LOCUS       NP_001128115             951 aa            linear   ROD 01-APR-2024
DEFINITION  potassium voltage-gated channel subfamily KQT member 5 [Rattus
            norvegicus].
ACCESSION   NP_001128115 XP_237012
VERSION     NP_001128115.2
DBSOURCE    REFSEQ: accession NM_001134643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 951)
  AUTHORS   Redford,K.E., Rognant,S., Jepps,T.A. and Abbott,G.W.
  TITLE     KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea
  JOURNAL   Cell Physiol Biochem 55 (S3), 46-64 (2021)
   PUBMED   33667331
  REMARK    GeneRIF: KCNQ5 Potassium Channel Activation Underlies Vasodilation
            by Tea.
REFERENCE   2  (residues 1 to 951)
  AUTHORS   Djouhri,L., Zeidan,A. and Abd El-Aleem,S.A.
  TITLE     Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root
            ganglion neurons in the streptozotocin rat model of painful
            diabetic neuropathy
  JOURNAL   Neurosci Lett 736, 135277 (2020)
   PUBMED   32739272
  REMARK    GeneRIF: Changes in expression of Kv7.5 and Kv7.2 channels in
            dorsal root ganglion neurons in the streptozotocin rat model of
            painful diabetic neuropathy.
REFERENCE   3  (residues 1 to 951)
  AUTHORS   Manville,R.W., van der Horst,J., Redford,K.E., Katz,B.B.,
            Jepps,T.A. and Abbott,G.W.
  TITLE     KCNQ5 activation is a unifying molecular mechanism shared by
            genetically and culturally diverse botanical hypotensive folk
            medicines
  JOURNAL   Proc Natl Acad Sci U S A 116 (42), 21236-21245 (2019)
   PUBMED   31570602
  REMARK    GeneRIF: KCNQ5-selective activation is a defining molecular
            mechanistic signature of genetically diverse traditional botanical
            hypotensives.
REFERENCE   4  (residues 1 to 951)
  AUTHORS   Lehman,A., Thouta,S., Mancini,G.M.S., Naidu,S., van
            Slegtenhorst,M., McWalter,K., Person,R., Mwenifumbo,J.,
            Salvarinova,R., Guella,I., McKenzie,M.B., Datta,A., Connolly,M.B.,
            Kalkhoran,S.M., Poburko,D., Friedman,J.M., Farrer,M.J., Demos,M.,
            Desai,S. and Claydon,T.
  CONSRTM   CAUSES Study; EPGEN Study
  TITLE     Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause
            Intellectual Disability or Epileptic Encephalopathy
  JOURNAL   Am J Hum Genet 101 (1), 65-74 (2017)
   PUBMED   28669405
REFERENCE   5  (residues 1 to 951)
  AUTHORS   Zimmer,J., Takahashi,T., Hofmann,A.D. and Puri,P.
  TITLE     Downregulation of KCNQ5 expression in the rat pulmonary vasculature
            of nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (5), 702-705 (2017)
   PUBMED   28189443
  REMARK    GeneRIF: Downregulated pulmonary expression of KCNQ5 in rat
            nitrofen-induced congenital diaphragmatic hernia lungs suggests
            that this potassium channel may play an important role in the
            development of pulmonary hypertension in this model. KCNQ1 and
            KCNQ4 expression was not altered.
REFERENCE   6  (residues 1 to 951)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   7  (residues 1 to 951)
  AUTHORS   Shah,M., Mistry,M., Marsh,S.J., Brown,D.A. and Delmas,P.
  TITLE     Molecular correlates of the M-current in cultured rat hippocampal
            neurons
  JOURNAL   J Physiol 544 (Pt 1), 29-37 (2002)
   PUBMED   12356878
  REMARK    GeneRIF: Single-cell PCR of dissociated hippocampal pyramidal
            neurons gave detectable signals for KCNQ2, KCNQ3 and KCNQ5.
REFERENCE   8  (residues 1 to 951)
  AUTHORS   Yus-Najera,E., Santana-Castro,I. and Villarroel,A.
