LOCUS       NM_001270702            1871 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium calcium-activated channel subfamily N
            member 4 (Kcnn4), transcript variant 3, mRNA.
ACCESSION   NM_001270702
VERSION     NM_001270702.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Tiwari,M.N., Mohan,S., Biala,Y., Shor,O., Benninger,F. and Yaari,Y.
  TITLE     Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy
  JOURNAL   J Neurosci 42 (30), 5843-5859 (2022)
   PUBMED   35732494
  REMARK    GeneRIF: Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy.
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Jiang,X.X., Bian,W., Zhu,Y.R., Wang,Z., Ye,P., Gu,Y., Zhang,H.,
            Zuo,G., Li,X., Zhu,L., Liu,Z., Sun,C., Chen,S.L. and Zhang,D.M.
  TITLE     Targeting the KCa3.1 channel suppresses diabetes-associated
            atherosclerosis via the STAT3/CD36 axis
  JOURNAL   Diabetes Res Clin Pract 185, 109776 (2022)
   PUBMED   35149165
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Bai,Y., Xu,J., Yang,S., Zhang,H., He,L., Zhou,W., Cheng,M. and
            Zhang,S.
  TITLE     The intermediate-conductance calcium-activated potassium channel
            KCa3.1 contributes to alkalinization-induced vascular calcification
            in vitro
  JOURNAL   J Clin Lab Anal 35 (8), e23854 (2021)
   PUBMED   34313357
  REMARK    GeneRIF: The intermediate-conductance calcium-activated potassium
            channel KCa3.1 contributes to alkalinization-induced vascular
            calcification in vitro.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Suss,C., Broncy,L., Pollinger,K., Kunst,C., Gulow,K., Muller,M. and
            Wolfel,G.
  TITLE     KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This
            Might Be a Novel Marker and Therapeutic Option Targeting Potassium
            Channels
  JOURNAL   J Gastrointestin Liver Dis 29 (4), 539-547 (2020)
   PUBMED   33331347
  REMARK    GeneRIF: KCNN4 Expression Is Elevated in Inflammatory Bowel
            Disease: This Might Be a Novel Marker and Therapeutic Option
            Targeting Potassium Channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Roshchin,M.V., Ierusalimsky,V.N., Balaban,P.M. and Nikitin,E.S.
  TITLE     Ca2+-activated KCa3.1 potassium channels contribute to the slow
            afterhyperpolarization in L5 neocortical pyramidal neurons
  JOURNAL   Sci Rep 10 (1), 14484 (2020)
   PUBMED   32879404
  REMARK    GeneRIF: Ca(2+)-activated KCa3.1 potassium channels contribute to
            the slow afterhyperpolarization in L5 neocortical pyramidal
            neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  AUTHORS   Joiner,W.J., Basavappa,S., Vidyasagar,S., Nehrke,K., Krishnan,S.,
            Binder,H.J., Boulpaep,E.L. and Rajendran,V.M.
  TITLE     Active K+ secretion through multiple KCa-type channels and
            regulation by IKCa channels in rat proximal colon
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (1), G185-G196 (2003)
   PUBMED   12606302
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Nehrke,K., Quinn,C.C. and Begenisich,T.
  TITLE     Molecular identification of Ca2+-activated K+ channels in parotid
            acinar cells
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C535-C546 (2003)
   PUBMED   12388098
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Ayabe,T., Wulff,H., Darmoul,D., Cahalan,M.D., Chandy,K.G. and
            Ouellette,A.J.
  TITLE     Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1,
            a Ca2+-activated, intermediate conductance potassium channel
  JOURNAL   J Biol Chem 277 (5), 3793-3800 (2002)
   PUBMED   11724775
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Neylon,C.B., Lang,R.J., Fu,Y., Bobik,A. and Reinhart,P.H.
  TITLE     Molecular cloning and characterization of the
            intermediate-conductance Ca(2+)-activated K(+) channel in vascular
            smooth muscle: relationship between K(Ca) channel diversity and
            smooth muscle cell function
  JOURNAL   Circ Res 85 (9), e33-e43 (1999)
   PUBMED   10532960
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Warth,R., Hamm,K., Bleich,M., Kunzelmann,K., von Hahn,T.,
            Schreiber,R., Ullrich,E., Mengel,M., Trautmann,N., Kindle,P.,
            Schwab,A. and Greger,R.
