LOCUS       NM_021853               4686 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Rattus norvegicus potassium sodium-activated channel subfamily T
            member 1 (Kcnt1), transcript variant 1, mRNA.
ACCESSION   NM_021853
VERSION     NM_021853.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4686)
  AUTHORS   Wu,J., El-Hassar,L., Datta,D., Thomas,M., Zhang,Y., Jenkins,D.P.,
            DeLuca,N.J., Chatterjee,M., Gribkoff,V.K., Arnsten,A.F.T. and
            Kaczmarek,L.K.
  TITLE     Interaction Between HCN and Slack Channels Regulates mPFC Pyramidal
            Cell Excitability in Working Memory Circuits
  JOURNAL   Mol Neurobiol 61 (4), 2430-2445 (2024)
   PUBMED   37889366
  REMARK    GeneRIF: Interaction Between HCN and Slack Channels Regulates mPFC
            Pyramidal Cell Excitability in Working Memory Circuits.
REFERENCE   2  (bases 1 to 4686)
  AUTHORS   Xu,J., Lv,Y.T., Zhao,X.Y., Wang,J.J., Shen,Z.S., Li,J., Zhang,F.F.,
            Liu,J., Wang,X.H., Xu,Y., Geng,Q., Ding,Y.T., Xu,J.J., Tan,M.J.,
            Li,Z.X., Wang,R., Chen,J., Sun,W., Cui,M., Logothetis,D.E.,
            Cao,J.L., Tang,Q.Y. and Zhang,Z.
  TITLE     Identification of Sodium- and Chloride-Sensitive Sites in the Slack
            Channel
  JOURNAL   J Neurosci 43 (15), 2665-2681 (2023)
   PUBMED   36898835
  REMARK    GeneRIF: Identification of Sodium- and Chloride-Sensitive Sites in
            the Slack Channel.
REFERENCE   3  (bases 1 to 4686)
  AUTHORS   Pryce,K.D., Powell,R., Agwa,D., Evely,K.M., Sheehan,G.D., Nip,A.,
            Tomasello,D.L., Gururaj,S. and Bhattacharjee,A.
  TITLE     Magi-1 scaffolds NaV1.8 and Slack KNa channels in dorsal root
            ganglion neurons regulating excitability and pain
  JOURNAL   FASEB J 33 (6), 7315-7330 (2019)
   PUBMED   30860870
  REMARK    GeneRIF: Magi-1 bound to sequence like a calcium-activated
            potassium channel sodium-activated (Slack) potassium channels,
            demonstrating macrocomplexing with NaV1.8 channels.
REFERENCE   4  (bases 1 to 4686)
  AUTHORS   Evely,K.M., Pryce,K.D. and Bhattacharjee,A.
  TITLE     The Phe932Ile mutation in KCNT1 channels associated with severe
            epilepsy, delayed myelination and leukoencephalopathy produces a
            loss-of-function channel phenotype
  JOURNAL   Neuroscience 351, 65-70 (2017)
   PUBMED   28366665
  REMARK    GeneRIF: characterized an analogous mutation in the rat Slack
            channel and unexpectedly found this mutation to produce a
            loss-of-function phenotype
REFERENCE   5  (bases 1 to 4686)
  AUTHORS   Tejada,M.A., Hashem,N., Calloe,K. and Klaerke,D.A.
  TITLE     Heteromeric Slick/Slack K+ channels show graded sensitivity to cell
            volume changes
  JOURNAL   PLoS One 12 (2), e0169914 (2017)
   PUBMED   28222129
  REMARK    GeneRIF: mRNA of aquaporin 1 was co-expressed in Xenopus oocytes
            with homomeric or heteromeric Slick and Slack alpha-subunits.
            Hypotonic or hypertonic buffers caused changes in current. The
            heteromeric channel had a characteristic graded sensitivity to
            small and fast changes in cell volume. This the cell volume
            sensitivity is dependent on the number of volume sensitive Slick
            alpha-subunits in the tetrameric channels.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4686)
  AUTHORS   Ruffin,V.A., Gu,X.Q., Zhou,D., Douglas,R.M., Sun,X., Trouth,C.O.
            and Haddad,G.G.
