LOCUS       NP_001094149            1305 aa            linear   ROD 03-APR-2023
DEFINITION  lysine-specific demethylase 2B [Rattus norvegicus].
ACCESSION   NP_001094149 XP_001075313 XP_001075343 XP_222177
VERSION     NP_001094149.1
DBSOURCE    REFSEQ: accession NM_001100679.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1305)
  AUTHORS   Mao X, Li Z, Gu S, Song W, Zhang M, Tan X and Mao Z.
  TITLE     MicroRNA-211-5p in extracellular vesicles derived from BMSCs
            facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis
  JOURNAL   Tissue Cell 81, 102006 (2023)
   PUBMED   36610229
  REMARK    GeneRIF: MicroRNA-211-5p in extracellular vesicles derived from
            BMSCs facilitates the repair of rat frozen shoulder via regulating
            KDM2B/LACC1 axis.
REFERENCE   2  (residues 1 to 1305)
  AUTHORS   Yin L, Fang Y, Song T, Lv D, Wang Z, Zhu L, Zhao Z and Yin X.
  TITLE     FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via
            the PKC beta2 pathway
  JOURNAL   J Cell Mol Med 23 (4), 2558-2567 (2019)
   PUBMED   30701683
  REMARK    GeneRIF: FBXL10 regulates cardiac dysfunction in diabetic
            cardiomyopathy via the PKC beta2 pathway.
REFERENCE   3  (residues 1 to 1305)
  AUTHORS   Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR and Min J.
  TITLE     DNA Sequence Recognition of Human CXXC Domains and Their Structural
            Determinants
  JOURNAL   Structure 26 (1), 85-95 (2018)
   PUBMED   29276034
REFERENCE   4  (residues 1 to 1305)
  AUTHORS   Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng
            G, Lin SY and Lu Z.
  TITLE     Local generation of fumarate promotes DNA repair through inhibition
            of histone H3 demethylation
  JOURNAL   Nat Cell Biol 17 (9), 1158-1168 (2015)
   PUBMED   26237645
  REMARK    Erratum:[Nat Cell Biol. 2018 Apr 9;:. PMID: 29632342]
REFERENCE   5  (residues 1 to 1305)
  AUTHORS   Long HK, Blackledge NP and Klose RJ.
  TITLE     ZF-CxxC domain-containing proteins, CpG islands and the chromatin
            connection
  JOURNAL   Biochem Soc Trans 41 (3), 727-740 (2013)
   PUBMED   23697932
  REMARK    Review article
REFERENCE   6  (residues 1 to 1305)
  AUTHORS   Bottardi S, Zmiri FA, Bourgoin V, Ross J, Mavoungou L and Milot E.
  TITLE     Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance
            transcription elongation
  JOURNAL   Nucleic Acids Res 39 (9), 3505-3519 (2011)
   PUBMED   21245044
REFERENCE   7  (residues 1 to 1305)
  AUTHORS   He J, Nguyen AT and Zhang Y.
  TITLE     KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for
            initiation and maintenance of acute myeloid leukemia
  JOURNAL   Blood 117 (14), 3869-3880 (2011)
   PUBMED   21310926
REFERENCE   8  (residues 1 to 1305)
  AUTHORS   Fukuda T, Tokunaga A, Sakamoto R and Yoshida N.
  TITLE     Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death
            and leads to exencephaly
  JOURNAL   Mol Cell Neurosci 46 (3), 614-624 (2011)
   PUBMED   21220025
REFERENCE   9  (residues 1 to 1305)
  AUTHORS   Pfau R, Tzatsos A, Kampranis SC, Serebrennikova OB, Bear SE and
            Tsichlis PN.
  TITLE     Members of a family of JmjC domain-containing oncoproteins
            immortalize embryonic fibroblasts via a JmjC domain-dependent
            process
  JOURNAL   Proc Natl Acad Sci U S A 105 (6), 1907-1912 (2008)
   PUBMED   18250326
REFERENCE   10 (residues 1 to 1305)
  AUTHORS   Gearhart MD, Corcoran CM, Wamstad JA and Bardwell VJ.
  TITLE     Polycomb group and SCF ubiquitin ligases are found in a novel BCOR
            complex that is recruited to BCL6 targets
  JOURNAL   Mol Cell Biol 26 (18), 6880-6889 (2006)
   PUBMED   16943429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473973.1.
