LOCUS       NM_198736               1716 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus potassium channel tetramerization domain
            containing 13 (Kctd13), mRNA.
ACCESSION   NM_198736 XM_238132
VERSION     NM_198736.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1716)
  AUTHORS   Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R,
            Espinosa F, Liu S, Thyme SB, Lopez-Garcia IA, Mendoza DB, Usui N,
            Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE and
            Powell CM.
  TITLE     Kctd13 deletion reduces synaptic transmission via increased RhoA
  JOURNAL   Nature 551 (7679), 227-231 (2017)
   PUBMED   29088697
REFERENCE   2  (bases 1 to 1716)
  AUTHORS   Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L and
            Ciccarelli L.
  TITLE     The BTB domains of the potassium channel tetramerization domain
            proteins prevalently assume pentameric states
  JOURNAL   FEBS Lett 590 (11), 1663-1671 (2016)
   PUBMED   27152988
REFERENCE   3  (bases 1 to 1716)
  AUTHORS   Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, Peng
            HB and Shao F.
  TITLE     Cullin mediates degradation of RhoA through evolutionarily
            conserved BTB adaptors to control actin cytoskeleton structure and
            cell movement
  JOURNAL   Mol Cell 35 (6), 841-855 (2009)
   PUBMED   19782033
  REMARK    Erratum:[Mol Cell. 2011 Dec 23;44(6):1005]
REFERENCE   4  (bases 1 to 1716)
  AUTHORS   Zhou J, Hu X, Xiong X, Liu X, Liu Y, Ren K, Jiang T, Hu X and Zhang
            J.
  TITLE     Cloning of two rat PDIP1 related genes and their interactions with
            proliferating cell nuclear antigen
  JOURNAL   J Exp Zool A Comp Exp Biol 303 (3), 227-240 (2005)
   PUBMED   15726626
REFERENCE   5  (bases 1 to 1716)
  AUTHORS   He H, Tan CK, Downey KM and So AG.
  TITLE     A tumor necrosis factor alpha- and interleukin 6-inducible protein
            that interacts with the small subunit of DNA polymerase delta and
            proliferating cell nuclear antigen
  JOURNAL   Proc Natl Acad Sci U S A 98 (21), 11979-11984 (2001)
   PUBMED   11593007
REFERENCE   6  (bases 1 to 1716)
  AUTHORS   Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S,
            Bono H, Okazaki Y and Hayashizaki Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY305029.1.
            
            On Dec 17, 2003 this sequence version replaced XM_238132.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY305029.1, BE110670.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1716
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..1716
                     /gene="Kctd13"
                     /note="potassium channel tetramerization domain containing
                     13"
                     /db_xref="GeneID:293497"
                     /db_xref="RGD:735189"
     exon            1..421
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1167
                     /gene="Kctd13"
                     /note="BTB/POZ domain-containing protein KCTD13; PDIP1;
                     potassium channel tetramerisation domain containing 13"
                     /codon_start=1
                     /product="BTB/POZ domain-containing adapter for
                     CUL3-mediated RhoA degradation protein 1"
                     /protein_id="NP_942031.1"
                     /db_xref="GeneID:293497"
                     /db_xref="RGD:735189"
                     /translation="MSAEASGPAAAAAECLESPNPSGVEPGSPSYSLKPLTPNSKYVK
                     LNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRD
                     GSVPLPESTRELGELLGEARYYLVQGLIEDCQLALQQKREKLSPLCLIPTVTSPREEQ
                     QLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLG
                     DEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENSRGPD
                     LALLEATGGAAGGGGAGRGDDEENREHRVRRIHVRRHITHDERPHGQQIVFKD"
     exon            422..591
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
     exon            592..681
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
     exon            682..734
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
     exon            735..930
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1699
                     /gene="Kctd13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcttccg ggtggagaga gcgcgcgatg gggcggctgg tggacgtagc agagtagcgg
       61 cggcgagtgg gcgtgtgcgc cgagcggtcg ggcgcccgcg caggagtcgc ggggtctcag
      121 ggagcgggtc cggggcgcgg agagagcttc gactgtcacc cgcgtccgct cactggcatg
      181 tcggccgagg cctctggccc ggcggcggct gcggccgaat gcctggagtc ccctaacccc
      241 tcaggtgtcg aacctggctc cccctcgtac agtctgaagc ccctgacccc gaacagcaag
      301 tatgtgaagc tgaacgtggg cggctcgctg cactacacca cgctgcgcac cctcacgggg
      361 caggacacca tgctcaaggc catgttcagc ggccgcgtgg aagtgctcac agatgcggga
      421 ggttgggtgc tgattgaccg gagtggccga cactttggta caattctcaa ctacctgcgg
      481 gacgggtcag tgccactgcc tgagagtacc agagaactgg gggagctgct aggtgaagcc
      541 cgatactacc tggtacaggg cctgattgaa gactgtcagc tggcgctgca gcaaaaaagg
      601 gagaagttgt cgccactatg cctcatcccg acagtgacat caccccggga agagcagcag
      661 ctcctggcca gcacctccaa gcctgtggta aagcttctgc acaatcgcag taacaacaag
      721 tactcctata ccagcacttc agatgacaac ttactgaaga acatcgagct gtttgacaaa
      781 ctagccctgc gctttcatgg gcggctgctc ttcctcaagg acgtcctggg ggacgagatt
      841 tgctgctggt ctttctacgg gcagggccga aaaatcgccg aggtgtgctg cacctccata
      901 gtctatgcta cggagaagaa gcagaccaag gtggaattcc ctgaagctcg gatcttcgag
      961 gagaccctga acatcttaat ttatgagaat tcccgtggcc cagatctggc tctcctggag
     1021 gccacagggg gtgcagctgg aggtggtggg gcaggccgag gagatgatga agagaacaga
     1081 gagcaccgtg ttcgaaggat tcacgtccgc cgccatatca cccatgatga gcgtcctcat
     1141 ggccaacaga ttgtcttcaa ggactgacct tgatcttccc ctgcttttct cttgcttctg
     1201 ggacctagtc cctctctctc tttgccccgg ctctgctggc caagtcgtgg gtcttccctc
     1261 tatcccctca ttgcatgata tgttcagtga gccctctcca gtcattgcca ctcactgcta
     1321 accacacggt acattccagc attaccctct ggtggggctc ttcagaaagc cagtgtccac
     1381 cctcctccac aacctcgttc tgccatcttt ctcttaccat ctggtttaga atgaggcagg
     1441 attccctttc ccatttgtta acacattgaa cacacgtgta gaaggagaca gtaccatcaa
     1501 ccatactcca agctgctttc cgccattgca acagagatct tcactcccct gcctcaccat
     1561 tctccctgcc tccttaactt tgtactaggc tggcctggac ctgtaccagc tcggctatct
     1621 tcatctgttt catattattt attattttaa ttttctatta aattattgga ataaagttga
     1681 gctgaaggtc tgctgctgaa aaaaaaaaaa aaaaaa
//