  TITLE     The sodium-activated potassium channel Slack is modulated by
            hypercapnia and acidosis
  JOURNAL   Neuroscience 151 (2), 410-418 (2008)
   PUBMED   18082331
  REMARK    GeneRIF: Slack may play an important role in pathological
            conditions during which there is an increase in the intracellular
            concentrations of both acid and Na(+), such as in ischemia/hypoxia
REFERENCE   7  (bases 1 to 4686)
  AUTHORS   Bhattacharjee,A., Joiner,W.J., Wu,M., Yang,Y., Sigworth,F.J. and
            Kaczmarek,L.K.
  TITLE     Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel
            inhibited by ATP
  JOURNAL   J Neurosci 23 (37), 11681-11691 (2003)
   PUBMED   14684870
REFERENCE   8  (bases 1 to 4686)
  AUTHORS   Yuan,A., Santi,C.M., Wei,A., Wang,Z.W., Pollak,K., Nonet,M.,
            Kaczmarek,L., Crowder,C.M. and Salkoff,L.
  TITLE     The sodium-activated potassium channel is encoded by a member of
            the Slo gene family
  JOURNAL   Neuron 37 (5), 765-773 (2003)
   PUBMED   12628167
  REMARK    GeneRIF: The Slo2 gene (also called Slack), is heterologously
            expressed, shares many properties of native K(Na) channels
            including activation by intracellular Na+, high conductance, and
            prominent subconductance states.
REFERENCE   9  (bases 1 to 4686)
  AUTHORS   Bhattacharjee,A., Gan,L. and Kaczmarek,L.K.
  TITLE     Localization of the Slack potassium channel in the rat central
            nervous system
  JOURNAL   J Comp Neurol 454 (3), 241-254 (2002)
   PUBMED   12442315
  REMARK    GeneRIF: Localization of Slack protein has been determined to be
            most prominent in the brainstem, in particular the trigeminal
            system and reticular formation, in both cell bodies and axonal
            fibers of associated nuclei.
REFERENCE   10 (bases 1 to 4686)
  AUTHORS   Joiner,W.J., Tang,M.D., Wang,L.Y., Dworetzky,S.I., Boissard,C.G.,
            Gan,L., Gribkoff,V.K. and Kaczmarek,L.K.
  TITLE     Formation of intermediate-conductance calcium-activated potassium
            channels by interaction of Slack and Slo subunits
  JOURNAL   Nat Neurosci 1 (6), 462-469 (1998)
   PUBMED   10196543
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_021853.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF089730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JAXUCZ010000003.1  29096096-29096274
            180-221             JAXUCZ010000003.1  29100382-29100423
            222-301             JAXUCZ010000003.1  29106374-29106453
            302-401             JAXUCZ010000003.1  29107087-29107186
            402-458             JAXUCZ010000003.1  29109233-29109289
            459-507             JAXUCZ010000003.1  29109570-29109618
            508-567             JAXUCZ010000003.1  29110229-29110288
            568-642             JAXUCZ010000003.1  29110498-29110572
            643-726             JAXUCZ010000003.1  29110640-29110723
            727-821             JAXUCZ010000003.1  29111307-29111401
            822-1002            JAXUCZ010000003.1  29112338-29112518
            1003-1167           JAXUCZ010000003.1  29116544-29116708
            1168-1304           JAXUCZ010000003.1  29117000-29117136
            1305-1368           JAXUCZ010000003.1  29118589-29118652
            1369-1477           JAXUCZ010000003.1  29118747-29118855
            1478-1586           JAXUCZ010000003.1  29119254-29119362
            1587-1736           JAXUCZ010000003.1  29119574-29119723
            1737-1975           JAXUCZ010000003.1  29120100-29120338
            1976-2204           JAXUCZ010000003.1  29121495-29121723
            2205-2310           JAXUCZ010000003.1  29123213-29123318
            2311-2483           JAXUCZ010000003.1  29124315-29124487
            2484-2555           JAXUCZ010000003.1  29125129-29125200
            2556-2690           JAXUCZ010000003.1  29125326-29125460
