LOCUS       NM_053954               2701 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel, modifier
            subfamily S, member 1 (Kcns1), mRNA.
ACCESSION   NM_053954
VERSION     NM_053954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2701)
  AUTHORS   Farago,N., Kocsis,A.K., Brasko,C., Lovas,S., Rozsa,M., Baka,J.,
            Kovacs,B., Mikite,K., Szemenyei,V., Molnar,G., Ozsvar,A., Olah,G.,
            Piszar,I., Zvara,A., Patocs,A., Barzo,P., Puskas,L.G. and Tamas,G.
  TITLE     Human neuronal changes in brain edema and increased intracranial
            pressure
  JOURNAL   Acta Neuropathol Commun 4 (1), 78 (2016)
   PUBMED   27487831
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2701)
  AUTHORS   Tsantoulas,C., Zhu,L., Shaifta,Y., Grist,J., Ward,J.P., Raouf,R.,
            Michael,G.J. and McMahon,S.B.
  TITLE     Sensory neuron downregulation of the Kv9.1 potassium channel
            subunit mediates neuropathic pain following nerve injury
  JOURNAL   J Neurosci 32 (48), 17502-17513 (2012)
   PUBMED   23197740
  REMARK    GeneRIF: our results demonstrate that Kv9.1 dysfunction leads to
            spontaneous and evoked neuronal hyperexcitability in myelinated
            fibers, coupled with development of neuropathic pain behaviors.
REFERENCE   3  (bases 1 to 2701)
  AUTHORS   Shepard,A.R. and Rae,J.L.
  TITLE     Electrically silent potassium channel subunits from human lens
            epithelium
  JOURNAL   Am J Physiol 277 (3), C412-C424 (1999)
   PUBMED   10484328
REFERENCE   4  (bases 1 to 2701)
  AUTHORS   Stocker,M. and Kerschensteiner,D.
  TITLE     Cloning and tissue distribution of two new potassium channel
            alpha-subunits from rat brain
  JOURNAL   Biochem Biophys Res Commun 248 (3), 927-934 (1998)
   PUBMED   9704029
REFERENCE   5  (bases 1 to 2701)
  AUTHORS   Salinas,M., Duprat,F., Heurteaux,C., Hugnot,J.P. and Lazdunski,M.
  TITLE     New modulatory alpha subunits for mammalian Shab K+ channels
  JOURNAL   J Biol Chem 272 (39), 24371-24379 (1997)
   PUBMED   9305895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Mar 19, 2021 this sequence version replaced NM_053954.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y17606.1, SRR26643298.20130.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000003.1  173262272-173262346 c
            76-210              JAXUCZ010000003.1  173260329-173260463 c
            211-1255            JAXUCZ010000003.1  173259073-173260117 c
            1256-2701           JAXUCZ010000003.1  173255028-173256473 c
FEATURES             Location/Qualifiers
     source          1..2701
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2701
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="potassium voltage-gated channel, modifier subfamily
                     S, member 1"
                     /db_xref="GeneID:117023"
                     /db_xref="RGD:621524"
     exon            1..75
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            76..210
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1255
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1723
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /note="potassium voltage-gated channel subfamily S member
                     1; potassium voltage-gated channel, delayed-rectifier,
                     subfamily S, member 1; voltage-gated potassium channel
                     subunit Kv9.1; delayed-rectifier K(+) channel alpha
                     subunit 1; K+ voltage-gated channel, subfamily S, 1;
                     delayed-rectifier potassium channel subunit Kv9.1"
                     /codon_start=1
                     /product="delayed-rectifier potassium channel regulatory
                     subunit KCNS1"
                     /protein_id="NP_446406.1"
                     /db_xref="GeneID:117023"
                     /db_xref="RGD:621524"
                     /translation="MVSEFPGPGSRVPWRPRDEALRVNVGGVRRLLSARALARFPGTR
                     LGRLQAAVSEEQARRLCDDYDAAAREFYFDRHPGFFLGLLHFYRTGHLHVLDELCVFA
                     FGQEADYWGLGENALATCCRARYLERRVTRPRAWDEDSDAPSSVDPCPDEISDVQREL
