LOCUS       NM_001399515            5940 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium channel tetramerization domain
            containing 12 (Kctd12), mRNA.
ACCESSION   NM_001399515 XM_006252420
VERSION     NM_001399515.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Booker,S.A., Althof,D., Gross,A., Loreth,D., Muller,J., Unger,A.,
            Fakler,B., Varro,A., Watanabe,M., Gassmann,M., Bettler,B.,
            Shigemoto,R., Vida,I. and Kulik,A.
  TITLE     KCTD12 Auxiliary Proteins Modulate Kinetics of GABAB
            Receptor-Mediated Inhibition in Cholecystokinin-Containing
            Interneurons
  JOURNAL   Cereb Cortex 27 (3), 2318-2334 (2017)
   PUBMED   27073217
  REMARK    GeneRIF: Study highlights that GABABRs differentially control
            cholecystokinin-expressing interneuron subtypes, and the kinetics
            and desensitization of GABABR-mediated currents are modulated by
            KCTD12 proteins
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Smaldone,G., Pirone,L., Pedone,E., Marlovits,T., Vitagliano,L. and
            Ciccarelli,L.
  TITLE     The BTB domains of the potassium channel tetramerization domain
            proteins prevalently assume pentameric states
  JOURNAL   FEBS Lett 590 (11), 1663-1671 (2016)
   PUBMED   27152988
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Schwenk,J., Metz,M., Zolles,G., Turecek,R., Fritzius,T., Bildl,W.,
            Tarusawa,E., Kulik,A., Unger,A., Ivankova,K., Seddik,R., Tiao,J.Y.,
            Rajalu,M., Trojanova,J., Rohde,V., Gassmann,M., Schulte,U.,
            Fakler,B. and Bettler,B.
  TITLE     Native GABA(B) receptors are heteromultimers with a family of
            auxiliary subunits
  JOURNAL   Nature 465 (7295), 231-235 (2010)
   PUBMED   20400944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Jan 10, 2022 this sequence version replaced XM_006252420.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR21887622.2964310.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5940              JAXUCZ010000015.1  86214786-86220725   c
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q21"
     gene            1..5940
                     /gene="Kctd12"
                     /note="potassium channel tetramerization domain containing
                     12"
                     /db_xref="GeneID:364458"
                     /db_xref="RGD:1309421"
     exon            1..5940
                     /gene="Kctd12"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1182
                     /gene="Kctd12"
                     /note="potassium channel tetramerisation domain containing
                     12"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD12"
                     /protein_id="NP_001386444.1"
                     /db_xref="GeneID:364458"
                     /db_xref="RGD:1309421"
                     /translation="MALADSTRGLPNGGGGGGGSGSSSSSAEPPLFPDIVELNVGGQV
                     YVTRRCTVVSVPDSLLWRMFTQQQPQELARDSKGRFFLDRDGFLFRYILDYLRDLQLV
                     LPDYFPERSRLQREAEYFELPELVRRLGAPQQPGPGPPPPHSRRGVHKEGSLGDELLP
                     LGYAEPEPQEGASAGAPSPTLDLASRSPSGGAAGPLLTPSQSLDGSRRSGYITIGYRG
                     SYTIGRDAQADAKFRRVARITVCGKTSLAKEVFGDTLNESRDPDRPPERYTSRYYLKF
                     NFLEQAFDKLSESGFHMVACSSTGTCAFASSTDQSEDKIWTSYTEYVFCRE"
ORIGIN      
        1 actcgcctgg agcgcgcggg cgaggcgggc gcagcgcacc ggggctctcg tgggcgcact
       61 gctgcgcgct cgctccgcgc ggctctccgt ggccagccgc cgcctgagcg cagggctccc
      121 gggctaagag ccgctgcggc ttctgatcgc gaccccgctc cctgccactt ggcacagccc
      181 ggccacctct ttttggccat ggctctggcg gacagcaccc gaggattacc caacgggggc
