LOCUS       NM_001389230            2355 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel, modifier
            subfamily S, member 3 (Kcns3), transcript variant 2, mRNA.
ACCESSION   NM_001389230
VERSION     NM_001389230.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2355)
  AUTHORS   Coma,M., Vicente,R., Tsevi,I., Grande,M., Tamkun,M.M. and Felipe,A.
  TITLE     Different Kv2.1/Kv9.3 heteromer expression during brain and lung
            post-natal development in the rat
  JOURNAL   J Physiol Biochem 58 (4), 195-203 (2002)
   PUBMED   12744302
  REMARK    GeneRIF: different Kv9.3/Kv2.1 ratios could have physiological
            implications in lung and brain during post-natal development, and
            that diet composition and selective tissue-specific insulin
            regulation modulate the expression of Kv2.1 and Kv9.3.
REFERENCE   2  (bases 1 to 2355)
  AUTHORS   Stocker,M. and Kerschensteiner,D.
  TITLE     Cloning and tissue distribution of two new potassium channel
            alpha-subunits from rat brain
  JOURNAL   Biochem Biophys Res Commun 248 (3), 927-934 (1998)
   PUBMED   9704029
REFERENCE   3  (bases 1 to 2355)
  AUTHORS   Patel,A.J., Lazdunski,M. and Honore,E.
  TITLE     Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in
            oxygen-sensitive pulmonary artery myocytes
  JOURNAL   EMBO J 16 (22), 6615-6625 (1997)
   PUBMED   9362476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CK366986.1, SRR26643429.23213.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840113,
                                           SAMN12840120 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               JAXUCZ010000006.1  39583251-39583394   c
            145-335             JAXUCZ010000006.1  39556265-39556455   c
            336-2355            JAXUCZ010000006.1  39527410-39529429   c
FEATURES             Location/Qualifiers
     source          1..2355
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q15"
     gene            1..2355
                     /gene="Kcns3"
                     /gene_synonym="Kv9.3"
                     /note="potassium voltage-gated channel, modifier subfamily
                     S, member 3"
                     /db_xref="GeneID:83588"
                     /db_xref="RGD:621527"
     exon            1..144
                     /gene="Kcns3"
                     /gene_synonym="Kv9.3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..335
                     /gene="Kcns3"
                     /gene_synonym="Kv9.3"
                     /inference="alignment:Splign:2.1.0"
     exon            336..2355
                     /gene="Kcns3"
                     /gene_synonym="Kv9.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             395..1870
                     /gene="Kcns3"
                     /gene_synonym="Kv9.3"
                     /note="potassium voltage-gated channel subfamily S member
                     3; voltage-gated potassium channel subunit Kv9.3;
                     delayed-rectifier K(+) channel alpha subunit 3;
                     Shab-related delayed-rectifier K+ channel (Kv9.3);
                     potassium voltage-gated channel, delayed-rectifier,
                     subfamily S, member 3; delayed-rectifier potassium channel
                     subunit Kv9.3"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS3"
                     /protein_id="NP_001376159.1"
                     /db_xref="GeneID:83588"
                     /db_xref="RGD:621527"
                     /translation="MVFGEFFHRPGQDEELVNLNVGGFKQSVDQSTLLRFPHTRLGKL