            
            On or before Dec 19, 2009 this sequence version replaced
            XP_222177.4, XP_001075343.1, XP_001075313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1305
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q16"
     Protein         1..1305
                     /product="lysine-specific demethylase 2B"
                     /EC_number="1.14.11.27"
                     /note="F-box and leucine-rich repeat protein 10; lysine
                     (K)-specific demethylase 2B"
                     /calculated_mol_wt=149323
     Region          151..226
                     /region_name="JmjC"
                     /note="A domain family that is part of the cupin
                     metalloenzyme superfamily; smart00558"
                     /db_xref="CDD:214721"
     Region          198..304
                     /region_name="cupin_RmlC-like"
                     /note="RmlC-like cupin superfamily; cl40423"
                     /db_xref="CDD:477354"
     Region          303..>338
                     /region_name="JHD"
                     /note="Jumonji helical domain; pfam17811"
                     /db_xref="CDD:465515"
     Region          476..542
                     /region_name="CTD_KDM2B"
                     /note="C-terminal domain found in Lysine-specific
                     demethylase 2B; cd21785"
                     /db_xref="CDD:412026"
     Region          <584..620
                     /region_name="zf-CXXC"
                     /note="CXXC zinc finger domain; pfam02008"
                     /db_xref="CDD:366873"
     Region          630..691
                     /region_name="PHD_KDM2B"
                     /note="PHD finger found in Lysine-specific demethylase 2B
                     (KDM2B); cd15644"
                     /db_xref="CDD:277114"
     Site            order(630,653..657,661,686)
                     /site_type="other"
                     /note="putative histone H3 binding site [polypeptide
                     binding]"
                     /db_xref="CDD:277114"
     Region          <689..922
                     /region_name="PTZ00449"
                     /note="104 kDa microneme/rhoptry antigen; Provisional"
                     /db_xref="CDD:185628"
     Region          1029..1073
                     /region_name="F-box_FBXL10"
                     /note="F-box domain found in F-box/LRR-repeat protein 10
                     (FBXL10) and similar proteins; cd22180"
                     /db_xref="CDD:438951"
     Site            order(1034..1035,1037..1039,1041..1042,1044..1046,
                     1048..1049,1052..1053,1055..1057,1061)
                     /site_type="other"
                     /note="Skp1 binding site [polypeptide binding]"
                     /db_xref="CDD:438951"
     Region          1071..1095
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1087..1276
                     /region_name="AMN1"
                     /note="Antagonist of mitotic exit network protein 1;
                     cd09293"
                     /db_xref="CDD:187754"
     Region          1096..1119
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1120..1143
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1144..1183
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1184..1208
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1209..1238
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1239..1263
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     Region          1264..1288
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275381"
     CDS             1..1305
                     /gene="Kdm2b"
                     /gene_synonym="Fbxl10"
                     /coded_by="NM_001100679.1:197..4114"
                     /note="gene_id=rCG21405.0 transcript_id=rCT21405.0
                     protein_id=rCP49624.0"
                     /db_xref="GeneID:304495"
                     /db_xref="RGD:1310217"
ORIGIN      
        1 meaekdsgrr lraidrqryd enedlsdvee ivsvrgfsle eklrsqlyqg dfvhamegkd
       61 fnyeyvqrea lrvplvfrdk dglgikmpdp dftvrdvkll vgsrrlvdvm dvntqkgtem
      121 smsqfvryye tpeaqrdkly nvislefsht klehlvkrpt vvdlvdwvdn mwpqhlkekq
      181 teatnalaem kypkvkkycl msvkgcftdf hidfggtsvw yhvfrggkif wlipptlhnl
      241 alyeewvlsg kqsdiflgdr vercqrielk qgytffipsg wihavytpvd slvfggnilh
      301 sfnvpmqlri yeiedrtrvq pkfrypfyye mcwyvleryv ycvtqrsylt qeyqrelmli
      361 daprknsvdg fssdswleme eesreqqlqe eedkeeegdg adktpkppte gptsptstqs
      421 edqdstgkkp kapamrflkr tlsneseesv kstampvdyp ktptgspate vstkwthlte
      481 felkglkalv ekleslpenk kcvpegiedp qallegvknv lkehvdddpn laitgvpvvs
      541 wpkktpknrv vgrpkgklgp asavklaanr ttagarrrrt rcrkceaclr tecgechfck
      601 dmkkfggpgr mkqscimrqc iapvlphtav clvcgeagke dtveeeegkf nlmlmecsic
      661 neiihpgclk ikesegvvnd elpncwecpk cnhagktgkq krgpgfkyas nlpgsllkeq
      721 kmnrdnkegq epakrrsece eaprrrsdeh pkkvptdgil rrksddvhlr rkrkyekpqe
      781 lsarkrastl qtspgssshl sprpplgssl spwwrsslty fqqqlkpgke dkllrkkrrs
      841 wknaedrlsl ankplrrfkq epeddlpeap pktresdqsr sssptagpst egaegpeekr
      901 kvkmrrkrrl pnkelskels kelnheiqkt estlahenhq piksepesen eepkrplshc
      961 erphrfskgl ngtprelrhs lgpglrsppr visrpppsts ppkciqmerh virpppispp
     1021 pdslplddga ahvmhrevwm avfsylshqd lcvcmrvcrt wnrwccdkrl wtridlnhck
     1081 sitplmlsgi irrqpvsldl swtniskkql swlinrlpgl rdlvlsgcsw iavsalcsss
     1141 cpllrtldvq wveglkdaqm rdllspptdn rpgqmdnrsk lrnivelrla glditdvslr
     1201 liirhmplls klhlsycnhv tdqsinllta vgtttrdslt einlsdcnkv tdqclsffkr
     1261 cgnichidlr yckqvtkegc eqfiaemsvs vqfgqveekl lqkls
//
