LOCUS       NM_133322               4158 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily Q
            member 2 (Kcnq2), mRNA.
ACCESSION   NM_133322
VERSION     NM_133322.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4158)
  AUTHORS   Zhang,Z.X., Tian,Y., Li,S., Jing,H.B., Cai,J., Li,M. and Xing,G.G.
  TITLE     Involvement of HDAC2-mediated kcnq2/kcnq3 genes transcription
            repression activated by EREG/EGFR-ERK-Runx1 signaling in bone
            cancer pain
  JOURNAL   Cell Commun Signal 22 (1), 416 (2024)
   PUBMED   39192337
  REMARK    GeneRIF: Involvement of HDAC2-mediated kcnq2/kcnq3 genes
            transcription repression activated by EREG/EGFR-ERK-Runx1 signaling
            in bone cancer pain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4158)
  AUTHORS   Muller,S., Kartheus,M., Hendinger,E., Hubner,D.C., Schnell,E.,
            Rackow,S., Bertsche,A., Kohling,R. and Kirschstein,T.
  TITLE     Persistent Kv7.2/7.3 downregulation in the rat pilocarpine model of
            mesial temporal lobe epilepsy
  JOURNAL   Epilepsy Res 200, 107296 (2024)
   PUBMED   38219422
  REMARK    GeneRIF: Persistent Kv7.2/7.3 downregulation in the rat pilocarpine
            model of mesial temporal lobe epilepsy.
REFERENCE   3  (bases 1 to 4158)
  AUTHORS   Tonomura,S., Ling,J. and Gu,J.G.
  TITLE     Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal
            ventral nerves of rats
  JOURNAL   Mol Brain 15 (1), 64 (2022)
   PUBMED   35858950
  REMARK    GeneRIF: Function of KCNQ2 channels at nodes of Ranvier of lumbar
            spinal ventral nerves of rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4158)
  AUTHORS   Kim,K.W., Kim,K., Kim,H.J., Kim,B.I., Baek,M. and Suh,B.C.
  TITLE     Posttranscriptional modulation of KCNQ2 gene expression by the
            miR-106b microRNA family
  JOURNAL   Proc Natl Acad Sci U S A 118 (47) (2021)
   PUBMED   34785595
  REMARK    GeneRIF: Posttranscriptional modulation of KCNQ2 gene expression by
            the miR-106b microRNA family.
REFERENCE   5  (bases 1 to 4158)
  AUTHORS   Manville,R.W. and Abbott,G.W.
  TITLE     The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated
            Potassium Channels
  JOURNAL   Cell Physiol Biochem 55 (S3), 157-170 (2021)
   PUBMED   34318654
  REMARK    GeneRIF: The Amyloid Precursor Protein C99 Fragment Modulates
            Voltage-Gated Potassium Channels.
REFERENCE   6  (bases 1 to 4158)
  AUTHORS   Pan,Z., Selyanko,A.A., Hadley,J.K., Brown,D.A., Dixon,J.E. and
            McKinnon,D.
  TITLE     Alternative splicing of KCNQ2 potassium channel transcripts
            contributes to the functional diversity of M-currents
  JOURNAL   J Physiol 531 (Pt 2), 347-358 (2001)
   PUBMED   11230508
REFERENCE   7  (bases 1 to 4158)
  AUTHORS   Jow,F. and Wang,K.
  TITLE     Cloning and functional expression of rKCNQ2 K(+) channel from rat
            brain
  JOURNAL   Brain Res Mol Brain Res 80 (2), 269-278 (2000)
   PUBMED   11038262
REFERENCE   8  (bases 1 to 4158)
  AUTHORS   Watanabe,H., Nagata,E., Kosakai,A., Nakamura,M., Yokoyama,M.,
            Tanaka,K. and Sasai,H.
