LOCUS       NP_062187                580 aa            linear   ROD 27-APR-2025
DEFINITION  small conductance calcium-activated potassium channel protein 2
            isoform 2 [Rattus norvegicus].
ACCESSION   NP_062187
VERSION     NP_062187.1
DBSOURCE    REFSEQ: accession NM_019314.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   Rahman,M.A., Orfali,R., Dave,N., Lam,E., Naguib,N., Nam,Y.W. and
            Zhang,M.
  TITLE     KCa 2.2 (KCNN2): A physiologically and therapeutically important
            potassium channel
  JOURNAL   J Neurosci Res 101 (11), 1699-1710 (2023)
   PUBMED   37466411
  REMARK    GeneRIF: KCa 2.2 (KCNN2): A physiologically and therapeutically
            important potassium channel.
            Review article
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Nam,Y.W., Rahman,M.A., Yang,G., Orfali,R., Cui,M. and Zhang,M.
  TITLE     Loss-of-function KCa2.2 mutations abolish channel activity
  JOURNAL   Am J Physiol Cell Physiol 324 (3), C658-C664 (2023)
   PUBMED   36717104
  REMARK    GeneRIF: Loss-of-function KCa2.2 mutations abolish channel
            activity.
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Yang,B., Jiang,Q., He,S., Li,T., Ou,X., Chen,T., Fan,X., Jiang,F.,
            Zeng,X., Huang,C.L., Lei,M. and Tan,X.
  TITLE     Ventricular SK2 upregulation following angiotensin II challenge:
            Modulation by p21-activated kinase-1
  JOURNAL   J Mol Cell Cardiol 164, 110-125 (2022)
   PUBMED   34774547
  REMARK    GeneRIF: Ventricular SK2 upregulation following angiotensin II
            challenge: Modulation by p21-activated kinase-1.
REFERENCE   4  (residues 1 to 580)
  AUTHORS   Autuori,E., Sedlak,P., Xu,L., C Ridder,M., Tedoldi,A. and Sah,P.
  TITLE     rSK1 in Rat Neurons: A Controller of Membrane rSK2?
  JOURNAL   Front Neural Circuits 13, 21 (2019)
   PUBMED   31001092
  REMARK    GeneRIF: rSK1 appears to act as chaperone for rSK2 channels and
            expression of rSK1 may control the level of functional SK current
            in rat neurons.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 580)
  AUTHORS   Ewin,S.E., Morgan,J.W., Niere,F., McMullen,N.P., Barth,S.H.,
            Almonte,A.G., Raab-Graham,K.F. and Weiner,J.L.
  TITLE     Chronic Intermittent Ethanol Exposure Selectively Increases
            Synaptic Excitability in the Ventral Domain of the Rat Hippocampus
  JOURNAL   Neuroscience 398, 144-157 (2019)
   PUBMED   30481568
REFERENCE   6  (residues 1 to 580)
  AUTHORS   Schumacher,M.A., Crum,M. and Miller,M.C.
  TITLE     Crystal structures of apocalmodulin and an apocalmodulin/SK
            potassium channel gating domain complex
  JOURNAL   Structure 12 (5), 849-860 (2004)
   PUBMED   15130477
REFERENCE   7  (residues 1 to 580)
  AUTHORS   Monaghan,A.S., Benton,D.C., Bahia,P.K., Hosseini,R., Shah,Y.A.,
            Haylett,D.G. and Moss,G.W.
  TITLE     The SK3 subunit of small conductance Ca2+-activated K+ channels
            interacts with both SK1 and SK2 subunits in a heterologous
            expression system
  JOURNAL   J Biol Chem 279 (2), 1003-1009 (2004)
   PUBMED   14559917
REFERENCE   8  (residues 1 to 580)
  AUTHORS   Schumacher,M.A., Rivard,A.F., Bachinger,H.P. and Adelman,J.P.
  TITLE     Structure of the gating domain of a Ca2+-activated K+ channel
            complexed with Ca2+/calmodulin
  JOURNAL   Nature 410 (6832), 1120-1124 (2001)
   PUBMED   11323678
REFERENCE   9  (residues 1 to 580)
  AUTHORS   Xia,X.M., Fakler,B., Rivard,A., Wayman,G., Johnson-Pais,T.,
            Keen,J.E., Ishii,T., Hirschberg,B., Bond,C.T., Lutsenko,S.,
            Maylie,J. and Adelman,J.P.
  TITLE     Mechanism of calcium gating in small-conductance calcium-activated
            potassium channels
  JOURNAL   Nature 395 (6701), 503-507 (1998)
   PUBMED   9774106
REFERENCE   10 (residues 1 to 580)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 3' coding region compared to variant 1. It encodes
            isoform 2 which is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U69882.1, SRR26643298.73944.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q11"
     Protein         1..580
                     /product="small conductance calcium-activated potassium
                     channel protein 2 isoform 2"
                     /note="small conductance calcium-activated potassium
                     channel protein 2; small conductance calcium-activated
                     potassium channel protein 2-like; potassium
                     intermediate/small conductance calcium-activated channel,
                     subfamily N, member 2; potassium channel, calcium
                     activated intermediate/small conductance subfamily N
                     alpha, member 2"
                     /calculated_mol_wt=63717
     Region          1..68
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Region          88..116
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Region          122..231
                     /region_name="SK_channel"
                     /note="Calcium-activated SK potassium channel; pfam03530"
                     /db_xref="CDD:460958"
     Site            140..160
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:16641100; propagated from
                     UniProtKB/Swiss-Prot (P70604.1)"
     Site            169..189
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Site            215..235
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Site            257..277
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Site            306..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Region          320..399
                     /region_name="Ion_trans_2"
                     /note="Ion channel; pfam07885"
                     /db_xref="CDD:462301"
     Site            375..395
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Region          413..489
                     /region_name="Calmodulin-binding.
                     /evidence=ECO:0000269|PubMed:11323678"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     Region          413..488
                     /region_name="CaMBD"
                     /note="Calmodulin binding domain; smart01053"
                     /db_xref="CDD:198121"
     Region          551..580
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70604.1)"
     CDS             1..580
                     /gene="Kcnn2"
                     /gene_synonym="KCa2.2; SK2; SKCa 2; SKCa2"
                     /coded_by="NM_019314.2:1..1743"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="GeneID:54262"
                     /db_xref="RGD:2963"
ORIGIN      
        1 msscrynggv mrplsnlsss rrnlhemdse aqplqppasv vgggggassp saaaaasssa
       61 peivvskpeh nnsnnlalyg tggggstggg gggggggggs ghgsssgtks skkknqnigy
      121 klghrralfe krkrlsdyal ifgmfgivvm vietelswga ydkaslysla lkclislsti
      181 illgliivyh areiqlfmvd ngaddwriam tyerifficl eilvcaihpi pgnytftwta
      241 rlafsyapst ttadvdiils ipmflrlyli arvmllhskl ftdassrsig alnkinfntr
      301 fvmktlmtic pgtvllvfsi slwiiaawtv raceryhdqq dvtsnflgam wlisitflsi
      361 gygdmvpnty cgkgvclltg imgagctalv vavvarklel tkaekhvhnf mmdtqltkrv
      421 knaaanvlre twliykntkl vkkidhakvr khqrkflqai hqlrsvkmeq rklndqantl
      481 vdlaktqnim ydmisdlner sedfekrivt letkletlig sihalpglis qtirqqqrdf
      541 ietqmenydk hvtynaersr sssrrrrsss tapptssess
//
