LOCUS       NM_001419575            4100 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily Q
            member 4 (Kcnq4), mRNA.
ACCESSION   NM_001419575 XM_008764109
VERSION     NM_001419575.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4100)
  AUTHORS   McGuier,N.S., Rinker,J.A., Cannady,R., Fulmer,D.B., Jones,S.R.,
            Hoffman,M. and Mulholland,P.J.
  TITLE     Identification and validation of midbrain Kcnq4 regulation of heavy
            alcohol consumption in rodents
  JOURNAL   Neuropharmacology 138, 10-19 (2018)
   PUBMED   29775679
  REMARK    GeneRIF: Results indicate that midbrain Kcnq4 expression regulates
            alcohol-related behaviors and provide evidence that KV7.4 channels
            are a critical mediator of excessive alcohol drinking.
REFERENCE   2  (bases 1 to 4100)
  AUTHORS   Zimmer,J., Takahashi,T., Hofmann,A.D. and Puri,P.
  TITLE     Downregulation of KCNQ5 expression in the rat pulmonary vasculature
            of nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (5), 702-705 (2017)
   PUBMED   28189443
  REMARK    GeneRIF: Downregulated pulmonary expression of KCNQ5 in rat
            nitrofen-induced congenital diaphragmatic hernia lungs suggests
            that this potassium channel may play an important role in the
            development of pulmonary hypertension in this model. KCNQ1 and
            KCNQ4 expression was not altered.
REFERENCE   3  (bases 1 to 4100)
  AUTHORS   Stott,J.B., Barrese,V. and Greenwood,I.A.
  TITLE     Kv7 Channel Activation Underpins EPAC-Dependent Relaxations of Rat
            Arteries
  JOURNAL   Arterioscler Thromb Vasc Biol 36 (12), 2404-2411 (2016)
   PUBMED   27789473
  REMARK    GeneRIF: EPAC-dependent vasorelaxations occur in part via
            activation of Kv7 channels. This contributes to the
            isoproterenol-mediated relaxation in mesenteric, but not renal,
            arteries.
REFERENCE   4  (bases 1 to 4100)
  AUTHORS   Salomonsson,M., Brasen,J.C., Braunstein,T.H., Hagelqvist,P.,
            Holstein-Rathlou,N.H. and Sorensen,C.M.
  TITLE     K(V)7.4 channels participate in the control of rodent renal
            vascular resting tone
  JOURNAL   Acta Physiol (Oxf) 214 (3), 402-414 (2015)
   PUBMED   25965962
  REMARK    GeneRIF: is concluded that K(V)7 channels, via nifedipine sensitive
            channels, have a role in the regulation of basal renal vascular
            tone.
REFERENCE   5  (bases 1 to 4100)
  AUTHORS   Chadha,P.S., Jepps,T.A., Carr,G., Stott,J.B., Zhu,H.L., Cole,W.C.
            and Greenwood,I.A.
  TITLE     Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin
            gene-related peptide-induced cerebral reactivity
  JOURNAL   Arterioscler Thromb Vasc Biol 34 (4), 887-893 (2014)
   PUBMED   24558103
  REMARK    GeneRIF: In cerebral arteries, Kv7.4 and Kv7.5 proteins exist
            predominantly as a functional heterotetramer, which regulates
            intrinsic myogenicity and vasodilation attributed to CGRP.
REFERENCE   6  (bases 1 to 4100)
  AUTHORS   Hansen,H.H., Ebbesen,C., Mathiesen,C., Weikop,P., Ronn,L.C.,
            Waroux,O., Scuvee-Moreau,J., Seutin,V. and Mikkelsen,J.D.
  TITLE     The KCNQ channel opener retigabine inhibits the activity of
            mesencephalic dopaminergic systems of the rat
  JOURNAL   J Pharmacol Exp Ther 318 (3), 1006-1019 (2006)
   PUBMED   16775195
REFERENCE   7  (bases 1 to 4100)
  AUTHORS   Kharkovets,T., Dedek,K., Maier,H., Schweizer,M., Khimich,D.,
            Nouvian,R., Vardanyan,V., Leuwer,R., Moser,T. and Jentsch,T.J.
