LOCUS       NM_001270701            1931 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Rattus norvegicus potassium calcium-activated channel subfamily N
            member 4 (Kcnn4), transcript variant 2, mRNA.
ACCESSION   NM_001270701
VERSION     NM_001270701.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Tiwari,M.N., Mohan,S., Biala,Y., Shor,O., Benninger,F. and Yaari,Y.
  TITLE     Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy
  JOURNAL   J Neurosci 42 (30), 5843-5859 (2022)
   PUBMED   35732494
  REMARK    GeneRIF: Corticotropin Releasing Factor Mediates KCa3.1 Inhibition,
            Hyperexcitability, and Seizures in Acquired Epilepsy.
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Jiang,X.X., Bian,W., Zhu,Y.R., Wang,Z., Ye,P., Gu,Y., Zhang,H.,
            Zuo,G., Li,X., Zhu,L., Liu,Z., Sun,C., Chen,S.L. and Zhang,D.M.
  TITLE     Targeting the KCa3.1 channel suppresses diabetes-associated
            atherosclerosis via the STAT3/CD36 axis
  JOURNAL   Diabetes Res Clin Pract 185, 109776 (2022)
   PUBMED   35149165
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Bai,Y., Xu,J., Yang,S., Zhang,H., He,L., Zhou,W., Cheng,M. and
            Zhang,S.
  TITLE     The intermediate-conductance calcium-activated potassium channel
            KCa3.1 contributes to alkalinization-induced vascular calcification
            in vitro
  JOURNAL   J Clin Lab Anal 35 (8), e23854 (2021)
   PUBMED   34313357
  REMARK    GeneRIF: The intermediate-conductance calcium-activated potassium
            channel KCa3.1 contributes to alkalinization-induced vascular
            calcification in vitro.
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Suss,C., Broncy,L., Pollinger,K., Kunst,C., Gulow,K., Muller,M. and
            Wolfel,G.
  TITLE     KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This
            Might Be a Novel Marker and Therapeutic Option Targeting Potassium
            Channels
  JOURNAL   J Gastrointestin Liver Dis 29 (4), 539-547 (2020)
   PUBMED   33331347
  REMARK    GeneRIF: KCNN4 Expression Is Elevated in Inflammatory Bowel
            Disease: This Might Be a Novel Marker and Therapeutic Option
            Targeting Potassium Channels.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Roshchin,M.V., Ierusalimsky,V.N., Balaban,P.M. and Nikitin,E.S.
  TITLE     Ca2+-activated KCa3.1 potassium channels contribute to the slow
            afterhyperpolarization in L5 neocortical pyramidal neurons
  JOURNAL   Sci Rep 10 (1), 14484 (2020)
   PUBMED   32879404
  REMARK    GeneRIF: Ca(2+)-activated KCa3.1 potassium channels contribute to
            the slow afterhyperpolarization in L5 neocortical pyramidal
            neurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Joiner,W.J., Basavappa,S., Vidyasagar,S., Nehrke,K., Krishnan,S.,
            Binder,H.J., Boulpaep,E.L. and Rajendran,V.M.
  TITLE     Active K+ secretion through multiple KCa-type channels and
            regulation by IKCa channels in rat proximal colon
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (1), G185-G196 (2003)
   PUBMED   12606302
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Nehrke,K., Quinn,C.C. and Begenisich,T.
  TITLE     Molecular identification of Ca2+-activated K+ channels in parotid
            acinar cells
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C535-C546 (2003)
   PUBMED   12388098
REFERENCE   8  (bases 1 to 1931)
  AUTHORS   Ayabe,T., Wulff,H., Darmoul,D., Cahalan,M.D., Chandy,K.G. and
            Ouellette,A.J.
  TITLE     Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1,
            a Ca2+-activated, intermediate conductance potassium channel
  JOURNAL   J Biol Chem 277 (5), 3793-3800 (2002)
   PUBMED   11724775
REFERENCE   9  (bases 1 to 1931)
  AUTHORS   Neylon,C.B., Lang,R.J., Fu,Y., Bobik,A. and Reinhart,P.H.
  TITLE     Molecular cloning and characterization of the
            intermediate-conductance Ca(2+)-activated K(+) channel in vascular
            smooth muscle: relationship between K(Ca) channel diversity and
            smooth muscle cell function
  JOURNAL   Circ Res 85 (9), e33-e43 (1999)
   PUBMED   10532960
REFERENCE   10 (bases 1 to 1931)
  AUTHORS   Warth,R., Hamm,K., Bleich,M., Kunzelmann,K., von Hahn,T.,
            Schreiber,R., Ullrich,E., Mengel,M., Trautmann,N., Kindle,P.,
            Schwab,A. and Greger,R.
