LOCUS       NM_001100516            3431 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium channel tetramerization domain
            containing 1 (Kctd1), mRNA.
ACCESSION   NM_001100516 XM_001062225 XM_214617
VERSION     NM_001100516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Smaldone,G., Pirone,L., Pedone,E., Marlovits,T., Vitagliano,L. and
            Ciccarelli,L.
  TITLE     The BTB domains of the potassium channel tetramerization domain
            proteins prevalently assume pentameric states
  JOURNAL   FEBS Lett 590 (11), 1663-1671 (2016)
   PUBMED   27152988
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Ding,X., Luo,C., Zhou,J., Zhong,Y., Hu,X., Zhou,F., Ren,K., Gan,L.,
            He,A., Zhu,J., Gao,X. and Zhang,J.
  TITLE     The interaction of KCTD1 with transcription factor AP-2alpha
            inhibits its transactivation
  JOURNAL   J Cell Biochem 106 (2), 285-295 (2009)
   PUBMED   19115315
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Li,H., Gu,X., Dawson,V.L. and Dawson,T.M.
  TITLE     Identification of calcium- and nitric oxide-regulated genes by
            differential analysis of library expression (DAzLE)
  JOURNAL   Proc Natl Acad Sci U S A 101 (2), 647-652 (2004)
   PUBMED   14701905
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Luk,J.M., Mok,B.W., Shum,C.K., Yeung,W.S., Tam,P.C., Tse,J.Y.,
            Chow,J.F., Woo,J., Kam,K. and Lee,K.F.
  TITLE     Identification of novel genes expressed during spermatogenesis in
            stage-synchronized rat testes by differential display
  JOURNAL   Biochem Biophys Res Commun 307 (4), 782-790 (2003)
   PUBMED   12878178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On or before Feb 16, 2013 this sequence version replaced
            XM_001062225.2, XM_214617.6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the Celera
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.58958.1,
                                           SRR26643298.72600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1797              JAXUCZ010000018.1  6490307-6492103     c
            1798-1976           JAXUCZ010000018.1  6438724-6438902     c
            1977-2121           JAXUCZ010000018.1  6416513-6416657     c
            2122-2427           JAXUCZ010000018.1  6401897-6402202     c
            2428-3431           JAXUCZ010000018.1  6396947-6397950     c
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p13"
     gene            1..3431
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /note="potassium channel tetramerization domain containing
                     1"
                     /db_xref="GeneID:291772"
                     /db_xref="RGD:621566"
     CDS             1..2586
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /note="vitamin A-deficient testicular protein 6; vitamin
                     A-deficient testicular protein 5; potassium channel
                     tetramerisation domain containing 1"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein KCTD1"
