LOCUS       NM_001100679            5190 bp    mRNA    linear   ROD 03-APR-2023
DEFINITION  Rattus norvegicus lysine demethylase 2B (Kdm2b), mRNA.
ACCESSION   NM_001100679 XM_001075313 XM_001075343 XM_222177
VERSION     NM_001100679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5190)
  AUTHORS   Mao X, Li Z, Gu S, Song W, Zhang M, Tan X and Mao Z.
  TITLE     MicroRNA-211-5p in extracellular vesicles derived from BMSCs
            facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis
  JOURNAL   Tissue Cell 81, 102006 (2023)
   PUBMED   36610229
  REMARK    GeneRIF: MicroRNA-211-5p in extracellular vesicles derived from
            BMSCs facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis.
REFERENCE   2  (bases 1 to 5190)
  AUTHORS   Yin L, Fang Y, Song T, Lv D, Wang Z, Zhu L, Zhao Z and Yin X.
  TITLE     FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via
            the PKC beta2 pathway
  JOURNAL   J Cell Mol Med 23 (4), 2558-2567 (2019)
   PUBMED   30701683
  REMARK    GeneRIF: FBXL10 regulates cardiac dysfunction in diabetic
            cardiomyopathy via the PKC beta2 pathway.
REFERENCE   3  (bases 1 to 5190)
  AUTHORS   Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR and Min J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   4  (bases 1 to 5190)
  AUTHORS   Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng
            G, Lin SY and Lu Z.
  TITLE     Local generation of fumarate promotes DNA repair through inhibition
            of histone H3 demethylation
  JOURNAL   Nat Cell Biol 17 (9), 1158-1168 (2015)
   PUBMED   26237645
  REMARK    Erratum:[Nat Cell Biol. 2018 Apr 9;:. PMID: 29632342]
REFERENCE   5  (bases 1 to 5190)
  AUTHORS   Long HK, Blackledge NP and Klose RJ.
  TITLE     ZF-CxxC domain-containing proteins, CpG islands and the chromatin
            connection
  JOURNAL   Biochem Soc Trans 41 (3), 727-740 (2013)
   PUBMED   23697932
  REMARK    Review article
REFERENCE   6  (bases 1 to 5190)
  AUTHORS   Bottardi S, Zmiri FA, Bourgoin V, Ross J, Mavoungou L and Milot E.
  TITLE     Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance
            transcription elongation
  JOURNAL   Nucleic Acids Res 39 (9), 3505-3519 (2011)
   PUBMED   21245044
REFERENCE   7  (bases 1 to 5190)
  AUTHORS   He J, Nguyen AT and Zhang Y.
  TITLE     KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for
            initiation and maintenance of acute myeloid leukemia
  JOURNAL   Blood 117 (14), 3869-3880 (2011)
   PUBMED   21310926
REFERENCE   8  (bases 1 to 5190)
  AUTHORS   Fukuda T, Tokunaga A, Sakamoto R and Yoshida N.
  TITLE     Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death
            and leads to exencephaly
  JOURNAL   Mol Cell Neurosci 46 (3), 614-624 (2011)
   PUBMED   21220025
REFERENCE   9  (bases 1 to 5190)
  AUTHORS   Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE and
            Tsichlis PN.
  TITLE     Members of a family of JmjC domain-containing oncoproteins
            immortalize embryonic fibroblasts via a JmjC domain-dependent
            process
  JOURNAL   Proc Natl Acad Sci U S A 105 (6), 1907-1912 (2008)
   PUBMED   18250326
REFERENCE   10 (bases 1 to 5190)
  AUTHORS   Gearhart MD, Corcoran CM, Wamstad JA and Bardwell VJ.