  TITLE     Mice with altered KCNQ4 K+ channels implicate sensory outer hair
            cells in human progressive deafness
  JOURNAL   EMBO J 25 (3), 642-652 (2006)
   PUBMED   16437162
REFERENCE   8  (bases 1 to 4100)
  AUTHORS   Oliver,D., Knipper,M., Derst,C. and Fakler,B.
  TITLE     Resting potential and submembrane calcium concentration of inner
            hair cells in the isolated mouse cochlea are set by KCNQ-type
            potassium channels
  JOURNAL   J Neurosci 23 (6), 2141-2149 (2003)
   PUBMED   12657673
  REMARK    GeneRIF: KCNQ channels set the resting membrane potential of inner
            hair cells in the isolated organ of Corti and maintain [Ca2+]i at
            low levels
REFERENCE   9  (bases 1 to 4100)
  AUTHORS   Beisel,K.W., Nelson,N.C., Delimont,D.C. and Fritzsch,B.
  TITLE     Longitudinal gradients of KCNQ4 expression in spiral ganglion and
            cochlear hair cells correlate with progressive hearing loss in
            DFNA2
  JOURNAL   Brain Res Mol Brain Res 82 (1-2), 137-149 (2000)
   PUBMED   11042367
REFERENCE   10 (bases 1 to 4100)
  AUTHORS   Coucke,P.J., Van Hauwe,P., Kelley,P.M., Kunst,H., Schatteman,I.,
            Van Velzen,D., Meyers,J., Ensink,R.J., Verstreken,M., Declau,F.,
            Marres,H., Kastury,K., Bhasin,S., McGuirt,W.T., Smith,R.J.,
            Cremers,C.W., Van de Heyning,P., Willems,P.J., Smith,S.D. and Van
            Camp,G.
  TITLE     Mutations in the KCNQ4 gene are responsible for autosomal dominant
            deafness in four DFNA2 families
  JOURNAL   Hum Mol Genet 8 (7), 1321-1328 (1999)
   PUBMED   10369879
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Apr 12, 2023 this sequence version replaced XM_008764109.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.24023.1,
                                           SRR26643296.15950.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               JAXUCZ010000005.1  139611566-139612102 c
            538-628             JAXUCZ010000005.1  139581832-139581922 c
            629-755             JAXUCZ010000005.1  139581332-139581458 c
            756-931             JAXUCZ010000005.1  139580966-139581141 c
            932-1057            JAXUCZ010000005.1  139580172-139580297 c
            1058-1168           JAXUCZ010000005.1  139579630-139579740 c
            1169-1264           JAXUCZ010000005.1  139579365-139579460 c
            1265-1353           JAXUCZ010000005.1  139577469-139577557 c
            1354-1515           JAXUCZ010000005.1  139575740-139575901 c
            1516-1736           JAXUCZ010000005.1  139568763-139568983 c
            1737-1836           JAXUCZ010000005.1  139566771-139566870 c
            1837-1968           JAXUCZ010000005.1  139564009-139564140 c
            1969-2098           JAXUCZ010000005.1  139562699-139562828 c
            2099-4100           JAXUCZ010000005.1  139560366-139562367 c
FEATURES             Location/Qualifiers
     source          1..4100
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..4100
                     /gene="Kcnq4"
                     /note="potassium voltage-gated channel subfamily Q member
                     4"
                     /db_xref="GeneID:298496"
                     /db_xref="RGD:61799"
     exon            1..537
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2311
                     /gene="Kcnq4"
                     /note="KQT-like 4; potassium channel subunit alpha KvLQT4;
                     voltage-gated potassium channel subunit Kv7.4; potassium
                     voltage-gated channel, KQT-like subfamily, member 4;
                     potassium channel, voltage-gated KQT-like subfamily Q,