  TITLE     Molecular and functional characterization of the small
            Ca(2+)-regulated K+ channel (rSK4) of colonic crypts
  JOURNAL   Pflugers Arch 438 (4), 437-444 (1999)
   PUBMED   10519135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC128736.1.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site at the 5' end of an exon compared to variant 1. The
            resulting isoform (b) has the same N- and C-termini but is shorter
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU872451.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  89087248-89087296
            50-301              BC128736.1         1-252
            302-1871            BC128736.1         340-1909
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1871
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /note="potassium calcium-activated channel subfamily N
                     member 4"
                     /db_xref="GeneID:65206"
                     /db_xref="RGD:621476"
     exon            1..301
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1330
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /note="isoform b is encoded by transcript variant 3;
                     intermediate conductance calcium-activated potassium
                     channel protein 4; potassium intermediate/small
                     conductance calcium-activated channel, subfamily N, member
                     4; intermediate-conductance Ca-activated K channel;
                     intermediate conductance K channel; IK1; SK4; KCa4; SKCa4;
                     SKCa 4; potassium channel, calcium activated
                     intermediate/small conductance subfamily N alpha, member
                     4; smooth muscle intermediate-conductance KCa channel"
                     /codon_start=1
                     /product="intermediate conductance calcium-activated
                     potassium channel protein 4 isoform b"
                     /protein_id="NP_001257631.1"
                     /db_xref="GeneID:65206"
                     /db_xref="RGD:621476"
                     /translation="MGGELVTGLGALRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHA
                     EMLWFLGCKEVQLFMTDNGLRDWRVALTRRQVAQILLELLVCGVHPVPLRSPHCTLAG
                     EATDSQAWPGFLGEGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYRSIGALNQVRFR
                     HWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLTDTLWLIPITFL
                     TIGYGDVVPGTLWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHNFMMDIHY
                     AKEMKESAARLLQEAWMYYKHTRRKDSRAARRHQRKMLAAIHTFRQVRLKHRKLREQV
                     NSMVDISKMHMILCDLQLGLSASHLALEKRIDGLAGKLDALTELLSTALQQQPPEPIQ
                     EAT"
     exon            302..310
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            311..732
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            733..868
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            869..979
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1098
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1168
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1333
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1845
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaggctg tgccttccag ccaaagtccc agggtgagca gaacaggccg ctggcctgga
       61 agccaagctg gctgccattt gcgtactgag aggtggggga ccctgggcag gaagctggct
      121 gagcaccaag agctcggggg ccatgggcgg ggagctggtg actggcctgg gggccctgag
      181 acggagaaag cgcctgctgg agcaggagaa gagggtggcc ggctgggcac tggtactggc
      241 gggaactggc atcggactca tggtgctgca cgctgagatg ttgtggttcc tgggttgcaa
      301 ggaggtccag ctgttcatga ctgacaacgg gctccgggac tggcgcgtgg cgctgacccg
      361 gcggcaggtg gcgcagatcc tgctggagct gctggtatgc ggggtgcacc cggtgcccct
      421 acggagcccg cactgcaccc tggcggggga ggccacagac tcacaggcct ggccgggctt
      481 cctgggcgaa ggcgaggcgt tgctgtccct ggccatgctg ctacgtctct acctggtgcc
      541 tcgcgcggta cttctgcgta gcggggtcct gctcaacgcg tcttaccgca gcatcggggc
      601 gctcaaccaa gtccgattcc gccactggtt cgtggccaaa ctatacatga acacgcaccc
      661 gggtcgcctg cttctgggcc tcacgctggg cctctggctc accacagctt gggtgctgtc
      721 tgtggctgag aggcaggctg tcaatgccac gggacacctc acagacacac tgtggctgat
      781 acccatcacg ttcctgacca ttggctatgg ggacgtcgta cctggcaccc tatggggcaa
      841 gattgtctgc ttgtgcaccg gagtcatggg ggtctgctgc acggctctac tagtggctgt
      901 ggtggcccgg aagctggagt tcaacaaggc ggagaaacac gtgcacaact tcatgatgga
      961 catccattat gccaaagaga tgaaggagtc ggccgctcgg ctgctgcagg aagcctggat
     1021 gtactacaaa cacactcgaa ggaaggactc ccgagcggct cgcaggcatc agcgcaagat
     1081 gctggctgcc atccacacgt tccgccaggt acggctgaaa catcggaagc tccgggaaca
     1141 agtgaattcc atggtggaca tctccaagat gcacatgatc ctgtgcgacc tgcagctcgg
     1201 gctcagcgcc tcgcaccttg ccctggagaa gagaatcgat gggctggcag ggaagctgga
     1261 tgccctgact gaactgctca gtactgccct gcagcagcag ccgccagaac ccatccagga
     1321 ggccacatag ctgcctgtta tcgatctaca ttctactcag gacccacaga agaatcaggc
     1381 tatgtaccga aggactgagc tcaaggacat cctccctgcc tattctgacc aagccccatg
     1441 aataaatcac ctcaagatgc caggacacaa gtggatccac gttgagatgc atggactctg
     1501 gtggtggcag ccatgagtgg acactggctt ggacctccca tggcagtggg gttactatgg
     1561 tcaccactac acataggcca tcatcaaaag tcctttctgc tgtgctgctg ctgttcatga
     1621 cccctcaagc tctgttggaa gaggaggtgc ccggggtcca agatgctagg aagaagcttc
     1681 agtcaccgca ggccggcctc gctgaaggaa ccaggtccga gcggcgggag gtgctgcccc
     1741 ctggtggacg ctgcttcccc cagaatgcgg aaactgcgcg ggagtagggt gcggggtgcc
     1801 gctcaccaat ccaccctcat actttgtaat aaatggtaaa caaagaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa a
//