  TITLE     Polycomb group and SCF ubiquitin ligases are found in a novel BCOR
            complex that is recruited to BCL6 targets
  JOURNAL   Mol Cell Biol 26 (18), 6880-6889 (2006)
   PUBMED   16943429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473973.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XM_222177.4, XM_001075343.1, XM_001075313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     gene            1..5190
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /note="lysine demethylase 2B"
                     /db_xref="GeneID:304495"
                     /db_xref="RGD:1310217"
     exon            1..229
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..4114
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /EC_number="1.14.11.27"
                     /note="gene_id=rCG21405.0 transcript_id=rCT21405.0
                     protein_id=rCP49624.0; F-box and leucine-rich repeat
                     protein 10; lysine (K)-specific demethylase 2B"
                     /codon_start=1
                     /product="lysine-specific demethylase 2B"
                     /protein_id="NP_001094149.1"
                     /db_xref="GeneID:304495"
                     /db_xref="RGD:1310217"
                     /translation="MEAEKDSGRRLRAIDRQRYDENEDLSDVEEIVSVRGFSLEEKLR
                     SQLYQGDFVHAMEGKDFNYEYVQREALRVPLVFRDKDGLGIKMPDPDFTVRDVKLLVG
                     SRRLVDVMDVNTQKGTEMSMSQFVRYYETPEAQRDKLYNVISLEFSHTKLEHLVKRPT
                     VVDLVDWVDNMWPQHLKEKQTEATNALAEMKYPKVKKYCLMSVKGCFTDFHIDFGGTS
                     VWYHVFRGGKIFWLIPPTLHNLALYEEWVLSGKQSDIFLGDRVERCQRIELKQGYTFF
                     IPSGWIHAVYTPVDSLVFGGNILHSFNVPMQLRIYEIEDRTRVQPKFRYPFYYEMCWY
                     VLERYVYCVTQRSYLTQEYQRELMLIDAPRKNSVDGFSSDSWLEMEEESREQQLQEEE
                     DKEEEGDGADKTPKPPTEGPTSPTSTQSEDQDSTGKKPKAPAMRFLKRTLSNESEESV
                     KSTAMPVDYPKTPTGSPATEVSTKWTHLTEFELKGLKALVEKLESLPENKKCVPEGIE
                     DPQALLEGVKNVLKEHVDDDPNLAITGVPVVSWPKKTPKNRVVGRPKGKLGPASAVKL
                     AANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPV
                     LPHTAVCLVCGEAGKEDTVEEEEGKFNLMLMECSICNEIIHPGCLKIKESEGVVNDEL
                     PNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRSECE
                     EAPRRRSDEHPKKVPTDGILRRKSDDVHLRRKRKYEKPQELSARKRASTLQTSPGSSS
                     HLSPRPPLGSSLSPWWRSSLTYFQQQLKPGKEDKLLRKKRRSWKNAEDRLSLANKPLR
                     RFKQEPEDDLPEAPPKTRESDQSRSSSPTAGPSTEGAEGPEEKRKVKMRRKRRLPNKE
                     LSKELSKELNHEIQKTESTLAHENHQPIKSEPESENEEPKRPLSHCERPHRFSKGLNG
                     TPRELRHSLGPGLRSPPRVISRPPPSTSPPKCIQMERHVIRPPPISPPPDSLPLDDGA
                     AHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLS
                     GIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRT
                     LDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDVSLRLIIR
                     HMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINLSDCNKVTDQCLSFFKRCG
                     NICHIDLRYCKQVTKEGCEQFIAEMSVSVQFGQVEEKLLQKLS"
     exon            230..374
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            375..453
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            454..500
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            501..679
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            680..786
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            787..880
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1034
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1150
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1277
