LOCUS       NM_001130098            3066 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lysine demethylase 1A (Kdm1a), mRNA.
ACCESSION   NM_001130098 XM_001069483 XM_575936
VERSION     NM_001130098.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3066)
  AUTHORS   Zhang,X., Li,L.X., Yu,C., Nath,K.A., Zhuang,S. and Li,X.
  TITLE     Targeting lysine-specific demethylase 1A inhibits renal
            epithelial-mesenchymal transition and attenuates renal fibrosis
  JOURNAL   FASEB J 36 (1), e22122 (2022)
   PUBMED   34958158
  REMARK    GeneRIF: Targeting lysine-specific demethylase 1A inhibits renal
            epithelial-mesenchymal transition and attenuates renal fibrosis.
REFERENCE   2  (bases 1 to 3066)
  AUTHORS   Zhang,X., Huang,T., Zhai,H., Peng,W., Zhou,Y., Li,Q. and Yang,H.
  TITLE     Inhibition of lysine-specific demethylase 1A suppresses neointimal
            hyperplasia by targeting bone morphogenetic protein 2 and mediating
            vascular smooth muscle cell phenotype
  JOURNAL   Cell Prolif 53 (1), e12711 (2020)
   PUBMED   31737960
  REMARK    GeneRIF: The regulatory correlation between KDM1A and BMP-2 offers
            insights into vascular remodelling and VSMC phenotypic modulation.
            The reported findings contribute to the development of innovative
            strategies against vascular disorders.
REFERENCE   3  (bases 1 to 3066)
  AUTHORS   Patel,D., Shimomura,A., Majumdar,S., Holley,M.C. and Hashino,E.
  TITLE     The histone demethylase LSD1 regulates inner ear progenitor
            differentiation through interactions with Pax2 and the NuRD
            repressor complex
  JOURNAL   PLoS One 13 (1), e0191689 (2018)
   PUBMED   29370269
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3066)
  AUTHORS   Muralidharan,B., Khatri,Z., Maheshwari,U., Gupta,R., Roy,B.,
            Pradhan,S.J., Karmodiya,K., Padmanabhan,H., Shetty,A.S., Balaji,C.,
            Kolthur-Seetharam,U., Macklis,J.D., Galande,S. and Tole,S.
  TITLE     LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron
            Subtype Determinants Fezf2 and Sox11
  JOURNAL   J Neurosci 37 (1), 194-203 (2017)
   PUBMED   28053041
REFERENCE   5  (bases 1 to 3066)
  AUTHORS   Tsutsumi,T., Iwao,K., Hayashi,H., Kirihara,T., Kawaji,T., Inoue,T.,
            Hino,S., Nakao,M. and Tanihara,H.
  TITLE     Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal
            Ganglion Cells via p38 MAPK Activity
  JOURNAL   Invest Ophthalmol Vis Sci 57 (14), 6461-6473 (2016)
   PUBMED   27893888
  REMARK    GeneRIF: pharmacologic treatments that suppress LSD1 activity may
            be a novel therapeutic strategy that can be used to treat
            neurodegenerative diseases.
REFERENCE   6  (bases 1 to 3066)
  AUTHORS   Saleque,S., Kim,J., Rooke,H.M. and Orkin,S.H.
  TITLE     Epigenetic regulation of hematopoietic differentiation by Gfi-1 and
            Gfi-1b is mediated by the cofactors CoREST and LSD1
  JOURNAL   Mol Cell 27 (4), 562-572 (2007)
   PUBMED   17707228
REFERENCE   7  (bases 1 to 3066)
  AUTHORS   Wang,J., Scully,K., Zhu,X., Cai,L., Zhang,J., Prefontaine,G.G.,
            Krones,A., Ohgi,K.A., Zhu,P., Garcia-Bassets,I., Liu,F., Taylor,H.,
            Lozach,J., Jayes,F.L., Korach,K.S., Glass,C.K., Fu,X.D. and
            Rosenfeld,M.G.
  TITLE     Opposing LSD1 complexes function in developmental gene activation
            and repression programmes
  JOURNAL   Nature 446 (7138), 882-887 (2007)
   PUBMED   17392792
REFERENCE   8  (bases 1 to 3066)
  AUTHORS   Wissmann,M., Yin,N., Muller,J.M., Greschik,H., Fodor,B.D.,
            Jenuwein,T., Vogler,C., Schneider,R., Gunther,T., Buettner,R.,
            Metzger,E. and Schule,R.