                     member 4"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 4"
                     /protein_id="NP_001406504.1"
                     /db_xref="GeneID:298496"
                     /db_xref="RGD:61799"
                     /translation="MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRR
                     LGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYH
                     VFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRY
                     RGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMD
                     RRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWW
                     GTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKH
                     FEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFEHIQRARNG
                     GLRPLEVRRAPVPDGAASRYPPVATCHRPGSASFCPGESSRMGIKDRIRMSSSQKRTG
                     PSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSTEEGPS
                     EEVAEEKSYQCELTVDDVMPTVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYS
                     AGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPSDTEAVDEISMMGRVVKVEK
                     QVQSIEHKLDLLLGFYSRCLRSGTSASLGTVQVPLFDPDITSDYHSPVDHEDISVSAQ
                     TLSISRSVSTNMD"
     exon            538..628
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            629..755
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            756..931
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1057
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1168
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1264
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1353
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1515
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1736
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1836
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1968
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2098
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..4100
                     /gene="Kcnq4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccagtcgcc ggggaagcgg gcggtcagta cgggctcccg cggccccgag gctccgagcg
       61 accgccaccg gaccctgcgt ggacccgacc tggtccctag cccccgccgc ctgcgtgagc
      121 gcccagggtc gcctcgccgg cccagggttc cagccatgcg actctgagcc gccggagcgc
      181 gcccccgccc cgcaacgccc cggccccccg cccggcgccg cccatggccg aggccccccc
      241 gcgccgcctc ggcctgggcc ccccgcccgg ggacgccccc cgcgcggagt tggtggcgct
      301 cacggccgtg cagagtgaac agggtgaggc gggcgggggc ggctctccgc gtcgcctggg
      361 ccttctgggc agccccctgc cgccgggcgc gcccctccct gggccgggct cgggctcggg
      421 ctccgcctgc ggccagcgct cctccgccgc gcacaagcgc taccgccgcc tgcagaactg
      481 ggtctacaac gtgctggagc ggccccgtgg gtgggccttc gtctaccacg tcttcatatt
      541 tttgctagtc ttcagctgcc tggtgctgtc tgtgctgtcc accatccagg agcaccagga
      601 acttgccaac gagtgtctcc ttatcttgga attcgtgatg atcgtggtct ttggtttgga
      661 gtatataatc cgtgtctggt cagctggatg ctgttgtcgc tacagaggat ggcagggccg
      721 cttccgcttc gccaggaaac ccttctgtgt catcgacttc atcgtgttcg tggcctcggt
      781 ggcggtgatc gccgcaggca cacagggcaa catctttgct acgtctgcgc tgcgcagtat
      841 gcgcttcctg cagatcctgc gcatggtgcg tatggaccgc cgcggtggca cctggaagct
      901 gttgggatcg gtggtctacg cgcacagtaa ggagctgatc accgcctggt acatcgggtt
      961 cctggtgctc atcttcgcct ctttcctcgt ttacctggct gagaaggatg ccaactctga
     1021 cttctcctcc tatgccgact cgctctggtg ggggacgatt acactgacga ccattggcta
     1081 tggcgacaag actccacata catggctggg cagggttctg gctgccggct tcgccttact
     1141 gggcatctcc ttctttgccc tgcctgccgg gatcctgggc tctggctttg ccctgaaggt