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1750
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1837
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..2062
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2206
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2293
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2554
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2668
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2707
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..3387
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3551
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3713
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3714..3932
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..5190
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgaaaatggt ttcctaggac tttgcaaacg gatctgctta agtgttggtg caaaactttg
       61 tagatatcgg ctctggcttg ctctatttat ttattttttt tttggtttct tttctttggt
      121 cttccctcct ttccccctcc gccaaaatgc agggggcagg agtgttgaca attaattggt
      181 gaactcccct aaaaaaatgg aggcagagaa agactctgga agaagattgc gtgcgattga
      241 ccgccagaga tacgacgaga acgaagactt gtcggacgtg gaggaaattg tcagcgtccg
      301 tggcttcagc ctggaggaga agctacgtag ccagctatac cagggggact tcgtgcatgc
      361 catggaaggc aaagatttta actatgagta cgtacagaga gaagctctca gggttcccct
      421 ggtttttcga gacaaggatg gactaggaat caagatgcca gaccctgact tcacagtccg
      481 agacgtcaaa ctcctggtgg ggagtcgccg gctggtggac gtgatggacg tgaacaccca
      541 gaagggcacg gagatgagca tgtcccagtt cgtgcgttac tacgagacac cagaggcaca
      601 gagggacaaa ctgtacaatg tcatcagcct cgagttcagc catacgaagc tggagcatct
      661 agtcaagcgt cccactgtgg tggacctggt cgactgggtg gacaacatgt ggccccaaca
      721 tctaaaggaa aagcagacag aagccacaaa cgcccttgcc gagatgaaat accccaaagt
      781 gaagaagtac tgtctgatga gcgtgaaggg ctgtttcacc gacttccaca ttgactttgg
      841 aggcacctcc gtgtggtacc atgttttccg tggcgggaag atcttttggc tgatcccccc
      901 aaccctgcac aacttggctc tgtatgagga gtgggtgctg tctggcaaac agagtgacat
      961 ctttctggga gaccgagtgg aacgctgcca aagaattgag ctgaagcaag gctacacatt
     1021 tttcatccct tctggttgga tccatgcagt gtacacgccc gtggactctc tggtgttcgg
     1081 cgggaacatc ctgcacagct tcaacgtgcc catgcagctg cgcatctacg agatcgagga
     1141 caggacccgg gttcagccca agttccgtta ccccttctac tatgagatgt gctggtatgt
     1201 cttggagaga tacgtgtact gtgtgaccca gcgctcctac ctcactcagg aataccagcg
     1261 agaattaatg ctcattgatg ccccaagaaa aaacagtgta gacggtttct catctgattc
     1321 ctggctggag atggaggagg agtcccgtga gcagcagctc caggaggagg aggacaagga
     1381 agaggaaggg gatggtgcag acaaaacacc caagccaccc accgagggcc ccacctcacc
     1441 caccagcacc cagtcggaag accaggacag cacagggaag aagcctaaag cccctgctat
     1501 gcgattcctc aagaggactt tgtccaatga gtccgaggaa agtgtcaagt ccacagcgat
     1561 gcccgtagac taccccaaga cgcccacagg ctccccggcc actgaggttt ctaccaagtg
     1621 gactcacctt accgaatttg aactgaaggg cttgaaagcc ctggttgaaa aactagagtc
     1681 tcttccggag aataagaagt gtgtccctga gggaattgag gacccccagg ccctcctgga
     1741 aggtgttaag aatgtactga aggaacacgt ggatgatgac cccaacctgg ccatcaccgg
     1801 ggtccccgtg gtcagttggc caaagaaaac tccaaagaac cgggtggtgg gtcggcctaa
     1861 gggcaagttg ggcccggcct cagcggtgaa gttggctgcc aaccgaacaa cagcaggagc
     1921 tcgcaggcgc cggacgcgat gccgcaagtg cgaggcctgc ctgcggacgg agtgtggaga
     1981 gtgccacttt tgcaaggaca tgaagaagtt cggaggtcct gggcgcatga agcagagctg
     2041 catcatgcgg cagtgcatcg cgccagtgct gccccacacc gccgtgtgcc ttgtgtgtgg
     2101 cgaggcaggg aaggaggaca cagtggaaga ggaagaaggc aagtttaacc tcatgctcat
     2161 ggagtgctcc atctgcaacg agatcatcca ccctggatgc cttaagatta aggaatcaga
     2221 gggtgtggtc aacgatgagc ttcccaactg ctgggagtgt ccgaagtgta accatgccgg
