LOCUS       NM_032073               3017 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus potassium voltage-gated channel subfamily Q
            member 1 (Kcnq1), mRNA.
ACCESSION   NM_032073
VERSION     NM_032073.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3017)
  AUTHORS   Braun,C., Parks,X.X., Qudsi,H. and Lopes,C.M.B.
  TITLE     Membrane pools of phosphatidylinositol-4-phosphate regulate
            KCNQ1/KCNE1 membrane expression
  JOURNAL   Commun Biol 4 (1), 1392 (2021)
   PUBMED   34907346
  REMARK    GeneRIF: Membrane pools of phosphatidylinositol-4-phosphate
            regulate KCNQ1/KCNE1 membrane expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3017)
  AUTHORS   Redford,K.E., Rognant,S., Jepps,T.A. and Abbott,G.W.
  TITLE     KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea
  JOURNAL   Cell Physiol Biochem 55 (S3), 46-64 (2021)
   PUBMED   33667331
  REMARK    GeneRIF: KCNQ5 Potassium Channel Activation Underlies Vasodilation
            by Tea.
REFERENCE   3  (bases 1 to 3017)
  AUTHORS   Vay,S.U., Flitsch,L.J., Rabenstein,M., Moniere,H., Jakovcevski,I.,
            Andjus,P., Bijelic,D., Blaschke,S., Walter,H.L., Fink,G.R.,
            Schroeter,M. and Rueger,M.A.
  TITLE     The impact of hyperpolarization-activated cyclic nucleotide-gated
            (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary
            microglia function
  JOURNAL   J Neuroinflammation 17 (1), 100 (2020)
   PUBMED   32248813
  REMARK    GeneRIF: The impact of hyperpolarization-activated cyclic
            nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7
            channels on primary microglia function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3017)
  AUTHORS   Jiang,M., Wang,Y. and Tseng,G.N.
  TITLE     Adult Ventricular Myocytes Segregate KCNQ1 and KCNE1 to Keep the
            IKs Amplitude in Check Until When Larger IKs Is Needed
  JOURNAL   Circ Arrhythm Electrophysiol 10 (6) (2017)
   PUBMED   28611207
  REMARK    GeneRIF: In adult ventricular myocytes, KCNE1 maintains a stable
            presence on the cell surface, whereas KCNQ1 is dynamic in its
            localization. KCNQ1 is largely in an intracellular reservoir under
            basal conditions but can traffic to the cell surface and boost the
            IKs amplitude in response to stress.
REFERENCE   5  (bases 1 to 3017)
  AUTHORS   Zimmer,J., Takahashi,T., Hofmann,A.D. and Puri,P.
  TITLE     Downregulation of KCNQ5 expression in the rat pulmonary vasculature
            of nitrofen-induced congenital diaphragmatic hernia
  JOURNAL   J Pediatr Surg 52 (5), 702-705 (2017)
   PUBMED   28189443
  REMARK    GeneRIF: Downregulated pulmonary expression of KCNQ5 in rat
            nitrofen-induced congenital diaphragmatic hernia lungs suggests
            that this potassium channel may play an important role in the
            development of pulmonary hypertension in this model. KCNQ1 and
            KCNQ4 expression was not altered.
REFERENCE   6  (bases 1 to 3017)
  AUTHORS   Jiang,M., Tseng-Crank,J. and Tseng,G.N.
  TITLE     Suppression of slow delayed rectifier current by a truncated
            isoform of KvLQT1 cloned from normal human heart
  JOURNAL   J Biol Chem 272 (39), 24109-24112 (1997)
   PUBMED   9305853
REFERENCE   7  (bases 1 to 3017)
  AUTHORS   Yang,W.P., Levesque,P.C., Little,W.A., Conder,M.L., Shalaby,F.Y.
            and Blanar,M.A.
  TITLE     KvLQT1, a voltage-gated potassium channel responsible for human
            cardiac arrhythmias
  JOURNAL   Proc Natl Acad Sci U S A 94 (8), 4017-4021 (1997)
   PUBMED   9108097
REFERENCE   8  (bases 1 to 3017)
  AUTHORS   Sanguinetti,M.C., Curran,M.E., Zou,A., Shen,J., Spector,P.S.,
            Atkinson,D.L. and Keating,M.T.
  TITLE     Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac
            I(Ks) potassium channel
  JOURNAL   Nature 384 (6604), 80-83 (1996)
   PUBMED   8900283
REFERENCE   9  (bases 1 to 3017)
  AUTHORS   Barhanin,J., Lesage,F., Guillemare,E., Fink,M., Lazdunski,M. and
            Romey,G.
