LOCUS       NM_001134643            3807 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily Q
            member 5 (Kcnq5), mRNA.
ACCESSION   NM_001134643 XM_237012
VERSION     NM_001134643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3807)
  AUTHORS   Redford,K.E., Rognant,S., Jepps,T.A. and Abbott,G.W.
  TITLE     KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea
  JOURNAL   Cell Physiol Biochem 55 (S3), 46-64 (2021)
   PUBMED   33667331
  REMARK    GeneRIF: KCNQ5 Potassium Channel Activation Underlies Vasodilation
            by Tea.
REFERENCE   2  (bases 1 to 3807)
  AUTHORS   Djouhri,L., Zeidan,A. and Abd El-Aleem,S.A.
  TITLE     Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root
            ganglion neurons in the streptozotocin rat model of painful
            diabetic neuropathy
  JOURNAL   Neurosci Lett 736, 135277 (2020)
   PUBMED   32739272
  REMARK    GeneRIF: Changes in expression of Kv7.5 and Kv7.2 channels in
            dorsal root ganglion neurons in the streptozotocin rat model of
            painful diabetic neuropathy.
REFERENCE   3  (bases 1 to 3807)
  AUTHORS   Manville,R.W., van der Horst,J., Redford,K.E., Katz,B.B.,
            Jepps,T.A. and Abbott,G.W.
  TITLE     KCNQ5 activation is a unifying molecular mechanism shared by
            genetically and culturally diverse botanical hypotensive folk
            medicines
  JOURNAL   Proc Natl Acad Sci U S A 116 (42), 21236-21245 (2019)
   PUBMED   31570602
  REMARK    GeneRIF: KCNQ5-selective activation is a defining molecular
            mechanistic signature of genetically diverse traditional botanical
            hypotensives.
REFERENCE   4  (bases 1 to 3807)
  AUTHORS   Lehman,A., Thouta,S., Mancini,G.M.S., Naidu,S., van
            Slegtenhorst,M., McWalter,K., Person,R., Mwenifumbo,J.,
            Salvarinova,R., Guella,I., McKenzie,M.B., Datta,A., Connolly,M.B.,
            Kalkhoran,S.M., Poburko,D., Friedman,J.M., Farrer,M.J., Demos,M.,
            Desai,S. and Claydon,T.
  CONSRTM   CAUSES Study; EPGEN Study
  TITLE     Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause
            Intellectual Disability or Epileptic Encephalopathy
  JOURNAL   Am J Hum Genet 101 (1), 65-74 (2017)
   PUBMED   28669405
REFERENCE   5  (bases 1 to 3807)
  AUTHORS   Zimmer,J., Takahashi,T., Hofmann,A.D. and Puri,P.
  TITLE     Downregulation of KCNQ5 expression in the rat pulmonary vasculature
            of nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (5), 702-705 (2017)
   PUBMED   28189443
  REMARK    GeneRIF: Downregulated pulmonary expression of KCNQ5 in rat
            nitrofen-induced congenital diaphragmatic hernia lungs suggests
            that this potassium channel may play an important role in the
            development of pulmonary hypertension in this model. KCNQ1 and
            KCNQ4 expression was not altered.
REFERENCE   6  (bases 1 to 3807)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (bases 1 to 3807)
  AUTHORS   Shah,M., Mistry,M., Marsh,S.J., Brown,D.A. and Delmas,P.
  TITLE     Molecular correlates of the M-current in cultured rat hippocampal
            neurons
  JOURNAL   J Physiol 544 (Pt 1), 29-37 (2002)
   PUBMED   12356878
  REMARK    GeneRIF: Single-cell PCR of dissociated hippocampal pyramidal
            neurons gave detectable signals for KCNQ2, KCNQ3 and KCNQ5.
REFERENCE   8  (bases 1 to 3807)
  AUTHORS   Yus-Najera,E., Santana-Castro,I. and Villarroel,A.
