LOCUS       NP_001100813             824 aa            linear   ROD 03-APR-2024
DEFINITION  lysine-specific histone demethylase 2 [Rattus norvegicus].
ACCESSION   NP_001100813 XP_001055844 XP_225213
VERSION     NP_001100813.1
DBSOURCE    REFSEQ: accession NM_001107343.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 824)
  AUTHORS   Fang,R., Chen,F., Dong,Z., Hu,D., Barbera,A.J., Clark,E.A.,
            Fang,J., Yang,Y., Mei,P., Rutenberg,M., Li,Z., Zhang,Y., Xu,Y.,
            Yang,H., Wang,P., Simon,M.D., Zhou,Q., Li,J., Marynick,M.P., Li,X.,
            Lu,H., Kaiser,U.B., Kingston,R.E., Xu,Y. and Shi,Y.G.
  TITLE     LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and
            molecular model for regulation of H3K4 demethylation
  JOURNAL   Mol Cell 49 (3), 558-570 (2013)
   PUBMED   23260659
REFERENCE   2  (residues 1 to 824)
  AUTHORS   Zhang,Q., Qi,S., Xu,M., Yu,L., Tao,Y., Deng,Z., Wu,W., Li,J.,
            Chen,Z. and Wong,J.
  TITLE     Structure-function analysis reveals a novel mechanism for
            regulation of histone demethylase LSD2/AOF1/KDM1b
  JOURNAL   Cell Res 23 (2), 225-241 (2013)
   PUBMED   23266887
REFERENCE   3  (residues 1 to 824)
  AUTHORS   Black,J.C., Van Rechem,C. and Whetstine,J.R.
  TITLE     Histone lysine methylation dynamics: establishment, regulation, and
            biological impact
  JOURNAL   Mol Cell 48 (4), 491-507 (2012)
   PUBMED   23200123
  REMARK    Review article
REFERENCE   4  (residues 1 to 824)
  AUTHORS   Ciccone,D.N., Su,H., Hevi,S., Gay,F., Lei,H., Bajko,J., Xu,G.,
            Li,E. and Chen,T.
  TITLE     KDM1B is a histone H3K4 demethylase required to establish maternal
            genomic imprints
  JOURNAL   Nature 461 (7262), 415-418 (2009)
   PUBMED   19727073
REFERENCE   5  (residues 1 to 824)
  AUTHORS   Karytinos,A., Forneris,F., Profumo,A., Ciossani,G., Battaglioli,E.,
            Binda,C. and Mattevi,A.
  TITLE     A novel mammalian flavin-dependent histone demethylase
  JOURNAL   J Biol Chem 284 (26), 17775-17782 (2009)
   PUBMED   19407342
REFERENCE   6  (residues 1 to 824)
  AUTHORS   Orlic,M., Spencer,C.E., Wang,L. and Gallie,B.L.
  TITLE     Expression analysis of 6p22 genomic gain in retinoblastoma
  JOURNAL   Genes Chromosomes Cancer 45 (1), 72-82 (2006)
   PUBMED   16180235
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473977.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_001055844.1, XP_225213.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..824
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p14"
     Protein         1..824
                     /product="lysine-specific histone demethylase 2"
                     /EC_number="1.14.99.66"
                     /note="lysine-specific histone demethylase 1B; amine
                     oxidase, flavin containing 1; amine oxidase (flavin
                     containing) domain 1; lysine (K)-specific demethylase 1B"
                     /calculated_mol_wt=92425
     Region          138..191
                     /region_name="zf-CW"
                     /note="CW-type Zinc Finger; pfam07496"
                     /db_xref="CDD:462181"
     Region          <306..821
                     /region_name="PLN02328"
                     /note="lysine-specific histone demethylase 1 homolog"
                     /db_xref="CDD:215187"
     CDS             1..824
                     /gene="Kdm1b"
                     /gene_synonym="Aof1"
                     /coded_by="NM_001107343.1:116..2590"
                     /db_xref="GeneID:306819"
                     /db_xref="RGD:1310701"
ORIGIN      
        1 maasrgrskk rsnfelspdt lplrssgrqa kkkaveitee dedgssekky rkcekagctt
       61 aypvcfasas ercakngyts rwyhlscgeh fcnecfdhyy rshkdgydky tawkrvwtsn
      121 gktepspkaf madqqlpywv qctkpecrkw rqltkeiqlt phmartyrcg mkpntitkpd
      181 tpdhcsfped lrvlevsnhw wysmliqppl lkdsvaapll sayypdcvgm spsctsthra
      241 avtatatgsa spgemepska apaslvlgmn ryfqpfyqpn ecgkalcvrp dvmeldelye
      301 fpeysrdptm ylalrnlila lwytnckeal tpqkciphvi vrglvrircv qeverilyfm
      361 trkglintgv ltvgagqhll pkhyhnksvl vvgagpagla aarqlhnfgm kvtvleakdr
      421 iggrvwddks fkgvvvgrgp qivngcinnp valmceqlgi rmhklgercd liqeggritd
      481 ptidkrmdfh fnalldvvse wrkdktllqd vplgekieei yrafvkesgi qfselegqvl
      541 qfhlsnleya cgsslhqvsa rswdhneffa qfagdhtllt pgystivekl aegldirlks
      601 pvqsidytgd evqvtttdgv vhsaqkvlvt vplamlqrga iqfnpplsek kmkainslga
      661 giiekialqf pyrfwdskvq gadffghvpp sasqrglfav fydmgpqqsv lmsvitgeav
      721 aslrtmddkq vlqqclgvlr elfkeqeipd ptkyfvtrwn tepwiqmays fvktfgsgea
      781 ydiiaeeiqg tvyfageatn rhfpqtvtga ylsgvreask iaaf
//