  TITLE     Disruption of the epilepsy KCNQ2 gene results in neural
            hyperexcitability
  JOURNAL   J Neurochem 75 (1), 28-33 (2000)
   PUBMED   10854243
REFERENCE   9  (bases 1 to 4158)
  AUTHORS   Schwake,M., Pusch,M., Kharkovets,T. and Jentsch,T.J.
  TITLE     Surface expression and single channel properties of KCNQ2/KCNQ3,
            M-type K+ channels involved in epilepsy
  JOURNAL   J Biol Chem 275 (18), 13343-13348 (2000)
   PUBMED   10788442
REFERENCE   10 (bases 1 to 4158)
  AUTHORS   Wang,H.S., Pan,Z., Shi,W., Brown,B.S., Wymore,R.S., Cohen,I.S.,
            Dixon,J.E. and McKinnon,D.
  TITLE     KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of
            the M-channel
  JOURNAL   Science 282 (5395), 1890-1893 (1998)
   PUBMED   9836639
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087453.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               JAXUCZ010000003.1  188630892-188631302 c
            412-502             JAXUCZ010000003.1  188611121-188611211 c
            503-629             JAXUCZ010000003.1  188610066-188610192 c
            630-805             JAXUCZ010000003.1  188609559-188609734 c
            806-931             JAXUCZ010000003.1  188608372-188608497 c
            932-1042            JAXUCZ010000003.1  188606015-188606125 c
            1043-1138           JAXUCZ010000003.1  188605380-188605475 c
            1139-1233           JAXUCZ010000003.1  188601473-188601567 c
            1234-1263           JAXUCZ010000003.1  188599821-188599850 c
            1264-1332           JAXUCZ010000003.1  188596782-188596850 c
            1333-1362           JAXUCZ010000003.1  188593958-188593987 c
            1363-1586           JAXUCZ010000003.1  188585118-188585341 c
            1587-1695           JAXUCZ010000003.1  188584334-188584442 c
            1696-1827           JAXUCZ010000003.1  188583721-188583852 c
            1828-1951           JAXUCZ010000003.1  188579135-188579258 c
            1952-4158           JAXUCZ010000003.1  188576356-188578562 c
FEATURES             Location/Qualifiers
     source          1..4158
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..4158
                     /gene="Kcnq2"
                     /note="potassium voltage-gated channel subfamily Q member
                     2"
                     /db_xref="GeneID:170848"
                     /db_xref="RGD:621504"
     exon            1..411
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2674
                     /gene="Kcnq2"
                     /note="potassium voltage-gated channel, KQT-like
                     subfamily, member 2; KQT-like 2; potassium channel subunit
                     alpha KvLQT2; voltage-gated potassium channel subunit
                     Kv7.2; potassium channel, voltage-gated KQT-like subfamily
                     Q, member 2"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 2"
                     /protein_id="NP_579856.2"
                     /db_xref="GeneID:170848"
                     /db_xref="RGD:621504"
                     /translation="MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAG
                     SEAPKRGSVLSKPRTGGAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLL
                     VFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGR
                     LKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTW
                     KLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLT
                     TIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQEQHRQKHFEKRRN
                     PAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGASRLIPPLNQLE
                     LLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPS
                     ADQSLDDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVEDNKSCNC
                     EFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIK
                     SLQSRVDQIVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLV
                     SIYTQRMGIPPAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQR
                     NYAAPPVMPPAQCPPSTSWQQSHQRHGTSPVGDHGSLVRIPPPPAHERSLSAYSGGNR
                     ASTEFLRLEGTPACRPSEAALRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALA
                     SCYAAVAPCAKVRPYIAEGESDTDSDLCTPCGPPPRSATGEGPFGDVAWAGPRK"
     exon            412..502
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..629
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..805
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..931
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1042
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1138
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1233
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1263
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1332
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1362
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1586
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1695
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1827
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1951
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..4158
                     /gene="Kcnq2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccgcagcc gcctcggcca tgcggctgcc ggacccgggg cctgggctgg ggcccgcgcc
       61 accccctgcg cgccgccccc gctgagcccg cgccggatag ggcgccgccg gcaccatggt
      121 gcagaagtcg cgcaacggtg gcgtgtaccc cggcaccagc ggggaaaaaa agctcaaggt
      181 gggcttcgtg gggctggacc ccggcgcgcc cgactccact cgcgacggcg cgctactcat
      241 cgcgggctcc gaggccccca agcgcggcag cgttttgagc aagccgcgga cgggcggcgc
      301 gggagccggg aagcccccaa agcgcaacgc cttctaccgc aagctgcaga atttcctata
      361 caacgtgcta gagcggcccc gcggttgggc gttcatctac cacgcctacg tgtttctttt
      421 agtcttctcc tgccttgtgc tttccgtgtt ttccaccatc aaggagtatg agaagagttc
      481 cgagggggcc ctctacatct tggaaatcgt gaccatcgtg gtattcggtg ttgagtactt
      541 tgtgagaatc tgggctgcag gctgctgctg ccggtatcga ggctggaggg gccggctcaa
      601 gtttgccagg aagccattct gtgtgatcga catcatggtg ctgattgcct ccattgctgt
      661 gctggctgct ggctcccagg gcaatgtctt tgccacatct gcacttcgga gcttgcggtt
      721 cttacaaatc ttacggatga tccgtatgga ccggaggggc ggcacctgga agctcctggg
      781 atcggtggtc tacgctcaca gcaaggagct ggtgactgcg tggtacattg gcttcctctg
      841 cctcatcctg gcctcgtttc tggtgtactt ggcagaaaag ggtgagaatg accacttcga
      901 cacctacgcg gatgcactct ggtggggtct gatcaccctg acaaccattg gctacgggga
      961 caagtaccct cagacctgga acgggaggct gttagcagcg acgtttaccc tcattggtgt
     1021 ctcattcttc gctcttcctg ctggcatttt gggatccggc tttgccctga aagtccaaga
     1081 gcagcatcgg caaaaacact ttgagaaacg gcggaatcct gcggcaggtc tgatccagtc
     1141 tgcctggaga ttctatgcta ctaacctctc acgcaccgac ctgcactcca cgtggcagta
     1201 ctacgagcgg acagtcactg tccccatgta cagctcacaa actcaaacct atggggcctc
     1261 cagactcatt ccgcctctga accagctgga gctgctgagg aatctcaaga gcaaatctgg
     1321 actcaccttc aggaaggagc cacagccaga gccatcacca agtcagaagg tcagtttgaa