                     /protein_id="NP_001093986.1"
                     /db_xref="GeneID:291772"
                     /db_xref="RGD:621566"
                     /translation="MARMPGSGDCNTSAGGSAAAGAENNGERGEGERGAGGRGRRYGR
                     PHYCSAGEEEEEEEEEDEIQEVQITGDEEEDGGGGLEEDEEEEEEEEMGMDWEEPLEP
                     EDSAGEELEPEPVHMIHMDQSAALEPEAPPRLLAPRARAGPPGDSAELDPDVLQRPER
                     ARLSENTRLATRYAVRIFREYLSEKAQSPDFETMDKGALCRVLRSFYAEARSKSGQLY
                     SKSSLISIRSSLNRYLNEPPYCRTLDLTKDPELRSANLTLAAVIRKLEEQGAGPVVQK
                     QAITRADLRKLYTSSVFSTNTPFGLLNKVWFETCMYFCTRGRENQRELEEDSFGLAMD
                     EDGRKFVYFKSLGPYHKSRSSSWSKKRAESSDEENLPRMYETGTEFCPYASFVKYLSK
                     RNPLCKAFFQRPRDHCSEGDVTWYENKAIGKNLLGTRMQMLSKAAKLSKTYTNHCIGA
                     VSIATLNSIAGIGTKLGSPAPQGCYTDSLNGSARHHSHHAPTHPSHHHRPQPSSLGST
                     YILPKDSQVGPDVKSEAAPKRALYESVFGSGEICGPSSPKRLCIRPSSEPVDAVVVVS
                     VKHDPLPLLPEVNGHRSTNSPTIVSPAIVSPTQDSRPNMSRPLITRSPASPLNNQGIP
                     TPAQLTKSNAPVHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPIVLDSLKQHYFID
                     RDGQMFRYILNFLRTSKLLIPDDFKDYTLLYEEAKYFQLQPMLLEMERWKQDRETSRF
                     SRPCECLVVRVAPDLGERITLSGDKSLIEEVFPEIGDVMCNSVNAGWNHDSTHVIRFP
                     LNGYCHLNSVQVLERLQQRGFEIVGSCGGGVDSSQFSEYVLRRELRRTPRVPSVIRIK
                     QEPLD"
     exon            1..1797
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1976
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2121
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2427
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..3431
                     /gene="Kctd1"
                     /gene_synonym="Vad; Vad5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcgagaa tgcctggcag cggggactgt aacaccagcg cgggcggcag cgccgccgct
       61 ggggccgaga acaatgggga gcggggcgag ggcgagcgcg gggccggggg ccgcggtcgc
      121 cgctacggcc gcccgcatta ctgcagcgcg ggcgaggagg aggaggaaga ggaggaggag
      181 gacgagatcc aggaggtgca gataacgggg gacgaggagg aggacggagg tggggggctg
      241 gaggaggacg aggaggagga ggaagaggag gagatgggga tggactggga agagcccctg
      301 gagccagagg actcggccgg ggaggagctg gagcccgagc cggtccatat gatccatatg
      361 gaccagagcg ccgcgctgga gcccgaggcg ccgccacgac tgctggcgcc ccgggcccgc
      421 gcggggccgc ccggggacag cgcggagctg gaccccgacg tgctgcagcg ccccgagcgg
      481 gcccggctga gcgagaacac ccggctggcc acccgctacg ccgtgcgcat cttccgggag
      541 tacctgagcg aaaaggctca gagcccagac ttcgagacca tggacaaggg ggcgctgtgc
      601 cgcgtgctgc gctccttcta tgccgaggcc cgttctaaga gcggccagct ctacagcaag
      661 tcctcgctca tcagcatccg cagctccctc aaccgctacc tcaacgagcc cccttactgt
      721 cgcacgctcg acctcaccaa ggaccccgag ctgcgcagcg ccaacctgac gctggccgca
      781 gtcatccgca agctcgagga gcagggcgcg gggcccgtgg tgcagaagca agccatcacg
      841 cgcgccgacc tgcgcaagct ctacacctcc agcgtcttca gcaccaacac gccctttgga
      901 ctgctcaaca aggtctggtt cgagacgtgc atgtactttt gcacgcgagg ccgcgagaac
      961 cagcgcgagc tggaggagga ctccttcggg ctggccatgg acgaggacgg tcgcaagttc
