LOCUS       NM_031597               5799 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily Q
            member 3 (Kcnq3), mRNA.
ACCESSION   NM_031597
VERSION     NM_031597.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5799)
  AUTHORS   Zhang,Z.X., Tian,Y., Li,S., Jing,H.B., Cai,J., Li,M. and Xing,G.G.
  TITLE     Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription
            repression activated by EREG/EGFR-ERK-Runx1 signaling in bone
            cancer pain
  JOURNAL   Cell Commun Signal 22 (1), 416 (2024)
   PUBMED   39192337
  REMARK    GeneRIF: Involvement of HDAC2-mediated kcnq2/kcnq3 genes
            transcription repression activated by EREG/EGFR-ERK-Runx1 signaling
            in bone cancer pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5799)
  AUTHORS   Muller,S., Kartheus,M., Hendinger,E., Hubner,D.C., Schnell,E.,
            Rackow,S., Bertsche,A., Kohling,R. and Kirschstein,T.
  TITLE     Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of
            mesial temporal lobe epilepsy
  JOURNAL   Epilepsy Res 200, 107296 (2024)
   PUBMED   38219422
  REMARK    GeneRIF: Persistent Kv7.2/7.3 downregulation in the rat pilocarpine
            model of mesial temporal lobe epilepsy.
REFERENCE   3  (bases 1 to 5799)
  AUTHORS   Sheng,Z.F., Zhang,H., Zheng,P., Chen,S., Gu,Z., Zhou,J.J.,
            Phaup,J.G., Chang,H.M., Yeh,E.T.H., Pan,H.L. and Li,D.P.
  TITLE     Impaired Kv7 channel activity in the central amygdala contributes
            to elevated sympathetic outflow in hypertension
  JOURNAL   Cardiovasc Res 118 (2), 585-596 (2022)
   PUBMED   33512443
  REMARK    GeneRIF: Impaired Kv7 channel activity in the central amygdala
            contributes to elevated sympathetic outflow in hypertension.
REFERENCE   4  (bases 1 to 5799)
  AUTHORS   Manville,R.W. and Abbott,G.W.
  TITLE     The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated
            Potassium Channels
  JOURNAL   Cell Physiol Biochem 55 (S3), 157-170 (2021)
   PUBMED   34318654
  REMARK    GeneRIF: The Amyloid Precursor Protein C99 Fragment Modulates
            Voltage-Gated Potassium Channels.
REFERENCE   5  (bases 1 to 5799)
  AUTHORS   Li,B.G., Wu,W.J., Zheng,H.C., Yang,H.F., Zuo,Y.X. and Cui,X.P.
  TITLE     Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3
            by sponging miR-135a-5p to prevent the progression of epilepsy
  JOURNAL   Kaohsiung J Med Sci 35 (9), 527-534 (2019)
   PUBMED   31373759
  REMARK    GeneRIF: The key findings of the present study provide evidence
            emphasizing that lncRNA GAS5 functions as a competitive endogenous
            RNA of miR-135a-5p to increase expression of KCNQ3
REFERENCE   6  (bases 1 to 5799)
  AUTHORS   Wickenden,A.D., Zou,A., Wagoner,P.K. and Jegla,T.
  TITLE     Characterization of KCNQ5/Q3 potassium channels expressed in
            mammalian cells
  JOURNAL   Br J Pharmacol 132 (2), 381-384 (2001)
   PUBMED   11159685
REFERENCE   7  (bases 1 to 5799)
  AUTHORS   Hirose,S., Zenri,F., Akiyoshi,H., Fukuma,G., Iwata,H., Inoue,T.,
            Yonetani,M., Tsutsumi,M., Muranaka,H., Kurokawa,T., Hanai,T.,
            Wada,K., Kaneko,S. and Mitsudome,A.
  TITLE     A novel mutation of KCNQ3 (c.925T-->C) in a Japanese family with
            benign familial neonatal convulsions
  JOURNAL   Ann Neurol 47 (6), 822-826 (2000)
   PUBMED   10852552
REFERENCE   8  (bases 1 to 5799)
  AUTHORS   Schwake,M., Pusch,M., Kharkovets,T. and Jentsch,T.J.