      241 ggaggcggag gtggcagcgg ctcgtcgtcg tcctcagcgg agccgccgct cttcccggac
      301 atcgtggagc tgaacgtggg agggcaggtg tatgtgaccc ggcgctgtac cgtggtgtcc
      361 gtgcccgact cgctgctctg gcgtatgttc acgcagcagc agccgcagga gctggcccgg
      421 gacagcaaag gccgcttctt tctggaccgg gatggcttcc tcttccgcta catcctggat
      481 tacctgcggg acttgcagct cgtgctgccc gactacttcc cggagcgcag ccggctgcag
      541 cgcgaggccg agtacttcga gctgccggag ctcgtgcgac gcctcggggc gccccagcag
      601 cccggtccgg ggccaccgcc gccgcactcg cgccgcgggg tgcacaagga gggctcactg
      661 ggcgacgagc tgctgccgct gggctacgcg gagccggagc cgcaggaggg cgcctcggcc
      721 ggggcgccgt cgcccacgct ggatctggct agccgtagcc cgtccggggg cgcggcgggc
      781 cccctgctca cgccgtccca gtctttggac ggcagccggc gctcgggcta catcaccatc
      841 ggctaccgcg gctcctacac catcgggcgc gacgctcagg cggacgccaa gttccggagg
      901 gtggcgcgca tcaccgtgtg cggcaagacg tcgctggcca aggaggtgtt tggggacacc
      961 ctgaatgaga gccgggaccc cgaccggccc ccggagcgct acacctcgcg ctattacctc
     1021 aagttcaact tcctagagca ggcgttcgat aagctgtcgg agtcaggctt ccacatggtg
     1081 gcgtgcagct ccaccggcac ctgcgccttt gctagtagca ccgaccagag cgaggacaag
     1141 atctggacca gctacaccga gtacgtcttc tgcagggagt gagctcccca cgcccctcgc
     1201 cactccggag cccacttccc ttcctccccg cgggggatag gattatagat accctcgctc
     1261 cttccctgtc tccccattcc ttctgccccg cccccaggcc cccagtagct cgcccagacc
     1321 cgtctgctcc ccacttgaga atctgcagcc acaaatcctc tgggcttctt cgtcttcttt
     1381 ggaccccact aaccgagaga gtgcccagat gtagcccttc actcacgctt cctctactcc
     1441 gggcctccaa acacccttcc ccccagattg tcgtgatcta gtggggcagt gcgggagcag
     1501 tcgccaagta tctgggaatg actgagttgc tcagaccccg actgcacggt gtctggcgtg
     1561 cagtgaggac aagtccttga aatcttaaac cctttgactc catagcggtt ttcagagatc
     1621 agaactgaga gcgctgtgtg gagacagtgt tttaaaacgt tgttacggac ttgatcctca
     1681 ttagaaagat aaaagtttta gacaaccgaa aggaaaaccg taagttggaa ttaagacccc
     1741 atggaggcag ttcaaagact gtaaataaag tgcttttttt gttttttaaa gttacaggta
     1801 gaagtaaatt ctagtactgg caatagatct cctgtggctt aaaattgtag aaagcaatcc
     1861 tcctgcctgc ggaggcgccc tttctcttca gctacttgcc tgagctctag gttttgttgg
     1921 ttaagtcagt acttctaggc taggagcaag gagcaggggg caaggttgcc taggcccgcg
     1981 gtgaccaatt aatacaggaa tggttagtag ggtcagacag cccttactta ggtctaggac
     2041 tgtgggaggg ttggggaggg aggaaagagg ggaggaaggg cgggagggag gaggggacat
     2101 actcatttat tatttgagag ttggacgttt gtatgatcca cttgagtacg tgcacattta
     2161 aaaaaatatg aaacagtacg tgtaaactta gattttatca aggttagtaa aagacctatc
     2221 ttcagctgga agtctatcga gccattttga gtcctaaact tagttgctaa tacccgtcta
     2281 acctaaccaa agagttacct agtagaattt tagtgctttg aacatttatt ttcttgttgg
     2341 ttgtatttcc tcatttttag cctatttact taagcaaaaa taagttcgat tttagttact
     2401 tagacttaag atctcttact attattatta ttagtagtag tagtattttt aaattgctgt
     2461 tttctgcaag cccagcaagt gtggactcct aggcagttct gaaaaccgga acaaggctcg
     2521 ctcgcccttt catgcgtttg cttgacgttg cagtggaatc tgctcctgtc agagctgaag
     2581 acaaacggaa gcgccctggg agctgcccat ctgtagagag ctgtgaagtg ggatgttctt
     2641 taaatgaagg caaacaaata cttcagtgtg ggctgagcaa taacgcggtg ttttaggtga
     2701 acgcagcaga agcaggagac ccggttgcct tacgccttta gtcccacgtg gaatgaattc
     2761 ccagcgtgga tcctgtgcac accacagccg gaaggaggtg aatccgtacg cttcctgctg
     2821 acaggcatct tttggatgat ctgtgattac ggagaagcct ttttatgtgt gtgcttgttt
     2881 taccatttca ctcagagatg tgtttttaag gatatttgta agagccattt taagtgttta
     2941 aattagcgcc gtgtttcctt ctttctaaaa aacgaacctt gtactgtata tgtcatcgtg
     3001 tccatggcag atgttatgaa ttgggacagt tttattgtca gactcctgcg gtccactctg
