LOCUS       NM_019315               2518 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium calcium-activated channel subfamily N
            member 3 (Kcnn3), mRNA.
ACCESSION   NM_019315
VERSION     NM_019315.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Zhao,J., Zhang,Y., Liu,X., Rao,Y., Fu,J., Hua,L. and Ou,C.
  TITLE     Activation of SK3 channel plays a pivotal role in modulation of
            trigeminal neuralgia
  JOURNAL   Neurol Res 43 (12), 1005-1012 (2021)
   PUBMED   34233598
  REMARK    GeneRIF: Activation of SK3 channel plays a pivotal role in
            modulation of trigeminal neuralgia.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Bauer,C.K., Schneeberger,P.E., Kortum,F., Altmuller,J.,
            Santos-Simarro,F., Baker,L., Keller-Ramey,J., White,S.M.,
            Campeau,P.M., Gripp,K.W. and Kutsche,K.
  TITLE     Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance
            Ca2+-Activated K+ Channel SK3 Cause Zimmermann-Laband Syndrome
  JOURNAL   Am J Hum Genet 104 (6), 1139-1157 (2019)
   PUBMED   31155282
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Li,N., Ding,H., Li,Z., Liu,Y. and Wang,P.
  TITLE     Effect of high-fat diet-induced obesity on the small-conductance
            Ca2+-activated K+ channel function affecting the contractility of
            rat detrusor smooth muscle
  JOURNAL   Int Urol Nephrol 51 (1), 61-72 (2019)
   PUBMED   30361965
  REMARK    GeneRIF: Reduced expression and activity of SK channels in the
            detrusor smooth muscle contribute to Obesity-related Overactive
            Bladder.
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Zhao,H., Jiang,J., Xia,J. and Jiang,R.
  TITLE     Effect of low androgen levels on IKca and SKca3 channels in rat
            penile corpus cavernosum
  JOURNAL   Andrologia 50 (9), e13075 (2018)
   PUBMED   29952429
  REMARK    GeneRIF: expression significantly decreased in the penile corpus
            cavernosum of castrated groups, and expression positively
            correlated with level of androgen
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Kloza,M., Baranowska-Kuczko,M., Malinowska,B., Karpinska,O.,
            Harasim-Symbor,E., Kasacka,I. and Kozlowska,H.
  TITLE     The influence of DOCA-salt hypertension and chronic administration
            of the FAAH inhibitor URB597 on KCa2.3/KCa3.1-EDH-type relaxation
            in rat small mesenteric arteries
  JOURNAL   Vascul Pharmacol 99, 65-73 (2017)
   PUBMED   29038048
  REMARK    GeneRIF: The hypotensive effect of FAAH inhibitor URB597 is
            independent of KCa2.3/KCa3.1-endothelium dependent
            hyperpolarization-type relaxation.
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Hosseini,R., Benton,D.C., Dunn,P.M., Jenkinson,D.H. and Moss,G.W.
  TITLE     SK3 is an important component of K(+) channels mediating the
            afterhyperpolarization in cultured rat SCG neurones
  JOURNAL   J Physiol 535 (Pt 2), 323-334 (2001)
   PUBMED   11533126
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Barfod,E.T., Moore,A.L. and Lidofsky,S.D.
  TITLE     Cloning and functional expression of a liver isoform of the small
            conductance Ca2+-activated K+ channel SK3
  JOURNAL   Am J Physiol Cell Physiol 280 (4), C836-C842 (2001)
   PUBMED   11245600
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Roncarati,R., Di Chio,M., Sava,A., Terstappen,G.C. and Fumagalli,G.
  TITLE     Presynaptic localization of the small conductance calcium-activated
            potassium channel SK3 at the neuromuscular junction
  JOURNAL   Neuroscience 104 (1), 253-262 (2001)
   PUBMED   11311547
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Bowen,T., Guy,C.A., Craddock,N., Cardno,A.G., Williams,N.M.,
            Spurlock,G., Murphy,K.C., Jones,L.A., Gray,M., Sanders,R.D.,
            McCarthy,G., Chandy,K.G., Fantino,E., Kalman,K., Gutman,G.A.,
            Gargus,J.J., Williams,J., McGuffin,P., Owen,M.J. and O'Donovan,M.C.