            2691-2802           JAXUCZ010000003.1  29125833-29125944
            2803-2904           JAXUCZ010000003.1  29127019-29127120
            2905-2988           JAXUCZ010000003.1  29127412-29127495
            2989-3114           JAXUCZ010000003.1  29127620-29127745
            3115-3135           JAXUCZ010000003.1  29128079-29128099
            3136-3466           JAXUCZ010000003.1  29128826-29129156
            3467-3529           JAXUCZ010000003.1  29130403-29130465
            3530-3617           JAXUCZ010000003.1  29133507-29133594
            3618-4686           JAXUCZ010000003.1  29133689-29134757
FEATURES             Location/Qualifiers
     source          1..4686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..4686
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /note="potassium sodium-activated channel subfamily T
                     member 1"
                     /db_xref="GeneID:60444"
                     /db_xref="RGD:621106"
     exon            1..179
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..3738
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /function="heteromultimerizes with maxi-K (Slo) subunits
                     to generate intermediate-conductance calcium-activated
                     potassium channels"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sequence like a calcium-activated potassium channel
                     subunit; potassium channel subunit (Slack); potassium
                     channel, subfamily T, member 1; potassium channel,
                     sodium-activated subfamily T, member 1"
                     /codon_start=1
                     /product="potassium channel subfamily T member 1 isoform
                     1"
                     /protein_id="NP_068625.2"
                     /db_xref="GeneID:60444"
                     /db_xref="RGD:621106"
                     /translation="MARAKLPRSPSEGKAGPGDTPAGSAAPEEPHGLSPLLPTRGGGS
                     VGSDVGQRLHVEDFSLDSSLSQVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFS
                     LKLLTCLLYIVRVLLDNPDQGIGCWGCTKYNYTFNGSSSEFHWAPILWVERKMALWVI
                     QVIVATISFLETMLLIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIP
                     VFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERA
                     GGNLNLLTSFYFCIVTFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLW
                     MERQKSGGNYSRHRARTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSE
                     MDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADH
                     QTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATS
                     TLITLLVHTSRGQEGQESPEQWQRMYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAF
                     HAHKKYGVCLIGLKREENKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKQ
                     KRRGLAGQALYEGPSRLPVHSIIASMVAMDLQNTDCRPSQGGSGGGGGKLTLPTENGS
                     GSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIG
                     SSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIV
                     PLRAYYRSRRELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYA
                     DNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAK
                     DSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITR
                     LLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIYRTECHVFSSE
                     PHDLRAQSQISVNMEDCEDTREAKGPWGTRAASGGGSTHGRHGGSADPVEHPLLRRKS
                     LQWARKLSRKSSKQAGKAPMTTDWITQQRLSLYRRSERQELSELVKNRMKHLGLPTTG
                     YEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVLINPPPDTRLEPNDIVYLIRSD
                     PLAHVTSSSQSRKSSCSNKLSSCNPETRDETQL"
     exon            180..221
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            222..301
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            302..401