     1381 agatcgtgtc ttctccagcc cccgaggcgt ggctgccaag gggaaggggt ctccccaggc
     1441 ccagacggtc cggcggtccc ccagtgcgga tcagagtctc gatgacagcc caagcaaggt
     1501 gcccaagagc tggagctttg gtgaccgcag ccgtgcacgc caggctttcc gtatcaaggg
     1561 cgctgcatcc cggcagaact cagaagaagc aagcctccct ggggaggata tcgtggagga
     1621 caacaagagc tgtaactgcg agtttgtgac tgaagatctt acccctggcc tcaaagtcag
     1681 catcagagct gtgtgtgtta tgcggttctt ggtatctaag cgaaagttca aagagagtct
     1741 gcgcccatat gacgtgatgg atgtcatcga acagtactcg gccggacact tggatatgtt
     1801 gtcccgaatc aagagcctgc agtccagagt ggaccagatt gtggggcggg gcccgacaat
     1861 aacggacaag gaccgcacca aaggcccagc ggagacggaa ctgcccgaag accccagcat
     1921 gatgggacgc cttgggaagg tggaaaaaca ggtcttgtcc atggaaaaga agctagactt
     1981 cctggtgagc atctacacac agagaatggg catcccacca gcagagacag aggcctattt
     2041 cggggccaag gagcctgagc cggcaccacc ctaccacagc ccggaggaca gccgtgacca
     2101 tgcagacaag catggctgta ttattaagat tgtccgctcc accagctcta cgggccagag
     2161 gaactacgcc gcacccccag tcatgccccc tgcccagtgt cccccatcca cctcgtggca
     2221 gcagagccac cagcgccacg gcacctcccc cgtgggagac catggctcac tggtacgcat
     2281 cccaccaccc cctgcgcacg agcgctcact gtctgcctac agtgggggca acagagccag
     2341 taccgagttc ttgaggctgg agggcacccc agcctgcagg ccctctgagg cagccctgcg
     2401 ggatagcgac acgtccatct ccatcccttc ggtggaccac gaggagctgg agcgttcctt
     2461 tagcggtttc agtatctccc agtccaagga gaacctggat gccctggcca gctgttatgc
     2521 agctgtggcg ccgtgcgcca aggtcaggcc ctacattgca gagggtgagt ctgacacaga
     2581 ctcagacctc tgcacaccgt gtgggccacc cccacgctct gccactggtg aaggcccctt
     2641 tggagatgtg gcttgggcag ggcctaggaa gtgagtctgg gttgggctgc tggccccatg
     2701 ccacacccac tcttgttcag ttttagagct ggagttccag ggcctttctt aaagtgacag
     2761 agcggcatag agtagtgtgg gttgtgagga tgctcatggg atctcgctct cagggtcaat
     2821 gtggagtgga aatgaggcag ggttccttag cacatacagt aacattttat agaagttctt
     2881 ttccaaccag gagagggtgg ttgaggccgg gccctggagg cccttgggag ctccctatgg
     2941 cagcaaagct agccctgcct agtcttcttg ggggacatat tgccctgtga gtgaggaggg
     3001 acagcgtgat ggttagcctc tgtgagtggg ggtgtggctg ggagcaagtc cgtgggaggt
     3061 agtggtgaaa tgaaacaggc ccgtctactg ctgatagcca gtcctgaggc ccatgggtct
     3121 ctcagtttag tctgggagct caggggtata gtaagtcact ggaaacggcc cactctcaca
     3181 cctgactgct tatccctcca tcccgactgc ccccagtaaa gcattaccag acccactgtt
     3241 gggtgtggct gggcaatgcc cctcatccct gggtaaccta gctaaagagc tgccacaatc
     3301 ttcctccctc ttccaggtta tgtggatctt tccatgggaa ccatctttag gtccttctcc
     3361 tggagctgag gaaggagtga ggcctcaggg accaatctgg aacttagaat tgatccttag
     3421 actctcttga cttccacctc ttaggggaag actcaactca cagccttttc tgaaagggtt
     3481 tcttcagcag gttctggctg cctcgtgcca ggtactgtag cccagtaggt atgagttgac
     3541 acttcaaggc ctctgctctt tcctggtgtg gcactggcct ccaggctgtg gccagcactt
     3601 taagagaatc accagataag cagaccagcc ttagccaggg cacctccttg cctgctgccc
     3661 acttggctct acggattcag gcagggctaa atgacatgac gtcttcaaac tgccggctct
     3721 ctctacacga gagcatggcc tttgagcctg gtcaaggatc cttcccaatg aagctggcca
     3781 tccagtcctt tatccactag taggtccctg gtctgtggcc cctgggtgtt tgaggaattg
     3841 ggaacacctt ggcctctact ctggtgagga ataatccctg tccatcctgt gagtgggcat
     3901 cttgggccat cagcagctga ctttagaggg aaacatggta gatataatag agccctcggt
     3961 tgtggcccca taatatctgg cccagaggtg cctggcatta aatgataaca ttttggggtg
     4021 ggggccctaa accctcttgc cctcagtttt cctggtcact gaggacaagc gctacagagc
     4081 ttgtgcttgg gcagagcttt atttacttct tccacccttt tgaaatgtgt gttctggcag
     4141 gggtagaggc aacttggg
//