  TITLE     Surface expression and single channel properties of KCNQ2/KCNQ3,
            M-type K+ channels involved in epilepsy
  JOURNAL   J Biol Chem 275 (18), 13343-13348 (2000)
   PUBMED   10788442
REFERENCE   9  (bases 1 to 5799)
  AUTHORS   Wang,H.S., Pan,Z., Shi,W., Brown,B.S., Wymore,R.S., Cohen,I.S.,
            Dixon,J.E. and McKinnon,D.
  TITLE     KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of
            the M-channel
  JOURNAL   Science 282 (5395), 1890-1893 (1998)
   PUBMED   9836639
REFERENCE   10 (bases 1 to 5799)
  AUTHORS   Charlier,C., Singh,N.A., Ryan,S.G., Lewis,T.B., Reus,B.E.,
            Leach,R.J. and Leppert,M.
  TITLE     A pore mutation in a novel KQT-like potassium channel gene in an
            idiopathic epilepsy family
  JOURNAL   Nat Genet 18 (1), 53-55 (1998)
   PUBMED   9425900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Feb 25, 2021 this sequence version replaced NM_031597.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-816               JAXUCZ010000007.1  99913905-99914720   c
            817-907             JAXUCZ010000007.1  99658271-99658361   c
            908-1034            JAXUCZ010000007.1  99657422-99657548   c
            1035-1207           JAXUCZ010000007.1  99655942-99656114   c
            1208-1363           JAXUCZ010000007.1  99652526-99652681   c
            1364-1474           JAXUCZ010000007.1  99650838-99650948   c
            1475-1570           JAXUCZ010000007.1  99648926-99649021   c
            1571-1665           JAXUCZ010000007.1  99647514-99647608   c
            1666-1692           JAXUCZ010000007.1  99643752-99643778   c
            1693-1895           JAXUCZ010000007.1  99633261-99633463   c
            1896-1998           JAXUCZ010000007.1  99632223-99632325   c
            1999-2130           JAXUCZ010000007.1  99630239-99630370   c
            2131-2229           JAXUCZ010000007.1  99628152-99628250   c
            2230-2314           JAXUCZ010000007.1  99625888-99625972   c
            2315-5799           JAXUCZ010000007.1  99619298-99622782   c
FEATURES             Location/Qualifiers
     source          1..5799
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q33"
     gene            1..5799
                     /gene="Kcnq3"
                     /note="potassium voltage-gated channel subfamily Q member
                     3"
                     /db_xref="GeneID:29682"
                     /db_xref="RGD:69222"
     exon            1..816
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     CDS             428..3049
                     /gene="Kcnq3"
                     /note="KQT-like 3; potassium channel subunit alpha KvLQT3;
                     voltage-gated potassium channel subunit Kv7.3; potassium
                     voltage-gated channel, KQT-like subfamily, member 3;
                     potassium channel, voltage-gated KQT-like subfamily Q,
                     member 3"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 3"
                     /protein_id="NP_113785.4"
                     /db_xref="GeneID:29682"
                     /db_xref="RGD:69222"