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            402..458
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            459..507
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            508..567
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            568..642
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            643..726
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            727..821
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1002
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1167
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1304
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1368
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1477
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1586
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1736
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1975
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2204
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2310
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2483
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2555
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2556..2690
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2802
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2904
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..2988
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3114
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3135
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            3136..3466
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            3467..3529
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            3530..3617
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..4686
                     /gene="Kcnt1"
                     /gene_synonym="rSlo2; Slack"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccgcgcca agcgctcccg caggatggcg cgggccaagc tgccgcgctc accgtccgag
       61 ggcaaggcgg gtccggggga caccccagcc ggctctgcag cccctgagga gccgcacgga
      121 ctcagcccgc tactgcccac ccgcggcggg ggctccgtgg gcagcgacgt gggccagagg
      181 cttcatgtgg aagatttcag cctggactct tccctttctc aggtccaggt ggaattctat
      241 gtcaatgaga acaccttcaa agaacgcctc aagctgttct tcatcaaaaa ccagagatcc
      301 agcctgagga tccggctgtt caacttctcc ctcaagctcc tcacctgcct gctgtacatt
      361 gtccgtgtcc tgctcgacaa cccagaccag ggcatcggat gctggggctg cacgaagtat
      421 aactacacgt tcaatggttc gtcctcggag ttccactggg ctcccatcct gtgggtggag
      481 aggaaaatgg ctctgtgggt gatccaggtc attgtggcca caataagctt cttagagacc
      541 atgctcctca tttacctcag ctacaaaggc aacatctggg agcagatatt ccatgtgtct
      601 ttcgtcttgg agatgatcaa cacactgccc ttcatcatca cggtcttctg gccacctctc
      661 cggaacctgt tcatccctgt gtttctcaac tgctggctgg ccaagcacgc cctggagaac
      721 atgatcaatg acttccaccg tgccatcctg cgcacacagt cagccatgtt caaccaggtg
      781 ctcatcctgt tctgcaccct gctgtgcctg gtcttcacag ggacctgtgg gattcagcac
      841 ttagagcggg caggtggcaa cttgaacttg ctgacctcct tctacttctg cattgtgact
      901 ttctcaaccg tgggcttcgg tgatgtgaca cccaagatct ggccatccca gctcctggtg
      961 gtcatcctga tctgtgtcac ccttgtggtg ctcccactgc agtttgaaga gcttgtctac
     1021 ctctggatgg agcggcagaa gtcagggggc aactatagcc gccaccgagc acggacagag
     1081 aagcatgtgg tcctgtgtgt gagctccctc aagatcgatc tcctcatgga tttcctgaat
     1141 gagttctatg cccacccccg tctccaggac tactacgtgg tcatcctgtg tccctcggaa
     1201 atggatgtcc aggtgcgcag ggtcctacag attcccctgt ggtcccagcg tgtcatctac
     1261 ctccagggct ctgccctcaa ggaccaggac ctcatgcgag ctaagatgga caacggagag
     1321 gcctgcttta tcctcagcag caggaatgag gtggaccgca cagctgcgga tcaccagacc
     1381 atccttcgag cctgggctgt gaaagacttt gcccccaact gccccctcta tgtccagatt
     1441 ctcaagcccg aaaacaagtt tcacgtcaaa tttgctgacc atgtggtgtg cgaggaagag
     1501 tgcaagtacg ccatgctggc cctgaactgc atctgcccgg ccacctccac cctcatcacc
     1561 ctgctggtgc acacatcccg tggccaggaa ggacaggagt caccagagca gtggcagcgc