     1201 ccaggagcag cataggcaga aacactttga gaagcggagg atgccagcag ctaacctcat
     1261 ccaggctgcg tggcgcctgt attccactga cacgagccgg gcctatttga cagccacctg
     1321 gtattactat gacagtattc tcccatcttt cagagagctg gccctcttgt ttgagcatat
     1381 acaacgggcc cgcaatgggg gcctacggcc cctggaggtg aggcgggcgc cagtacctga
     1441 tggagcagcc tcccgctacc cgcccgttgc cacctgccac cggccgggca gtgcctcctt
     1501 ctgccctggg gaaagcagcc ggatgggcat caaagaccgg atccgaatga gcagctccca
     1561 gaagcggaca ggcccttcca agcagcatct ggcaccccca ccgattccca cctctccaag
     1621 cagtgagcag gtgggtgaag catccagccc cagcaaggtg cagaaaagct ggagcttcaa
     1681 tgaccgcacc cgcttccggg cctctctaag actcaagccc cgctgctcta ctgaggaggg
     1741 cccctcggag gaagtagctg aggagaagag ctaccagtgt gagctcacgg tggatgatgt
     1801 catgcccact gtgaagacgg tcatccgttc tgtcaggatt ctgaagttcc tggtagccaa
     1861 aaggaaattc aaggagacac ttcggccata cgatgtgaag gacgtcatcg agcagtattc
     1921 agcgggacac ctggatatgc tggggcggat caagagcctg caagctcggg tggaccaaat
     1981 tgtgggtcga gggccggggg accgcaagac tagggagaag ggcgataagg gtccatcaga
     2041 cacggaggca gtggatgaaa tcagcatgat ggggcgcgta gtcaaggtgg aaaagcaggt
     2101 gcagtccatc gagcacaagc ttgatctgct gctgggcttc tactcgcgct gcctacgctc
     2161 tggcacctcg gccagcctgg gcaccgtgca agtgccgctc ttcgaccccg acatcacctc
     2221 ggactaccac agccctgtag accacgagga catctctgtc tcggcacaga cgctcagcat
     2281 ctctcgctca gtcagcacca acatggactg aagggcttct caggggcggg gcagccttcg
     2341 gtttgcccct cggactcacc cggaggcctc tggactcctc tcttacttga actcgctccc
     2401 tgccagggag agaggccata cgcagtattg agctgtctgg gtgggcgaga tacccgatgc
     2461 cgggtgccag cgccccagga gcatgaaatg ccaggccacg tggtgggcca cagcaatggc
     2521 tgaccggagg cctctgggcg gtcccggacc ctgcctactc catcaaggca caatgtggcc
     2581 cgcctggcag gggctctgcc ctaggaatgt gagcagagct ctggggccgc gtccccgacc
     2641 cagcttctag ctatgcaagg tgaggtctcc aggcccgccc ttccaggcag agcagggaag
     2701 ccctcctgcc aagccccgcc ccacccgggg acgggcccaa ggtgccccca caggtgccca
     2761 caaagcacag gactctgcca taaggtagat gggcatcata tatgcaaact atgttaaata
     2821 tgcaacttta gggaccccca tggggttcct ctgcccctcc ctcactggga gatggacccc
     2881 agcagtagct ggtctcaggc tgcttggcca tactccaccc ccattctttg acttatcatc
     2941 catcctcacc cagcatgggg cctaaacctc tctgtcctct cccgagggca gtacccgggc
     3001 ccttctgccc ctttggaggt gtcacctcag gggcttcctc ttgctgctgg atgtccattc
     3061 ccatcggccc tccaaaccgt tttgacagca ctagttcctg tattttctcc aaacctacca
     3121 gacagtggcc gaccaccaga aaccacaagc atggcccttt tatttctcca gcagaatgtc
     3181 gcacacaccg atgcacacga caccacgcac accgatgcac acgacaccac gcacaccgat
     3241 gcacacgaca ccacgcactc cgatgcacac gacaccacac acacttgaag gcgtgaacac
     3301 aaagccactt gatctttccc gggaaggaca ggaggattta gagcatccac atgtctcccc
     3361 aggccctgcc tcagagtttg acttgctccc ctcctcaaaa aaaggttcca ggagtcctct
     3421 ggttgcccta aggactacct tggtgtcccc acagtgtaac tcaggcctag tctcagcgag
     3481 gacacatgca tccagtgcta cagccactgc acctggctct catgggcacc ggtctctgcc
     3541 ccactttctc gtttctattg gcagcacagc atattggcac aaatgctcaa acactgcagg
     3601 ccccatcacc cgttttaggt tcctaccctt ctgtccctct cctgctaagc taatgcaggt
     3661 gtcaagagag tgaggggtgg ggttccaatg acaacactct ggggggtgat gggaataagg
     3721 ggttgaggcc gaactgtctg catctcatac tgggacctgc atgtaccagt gccagggctt
     3781 gggttgaatt ctgctcaacc ctatggtgcc caatctctgc cctgccatct gcatgtacca
     3841 tcatgccctg gagggagccc atcctggctc tcacttcact cgcattgtat tgccccctgg
     3901 ggagcccctc caccacctca gagatggagt tgtacagagg gtgtggagaa taaggttatc
     3961 ctgtgaccaa aggagacatg ggaagaagcc ccccacttcc acgaccgagg gtcccccacc
     4021 aacccggttc tcagatatgc aagtacctca ctttgttaac ttaattaact tatgggtttc
     4081 attaaagttt tcagtaggaa
//