                     /translation="MGLKARRAAGAAGGGGGEGGGGGGGAANPAGGDSAVAGDEERKV
                     GLAPGDVEQVTLALGTGADKDGTLLLEGGGREEGQRRTPQGIGLLAKTPLSRPVKRNN
                     AKYRRIQTLIYDALERPRGWALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLL
                     ETFAIFIFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGN
                     QGNVLATSLRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILS
                     SFLVYLVEKDVPEMDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIA
                     ATFSLIGVSFFALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYATNPN
                     RLDLVATWRFYESVVSFPFFRKEQLEAAASQKLGLLDRVRLSNPRGSNTKGKLFTPLN
                     VDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMTEDRGYGNDFL
                     IEDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQ
                     TRIDMIFTPGPPSTPKHKKSQKGSAFTYPSQQSPRNEPYVARAATSETEDQSMMGKFV
                     KVERQVHDMGKKLDFLVDMHMQHMERLQVHVTEYYPTKGASSPAEGEKKEDNRYSDLK
                     TIICNYSESGPPDPPYSFHQVPIDRVGPYGFFAHDPVKLTRGGPSSTKAQANLPSSGS
                     TYAERPTVLPILTLLDSCVSYHSQTELQGPYSDHISPRQRRSITRDSDTPLSLMSVNH
                     EELERSPSGFSISQDRDDYVFGPSGGSSWMREKRYLAEGETDTDTDPFTPSGSMPMSS
                     TGDGISDSIWTPSNKPT"
     exon            817..907
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1034
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1207
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1363
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1474
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1570
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1665
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1692
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1895
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1998
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2130
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2229
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2314
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..5799
                     /gene="Kcnq3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctggcaca gggcttgtaa ataaactgcg atgctgtctc gggctcgccg gcccgggtgc
       61 cgccgtcgcc gccgcctccc tggagcttcg gtgccaggct cccgccgtcg cgcgccctag
      121 cgccaccgcg ccagcctcgc gcgccctcgc cgggctccgc acggaccccg gcttcccgcg
      181 cccctccggg tcctacaggg gacccgctcg ggatgtgacc ccttgactcc ccatccgacc
      241 tcccctgccc cccgggaggc ccgcctttgc cttcttttgg gggggtgggc ggggaggggc
      301 gcgcggatca tggcattgga gttcccgggc ttgcagccgc cgccgccgcc tcgtccacgt
      361 accccaagcg ctccttcttc ccggagcagc agcggagaag gcgaagcgcc cggtgggggc
      421 gaggcagatg gggctcaagg ctcgcagggc ggcgggggcg gccggcgggg gcggcggcga
      481 agggggcgga ggaggcggcg gggcggctaa cccggctgga ggggactcgg cagtggccgg
      541 cgacgaggag cggaaagtgg ggctggcgcc aggagacgtg gagcaagtca ccttggcgct
      601 agggaccgga gccgacaaag acgggaccct gctgctggag ggcggtggcc gcgaagaggg
      661 gcagaggagg accccgcagg gcatcgggct cctggcaaag acccccctga gccgtccagt
      721 taagaggaac aacgccaagt acaggcgcat ccaaactttg atctatgacg ccctggagag