  TITLE     The identification and characterization of a noncontinuous
            calmodulin-binding site in noninactivating voltage-dependent KCNQ
            potassium channels
  JOURNAL   J Biol Chem 277 (32), 28545-28553 (2002)
   PUBMED   12032157
  REMARK    GeneRIF: CaM acts as a mediator in the Ca2+-dependent modulation of
            KCNQ channels.
REFERENCE   9  (residues 1 to 951)
  AUTHORS   Wickenden,A.D., Zou,A., Wagoner,P.K. and Jegla,T.
  TITLE     Characterization of KCNQ5/Q3 potassium channels expressed in
            mammalian cells
  JOURNAL   Br J Pharmacol 132 (2), 381-384 (2001)
   PUBMED   11159685
REFERENCE   10 (residues 1 to 951)
  AUTHORS   Lerche,C., Scherer,C.R., Seebohm,G., Derst,C., Wei,A.D., Busch,A.E.
            and Steinmeyer,K.
  TITLE     Molecular cloning and functional expression of KCNQ5, a potassium
            channel subunit that may contribute to neuronal M-current diversity
  JOURNAL   J Biol Chem 275 (29), 22395-22400 (2000)
   PUBMED   10787416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1, AI705051.1, BE103175.1, FQ084615.1 and
            BF523361.1.
            
            On Sep 6, 2012 this sequence version replaced NP_001128115.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.23830.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..951
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     Protein         1..951
                     /product="potassium voltage-gated channel subfamily KQT
                     member 5"
                     /note="potassium voltage-gated channel, KQT-like
                     subfamily, member 5; potassium channel, voltage-gated
                     KQT-like subfamily Q, member 5"
                     /calculated_mol_wt=104577
     Region          125..357
                     /region_name="Ion_trans"
                     /note="Ion transport protein; pfam00520"
                     /db_xref="CDD:459842"
     Region          465..653
                     /region_name="KCNQ_channel"
                     /note="KCNQ voltage-gated potassium channel; pfam03520"
                     /db_xref="CDD:460954"
     CDS             1..951
                     /gene="Kcnq5"
                     /gene_synonym="Kcnq5l"
                     /coded_by="NM_001134643.2:177..3032"
                     /db_xref="GeneID:259273"
                     /db_xref="RGD:628848"
ORIGIN      
        1 mprhhaggee ggaaglwvrs gaaaaagggr pgsgmkdves grgrvllnsa aargdgllll
       61 gtraaalggg ggglresrrg kqgarmsllg kplsytssqs crrnvkyrrv qnylynvler
      121 prgwafvyha fvfllvfgcl ilsvfstipe htklasscll ilefvmivvf glefiiriws
      181 agcccryrgw qgrlrfarkp fcvidtivli asiavvsakt qgnifatsal rslrflqilr
      241 mvrmdrrggt wkllgsvvya hskelitawy igflvlifss flvylvekda nkefstyada
      301 lwwgtitltt igygdktplt wlgrllsagf allgisffal pagilgsgfa lkvqeqhrqk
      361 hfekrrnpaa nliqcvwrsy aadeksvsia twkphlkalh tcsptkkeqg eaasskfcsn
      421 kqkffrmyts rkqsqklsfk ervrmasprg qsiksrqasv gdrrspstdi taegsptkvq
      481 kswsfndrtr frpslrlkss qpktvidadt algiddvyde kgcqcdvsve dltpplktvi
      541 rairimkfhv akrkfketlr pydvkdvieq ysaghldmlc rikslqtrvd qilgkgqits
      601 dkksrekita ehetttddls mlgrvvkvek qvqsieskld clldiyqqvl rkgsasaltl
      661 tsfqippfec eqtsdyqspv eskdlsssaq nsgclsrsas anisrglqfi ltpnefsaqt
      721 fyalsptmhs qttqvpmsqn dgssvvatnn lanqisaapk paapttlqip pplsaikhls
      781 rpepllsnpp gvhesisdvt tclvaskenv qfaqsnltkd rslrksfdmg getllsvrpm
      841 vpkdlgksls vqnlirstee lnlqfsgses sgsrgsqdfy pkwresklfi tdeevgaeet
      901 etdtfdgtpp pageaafssd slrtgrsrss qnicktgdst dalslphvkl n
//