  TITLE     K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks)
            cardiac potassium current
  JOURNAL   Nature 384 (6604), 78-80 (1996)
   PUBMED   8900282
REFERENCE   10 (bases 1 to 3017)
  AUTHORS   Wang,Q., Curran,M.E., Splawski,I., Burn,T.C., Millholland,J.M.,
            VanRaay,T.J., Shen,J., Timothy,K.W., Vincent,G.M., de Jager,T.,
            Schwartz,P.J., Toubin,J.A., Moss,A.J., Atkinson,D.L., Landes,G.M.,
            Connors,T.D. and Keating,M.T.
  TITLE     Positional cloning of a novel potassium channel gene: KVLQT1
            mutations cause cardiac arrhythmias
  JOURNAL   Nat Genet 12 (1), 17-23 (1996)
   PUBMED   8528244
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 1, 2020 this sequence version replaced NM_032073.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ133685.1, SRR26643295.4914.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-455               JAXUCZ010000001.1  207721198-207721652
            456-546             JAXUCZ010000001.1  207763827-207763917
            547-673             JAXUCZ010000001.1  207797060-207797186
            674-752             JAXUCZ010000001.1  207797426-207797504
            753-849             JAXUCZ010000001.1  207797948-207798044
            850-990             JAXUCZ010000001.1  207798711-207798851
            991-1101            JAXUCZ010000001.1  207805615-207805725
            1102-1197           JAXUCZ010000001.1  207806814-207806909
            1198-1320           JAXUCZ010000001.1  207808456-207808578
            1321-1462           JAXUCZ010000001.1  207809529-207809670
            1463-1583           JAXUCZ010000001.1  207890033-207890153
            1584-1659           JAXUCZ010000001.1  207984308-207984383
            1660-1754           JAXUCZ010000001.1  207988204-207988298
            1755-1801           JAXUCZ010000001.1  207988883-207988929
            1802-1863           JAXUCZ010000001.1  207989806-207989867
            1864-3017           JAXUCZ010000001.1  208052920-208054073
FEATURES             Location/Qualifiers
     source          1..3017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q42"
     gene            1..3017
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /note="potassium voltage-gated channel subfamily Q member
                     1"
                     /db_xref="GeneID:84020"
                     /db_xref="RGD:621503"
     exon            1..455
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..2079
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /function="colonic potassium channel"
                     /note="KQT-like 1; voltage-gated potassium channel subunit
                     Kv7.1; IKs producing slow voltage-gated potassium channel
                     subunit alpha KvLQT1; potassium channel, voltage-gated
                     KQT-like subfamily Q, member 1; potassium voltage-gated
                     channel, KQT-like subfamily, member 1"
                     /codon_start=1
                     /product="potassium voltage-gated channel subfamily KQT
                     member 1"
                     /protein_id="NP_114462.2"
                     /db_xref="GeneID:84020"
                     /db_xref="RGD:621503"
                     /translation="MDTASSPPNAERKRAGWGRLLGARRGSAGLAKKCPFSLELAEGG
                     PTGGTVYAPIAPTGAPGLAPPMSPPVSPVPAPADLGPRPRVSLDPRVSIYSTRRPLLA
                     RTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWME
                     IVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSK
                     GQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFS
                     SYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSV
                     FAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTW
                     KIYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGLSPGEKIFNVPHITCDPPED
                     RRPDHFSIDGYDSSVRKSPTLLEVSTPHFLRTNSFAEDLDLEGETLLTPITHVSQLRD
                     HHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQS
                     IGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSLQQGGP
                     TCNNRSQVVASDEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS"
     exon            456..546
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..673
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..752
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..849
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..990