                     ARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQARE
                     AAAAVAAVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNL
                     IDIVSVLPFYLTLLAGAALGDRRGASGEELGDLGKVVQVFRLMRIFRVLKLARHSTGL
                     RSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEEKNVGFDTIPACWWWGTVSMTT
                     VGYGDVVPETVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKALEAAVRSSGQ
                     REFEDLLSSVDGVSDVSLETSRETSQEGRSTDLETQAPSEPAKSHSY"
     exon            1256..2701
                     /gene="Kcns1"
                     /gene_synonym="Kv9.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcctcagg gcagaaaaca gcccgggcgg cgacttgggg taacagcgcg ctggaatccc
       61 tggaggtcga ggcagagaac cctgaggatc agaagagcca ccgtggacat ttggctccct
      121 atatccaacc tcgtccagga aaaagagaga tgtcctgtac cagtctctat tagatgccag
      181 gccatcgcat gacttctata gccctgcaag ggagacacac tgtgtagcca tggtgagcga
      241 gtttccgggt ccgggctctc gggtcccctg gcggccaagg gacgaggcgc tgcgcgtgaa
      301 cgtgggcgga gtgcggcggc tgctgagcgc gcgcgccctc gcgcgattcc cgggcacgcg
      361 gctgggccgc ctacaggcgg cggtgtccga ggagcaggcg cggcgcctat gcgacgacta
      421 cgacgcggcg gcgcgcgagt tctacttcga tcggcacccg ggcttcttcc tcggcctgct
      481 gcacttctac cgcaccgggc acttgcatgt gctggacgag ctgtgcgtct tcgccttcgg
      541 ccaggaggct gactattggg gcctgggcga gaacgctctg gccacgtgct gccgcgcgcg
      601 ctacctggag cggcgtgtga cgcggcctcg cgcctgggac gaggacagcg atgccccgag
      661 cagcgtggac ccgtgtcccg acgagatctc cgacgtgcag cgggagctgg cgcgctatgg
      721 tgcggcccgc tgtggtcgcc tgcgccgtcg cctctggctc accatggaga accctggcta
      781 ctcgctgccc agcaagctct tcagctgcgt gtccatcggc gtggtgctcg cctccatcgc
      841 tgccatgtgc atccacagcc tgcccgagta ccaagcccgg gaggcagcgg cggcggtggc
      901 tgcagtggcc gcgggtcgca gcgcagagga cgtgcgcgac gacccggtgc tgcgccgcct
      961 ggagtacttc tgcatcgcct ggttcagctt cgaggtgtcg tcgcgcctgc tgctggctcc
     1021 cagcacgcgc aacttcttct gccatccgct caacctcatc gacatcgtgt cggtgctgcc
     1081 cttctatctc acactgctgg ccggcgcggc gcttggtgac cggcgcggag ccagcgggga
     1141 ggagctcgga gacctaggaa aggtggtaca agtgtttcgc ctcatgcgca tcttccgcgt
     1201 gctcaagctg gcccgccact ctaccgggct gcgctctctg ggcgccacgc tcaagcacag
     1261 ctaccgtgag gtgggcatct tactgctgta cctggccgtg ggtgtgtcag tgttctctgg
     1321 cgtggcctac acagccgaag aaaagaacgt gggcttcgac acgatccccg cctgctggtg
     1381 gtggggcacc gtgagcatga ccacagtggg ctatggggat gtggtcccgg agactgtggc
     1441 aggcaagctg gcagcctctg gctgcatcct ggggggcatc ctggtggtcg ccctccccat
     1501 caccatcatc ttcaacaagt tttcccactt ttaccggcgc cagaaggcac tggaggcggc
     1561 cgtgcggagc agcggccagc gggagtttga ggacttgctg agcagtgtgg atggcgtatc
     1621 agacgtgtct ctggaaacat ccagagagac ttctcaggaa gggcgctcca cagacctgga
     1681 gacccaagcc cccagtgagc ctgcaaaatc tcacagttat taaaacctgg gctctgcact
     1741 ccctccccac agcctgggaa tcagctaatg tagagcagag tcctcccctg cttaggttct
     1801 gcatgggagc catacgcctg agcaaaacat aggggccaca gatctttctc gaaaaagccc
     1861 agagcaggct agcaccgccc tccattccac cagcccacag agaggcctcc tctgaagtat
     1921 gtacacacca agaggaggaa gaagacagcc tctgtatgcg ccggttagcc ttgtgcagat
     1981 gattatcccc atttcacaga tgagagaact gaggctcagc cgaatggcac ggagaagtca
     2041 gcttttaatg ataagtccct ggaaggagtt gagggccgag tccttggaat ctgtaggatc
     2101 aataccacaa tcatctgcca tacccacttc ctagggtgac ttacagaagg agcctgacta
     2161 gagacccctc tgggacccaa tcccagctct acacctgcca cgggaaaggt ggccaacccc
     2221 ctgcccccag aactaggttc tagcggatct gtcacagcgt gggacccaga gagaaggtga
     2281 ctgagaagac ccagctcaac tctgaactgt tggcggcgga ggggtaccgc gcatgctcca
     2341 gtcctgctcg gctttcttca acttgacaca agctaaagta atctgggaag aggaggctca
     2401 atggagggaa cgcctccatc agattgcttg ttggcaagcc tgtgggacat tatcttgatt
     2461 aatgattgat gtgggagggc ccagcccact gtgcgtagca ccattcctaa gcagatggtc
     2521 ctgggggtct ataagaaagc agactgaaca agccacggga gcaagtcagt aagcagtatt
     2581 cctccatggt ctctgcttcc aggctcctgc ttccgggttc ctgccttatg ctcctgccct
     2641 ggcatccctc agtgaactat gacccaggat atgtaagcca aataaaccct ttcctctcca
     2701 a
//