  TITLE     Molecular and functional characterization of the small
            Ca(2+)-regulated K+ channel (rSK4) of colonic crypts
  JOURNAL   Pflugers Arch 438 (4), 437-444 (1999)
   PUBMED   10519135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1 and BC128736.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF190458.1, SRR26643292.1332.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760475, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                JAXUCZ010000001.1  89087248-89087296
            50-1420             BC128736.1         1-1371
            1421-1931           BC128736.1         1399-1909
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1931
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /note="potassium calcium-activated channel subfamily N
                     member 4"
                     /db_xref="GeneID:65206"
                     /db_xref="RGD:621476"
     exon            1..301
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1417
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /note="isoform a is encoded by transcript variant 2;
                     intermediate conductance calcium-activated potassium
                     channel protein 4; potassium intermediate/small
                     conductance calcium-activated channel, subfamily N, member
                     4; intermediate-conductance Ca-activated K channel;
                     intermediate conductance K channel; IK1; SK4; KCa4; SKCa4;
                     SKCa 4; potassium channel, calcium activated
                     intermediate/small conductance subfamily N alpha, member
                     4; smooth muscle intermediate-conductance KCa channel"
                     /codon_start=1
                     /product="intermediate conductance calcium-activated
                     potassium channel protein 4 isoform a"
                     /protein_id="NP_001257630.1"
                     /db_xref="GeneID:65206"
                     /db_xref="RGD:621476"
                     /translation="MGGELVTGLGALRRRKRLLEQEKRVAGWALVLAGTGIGLMVLHA
                     EMLWFLGCKWVLYLLLVKCLITLSTAFLLCLIVVFHAKEVQLFMTDNGLRDWRVALTR
                     RQVAQILLELLVCGVHPVPLRSPHCTLAGEATDSQAWPGFLGEGEALLSLAMLLRLYL
                     VPRAVLLRSGVLLNASYRSIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTA
                     WVLSVAERQAVNATGHLTDTLWLIPITFLTIGYGDVVPGTLWGKIVCLCTGVMGVCCT
                     ALLVAVVARKLEFNKAEKHVHNFMMDIHYAKEMKESAARLLQEAWMYYKHTRRKDSRA
                     ARRHQRKMLAAIHTFRQVRLKHRKLREQVNSMVDISKMHMILCDLQLGLSASHLALEK
                     RIDGLAGKLDALTELLSTALQQQPPEPIQEAT"
     exon            302..397
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            398..819
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            820..955
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1066
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1185
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1255
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1420
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1905
                     /gene="Kcnn4"
                     /gene_synonym="KCa3.1; rIK1; rKCNN4c; rSK4; SMIK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctaggctg tgccttccag ccaaagtccc agggtgagca gaacaggccg ctggcctgga
       61 agccaagctg gctgccattt gcgtactgag aggtggggga ccctgggcag gaagctggct
      121 gagcaccaag agctcggggg ccatgggcgg ggagctggtg actggcctgg gggccctgag
      181 acggagaaag cgcctgctgg agcaggagaa gagggtggcc ggctgggcac tggtactggc
      241 gggaactggc atcggactca tggtgctgca cgctgagatg ttgtggttcc tgggttgcaa
      301 gtgggtgctg tacctgctct tggttaagtg tttaatcacg ctgtccactg ccttcctcct
      361 ttgtcttatt gtggtcttcc atgccaagga ggtccagctg ttcatgactg acaacgggct
      421 ccgggactgg cgcgtggcgc tgacccggcg gcaggtggcg cagatcctgc tggagctgct
      481 ggtatgcggg gtgcacccgg tgcccctacg gagcccgcac tgcaccctgg cgggggaggc
      541 cacagactca caggcctggc cgggcttcct gggcgaaggc gaggcgttgc tgtccctggc
      601 catgctgcta cgtctctacc tggtgcctcg cgcggtactt ctgcgtagcg gggtcctgct
      661 caacgcgtct taccgcagca tcggggcgct caaccaagtc cgattccgcc actggttcgt
      721 ggccaaacta tacatgaaca cgcacccggg tcgcctgctt ctgggcctca cgctgggcct
      781 ctggctcacc acagcttggg tgctgtctgt ggctgagagg caggctgtca atgccacggg
      841 acacctcaca gacacactgt ggctgatacc catcacgttc ctgaccattg gctatgggga
      901 cgtcgtacct ggcaccctat ggggcaagat tgtctgcttg tgcaccggag tcatgggggt
      961 ctgctgcacg gctctactag tggctgtggt ggcccggaag ctggagttca acaaggcgga
     1021 gaaacacgtg cacaacttca tgatggacat ccattatgcc aaagagatga aggagtcggc
     1081 cgctcggctg ctgcaggaag cctggatgta ctacaaacac actcgaagga aggactcccg
     1141 agcggctcgc aggcatcagc gcaagatgct ggctgccatc cacacgttcc gccaggtacg
     1201 gctgaaacat cggaagctcc gggaacaagt gaattccatg gtggacatct ccaagatgca
     1261 catgatcctg tgcgacctgc agctcgggct cagcgcctcg caccttgccc tggagaagag
     1321 aatcgatggg ctggcaggga agctggatgc cctgactgaa ctgctcagta ctgccctgca
     1381 gcagcagccg ccagaaccca tccaggaggc cacatagctg gacccacaga agaatcaggc
     1441 tatgtaccga aggactgagc tcaaggacat cctccctgcc tattctgacc aagccccatg
     1501 aataaatcac ctcaagatgc caggacacaa gtggatccac gttgagatgc atggactctg
     1561 gtggtggcag ccatgagtgg acactggctt ggacctccca tggcagtggg gttactatgg
     1621 tcaccactac acataggcca tcatcaaaag tcctttctgc tgtgctgctg ctgttcatga
     1681 cccctcaagc tctgttggaa gaggaggtgc ccggggtcca agatgctagg aagaagcttc
     1741 agtcaccgca ggccggcctc gctgaaggaa ccaggtccga gcggcgggag gtgctgcccc
     1801 ctggtggacg ctgcttcccc cagaatgcgg aaactgcgcg ggagtagggt gcggggtgcc
     1861 gctcaccaat ccaccctcat actttgtaat aaatggtaaa caaagaaaaa aaaaaaaaaa
     1921 aaaaaaaaaa a
//