     1621 atgtacgggc gctgctcggg caacgaggtg taccacattc gcatgggtga cagtaaattc
     1681 ttccgggagt atgagggcaa gagcttcacc tacgcagcct tccacgcgca caagaagtat
     1741 ggggtgtgcc tcattgggct gaaacgtgaa gagaacaaga gtatcctgct gaacccgggg
     1801 ccacggcaca tcctggccgc ctctgacacc tgcttctata tcaatattac caaggaggag
     1861 aactcagctt tcatcttcaa gcaggaggaa aagcagaaga ggcggggcct ggcagggcag
     1921 gcactttacg aagggccctc ccggctccca gtgcacagca tcatcgcctc tatggtggcc
     1981 atggacctgc agaacacaga ttgccggccc tcccagggtg gcagtggtgg gggcggcggc
     2041 aagctgactc tgcccactga gaacggctct ggcagtcggc gtcccagcat cgcacccgtt
     2101 ctggagttgg cagacagctc agccctgttg ccctgcgacc tgctgagtga ccaatcagag
     2161 gatgaggtga caccctcaga cgacgagggg ctctctgtgg ttgagtatgt gaagggctac
     2221 cctcccaact caccctacat tggcagctcc ccgactttat gccacctctt gcctgtaaag
     2281 gcccccttct gctgcctgcg actggataag ggctgcaaac acaacagcta tgaggatgcc
     2341 aaggcctacg ggttcaagaa caagttgatc atcgtctctg ctgagacggc aggcaacggg
     2401 ctctacaact tcatcgtgcc tctgcgtgcc tactaccggt cccgccggga gctcaacccc
     2461 attgtgctgc tgcttgacaa caagcctgac caccacttcc tggaggccat ctgctgcttc
     2521 cccatggtct actacatgga gggatccgtg gacaacctgg acagcttgct gcagtgtggc
     2581 atcatctatg ctgacaatct ggtggtggtg gacaaggaga gtaccatgag cgctgaagag
     2641 gactacatgg cagatgccaa gaccattgtc aacgtgcaga ccatgttcag gcttttcccc
     2701 agtctcagca tcaccacgga gctcacgcac ccttccaaca tgcggttcat gcagttccgg
     2761 gccaaggaca gctactctct ggctctttcc aaacttgaaa agcaagaacg ggagaatggc
     2821 tccaacctgg ccttcatgtt ccgcctgcca tttgctgctg gtcgggtgtt tagtatcagc
     2881 atgttggata cgctgctcta ccagtccttc gtgaaggact acatgatcac catcaccagg
     2941 ctgctgctgg gccttgacac gacgccaggc tctggctacc tctgtgctat gaaggtaact
     3001 gaggatgacc tgtggatccg tacttatggc cgcctcttcc agaaactctg ctcctccagc
     3061 gctgagatcc ccatcggcat ctacaggacc gagtgccatg tcttctcctc tgagcctcat
     3121 gacctcagag cccagtctca gatctcggtg aacatggagg attgcgagga cactcgggag
     3181 gccaaggggc cctggggcac acgggctgcg tctggcggtg gcagcaccca tggccgtcac
     3241 gggggcagtg ctgacccggt ggagcaccca ctactgcgcc gcaagagcct gcagtgggcc
     3301 cgcaagctga gccgcaagag cagcaagcag gcggggaagg cacccatgac cacagactgg
     3361 atcacccagc agcgactcag cctgtaccgg cgctcagagc gccaggagct ctcggagctg
     3421 gtcaagaacc gaatgaagca cctggggctg cccaccactg gctacgagga cgtagcaaat
     3481 ttaacagcca gtgatgtgat gaatcgggta aacctgggat atttgcaaga tgagatgaat
     3541 gatcatcacc agaacaccct ttcctatgta ctcatcaacc ccccgccaga cacaagactg
     3601 gagcccaacg atattgtgta cctcatccgt tccgaccccc tggcccacgt gaccagcagc
     3661 tcccagagtc ggaaaagcag ctgcagcaac aaactgtcat cctgtaatcc tgagacccgg
     3721 gatgagaccc agctctgagc cccattctga ggcggacagg tggacgcggg agaatagagg
     3781 ggacattgtc acgggccagc ctgggccaag caggctgcat tatgacttta tacagtggtt
     3841 ccaagacttg cccccagaaa ggaaatcctc tcagtggggc caacagtgag accaccggac
     3901 caccctggaa attggcatga gacatttttt aacctatttt tacaaatctg aatgatttgc
     3961 atctccttac atagctgtac cacaactcgt gactagggtc tggcttaagt gtgaagcagg
     4021 caggcagaac aaggactgga cactaccctg gatcctacag tctctcatgg cttcactcag
     4081 caatgtctga aggggtgctg gggtgcatgg gagaaggaat gacctggaac tgcagagttc
     4141 cacagaggac tgagaagtcc tcctgcatgg aaaccaactg tactctgtag ccattcaaca
     4201 tgctgttctg atcagagctt ctgcatggct ctgggactac accacggcct atggggtgcc
     4261 tctccccaga accaggcaag gggctaacca ctaaaggtgc cgtgcccttt aagaggagaa
     4321 aaacaggggc ttagaaccct ggtcaggaga ccccaccctg aacctgagct ctgcagcccc
     4381 ctgcatgagt ggagggggga ttatagtgga tcctcaagtt ctgaggctgt gactatgaaa
     4441 gtcacacttg agcttcccca gccatagcct ttggggacac agatggcaga tggtgtgtct
     4501 ctgtggatca tttcacactc aaagcaagtc ttgtctctaa aactcctgat ctgagaagca
     4561 caattagctc tgggccctgg ccatgcctca ggtctccagg gattcctcca ggcagctgac
     4621 ttcattcttg tttatggttt gtatgatcag aaccggaacc ttctattaaa atggatacat
     4681 cctgca
//