     3061 tacataccat atataaacat tttacacgaa tcctttagtt ttttaattca tctacggatg
     3121 ctatagaatt tcctatattt gccccctggt aacttgcatt tatttgatgg tgtatataca
     3181 agagcaacgt gtttcggtga gtttctcaca cccttgcctg tggacttggg tcaggaactc
     3241 attcacagct aagtggctgg gtttgctcca cacatttttg ctgggacgtt agttgtatac
     3301 taatcatacg tcagttagct gtctacctgt actcaagcta ttcatatttc taatccaata
     3361 atgtttgcat tttgattggg acagatttac attcttttgt tacttttttt ttttaaagaa
     3421 aagttggctt tatgtgctga gtgtgcagtt ttaaagaaag ggaaacaggg atccaggagt
     3481 tgtgattact tcaaggttga ccttattttt aggcagtgga tcagaacctt tatttcaaac
     3541 ctgaagggac gtaggactgt cactcactgg tctaacgtga gtgtcagact tttccatgcc
     3601 atggaacagt gttagatggc ttaagaaaga aatgcactat taaaaaacac ctttaggacg
     3661 gatcagaata cattggcaga tggcaagacg gaggttctga ttccccttgt caatctgtgc
     3721 agcgataggg gccatgggaa acggctgaca ttttgaagtt ttgtctgcat tcaagtctga
     3781 gggattgtag cttggaaaac cattcagttg tctcactaac agagacatca ctgtaccttc
     3841 ccccacaccc tgactggtgt gttattttaa ggattgggaa gttagtgtta gccacagtac
     3901 acggaccttt tcctggaagc aactgtgccc tctgttgttg gatcccaggc atgaaaactt
     3961 tgtgcttttt agccccaagt taagtctgaa tggtcatctt attctgtgat aggtaagtat
     4021 gactgagtcg gggtgatttg gcgtgggcct tgggtggtag aagaaacatc tttagggctt
     4081 ataaaatgtt ctacaatatt tgtcagcacc catgaatttg agtactgcac cgaatagagt
     4141 agagctctca acagtatgtt tgaaatgacc cagaaggata ttataaacta ttcagatatt
     4201 cacaacggca atctatctca gagaggcgat catttgcata tgttgatcaa attagcatct
     4261 gatgctcata aataatggaa tgacattagg tttaataagt aatttttaaa gagaagtgct
     4321 gacagtcatt ggggttataa agaaaaccaa aataggtacc aggccctgtg cagtttatca
     4381 gacattcgac atgtctgttt tttaatgctt gtggactgca gtccacctca ttctaaattt
     4441 ttgaacatgt aaaggaaaat acactccccc cacctttttg atacttttct tactctagtg
     4501 gttttttttt aattttttta attttttttc aattgctagc aaggtgataa aactagccaa
     4561 attgtcttcc ttttcaaagc agaatcatat acgtgtgtgc ctgctgcttc tctgaggaca
     4621 tatataatgt gcaaatgccc agacaggcag ggcttacaac acagtccagt tcgtattgtt
     4681 ctttccgtgg aatgttgata ctacattaaa gccatgtatc acggagcttt ggtaattttt
     4741 ttaactattc atattatggt attcaagtcg tttttgtact cctatatata aaataaatta
     4801 tacagatatt tagaaaaata ctgagcgaag gaagtgaatt ccttaagcat tccttttgca
     4861 gtccaaatta caagttctat aaaactgaca tactttaaat ttggtatttt ttttaattgt
     4921 aaaactctta gttaagtctc tgcttgcaat ttttattgtt tttttttccc tcactacttt
     4981 tagtctttta aaatcttaat gttttgggta acttaagtct ctcaagtcat gaatcgaacc
     5041 cagtgttctt gttcccagag cctacagtac gtggatgaat ttttccacag tcggaagtag
     5101 gttgctgtag ctaacttttc tttgtgacag ttttggatag tacacatctc aaactatcag
     5161 tactggagga tttagatttc ctccagggcc cattgaacag gatggaagaa tcctaacaga
     5221 agacctccgc tggagtcagc tgttggatgg tagaaggatt gaccagttga ccaaacatgc
     5281 ttgccactgc attttgtaat gtttttccaa accagttttg tttatttaaa atgcgttttg
     5341 aggtgtgcag acatcaactg taatgtaaac tgctatacaa ctgtctttgt gacttgatag
     5401 ccatgtaaac tttactattg aaaacaaacg atgctcgttc tttcattacg accagtttag
     5461 tatccatttg atgacacagg attgaaacat ccatcacggg catacatttt gaacatgtaa
     5521 attaaatttt ctgggtattt gaaaacttgc tctttgtagt aattatttgg attccgacat
     5581 gttgaaaaac gtcacttgct aggtgataca tatctttgag ctctttctta gaaatctaag
     5641 gggacgtgga aaaatatcct aatatcccac ttttctagtg aaacatagac ccaagaataa
     5701 aagcccctcc atatcagcaa ggaaacaaaa acacatgggt gaaatctttt cagaggtgct
     5761 cacacttttg aaattgtctt catccatcca aatgctgttc cgttccttct actcacaacc
     5821 agttgtgtca tggaaacact ctgccggttt ccctgctgtg tgtgaagaaa tgaatcattg
     5881 attgtgtgac ttgttatgta ttctattaaa cactaaagaa taaaacattc actcctttaa
//
