LOCUS       NM_001107343            4202 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysine demethylase 1B (Kdm1b), mRNA.
ACCESSION   NM_001107343 XM_001055844 XM_225213
VERSION     NM_001107343.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4202)
  AUTHORS   Fang,R., Chen,F., Dong,Z., Hu,D., Barbera,A.J., Clark,E.A.,
            Fang,J., Yang,Y., Mei,P., Rutenberg,M., Li,Z., Zhang,Y., Xu,Y.,
            Yang,H., Wang,P., Simon,M.D., Zhou,Q., Li,J., Marynick,M.P., Li,X.,
            Lu,H., Kaiser,U.B., Kingston,R.E., Xu,Y. and Shi,Y.G.
  TITLE     LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and
            molecular model for regulation of H3K4 demethylation
  JOURNAL   Mol Cell 49 (3), 558-570 (2013)
   PUBMED   23260659
REFERENCE   2  (bases 1 to 4202)
  AUTHORS   Zhang,Q., Qi,S., Xu,M., Yu,L., Tao,Y., Deng,Z., Wu,W., Li,J.,
            Chen,Z. and Wong,J.
  TITLE     Structure-function analysis reveals a novel mechanism for
            regulation of histone demethylase LSD2/AOF1/KDM1b
  JOURNAL   Cell Res 23 (2), 225-241 (2013)
   PUBMED   23266887
REFERENCE   3  (bases 1 to 4202)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (bases 1 to 4202)
  AUTHORS   Ciccone,D.N., Su,H., Hevi,S., Gay,F., Lei,H., Bajko,J., Xu,G.,
            Li,E. and Chen,T.
  TITLE     KDM1B is a histone H3K4 demethylase required to establish maternal
            genomic imprints
  JOURNAL   Nature 461 (7262), 415-418 (2009)
   PUBMED   19727073
REFERENCE   5  (bases 1 to 4202)
  AUTHORS   Karytinos,A., Forneris,F., Profumo,A., Ciossani,G., Battaglioli,E.,
            Binda,C. and Mattevi,A.
  TITLE     A novel mammalian flavin-dependent histone demethylase
  JOURNAL   J Biol Chem 284 (26), 17775-17782 (2009)
   PUBMED   19407342
REFERENCE   6  (bases 1 to 4202)
  AUTHORS   Orlic,M., Spencer,C.E., Wang,L. and Gallie,B.L.
  TITLE     Expression analysis of 6p22 genomic gain in retinoblastoma
  JOURNAL   Genes Chromosomes Cancer 45 (1), 72-82 (2006)
   PUBMED   16180235
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001055844.1, XM_225213.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4202
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     gene            1..4202
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /note="lysine demethylase 1B"
                     /db_xref="GeneID:306819"
                     /db_xref="RGD:1310701"
     exon            1..101
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..202
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2590
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /EC_number="1.14.99.66"
                     /note="lysine-specific histone demethylase 1B; amine
                     oxidase, flavin containing 1; amine oxidase (flavin
                     containing) domain 1; lysine (K)-specific demethylase 1B"
                     /codon_start=1
                     /product="lysine-specific histone demethylase 2"
                     /protein_id="NP_001100813.1"
                     /db_xref="GeneID:306819"
                     /db_xref="RGD:1310701"
                     /translation="MAASRGRSKKRSNFELSPDTLPLRSSGRQAKKKAVEITEEDEDG
                     SSEKKYRKCEKAGCTTAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRS
                     HKDGYDKYTAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECRKWRQLTKEIQLT
                     PHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYSMLIQPPLLKDSVAAP
                     LLSAYYPDCVGMSPSCTSTHRAAVTATATGSASPGEMEPSKAAPASLVLGMNRYFQPF
                     YQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQK
                     CIPHVIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVGAGQHLLPKHYHNKSVLVV
                     GAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNP
                     VALMCEQLGIRMHKLGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTLL
                     QDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHN
                     EFFAQFAGDHTLLTPGYSTIVEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGVVHSA
                     QKVLVTVPLAMLQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGA
                     DFFGHVPPSASQRGLFAVFYDMGPQQSVLMSVITGEAVASLRTMDDKQVLQQCLGVLR
                     ELFKEQEIPDPTKYFVTRWNTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVYFAGEA
                     TNRHFPQTVTGAYLSGVREASKIAAF"
     exon            203..330
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..420
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            421..532
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..649
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..688
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..911
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1096
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1273
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1348
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1486
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1658
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1786
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1918
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1993
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2110
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2236
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2353
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2506
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..4202
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggaagcgg cggcggcggc cgagctgctg cagctggcag tgcggatccg gccgtccggt
       61 gcagccccag gcagcgctcg cctcctggct agcgctctga ggttttttca aaacaatggc
      121 ggcatctcga gggcggtcaa agaagagaag caatttcgag ctttctcctg ataccctgcc
      181 tttgaggagc tccgggcgac aggcaaagaa gaaggctgta gagatcacag aggaggacga
      241 ggatggttcg tcggagaaga agtacagaaa gtgtgaaaag gcaggctgta caacggcgta
      301 tcctgtgtgc tttgcaagcg cttctgagag gtgtgccaag aatggctaca cctcccgatg
      361 gtatcacctt tcctgtgggg aacacttctg caacgaatgc tttgaccact actacagaag
      421 ccacaaggat ggatacgaca agtacactgc atggaagaga gtgtggacca gcaacggcaa
      481 gacggagccc agccccaagg cattcatggc agaccagcag ctgccctact gggttcagtg
      541 cacaaaaccc gagtgtagaa agtggaggca gcttaccaag gagatccagc ttactccaca
      601 catggcgagg acgtaccgct gcggcatgaa gccaaatact attaccaagc ctgacacccc
      661 tgatcattgt tctttccccg aggatctaag agtgctggaa gtctccaacc actggtggta
      721 ctccatgctc atccagcctc cattgctgaa ggacagtgtg gcagccccgc tgctctctgc
      781 ctactacccg gactgcgtgg gcatgagccc ctcctgtacc agtacacatc gtgccgccgt
      841 cacagccact gccaccggca gtgccagccc aggggagatg gagccctcca aggcagcccc
      901 cgcttcgctc gttctaggca tgaaccggta tttccagccg ttctaccagc ccaacgagtg
      961 cggcaaggcc ctgtgtgtgc ggccagatgt gatggaactg gatgagctct atgagttccc
     1021 agagtactct cgggacccca ccatgtacct ggctttgaga aacctcatcc tcgctctgtg
     1081 gtatacaaac tgcaaagaag ctctcacccc acagaagtgc attccccatg tcatcgtccg
     1141 gggccttgta cgcatccgat gtgttcagga agtggagagg attctttatt tcatgacaag
     1201 gaaaggcctc atcaacacgg gagttctcac cgtgggagcc ggccagcatc ttcttcctaa
     1261 acactaccat aataaatctg ttctggttgt tggggctggt ccagcaggct tagcagctgc
     1321 taggcaacta cataactttg ggatgaaggt gactgtcctg gaagccaaag accgaatcgg