  TITLE     Further support for an association between a polymorphic CAG repeat
            in the hKCa3 gene and schizophrenia
  JOURNAL   Mol Psychiatry 3 (3), 266-269 (1998)
   PUBMED   9672903
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 3, 2020 this sequence version replaced NM_019315.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF292389.1, AF284345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1228              JAXUCZ010000002.1  177234340-177235567
            1229-1324           JAXUCZ010000002.1  177277144-177277239
            1325-1743           JAXUCZ010000002.1  177321761-177322179
            1744-1885           JAXUCZ010000002.1  177356801-177356942
            1886-1996           JAXUCZ010000002.1  177363341-177363451
            1997-2124           JAXUCZ010000002.1  177372618-177372745
            2125-2194           JAXUCZ010000002.1  177373927-177373996
            2195-2518           JAXUCZ010000002.1  177378526-177378849
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2518
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /note="potassium calcium-activated channel subfamily N
                     member 3"
                     /db_xref="GeneID:54263"
                     /db_xref="RGD:2964"
     exon            1..1228
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..2491
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /note="potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 3; SKCa3;
                     potassium channel, calcium activated intermediate/small
                     conductance subfamily N alpha, member 3; SKCa 3;
                     small-conductance Ca2+-activated K+ channel 3"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 3"
                     /protein_id="NP_062188.3"
                     /db_xref="GeneID:54263"
                     /db_xref="RGD:2964"
                     /translation="MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPA
                     VPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLH
                     SSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASP
                     LVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPE
                     IIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRAL
                     FEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLI
                     IAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAF
                     SYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFV
                     MKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSI
                     GYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTK
                     RIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQ
                     ANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLR
                     QQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC"
     exon            1229..1324
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1743
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1885
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..1996
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2124
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2194
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2518
                     /gene="Kcnn3"
                     /gene_synonym="KCa2.3; SK3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggagtga agctgagtct gcctcataca ctcctagagg accgccttca gaatagagtt
       61 cttttcgccc cttcctcctt ctcccagctc ctctcctggc ttttctatcc gcccaataca
      121 atgcacactc gagtggcagc cccagagaac tgaagcaaac caaagagaga ggactggagc
      181 caagacactt ctggtgggga agcttggatg cctggctttc tttgaggtca tctttggaac
      241 gagggtggct ttggggtgga gggtcgtgct gcagggaacc cagccaggcc ccaagatgga
      301 cacttctggg cacttccatg actcgggggt gggggatctg gatgaagacc ccaagtgtcc
      361 ctgtccatct tctggggacg agcaacagca gcaacagcaa ccgccaccac cgtcagcgcc
      421 accagcagtc ccccagcagc ctccgggacc cttgctgcag cctcagcctc cgcagcttca
      481 gcagcagcag cagcagcagc agcagcagca gcagcagcag cagcagcagc aggctccact
      541 gcaccccctg cctcagcttg cccaactcca gagccagctt gtccatcctg gtctgttgca
      601 ctcttctccc acggctttca gggctcccaa ttcagccaac tccaccgcca tcctccaccc
      661 ttcctccagg caaggcagcc agctaaatct caatgaccac ttgcttggcc actctccaag
      721 ttccacagcc acaagtgggc ctggtggagg cagccggcac cggcaggcca gccccctggt
      781 gcaccggcgg gacagcaatc ccttcacgga gatagctatg agctcctgca aatacagcgg
      841 tggggtcatg aagcccctca gccgcctcag cgcctctcgg agaaacctta tcgaggccga
      901 gcctgagggc caacccctcc agctcttcag tcccagcaac cccccagaga ttatcatctc
      961 ctccagggag gataaccatg cccaccagac tctgctccat caccccaacg ctacccacaa
     1021 ccaccagcat gccggcacca ctgctggcag caccaccttc cccaaagcca acaagcggaa
     1081 aaaccaaaac attggctata agctggggca caggagggcc ctgtttgaaa agagaaagcg
     1141 actgagtgac tatgctctga tttttgggat gtttggaatt gttgttatgg tgatagagac
     1201 cgaactgtct tggggtttgt actcaaagga ttccatgttt tcgttggccc tgaaatgcct
     1261 tatcagttta tccaccatca tcctgcttgg tttgatcatc gcctaccaca caagggaagt
     1321 acagctcttt gtgatcgaca atggtgcaga tgactggcgg atagccatga cctatgagcg
     1381 catcctctac atcagcctgg agatgctggt gtgcgccatc caccccattc ctggagagta
     1441 caagttcttc tggacggcac gcctggcctt ctcctacacc ccctctcggg cagaggctga
     1501 cgtggacatt attctgtcca tccccatgtt cttgcgccta tacctgatcg cccgagtcat
     1561 gctgctacat agcaagctct tcacggatgc ctcatcccga agcatcgggg ccctcaacaa
     1621 gatcaacttc aacacccgat tcgtcatgaa gacgctcatg accatctgcc cgggcacggt
     1681 gctgctggtg ttcagcatct ctctgtggat catcgctgcc tggactgtga gagtctgtga
     1741 aaggtaccat gaccagcagg acgtaactag taactttctg ggtgccatgt ggctcatctc
     1801 catcacgttc ctttccattg gctatgggga catggtgccc cacacatact gtgggaaagg
     1861 tgtctgtctt ctcactggca tcatgggtgc aggctgcact gccctcgtgg tagctgtggt
     1921 tgcccgaaag ctcgaactca ccaaagcaga gaagcatgtg cacaacttca tgatggacac
     1981 tcagctcacc aaacggatca agaacgctgc cgccaatgtc ctccgggaaa catggctgat
     2041 ctacaaacac acaaagctgc taaagaagat tgaccacgcc aaagtcagga aacaccagag
     2101 gaagttcctc caagctattc accaactgag gggtgtcaag atggaacaaa ggaagctgag
     2161 tgaccaagcc aacaccctgg tggacctttc caagatgcag aacgtcatgt atgacttgat
     2221 cacggagctc aacgaccgga gtgaagacct ggaaaagcag attggcagcc tggaatccaa
     2281 gctggagcac ctcacagcca gcttcaattc cctgcccctg ctcatcgcag acaccctgcg
     2341 ccaacagcag cagcagctgc tcactgcctt cgtggaggcc cggggcatca gtgtggctgt
     2401 gggaactagc cacgcccctc cctctgacag ccctatcggg atcagctcca cctctttccc
     2461 aaccccatac acaagttcaa gcagttgcta aataaaactc cccactccag aagcatta
//
