LOCUS       NM_001107199            3688 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus potassium channel tetramerization domain
            containing 3 (Kctd3), mRNA.
ACCESSION   NM_001107199 XM_001066967 XM_223057
VERSION     NM_001107199.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Cao-Ehlker X, Zong X, Hammelmann V, Gruner C, Fenske S, Michalakis
            S, Wahl-Schott C and Biel M.
  TITLE     Up-regulation of hyperpolarization-activated cyclic
            nucleotide-gated channel 3 (HCN3) by specific interaction with K+
            channel tetramerization domain-containing protein 3 (KCTD3)
  JOURNAL   J Biol Chem 288 (11), 7580-7589 (2013)
   PUBMED   23382386
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066967.1, XM_223057.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3688
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /note="potassium channel tetramerization domain containing
                     3"
                     /db_xref="GeneID:305055"
                     /db_xref="RGD:1310658"
     exon            1..294
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2662
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /note="potassium channel tetramerisation domain containing
                     3"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD3"
                     /protein_id="NP_001100669.1"
                     /db_xref="GeneID:305055"
                     /db_xref="RGD:1310658"
                     /translation="MAGGHCGSFAAAAASSGEIVQLNVGGTRFSTSRQTLMWIPDSFF
                     SSLLSGRISTLRDETGAIFIDRDPAAFAPILNFLRTKELDLRGVSINVLRHEAEFYGI
                     TPLVRRLLLCEELERSSCGSVLFHGYLPPPGIPSRKGTNTARSSVDARNGLSSMEGEA
                     RGSGTQPVLAGNGEDTIRLGVPVDPRKVLIVAGHHNWIVAAYAHFAVCYRIKESSGWQ
                     QVFTSPYLDWTIERVALNAKVVGGPHGDKDKMVAVASESSIILWSVQDGGSGSEIGVF
                     SLGVPVDALFFIGNQLVATSHTGKVGVWNAVTQHWQVQDVVPITSYDTAGSFLLLGCN
                     NGSIYYIDMQKFPLRMKDNDLLVTELYHDPSNDAITALSVYLTPKTSVSGNWIEIAYG
                     TSSGAVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLVSVCADNNHVRTWTV
                     TRFRGMISTQPGSTPLASFKILSLEETESHGSYSSGNDIGPFGERDDQQVFIQKVVPI
                     TNKLFVRLSSTGKRICEIQAVDCTTISSFTVRECEGSSRMGSRPRRYLFTGHTNGSIQ
                     MWDLTTAMDMVNKSEDKDAGGPTEEELLKLLDQCDLSTSRCATPNISPATSVLQHSRL
                     RESSSSLQLQHHETIHEAATYGATRPYRESPLLARARRTESFHSYRDLQTLNLNRTVE
                     RAVPENGHTGPAQAEAKGAAAGECAVCERKSPGTEGRCVREPDVGLDVHRPAEGLSEP
                     KKRSTEDENEPKVEFRKKGFEAGGFLGRKKVPYLASSPSTSDGGTDSPGTASPSPTKT
                     TPSPRHRKSDSSGQEYSL"
     exon            295..348
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            349..394
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            395..468
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            469..527
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            528..608
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            609..749
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            750..840
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1031
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1147
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1235
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1352
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1523
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1679
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1776
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1961
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2100
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..3688
                     /gene="Kctd3"
                     /gene_synonym="Ren-45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagacggttg tggcggccgc catggaggcg agtgggccct gaggagaggc cgggctgggc
       61 cggcggcctg cagccacgag aggcggaggc cgcgagcact cagcgggaga ggcaggctcg
      121 agccgggacg ctgcgagagg ctcggcgttc cgagtgcgct ctggccgccg agccgccgct
      181 cctggctcca gcctcggctc cgaccgcaga catggcgggc gggcactgcg gcagcttcgc
      241 tgcggcggcg gccagcagcg gggagatcgt gcagctgaat gttgggggga ccaggttcag
      301 tacctcaagg cagactctta tgtggattcc agattctttt ttttccagtt tgctgagtgg