  TITLE     Cooperative demethylation by JMJD2C and LSD1 promotes androgen
            receptor-dependent gene expression
  JOURNAL   Nat Cell Biol 9 (3), 347-353 (2007)
   PUBMED   17277772
REFERENCE   9  (bases 1 to 3066)
  AUTHORS   Metzger,E., Wissmann,M., Yin,N., Muller,J.M., Schneider,R.,
            Peters,A.H., Gunther,T., Buettner,R. and Schule,R.
  TITLE     LSD1 demethylates repressive histone marks to promote
            androgen-receptor-dependent transcription
  JOURNAL   Nature 437 (7057), 436-439 (2005)
   PUBMED   16079795
REFERENCE   10 (bases 1 to 3066)
  AUTHORS   Shi,Y., Lan,F., Matson,C., Mulligan,P., Whetstine,J.R., Cole,P.A.,
            Casero,R.A. and Shi,Y.
  TITLE     Histone demethylation mediated by the nuclear amine oxidase homolog
            LSD1
  JOURNAL   Cell 119 (7), 941-953 (2004)
   PUBMED   15620353
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF688598.1.
            
            On or before Jul 18, 2008 this sequence version replaced
            XM_575936.2, XM_001069483.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF688598.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3066
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Crl:CD(SD)"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3066
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /note="lysine demethylase 1A"
                     /db_xref="GeneID:500569"
                     /db_xref="RGD:1562975"
     exon            1..495
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..2763
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /EC_number="1.14.99.66"
                     /note="neuroprotective protein 3; lysine (K)-specific
                     demethylase 1A; amine oxidase (flavin containing) domain
                     2"
                     /codon_start=1
                     /product="lysine-specific histone demethylase 1A"
                     /protein_id="NP_001123570.1"
                     /db_xref="GeneID:500569"
                     /db_xref="RGD:1562975"
                     /translation="MLSGKKAAAAAAAAAAAAAGTEAGPGAAGGAENGSEVAAPPAGL
                     AGPADIATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIA
                     ETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPP
                     EEENESEPEEPSGQAGGLQDDSSGGYGDGQASGVEGAAFQSRLPHDRMTSQEAACFPD
                     IISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYL
                     ERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVG
                     GRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPK
                     EKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEH
                     WKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLT
                     ALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLST
                     LSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIA
                     VNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKV
                     VLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISD
                     DVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQ
                     PITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTL
                     PRQATPGVPAQQSPSM"
     exon            496..661
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            662..721
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            722..855
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            856..934
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1027
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1134
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1216
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1311
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1454
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1545
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1680
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1754
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1866
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1999
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2187
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2302