      781 accgaggggc tgggcgctgc tctaccacgc gcttgtgttc ctgattgtcc tgggatgctt
      841 gattctggcc gtgctcacca ctttcaagga gtatgagact gtgtctggag actggctttt
      901 gctgctggaa acatttgcta ttttcatctt tggagctgag tttgctttga ggatctgggc
      961 tgcaggatgt tgctgtcgat acaaaggctg gcgtggacgg ctgaagtttg ccaggaagcc
     1021 cctgtgcatg ttggatatct tcgtgctgat tgcttctgtg ccagtggttg ccgtgggaaa
     1081 ccagggcaat gtcctggcta cctctctgcg aagcctccgc ttcctgcaga tcctgcgcat
     1141 gcttcgaatg gataggaggg gtggcacctg gaagctcctg ggctcagcta tctgtgccca
     1201 cagcaaagaa ctcatcaccg cctggtacat cggcttcctg acactcatcc tttcttcatt
     1261 tcttgtctac ctggtggaga aggatgtgcc agagatggat gcccaaggag aggaaatgaa
     1321 agaggagttt gagacctatg ctgatgccct gtggtggggc ctgatcacac tggccaccat
     1381 tggttatgga gacaagacac ctaaaacctg ggaaggacgt ctgattgctg ccaccttttc
     1441 tttaatcggc gtctcctttt ttgctcttcc ggcaggcatc cttggctcag gactggcatt
     1501 gaaggttcag gaacagcacc gtcagaagca ctttgagaag agaaggaagc cagctgctga
     1561 actcatccag gctgcctgga gatattatgc taccaacccc aacaggcttg acctggtggc
     1621 aacctggaga ttttatgaat cagttgtctc tttcccattc ttcaggaaag aacaactgga
     1681 agcagcagcc agccaaaagc tgggtctctt ggatcgggtt cgcctttcta atcctcgtgg
     1741 tagcaatact aaaggaaagc tatttacccc tctgaatgta gatgccatag aagaaagccc
     1801 ttccaaagag ccaaagcccg ttggcttaaa caataaagag cgtttccgca ccgccttccg
     1861 catgaaagcc tacgctttct ggcagagttc tgaagatgcc gggacaggag accccatgac
     1921 agaagacagg ggctatggaa atgacttcct cattgaagac atgatcccca ccctaaaggc
     1981 tgccatccga gctgtcagaa ttctacaatt ccgtctgtat aaaaaaaaat tcaaggagac
     2041 attgaggcct tatgatgtaa aagatgtaat tgagcagtat tctgctggac atcttgacat
     2101 gctttccagg ataaagtacc ttcagacaag aatagatatg attttcaccc ctggacctcc
     2161 atccactcca aaacataaga agtctcagaa agggtcagca tttacctacc catcccagca
     2221 gtctccaagg aatgaaccat atgtagccag ggcagccaca tcagaaactg aagaccaaag
     2281 catgatgggg aagtttgtaa aagttgaaag acaggttcac gacatgggga agaaactgga
     2341 cttcctcgtg gacatgcaca tgcagcatat ggagcgtctg caggtgcacg tcaccgagta
     2401 ctacccaaca aagggggcct cctccccagc agaaggggag aagaaagagg acaacaggta
     2461 ttctgacttg aaaaccatca tctgtaacta ctcagaatca ggcccccccg acccacccta
     2521 cagcttccac caggtgccca tcgacagagt tggcccctat gggttttttg cacatgaccc
     2581 cgtgaaactg accagagggg gacccagttc tacaaaggct caggccaacc ttccctcctc
     2641 gggaagtaca tatgcagaga ggcccacagt cctgcccatc ttgactcttc tggactcatg
     2701 tgtgagctac cactcccaga cagaactgca aggcccctat tcggaccaca tctcaccccg
     2761 ccagagacgc agcatcacta gggacagtga cacaccactg tccctcatgt ccgtcaacca
     2821 cgaggaactg gaacggtctc caagtggctt cagcatctcc caagacagag atgattatgt
     2881 atttggcccc agtgggggtt cgagctggat gagggaaaag cggtacctgg ctgaaggaga
     2941 aacagacaca gatacagacc ccttcacgcc cagtggatcc atgcctatgt catctactgg
     3001 agatggtatt tcagattcca tatggacccc ttccaacaag cccacttaga aggggtcact
     3061 ggctgactcc tggtactgta gtcagacttt gtacagctca cttactctca cacctagcgc
     3121 ttaacaatga ggactccagt ggctgtgtca agcgcatgca tgtgcgcagt ggcccccctg
     3181 caagcagggg cttctcgcag ccttcttcct ccccatgtca ctgcaacaaa gtcgcttcct
     3241 tttcagcatg gtttgcatga cttgacacta tataaaatgc actgttagtc tcttctagat