     2281 caagaccggg aaacaaaagc gtggccctgg ctttaagtat gcctccaact tgcctggctc
     2341 cttgctcaag gagcagaaga tgaaccggga caacaaggaa gggcaggagc ctgccaagcg
     2401 gaggagtgag tgtgaagagg ccccccgtcg caggtcagac gagcacccca agaaggtgcc
     2461 tacagatggc atcctccgcc gaaagtctga cgatgtgcac ctgaggagga agcggaaata
     2521 cgagaagccc caagagctga gtgcacgcaa gcgagcctcg acgcttcaaa cgtcccccgg
     2581 ttcctcctct cacctctcgc cgaggccccc tctaggcagc agtctcagcc cttggtggag
     2641 atccagtctc acttacttcc agcagcagct aaaacctggc aaagaagata agcttctcag
     2701 gaaaaagcgg cggtcctgga agaacgctga ggatcggctg tcactggcca acaagcccct
     2761 tcggcgcttc aagcaggagc cagaggacga cctgcctgag gcacctccta agacccggga
     2821 gagtgatcag tcacggtcca gctcgcccac agctgggccc agcactgagg gggccgaggg
     2881 cccagaagag aagaggaagg tgaagatgcg ccggaaacgg cggcttccca acaaggagtt
     2941 gagcaaagag ctaagcaagg agctcaacca cgagatccaa aagacagaga gcaccttagc
     3001 ccacgagaac caccagccta tcaagtcaga gcccgagagt gaaaacgagg agccaaagag
     3061 gcccttaagc cactgcgagc gcccgcaccg cttcagcaaa gggctcaacg gcactcctcg
     3121 ggagctgcgg cactcactgg gacctgggct tcgcagccca cctcgtgtca tctcccggcc
     3181 cccgccctct acatccccac ccaagtgcat ccagatggag cgtcacgtga tccggccacc
     3241 acccatcagc cccccacctg actcgctgcc cctggatgat ggagcagccc atgtcatgca
     3301 tagggaggtg tggatggcag tcttcagcta cctcagccac caagacctgt gtgtctgcat
     3361 gcgggtctgc aggacctgga accgctggtg ctgcgataag cggttgtgga cccgcatcga
     3421 cctgaaccac tgcaagtcca tcactcccct gatgctgagc ggcatcatcc ggcggcagcc
     3481 ggtctccctg gatctcagct ggaccaacat ctccaagaag cagctgagct ggctcatcaa
     3541 ccggttgcct gggctccgag acttggtgct gtcaggctgc tcatggatcg ctgtctcagc
     3601 cctctgtagc tccagttgtc cactgctccg gaccctggat gtccagtggg tagaaggact
     3661 aaaggatgcc cagatgcggg atctcctgtc tccacccaca gacaacaggc caggtcaaat
     3721 ggacaatcgg agcaagctcc ggaacattgt ggaactgcgc ctagctggcc tggacatcac
     3781 agatgtctcc ctgcggctca ttattcgcca tatgcccctg ctctccaagc tccacctcag
     3841 ttactgtaac cacgtcactg atcagtccat caacctgctc actgcggtcg gcaccaccac
     3901 ccgggactct ctgacagaga tcaacctatc ggactgcaat aaggtcactg accagtgcct
     3961 gtccttcttc aaacgctgtg gaaatatctg tcatattgac ctgaggtact gcaagcaagt
     4021 caccaaggaa ggctgtgagc agttcatagc tgaaatgtct gtgagtgtcc agtttgggca
     4081 agtggaagag aaactcctgc aaaaactaag ttagctccag gacaaggatg taaatatggg
     4141 ggtttggggg aatacagcca gggagaggga agactgcaga gacaagtggg cctgtatttc
     4201 cctttggaat ctgaaacgag actacaggac acagttctgt tttgcaagtc ttgccaaggg
     4261 agaagccgtt caaccaccca tttggggatg agtgagccag atgttttcct ttgctctttc
     4321 tacatcgtaa ctgcactgct tctggaccat ttctaaggcg gcctttagaa gacattccaa
     4381 ttgcaaagga agatgagctt cagagaaatc ctcttagaag cctgagttta gtgtttttat
     4441 cagcagcttc tgtttgggac accttgttcc ttgcaatgct gaggcttctg gtgtcaacat
     4501 ggagtggacc acaaacacca cctgcagcca tcttgacaca ttttgtttag ttggttttgt
     4561 tacaccttac attatgcaga actatttttg tataaattgt ttaaaaatta tttatgcaag
     4621 atttgaatgc ataccagtgt ttttattatt tagattgcca actgtccttc aggtaggaga
     4681 gaacttaacc tgtattttgt caacataaaa agcccatctc cagatgtgcc caggtgtgac
     4741 gggggctatg accttccact taaaaaagca tgtttaactg gatgctgaga gcctactctg
     4801 tatgtcaaga agttacaagc atgttgtgga tgtgtgtaaa gtatagtcca ggtaaagaca
     4861 ctttgccaag tttcaataga attcaccttt tcctcaaagt tttacaatgc agacttcggc
     4921 ctttacactc aggagggttt tgctccaagc atgagctctt gtattctatt tacatagatc
     4981 taatttatac catgagtcag gtagagtaaa tgtgcccata gcctttcctc tgtcccctcc
     5041 tttcaagtgt tcagttctca cttaagttgg taagctggct attttctagt tgtcaagttc
     5101 tgcaaccctg tgtgccattg ttgtttggtg gtatcctaac ctttccctga tgaggtttta
     5161 cctttgttgg atttgtataa acagttgtac
//