  TITLE     The identification and characterization of a noncontinuous
            calmodulin-binding site in noninactivating voltage-dependent KCNQ
            potassium channels
  JOURNAL   J Biol Chem 277 (32), 28545-28553 (2002)
   PUBMED   12032157
  REMARK    GeneRIF: CaM acts as a mediator in the Ca2+-dependent modulation of
            KCNQ channels.
REFERENCE   9  (bases 1 to 3807)
  AUTHORS   Wickenden,A.D., Zou,A., Wagoner,P.K. and Jegla,T.
  TITLE     Characterization of KCNQ5/Q3 potassium channels expressed in
            mammalian cells
  JOURNAL   Br J Pharmacol 132 (2), 381-384 (2001)
   PUBMED   11159685
REFERENCE   10 (bases 1 to 3807)
  AUTHORS   Lerche,C., Scherer,C.R., Seebohm,G., Derst,C., Wei,A.D., Busch,A.E.
            and Steinmeyer,K.
  TITLE     Molecular cloning and functional expression of KCNQ5, a potassium
            channel subunit that may contribute to neuronal M-current diversity
  JOURNAL   J Biol Chem 275 (29), 22395-22400 (2000)
   PUBMED   10787416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1, AI705051.1, BE103175.1, FQ084615.1 and
            BF523361.1.
            
            On Sep 6, 2012 this sequence version replaced NM_001134643.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.23830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               JAXUCZ010000009.1  31891178-31891281   c
            105-330             AI705051.1         1-226               c
            331-738             BE103175.1         7-414
            739-1012            FQ084615.1         380-653
            1013-1298           BF523361.1         73-358              c
            1299-1393           JAXUCZ010000009.1  31405650-31405744   c
            1394-1420           JAXUCZ010000009.1  31402978-31403004   c
            1421-1477           JAXUCZ010000009.1  31397952-31398008   c
            1478-1698           JAXUCZ010000009.1  31393770-31393990   c
            1699-1807           JAXUCZ010000009.1  31354506-31354614   c
            1808-1939           JAXUCZ010000009.1  31333541-31333672   c
            1940-2069           JAXUCZ010000009.1  31332575-31332704   c
            2070-3807           JAXUCZ010000009.1  31329497-31331234   c
FEATURES             Location/Qualifiers
     source          1..3807
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..3807
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /note="potassium voltage-gated channel subfamily Q member
                     5"
                     /db_xref="GeneID:259273"
                     /db_xref="RGD:628848"
     exon            1..571
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..3032
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /note="potassium voltage-gated channel, KQT-like
                     subfamily, member 5; potassium channel, voltage-gated
                     KQT-like subfamily Q, member 5"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 5"
                     /protein_id="NP_001128115.2"
                     /db_xref="GeneID:259273"
                     /db_xref="RGD:628848"
                     /translation="MPRHHAGGEEGGAAGLWVRSGAAAAAGGGRPGSGMKDVESGRGR
                     VLLNSAAARGDGLLLLGTRAAALGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCR
                     RNVKYRRVQNYLYNVLERPRGWAFVYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLL
                     ILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSA
                     KTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVL
                     IFSSFLVYLVEKDANKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLG
                     ISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSIATW
                     KPHLKALHTCSPTKKEQGEAASSKFCSNKQKFFRMYTSRKQSQKLSFKERVRMASPRG
                     QSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLKSSQPKTVIDA
                     DTALGIDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKD
                     VIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTTDDLSMLGR
                     VVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALTLTSFQIPPFECEQTSDYQSPVES
                     KDLSSSAQNSGCLSRSASANISRGLQFILTPNEFSAQTFYALSPTMHSQTTQVPMSQN
                     DGSSVVATNNLANQISAAPKPAAPTTLQIPPPLSAIKHLSRPEPLLSNPPGVHESISD
                     VTTCLVASKENVQFAQSNLTKDRSLRKSFDMGGETLLSVRPMVPKDLGKSLSVQNLIR
                     STEELNLQFSGSESSGSRGSQDFYPKWRESKLFITDEEVGAEETETDTFDGTPPPAGE
                     AAFSSDSLRTGRSRSSQNICKTGDSTDALSLPHVKLN"
     exon            572..662
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            663..789
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            790..965
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1091
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1202
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1298
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1393
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1420
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1477
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1698
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1807
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1939
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2069
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3807
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggcctgc tccgcacacc ccgccgcccc cgcccggagc ccagaccctc ggcttgccgg
       61 ccccccaggg cgccccgtcg gctgcgggct tcctcctgca gacctgcccg cgcacatgaa
      121 gcggctgccc ccgccgcagg cgccggcgcc cccctcgcgg tgcccgtggt gatgccatgc
      181 cccgccacca cgcgggagga gaggagggcg gtgccgccgg gctctgggtg aggagcggcg
      241 cggcggcggc ggcgggtggg gggcgcccgg gcagcggcat gaaggatgtg gagtccggcc
      301 gcggcagggt gctgctgaac tcggcggccg ccaggggcga cggcctgctg ctgctcggca
      361 cccgcgcggc ggcgctcggc ggaggcggcg gcggcttgag agagagccgc cggggcaagc
      421 agggggcccg gatgagcctg ctggggaagc cgctctccta caccagcagc cagagctgtc
      481 ggcgcaacgt caagtaccgg agggtgcaga actatctgta caacgtgctg gagagacccc
      541 gcggctgggc gttcgtctac cacgcgttcg tttttctcct tgtgtttggt tgcttgattt
      601 tgtcagtgtt ttctaccatc cctgagcaca caaagttggc ttcaagttgc ctcttaattc
      661 tggagttcgt gatgatcgtt gtctttggct tggagttcat cattcgaatc tggtctgcag
      721 gttgctgttg tcgttataga ggatggcaag ggagactgag gtttgctcga aagcctttct
      781 gtgttataga taccattgtt cttatcgctt caatagcagt tgtttctgca aaaactcagg
      841 gtaatatttt cgccacgtca gcgctcagaa gtctccggtt cctacagatc ctgcgtatgg
      901 tgcgcatgga cagaagggga gggacctgga agttgctggg ctccgtggtt tacgctcaca
      961 gcaaggaatt aatcacagcc tggtacattg gatttctggt tcttattttt tcatccttcc
     1021 ttgtctatct tgtggaaaaa gatgccaata aagagttttc aacatatgcg gatgctctct
     1081 ggtggggcac aattacactg acaaccattg gctatggaga caaaacaccc ctaacttggc