      361 aaggatttca acacttcgag atgaaactgg tgctatattt attgataggg acccggcagc
      421 attcgccccc attctaaatt ttcttcggac aaaagaactc gacttaaggg gagtcagcat
      481 caacgttctc agacacgagg cagaatttta tgggatcact ccactagtgc gaaggctgct
      541 gctgtgtgag gagctggaga ggtcgtcctg cggcagtgtc ctgttccacg gctacttgcc
      601 cccgccaggc atccccagtc gtaaaggaac taacacagct aggtcctctg tggacgctag
      661 gaatggactg agttctatgg aaggcgaagc ccggggaagc gggacgcagc ctgtgcttgc
      721 tgggaatgga gaagacacta ttaggctggg agtcccagtg gacccaagaa aggtgctaat
      781 agttgctggc caccacaact ggattgtagc tgcctatgct cactttgctg tgtgttacag
      841 aatcaaagag tcttcagggt ggcagcaagt gtttacaagc ccatatctgg actggaccat
      901 tgaacgggtg gctttgaatg caaaagtggt tggaggtcct catggagaca aggacaaaat
      961 ggtggctgtg gcctcagaga gcagcatcat cctgtggagt gttcaggacg gaggaagcgg
     1021 aagtgaaatt ggtgtgttca gcctcggggt tcctgtagac gccctcttct tcattgggaa
     1081 tcagctggtg gccacgagtc acacaggcaa agtgggcgtg tggaatgctg tcacacagca
     1141 ctggcaggtg caggacgttg tcccgataac cagctacgac actgcaggct ccttcctcct
     1201 cctgggatgt aacaatgggt caatatatta catagacatg cagaagttcc cgttgcggat
     1261 gaaggataat gacctccttg tcactgagct ctaccacgac ccttccaacg acgccatcac
     1321 tgcgctgagt gtttacctca cccccaaaac cagtgtcagc gggaactgga tcgagatcgc
     1381 ctacggtaca agctctggag cagtgcgagt gattgtgcag catccagaga cagtcggctc
     1441 ggggccacag ctcttccaga cattcacggt tcaccggagc cctgtgacga agatcatgct
     1501 gtcagagaag cacctggtgt cagtgtgtgc tgacaacaac catgtgcgca cctggacggt
     1561 gacacggttc agagggatga tctctacgca gccaggctcc actcctttag catcgttcaa
     1621 gatcctgtcc ttggaagaga cagagagcca cggcagctat tcctctggaa atgacatcgg
     1681 gccttttgga gaacgagatg atcaacaagt gtttatccag aaggttgttc ccatcaccaa
     1741 caagctgttt gtcaggctgt catcgactgg aaaaaggata tgtgagatcc aggctgtgga
     1801 ctgcactaca atctcctcgt tcactgtgag agagtgcgag ggctccagcc ggatgggctc
     1861 ccggccaagg cgctacctgt tcactggcca caccaacggc agcatccaga tgtgggacct
     1921 gaccacagcc atggacatgg tcaacaagag cgaggacaag gacgcaggcg gccccactga
     1981 ggaagagctg ctcaagctgc tggaccagtg tgatctgagc acgtcccgct gcgccacgcc
     2041 caacatcagc cctgccacct ctgtgctcca gcacagccgc cttcgtgagt ccagctccag
     2101 ccttcagctc cagcaccacg aaaccatcca tgaagcagca acctatggtg ccacgcggcc
     2161 ttaccgagag agccctttgt tagccagagc aaggaggact gagagcttcc acagctacag
     2221 ggacttgcag actctcaatc tcaaccgaac tgtagagaga gctgtccctg agaatggtca
     2281 cacgggccca gcccaggctg aggcaaaagg ggcagcagca ggggagtgtg ctgtgtgtga
     2341 gaggaagtcc ccggggacag agggaagatg tgtgagggag cccgatgtgg gcttagacgt
     2401 gcacagacca gcggaaggtt tgtcagagcc caagaaaagg tcaacagagg atgaaaatga
     2461 gcccaaagtg gagttccgga agaaaggatt cgaagcaggg ggattccttg gaagaaagaa
     2521 agttccctat ctggcatcct caccaagtac ctctgatgga gggaccgact cccctggtac
     2581 agcatccccg tctccaacta agaccactcc gtcacctcgg cacagaaaga gcgactcctc
     2641 tggccaggag tacagcttgt gagctcaccc agtgcatggc agttcttcta aatctacgtg
     2701 aaaaacaaca ttccctgggt ttcagtcatt ggcttttaca tcaaaaactc tacagggcac
     2761 agttggctgt ttagtgtttt ctgggccgag cctgtagaag caggagcaga gcccactccc
     2821 cggtgcagtg atgccgtcct cacagctcgg aagtggctct agtcctgcag gcacgtgtga
     2881 cagcagtgtg tgagcaggag tcttgccctg ccgccctccc tgctggtgtt tggtcccagc
     2941 accacagtag taccttagag catgtgaggc agcggccgta ttcctgatgc cgttgcccag
     3001 gcctgtcttg cagtggtacc ctaaggttaa tctcatagtc ttggaacatg ggctccagcc
     3061 cttgtgattg cagtgtttac tagccacatg atgaggtgct atgctgtgaa aagtctcagt
     3121 agctcagaac actatcattg gtccgcgggc tccactatgc actacgtctt ccgggtggtt
     3181 tatttcattg tgggtcattt tctgcttctt gttgttggag tcaatatagc atgcgtcccc
     3241 agtgtttggt ccctgaagtc cttccagtgg gaacagcgtc tgtgtttgat tggtaaatat
     3301 aataacgaca gaggggaagt ctgggtgttc acagggaatc tccccatttg ctacttcagc
     3361 tactttggga gccactgtgt gtgcagtgtc tcacaggatt cgaattctgg atttggagtt
     3421 aagtaatata tgtaaaaatg ttggtttagc tttattttga attctgggag caaaagaatt
     3481 ttcatttaat cagaatggtt tacatatttc tgcaaatgga gaaaatgtag gtttaaaccc
     3541 atgagcattt actaagtgga tgatgtatat tccccattct cagaagtata atgaaagtag
     3601 aataaattct ttaaagttta ctatattgcc agtggtttca cacaaattcc cttgtattta
     3661 tttgtcgatt aaatcaagtg agaaaggt
//