     3301 acacatttat ctgctcttcc ttttaatcac gattgaacaa gtacagggag acttactgat
     3361 gagctgtgct attttgtttg gttggctggt ttgggttttg attcggataa actgagagca
     3421 tagtttcagt tatttctagg ctcacttccc ctttatgtaa aatgctccag ttaatttatt
     3481 gttttttaaa acaaggaaat aattttctca atcaaaacat actgcattac aatgagggta
     3541 gcctctgagc aaacagaaga gcaggaacaa gatagtcatt caaaccccaa agccaagatt
     3601 tcaaacaatt atctcactaa aggaaggctg acaaaattat tcaaaagctc ccaaggggat
     3661 ttggcctacc ccattgttca gaactgtgcc tcagtttcct tatctataag atgttggtga
     3721 tccaaaatat aacgtcacac atgttatgga ctggtgaaga gaaatcttac acacatacca
     3781 caaacataaa aaaagttccc aatttatgta gccaaagata ataaaattta ccagaagtgg
     3841 gatgaccttc taagcaggag ctaaatttgg tatcttaaaa tgaaattcca actcattctt
     3901 ctgtcttgcc tgttcttgaa tccaaaatgg agattagaac caagagcaat tatcattcca
     3961 tgtcctctat ttcaaagtga gaagtttggg gcacaaggca aatgccatgc cttgagacac
     4021 ttggctgtcc tgctgagaac aaggactcaa aacctctaca tgaggactca ctccttgccc
     4081 cagtcttccc tcatactatc ctagttgcat actgggatcc aggaattctg ccaagacacc
     4141 agcactcttt atccatagga tgcaatccgc agtctttact caaagggaga aagatgtctg
     4201 ctttgactgc aaagcatgct tatttgatgc attacaagtg ggatccagga tgaggaatgc
     4261 aaattagtca taaatataca aataggaaga attcccagaa tcacccattt ttactcctcc
     4321 tgatttttct taatgaaaat actagagcca cacaaaacta taagagctcc tgagatgaca
     4381 acttacagcc tggaaatccc tgccctgcta cagaaggatt gatgttaagc acaagccacc
     4441 acgtggccta ttggaagata ttgctacttg ctgaaaacct ccaatggaaa aggttagact
     4501 ctggctactc tttgtggaac gccacaccag agtattagta tcttagtcat ttcatgcctc
     4561 taaacactgg ttttaaatgg ttgccatggt gatcatcatg atgatggaaa taccctaaat
     4621 aagtgtttga atacaactct caccagtgct gtttctgtgt tgtcaagagc cataaatatc
     4681 acagcagact cctgggtgac gttttcatca atttgcaatg ttagtactct gtgctgtgtt
     4741 ggggagaggc tcctcagaga tcgatttctt acaacctaca tgctgattgg tcctttataa
     4801 agtactgaga atacagtagt gatgaaagtt tgtcccctga tgataggaac ttaaactcaa
     4861 agcctgcagc tccatgaatg atggcaagca ctgtgaatta gtagaggaat agccttcatg
     4921 gacagtatca caatggatgt atgtgcagtt agtgaccttt aagtccaagg caggcaatat
     4981 attaatacac tcacacacat tggaagaaaa gcttttctta tagttttcaa ttgatctttt
     5041 ttctggcaat ctgaaagaca aagactgtgg acctcctccc ttagttcttt caatatgact
     5101 tcagtggtgc cattgttgct ataatctaaa acttgcacct cttcctaggg atttggctct
     5161 tgagtatgat cttcctataa ttttttttca ccagaaatag ctgtcctgcc tagcatctaa
     5221 catatggtat tcttttttct tacatgcatg agttatcaga gacaaaaatg ataaagaata
     5281 aactgtgcca catggttttt ccctaacatt aacattctct cacaacctcc tagagttggt
     5341 atgttacatt aggatgcatt gcttcaagag ttcaaatggg aatcttggcc aagaattctt
     5401 tgaactggaa cttgcattat ttttcaagca agctctaagt gagtagtctt cctggagatt
     5461 caaaaatcag agtggcagga attagttttg tattggatac caagctaata taggtctagt
     5521 cagttgtctg tatcagccaa atacatattt gacaaaaaaa aaaagaatac taagggtcct
     5581 aagagctgct tgtttccatc taagaaaaca aacagaagaa agataataag ataatctgga
     5641 gtccttctct tgcaatatca tttaaaaaat agtgtagacc aacaaaccaa aagtactcat
     5701 ctgaacctgt cagtacactt catggccatc atggctggca tactggtcct ctgttgaaat
     5761 gtcattttgt gttctataaa gatctttgta agatgaaag
//