     1141 tgggaagatt gctctctgca ggcttcgccc ttcttggtat ttctttcttt gcacttcctg
     1201 ctggcattct tggctcaggt tttgccttaa aagtacagga acagcaccgc cagaagcatt
     1261 ttgagaaaag aaggaaccca gctgccaacc tcatccagtg tgtctggcgt agctatgcag
     1321 ctgatgagaa gtcggtctcc atcgcaacct ggaagccaca tctgaaggcc ttgcacacct
     1381 gcagccctac caagaaagaa caaggggagg cagcaagcag taagttctgt agtaataagc
     1441 agaagttctt cagaatgtac acctcacgga agcagagtca gaagctgagc tttaaggagc
     1501 gagtgcgcat ggctagccca agaggccaga gcattaagag cagacaagca tcggtaggtg
     1561 accggagatc cccaagcact gacatcactg ctgagggcag ccccaccaaa gtgcagaaga
     1621 gctggagctt caacgaccga acccgcttca ggccctcact acgcctcaag agttcccagc
     1681 cgaagacggt gatagacgct gacacagccc ttggcattga cgacgtatac gatgagaaag
     1741 gatgccagtg tgacgtgtcc gtggaggacc tcaccccacc actcaaaacc gtcatccgag
     1801 ccatcagaat catgaagttt catgttgcaa agcggaagtt taaggaaaca ttacgcccat
     1861 atgatgtaaa ggatgtcatt gagcaatact ctgctggcca tctggacatg ctatgtagaa
     1921 ttaaaagcct tcaaacacgc gttgatcaaa ttcttggaaa aggacaaatc acatcagata
     1981 aaaagagccg agagaaaata acggcagaac acgagacaac gacagatgac ctcagcatgc
     2041 tgggccgagt tgtgaaggtt gaaaaacagg tacaatccat tgaatccaag ctggactgct
     2101 tgctggatat ctaccagcag gtcctccgga aaggctctgc ctcggccctc actctgacgt
     2161 ccttccagat cccgcccttt gaatgtgaac agacctctga ctatcaaagt cccgtggaga
     2221 gcaaagacct gtcgagctcc gcgcaaaaca gtggctgctt aagcaggtca gccagtgcca
     2281 acatctcaag aggcctgcag ttcatcctaa cgccaaatga gttcagtgcc cagactttct
     2341 acgcgcttag ccctactatg cacagccaaa ctacacaggt gccaatgagt caaaacgacg
     2401 gctcctccgt ggtggccacc aataaccttg caaaccaaat aagcgccgca cccaagccag
     2461 cagctccaac aactttacag atcccacctc ctctctcagc catcaagcat ctatccaggc
     2521 cggaacccct gctgtccaac ccccctggcg tacacgagag tatttctgac gtcaccacct
     2581 gccttgttgc ctccaaggaa aacgttcagt tcgcccagtc aaacctgacc aaggaccgtt
     2641 ccctgaggaa aagttttgac atgggagggg aaactctgtt gtccgtccgc cccatggtgc
     2701 ccaaggactt gggcaaatct ctgtctgtac aaaacctgat cagatcgaca gaggaactga
     2761 acttacagtt ttcgggcagt gagtcaagtg gctctcgagg cagccaagat ttttatccca
     2821 agtggagaga atccaaattg tttataactg atgaggaggt cggtgccgag gagacagaaa
     2881 cagatacttt tgacggcacc ccaccgcctg ccggggaagc tgctttctca tcagattctc
     2941 taaggactgg aaggtcacgg tcatctcaga acatttgtaa gacgggagac agtacggatg
     3001 ccctcagttt gcctcacgtc aaactgaact aagttctttg tttcctttct aagcgtagct
     3061 gttcttttag ccatacatat cactgcatga actactctga aagcccttct aaaaagttaa
     3121 aaatcgcgca agagtcagga agaacatgaa aggccatgta tacgcccgtt atcttttaat
     3181 tgcatgaaaa tgcatgttta ggggtggcag aaattccaag gtacatcgac attaacccat
     3241 gcatttaata acgtaccttg agtctaaaat cccaagccaa cagtcgctgc tgatgctatg
     3301 gggtgtgtga agatgtcggg atattagttc aattgcaaga gttgacgctg tattttgaaa
     3361 ttgtgagagt aaacaccttc aaatttcagg catttctgct ttatgactag atacaaagta
     3421 cattttcaaa attaggccat aatgtatgtt ttagacacaa tggctatcaa cagctgctaa
     3481 taacacaagt aaagcagaat ttggaatata accgaaatgg ctgcttattt caagagacct
     3541 ttgccaaccc gttcctccta agtcatttca tcagtgtaat ttgaatgtca atctgtgtgc
     3601 ttctggtgac ttagcgctgt ggcaagcaaa tttgcacatt gttttcatgt tgtcctttat
     3661 gctgagaatg ttttccggtt agagtatggc caaataatat tatggggggc cagtgtgggg
     3721 ggagtgtccc tcttcctttg gcatctaacc acttgatgac aacatagcct ctactggagg
     3781 agtcagctct gtaaatggtc aacctct
//