     1021 gtctacttca agtcgctcgg gccttaccac aagtcgcgtt cctcgtcctg gagtaagaag
     1081 cgagcggaga gcagcgacga agagaacttg cctcgcatgt acgagacagg cactgagttc
     1141 tgtccctacg ccagctttgt caagtacctg tctaagcgca atcccctctg taaggcgttc
     1201 ttccagcggc cccgggacca ctgcagcgag ggcgatgtga catggtacga gaacaaagcc
     1261 ataggcaaga acttgctggg caccaggatg cagatgctct ccaaggcagc caagctgtcc
     1321 aagacctaca ctaaccactg catcggcgcg gtgtccatcg ccacgctcaa cagcatcgcg
     1381 ggcatcggga ccaagctagg ctccccagcc ccgcagggct gctacaccga ctctctgaac
     1441 gggtcagctc gtcaccactc ccaccatgcc cccacccatc cttcccacca ccaccgcccc
     1501 cagccgtcct cgctgggtag cacttatatc ctccccaaag acagccaggt cgggcccgac
     1561 gtgaagtccg aggctgcgcc caagcgcgcg ctgtacgagt cagtgttcgg gtccggggaa
     1621 atctgcggcc cttcttcccc caaaagactt tgtatccgtc cctcctcgga acctgtggat
     1681 gcggtggtag tggtttccgt gaaacacgac cccctgcctc ttcttccaga agtcaatggg
     1741 caccgaagca ccaattctcc caccatagtt tcacctgcta ttgtttcccc cacccaggac
     1801 agtcggccca atatgtcaag acctctgatc actagatccc ccgcatcgcc actgaacaac
     1861 caaggcattc caactccagc acagctcacc aagtccaatg ctcccgtcca cattgacgtg
     1921 ggcggccaca tgtacaccag cagcctggcc accctcacca aataccccga atcaagaatc
     1981 ggaagactct tcgatggcac agagcccatt gtcctggaca gtctcaaaca gcactatttc
     2041 attgacagag acgggcagat gttcagatat atcttgaatt ttctacgaac atcaaaactc
     2101 ctcattcccg atgatttcaa ggactacact ttgttgtatg aagaggcaaa atatttccaa
     2161 ctccagccca tgttgttgga gatggagcga tggaaacagg acagagaaac gagccgcttt
     2221 tcacggccct gcgagtgcct cgtggtgcgt gtggccccgg accttggaga aaggatcacg
     2281 ctcagtgggg acaagtcctt gatagaagaa gtgtttcccg agatcggcga cgtgatgtgc
     2341 aactccgtca atgcaggttg gaatcacgac tcgacgcatg tcatcaggtt tccactaaac
     2401 ggctactgcc acctcaactc agttcaggtc ctcgagcggt tgcagcaaag aggatttgaa
     2461 attgtgggtt cctgtggagg aggcgtggac tcatcccagt tcagtgaata cgtcctccga
     2521 cgggaactga gacggacacc ccgagtaccc tccgtcatcc ggataaaaca ggagccactg
     2581 gactaaacag acatatttct tatgcaaaaa gaaaatatac acaaccaata acaatatgag
     2641 aaaagggaca tttgtgtgca gctggacagt aaaccaagct ctgaacctaa aattgaataa
     2701 aagacgttta tatccactag aaatcacaac ctgtattcat atgagaacaa ttggaatcat
     2761 gataccctca agatgtaaaa aaatatataa atatataaat atatatatat gtcaaaaggt
     2821 aggaaatgcg gagagagaga gagagagaga gagagagaga gagagataga aagggcgctg
     2881 cagtgggtgc tgtgatgacc atggatgtcc tgggcctatg gggtctctgt ccagtaaata
     2941 agccatgagc agggaggaca gagtctcctc gcagtttcat tgccaactgc catccattgt
     3001 ttctttttcc tttatctttc ttccttttct ttttttttta aacaaacaaa acaaaacacc
     3061 ttggttggtg tttctttgca agtggaggtt tcatgtctgg tcaggtaggg accaggaggg
     3121 aattcagaga actgcttaag agcacaccgc accggacgta cagcagacag gacctctgga
     3181 ctgcagtccg cacaggactg acactctgtc caccgcacag ccgcgacatt tcctttgttt
     3241 taagctgatc gtttggcaga ggggccagag ttattacttg ctagagatcc ccagtttcgg
     3301 tctgctgctt tcctacaatt ttttcagatt ttataatgta ttaaatacaa taaactctgt
     3361 tttaaaaaat gagatctgtg tagaacacac gtgttgggat gagaatgaat taaaatgaaa
     3421 tttttccttt t
//