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2430
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            2431..2577
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
     exon            2578..3066
                     /gene="Kdm1a"
                     /gene_synonym="Aof2; Kdm1; RGD1562975"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgcagggc gcgtgcgcac gcggaggtgc tcggtttcgc gcggaccgtg tgaggttcgg
       61 agcggagagg cgagaggcgg ctgcggaccc acggagcggc agaccgagcg gcccctgcgg
      121 cccgcggcgg ccaggcggcc cgagatgttg tctgggaaga aggcggcggc ggcggcagcg
      181 gcggcggcgg cagcagcggc tgggacagag gccgggcccg gggcggcggg cggcgccgag
      241 aacggctctg aggtggccgc gccgcccgcg ggcctggcgg gccccgccga cattgctacg
      301 ggggcggcgg gcgagcgcac tccccgaaag aaggagcctc cgcgggcctc gccgcccgga
      361 ggcctggccg agccgcctgg gtccgccggg cctcaggcgg ggcccacagc cgggcccggc
      421 tccgctacac ccatggagac aggaatagcc gagaccccgg agggccgacg gaccagccga
      481 cgcaagcggg cgaaggtaga atacagagaa atggatgaaa gcttggccaa cctctcagaa
      541 gatgaatatt attcagaaga agaaagaaat gccaaagcag agaaggagaa gaagcttccc
      601 ccgccacctc ctcaagcccc acctgaggag gaaaatgaaa gtgagcccga ggagccgtct
      661 gggcaagcag gaggacttca agacgacagt tctggagggt atggagacgg ccaagcatca
      721 ggtgtggagg gtgcagcttt ccaaagcaga cttccccatg accgaatgac ctctcaggaa
      781 gcagcgtgtt tcccagacat catcagtggg cctcagcaga cacagaaggt ttttctgttc
      841 atcaggaatc gcacattgca gttatggttg gacaacccaa agattcagct gacatttgaa
      901 gctacgctcc agcagttaga agcaccttat aacagtgaca ctgtacttgt ccaccgagtt
      961 catagttact tagagcgcca cggtcttatc aacttcggca tctacaagag gataaaacct
     1021 ttaccaatta aaaagacagg aaaggtgatt attataggct caggtgtttc tggcttggca
     1081 gcagctcgac aactacagag ttttgggatg gatgtcacac ttctggaagc cagggatcgc
     1141 gtaggtggac gggtcgctac atttcgaaaa ggaaactatg tagctgatct tggagccatg
     1201 gtagtaacag gtcttggagg aaatcccatg gctgtcgtca gcaaacaagt aaatatggaa
     1261 ctggccaaga tcaagcaaaa atgcccactt tatgaagcca atggacaagc tgttccaaaa
     1321 gagaaagatg aaatggtaga acaagaattt aaccggttgc ttgaagccac ctcttacctt
     1381 agtcatcagt tagacttcaa cgtcctcaat aataaacctg tgtcccttgg ccaggcgttg
     1441 gaggttgtca ttcagctaca agaaaagcac gtcaaagatg agcagattga acactggaag
     1501 aagatagtga aaactcagga ggaattgaaa gagcttctca ataagatggt aaacttgaag
     1561 gagaaaatta aagagctcca ccagcaatac aaagaagctt cagaagtgaa gccgcccaga
     1621 gatattacag ctgagttcct agtgaaaagc aagcacaggg acctgactgc cctctgcaag
     1681 gaatatgatg aattagctga aacacaagga aagctagaag aaaaacttca agaattggaa
     1741 gccaatcccc caagtgatgt atatctctca tcaagagaca gacaaatact tgactggcat
     1801 tttgcaaatc ttgaatttgc caacgccaca cctctctcta ccctctctct taaacattgg
     1861 gatcaggatg atgacttcga gtttactggc agccacctga cagtgaggaa tggctactcg
     1921 tgtgtgcctg tggctttagc tgaaggtttg gacattaaac tgaacacagc agtgcggcag
     1981 gttcgctaca cagcctcagg atgtgaagtg attgctgtga acacacgctc cacaagtcag
     2041 accttcattt ataagtgtga cgcagtgctc tgtacccttc ctttgggagt gctgaagcag
     2101 cagccaccag ctgttcagtt tgtgccgcct cttcctgagt ggaaaacatc cgcagtccaa
     2161 aggatgggat ttggcaacct taacaaggtg gtgctatgtt ttgaccgtgt gttctgggat
     2221 ccaagtgtca atttgtttgg gcacgttggc agtacaactg ctagcagggg cgagctcttc
     2281 ctcttctgga acttatataa agctccaata ctcttggctc tggtagcagg cgaagctgct
     2341 ggcattatgg agaacattag tgatgatgtg attgtcggcc ggtgcctggc cattctcaaa
     2401 gggatttttg gcagcagtgc agtaccacag cccaaggaaa ctgtggtgtc tcgttggcgt
     2461 gctgatccct gggcccgggg ctcctattct tatgtggctg caggatcttc tggaaatgac
     2521 tatgatttaa tggctcagcc aatcactcct ggtccctcaa ttccaggtgc cccacagcca
     2581 attccaagac tcttctttgc tggagaacat acaatccgca actacccagc tacggtccat
     2641 ggtgctctgc tgagtgggct tcgagaagca ggaaggattg ccgaccagtt tttgggagcc
     2701 atgtacacgt tgcctcgtca ggccacaccg ggtgtccctg cacagcagtc cccaagtatg
     2761 tgagacaaat ggttctgaaa aagaggtcta acggacatgc cagctgccat tgtaagcaag
     2821 ctcctctagc aatactagat ccgactccca tgtcatcagc tgctgggact ccgagtttga
     2881 cagcagaggc tggctccttt ggctgacagc acagagagga actcacccat tgacttagaa
     2941 gtgcagctcc ataaagactt gagaagcagg tggtgtaaga taacctctta gtctatttgg
     3001 tgtttgtttt gtttttttaa tatattttga gaataaaact ttaaaataat tttatatgaa
     3061 aattta
//