     1381 aggccgtgtc tgggatgaca agtcctttaa aggcgtggta gtaggaagag gaccccagat
     1441 tgtcaatggc tgtattaata acccagtagc actgatgtgt gagcaacttg gcatccgcat
     1501 gcataagttg ggagagagat gtgacttaat tcaggaaggt ggacggataa ctgaccccac
     1561 tattgacaag cgcatggatt ttcattttaa tgccctcttg gatgttgtct ctgagtggag
     1621 gaaggataag actctgctcc aagatgtccc tttaggagaa aagatagagg agatctaccg
     1681 agccttcgtg aaggagtctg gcatccagtt cagtgagctg gagggacagg tgctgcagtt
     1741 ccacctgagt aacctggagt atgcgtgtgg cagcagcctg caccaggtgt ctgctcgctc
     1801 ctgggatcac aatgaattct tcgcccagtt tgctggtgac cataccctcc taactccagg
     1861 ctactccacg atcgttgaga aactggctga agggctagac attagactca agtctccagt
     1921 gcagagcata gattacactg gagatgaagt gcaggtgacc acgacagatg gcgtggtgca
     1981 ttccgcacaa aaggtattag tcaccgtgcc attggccatg ctacagagag gtgccatcca
     2041 gtttaaccca ccgttgtcag agaaaaagat gaaggccatc aacagcttgg gggcaggcat
     2101 cattgaaaag atcgccttgc agtttccata tagattttgg gacagtaaag ttcaaggtgc
     2161 tgactttttt ggccacgttc ctcccagtgc cagccaacga gggctcttcg ctgtgttcta
     2221 tgacatgggc ccccagcaga gtgtactgat gtcggtgatc acaggggagg cagtggcatc
     2281 cctcaggacc atggatgaca agcaggtgct gcagcagtgc ctgggcgtcc ttcgggagct
     2341 gttcaaggag caggagatcc cagatcccac aaagtatttt gtcacacggt ggaacacaga
     2401 gccatggatc cagatggcct atagctttgt gaagaccttc ggaagtggcg aggcctatga
     2461 cattattgct gaagaaatac aaggaactgt ttactttgct ggtgaggcaa caaacaggca
     2521 tttcccacaa actgttactg gagcatattt gagtggtgtt cgagaagcga gcaagatcgc
     2581 agccttttaa aaagaacttg tacagaccta atgttctgta tcccaaatgg aagtttgaaa
     2641 cataagttaa acgtaacttt tgcaagagag ggactctgta tagtaaaact gaaatgtttc
     2701 tgtggtgata ggaaaatgta aacccattgc actcttctgc aatcattgac cctcaaaacc
     2761 cttctaggca cttatgttgt attttccata tgtccaaata gtgctaagtc ctgtgggttt
     2821 cagaaggagg cacagtatat gattaagacc ttggctctgg ttggggtttc cctcagactg
     2881 gacattctgg ttggcagatt acttttcata gaacgtgaaa gcaaataacc cagcaggagt
     2941 cactagcaaa cttagaaagc catgtgctct tctgtgacag tttatcagta cctttaccaa
     3001 tgagccttaa tatttttaca gttccaatct ggggctgtcc ttaaaattta caattctttt
     3061 gtgatacagc gatttgaatt ttggcatgat gcttctaggc tattttatac tacatagctt
     3121 ttttttcatt gggtattcga aactcagatt cagatatatt ttgatattta gacctgtgca
     3181 cactcgtcag caacccaaga ctcaatccct taatagtgaa tacacgtgtg cacacatgct
     3241 cagtggatgc tttcacacta caaaaccatt tctgagtggg tagcacactt gaaatttagc
     3301 aaaaatcttg tcagaattga aaacccttct ttatttttaa agtgactttt acagcgtcta
     3361 atattttaca tagttgtaag tttcccatag gcaggtccac tggaaaactg cacagaatct
     3421 cgatcatttt ggtacaaagc acgttacttt ataaaccata tgataaagtc tgaacacggc
     3481 aaaagtgatt ctttcactaa agactttcat aaacatggtg tcagggtctt taggatgcct
     3541 attctgccaa gaaacttcag ttgatagact agaaatatac ttttgtttta aaaagtcttt
     3601 gaacaattct tctttgaatt atattggtct gcttttaaaa gggagctaca aaggacttta
     3661 cagccacctt ttgaaatatt aggtatttct gacattgaaa attagcttaa caaaagatct
     3721 tatgcaaaga atgtacagtg cagtgtgctt tagacagtca cgacactctc ctgtcacagt
     3781 aatacaaagg cagcgactgc ataggtaagg tcattattca ctgtacttag ggttctgttg
     3841 agactcattg gtactgataa gggaagaatt ctgctttcag tgtaagtaaa tgtttaagca
     3901 tgtgtgaggt gatgaacggc tcagtctaag ttatttagtt tctaggcact tgtgctttgt
     3961 tccatgctcc tttcaagtat aaatatttaa ttttctccaa ttgagtgaca ttcttagttt
     4021 cgtgttttgt tctagaggaa ctatggtact ttgagttgtt ttccaatctc taagattttt
     4081 gttaatgagc agaagtatac tttaactaca tatcatgaag aattggttat gccaaactgc
     4141 taaataagta gactcttgca aataccctta ataaatggtc atagcatcaa tatgtcaacc
     4201 tc
//
