaag acagaaaatg
     2881 gactaaaaaa cacacccaaa atccttgatg atatctttgc ctctttggta caaaacaaga
     2941 cttcttctga cttatccaag aggcctcaag gactgacgat caagcctagc attcttggtt
     3001 ttgacactcc tcactactgg ctgtgtgaca accgcctgct gtgcttgcaa gaccccaaca
     3061 ataagagcaa ttggaatgtc tttagggaat gctggaaaca ggggcagcca gtgatggtgt
     3121 cgggagtgca tcataaatta aacactgaac tctggaaacc cgagtccttc aggaaagagt
     3181 ttggcgagca agaagtagac ctagtcaatt gtaggaccaa tgaaatcatc acaggagcca
     3241 cagtgggaga cttctgggat ggatttgaag atgttccaaa ccgtttgaaa aacgaaaaag
     3301 aaaaagaacc aatggtgttg aaacttaagg actggccgcc aggagaagac tttagagata
     3361 tgatgccttc caggtttgat gatctgatgg ccaacattcc actgcctgag tataccaggc
     3421 gagatggcaa actgaacctg gcctctagac tgccaaacta ctttgtacgg ccagacctgg
     3481 gccccaagat gtacaatgct tatggattga tcactccaga agatcggaaa tatgggacca
     3541 cgaatcttca cttagatgta tctgatgcag ccaatgtcat ggtttatgtg ggaattccca
     3601 aaggacagtg tgaacaagag gaagaagtcc ttagaaccat ccaagatgga gattcggatg
     3661 aactcacaat caagcgattt attgaaggaa aagagaagcc aggcgccctt tggcacatat
     3721 atgctgctaa agacacagaa aagataagag aattccttaa aaaggtatct gaagagcagg
     3781 gtcaagaaaa ccccgcagac catgatccta ttcatgatca gagctggtat ttagaccgat
     3841 cactgagaaa gcgcctttat caagagtatg gagttcaagg ctgggctatt gtacaatttc
     3901 ttggcgatgt ggtgtttatc ccggcaggag ctccacatca ggttcataac ttatacagct
     3961 gtatcaaagt cgctgaagac ttcgtgtctc cagagcatgt gaaacactgc ttctggctca
     4021 ctcaggaatt ccgtcacttg tcacagactc ataccaacca cgaagataaa ctgcaggtaa
     4081 agaatgttat ctaccatgca gtaaaagatg cagttgctat gctgaaagcc agtgaatcca
     4141 gtttgggcaa atcttaactc ctctctgcac attggagatg attattggca gctgatcaaa
     4201 ctcttcaggc aggattcctg tggactttga gatttcctgt tacctcatct tcttttttaa
     4261 agtacacctg acttaggagg gtactgtctc taatgtatat ttctagtgtt tacagacact
     4321 aagtgtgtat atgtagtaac tatttacaga ccatgcatcc ttatactgtg acttcaccta
     4381 gtacagatct tcaaccaagc tgaagacctg ctgctctgaa acagtacttg cagttactcc
     4441 ccagctgttg tttggacagt tcattcgaat ggatttttaa ctattaggga tcacttcgaa
     4501 gtttcattgg attttatttt atgtccttca gagcaccctc ccgcacccac tagggtccca
     4561 gaagagcaat ggaggaagtg acagctaatg gtgcagttct aaatatattg cataggactg
     4621 gcatatagca gaaataacta ctgtataatt cttggggtta accatcttta gttaatggaa
     4681 ttttaattta aatgaagctt tgctaatttt aagtggtaag cattttgcat taaaatattc
     4741 atataatatt tttgctcta
//