                     LTCHSEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCVFSFCQE
                     IEYWGINELFIDSCCSSRYQERKEESHEKDWDQKSNDVSTDSSFEESSLFEKELEKFD
                     ELRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVLASIVAMCVHSMSEFQNEDGEVD
                     DPVLEGVEIACIAWFTGELAIRLVAAPSQKKFWKNPLNIIDFVSIIPFYATLAVDTKE
                     EESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVG
                     ISIFSVLIYSVEKDELASSLTSIPICWWWATISMTTVGYGDTHPVTLAGKIIASTCII
                     CGILVVALPITIIFNKFSKYYQKQKDMDVDQCSEDPPEKCHELPYFNIRDVYAQQVHA
                     FITSLSSIGIVVSDPDSTDASSVEDNEDAYNTASLENCTAK"
ORIGIN      
        1 ggcgacccgt gcgggctagc ccgctctcct gccgctgcgg cggcgggcgc ggggccgcgc
       61 ggcgaggccg gatccctgca gcgcgggcag gcggcgtcgc ggaacccagc cagccagacg
      121 cgccaggact cccgactcct gcaggtgaac ttcactttgt agcatctgct ttgactcgca
      181 caaccagagg accacatcct tctcttcttt gagccactaa atgccgatgc gcactccaca
      241 ctccagcaag ggaagatggg aggagcttct tggatgacga tggatggtcc actgtgcagg
      301 atgagggcag gctgtgtgac atcgccacca cgagggttca gcgtgatctt ctgtgtctcc
      361 cttctgggcc agcactctgc cttctcagtc catcatggtg tttggtgagt ttttccatcg
      421 ccctggacaa gatgaggaac ttgtcaactt gaacgtgggg ggttttaaac agtctgtgga
      481 tcagagtaca ctcctgcggt tcccccacac acgactgggg aagctgctta cctgccactc
      541 tgaggaggcc attctggagc tgtgtgatga ctacagcgtg gcagataaag agtactactt
      601 cgatcggaac ccctccctgt tcagatacgt tttgaacttt tattacacag ggaagctgca
      661 cgtcatggag gaactgtgtg tcttctcctt ttgccaggag attgagtact ggggcatcaa
      721 cgagctcttc attgactcct gctgtagcag tcggtaccag gagcgcaagg aggagagcca
      781 cgagaaggac tgggaccaga aaagcaatga tgtgagcaca gactcctcct ttgaggaatc
      841 gtctctgttt gagaaagagc tggagaagtt tgatgagctg agatttggtc agctccgaaa
      901 gaagatctgg atccgaatgg aaaacccagc ttattgcctg tcagccaagc tcatcgccat
      961 ctcctccttg agtgtggtgc tggcttccat cgtggccatg tgtgtacaca gcatgtcaga
     1021 attccagaac gaggatggag aagtggatga ccctgtgctg gaaggtgtgg agattgcctg
     1081 cattgcatgg ttcaccggtg agctggccat ccggctggtt gctgctccat cacaaaagaa
     1141 gttctggaaa aaccctctga acatcattga ctttgtctcc atcattccct tctatgccac
     1201 gttggctgtg gacaccaagg aagaagagag tgaggacatt gagaacatgg gcaaggtggt
     1261 ccagatcctc cggctcatga ggattttccg catcctgaag ctcgcccggc attccgtagg
     1321 gcttcgttct cttggggcca cgctgaggca cagttaccac gaagtggggc tactgcttct
     1381 cttcctctct gtgggtatct ccattttctc tgtgcttatt tactctgtgg agaaagatga
     1441 actcgcgtcc agtctcacta gcatccccat ctgctggtgg tgggccacta tcagtatgac
     1501 cacagtgggc tatggagaca cccacccagt caccttagct gggaaaatca ttgcgagcac
     1561 ctgcattatc tgtggcatct tagtggtagc ccttcccatc accatcatct tcaacaagtt
     1621 ttccaagtac taccagaagc agaaggacat ggatgtggac cagtgcagcg aggacccacc
     1681 ggagaagtgc cacgagctac cttactttaa cattagggac gtttatgcac agcaagtaca
     1741 cgccttcatc accagtctgt cttccattgg catcgtggtc agcgatcctg actccacaga
     1801 tgcctcaagt gtcgaagaca acgaggatgc ttacaacacc gcatccctgg agaactgtac
     1861 tgcaaaatga gcaggggcat ttgcacggac agctcatgtc ccttcctcac gttaggttaa
     1921 cacagcttta taaacctcag tgggtttgtt caaatcaatc atttaattct cagggtgtac
     1981 cttttagcca tagttggaca ttcattgccg aattctgaaa tgatagaatt atctttattt
     2041 ttctcagtga gatcaattaa aatgccttgt tctgaaattt attttttaac aagagagagt
     2101 tgtaatacgg ttttttgggg gaaaaatgtc aatgatattg ggaaggattt attgctacgg
     2161 cttacgcatc attctgtatc tgccattcac tcacattgag ctaactataa attactgatg
     2221 ttagagcaga ggcccagccg accgaagacg acatgcatgt aagatctaca acatgagaca
     2281 atgcatgtaa atccatgttc atgttccaga cacgggaatt aggagcccaa taaacttcta
     2341 attcggtatg gagaa
//