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1101
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1197
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1320
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1462
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1583
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1659
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1754
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1801
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1863
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..3017
                     /gene="Kcnq1"
                     /gene_synonym="Kvlqt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgccctgcg ctctgcgctg ccttcatctc tgctctgagg agcggcgggg tccggggtcc
       61 tgtctggcca tggacacggc ctcctccccg cccaatgctg agaggaagcg cgcgggttgg
      121 ggccgcctgc taggcgcccg gcggggaagc gcgggactag caaagaagtg tcccttttca
      181 ctggagctgg ccgaaggtgg cccgacggga ggcacggtct acgcgcccat cgcaccaacc
      241 ggagctccag ggctcgcgcc ccccatgtcg ccccctgtgt cgcccgtccc ggcccctgca
      301 gacctcggcc cacgtccgcg ggtgagcctt gacccgcgcg tctccatcta cagtacgcgt
      361 cgcccgctgc tggcgcgcac ccacatccag ggccgcgtct acaacttcct cgagcgcccc
      421 acgggttgga agtgtttcgt gtaccacttc accgtcttcc tcattgttct ggtctgcctc
      481 atcttcagtg tcctgtccac tattgagcag tatgccgctc tggccaccgg gaccctcttc
      541 tggatggaga ttgtccttgt ggtgttcttt gggacagagt atgtggtccg tctctggtct
      601 gcaggctgcc gcagcaagta cgtgggcatc tggggccggc tacgctttgc ccggaagccc
      661 atttccatca tcgacctcat cgtggttgta gcctctatgg ttgtcctctg tgtgggttcc
      721 aaagggcaag tgttcgccac atcagctatc aggggtatcc gcttccttca gatcctgcgg
      781 atgctgcatg ttgatcgcca gggaggtacc tggaggctcc tgggctctgt agtcttcatt
      841 caccgccagg agctgatcac caccctgtac attggctttc tgggtctcat cttctcctcc
      901 tactttgtct acctggctga gaaagatgca gtgaatgagt ccggccgcat cgagtttggc
      961 agctacgcag atgctctgtg gtggggagtg gtcacagtca ccaccattgg ctacggggat
     1021 aaggtacccc agacatgggt tgggaagacc atcgcctcct gtttctctgt cttcgccata
     1081 tccttctttg cactcccagc gggcatactt ggctctgggt ttgcactgaa ggtccagcag
     1141 aagcagaggc agaaacactt caaccggcag atcccagccg cagcctcact catccagact
     1201 gcatggaggt gctatgctgc agagaatcct gactcatcca cttggaagat ctatgtccgg
     1261 aagcctgctc ggagccacac tttgctctcc cccagcccca agcctaaaaa gtctgtcatg
     1321 gtaaagaaga agaagttcaa gctggataag gataacgggc tgagtcctgg agagaagata
     1381 ttcaatgtcc ctcacatcac ttgtgatccc ccagaggatc ggaggccaga ccatttctcc
     1441 attgatggct acgacagctc agtaaggaag agccctacac tgctggaagt aagcacaccc
     1501 catttcttga gaacaaacag ctttgctgag gacctggacc tggaagggga gaccctgctg
     1561 acccccatca cccatgtgtc acagctgcgg gatcaccatc gggccaccat caaggtcatc
     1621 aggcgcatgc agtactttgt agccaagaag aaattccagc aagcacggaa gccctacgat
     1681 gtgcgagatg tcatcgagca gtactcccag ggccacctca accttatggt gcgcattaaa
     1741 gaactacaga gaaggctgga tcagtccatc gggaagccat ctttgttcat ccccatctca
     1801 gaaaagagca aagaccgtgg cagcaacacc atcggtgccc gtttgaacag ggtggaagac
     1861 aaggtgacac aactggacca gagactggtg atcatcacag acatgctcca ccaactgctg
     1921 tccctgcaac aaggtggtcc aacctgcaac aacaggtcac aagtcgtagc cagtgatgaa
     1981 ggtggctcca tcaaccctga gctcttcctg cccagcaaca gcctgcccac ctatgaacag
     2041 ctgactgtgc cccagacagg ccctgatgaa ggctcctgaa ggagctcaga agggaggttc
     2101 agggtaacct tccacaggtc tgccccacct ccctctcaac aggggcacct gcctggttct
     2161 caccctcttg aaggcctgat atgacagcct agctccctaa agccccaaaa cccatgggtc
     2221 aagccactgg cctgaatctg gagctcacca agacccctct gcccagtcag tgggaactag
     2281 aacttggctg agcatggggt tcctctcagg cccctatcaa gatggtgatg ttattctcct
     2341 gatggctggg gacataggga tggggagtgt ctgaccagga tgcaactcag gcagaaggaa
     2401 gcccatccag gtgatgccaa atggcttcct aaagggaaac aggaagaatc tgaaagagtc
     2461 tggggtttcc accctcaact ctgaatccag agcccagcag ggagcaggca gggcaagaca
     2521 ggcccagccc acactaacta caagctgtag cccagtgggg gctcaacagg ccaaagtctg
     2581 actccttcac tctctagtga tgttgaccac ttccgaatac cagagggatt tccagcttcc
     2641 cccaaaggat atcccaggca ggggaccatt cactgtccac cctaaccaga tatggactga
     2701 caacttctcc cctaaagtga agagcagggc cctcaagccc tgtgataagc ccttcgtgca
     2761 gcctgcctcc tccttgctgg tcagaggtgc cggagagatg ttcagactcc agtctcttca
     2821 cgccacatcc ctcagccagc agctgagcca cagcaaggtt aagggcatcg cggtttctcc
     2881 caggatcggt tccttgggca tcacacctca cagaaatcaa gataatttct ggtgattcag
     2941 actctgtgtt ttaatgaatt tcatagtatg atcttgattg agaggctttt gcaaataaag
     3001 ctgggacatg ccaggtt
//
