LOCUS       NM_019313               3810 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium calcium-activated channel subfamily N
            member 1 (Kcnn1), mRNA.
ACCESSION   NM_019313
VERSION     NM_019313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3810)
  AUTHORS   Deng,S., Zhou,X., Ge,Z., Song,Y., Wang,H., Liu,X. and Zhang,D.
  TITLE     Exosomes from adipose-derived mesenchymal stem cells ameliorate
            cardiac damage after myocardial infarction by activating
            S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization
  JOURNAL   Int J Biochem Cell Biol 114, 105564 (2019)
   PUBMED   31276786
  REMARK    GeneRIF: these results indicate that ADSC-derived exosomes
            ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1
            signaling and promoting macrophage M2 polarization.
REFERENCE   2  (bases 1 to 3810)
  AUTHORS   Autuori,E., Sedlak,P., Xu,L., C Ridder,M., Tedoldi,A. and Sah,P.
  TITLE     rSK1 in Rat Neurons: A Controller of Membrane rSK2?
  JOURNAL   Front Neural Circuits 13, 21 (2019)
   PUBMED   31001092
  REMARK    GeneRIF: rSK1 appears to act as chaperone for rSK2 channels and
            expression of rSK1 may control the level of functional SK current
            in rat neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3810)
  AUTHORS   Wang,Y., Qu,L., Wang,X.L., Gao,L., Li,Z.Z., Gao,G.D. and Yang,Q.
  TITLE     Firing pattern modulation through SK channel current increase
            underlies neuronal survival in an organotypic slice model of
            Parkinson's disease
  JOURNAL   Mol Neurobiol 51 (1), 424-436 (2015)
   PUBMED   24841382
  REMARK    GeneRIF: SK channel current is a substantial element in sustaining
            the substantia nigra pars compacta dopaminergic neuroal rhythmic
            pacemaking.
REFERENCE   4  (bases 1 to 3810)
  AUTHORS   Gymnopoulos,M., Cingolani,L.A., Pedarzani,P. and Stocker,M.
  TITLE     Developmental mapping of small-conductance calcium-activated
            potassium channel expression in the rat nervous system
  JOURNAL   J Comp Neurol 522 (5), 1072-1101 (2014)
   PUBMED   24096910
  REMARK    GeneRIF: This study demonistrated that SK1 and SK2 transcripts
            showed strong expression starting from E15 in the striatum and
            decreased throughout pre- and postnatal development.
REFERENCE   5  (bases 1 to 3810)
  AUTHORS   Gui,L., LaGrange,L.P., Larson,R.A., Gu,M., Zhu,J. and Chen,Q.H.
  TITLE     Role of small conductance calcium-activated potassium channels
            expressed in PVN in regulating sympathetic nerve activity and
            arterial blood pressure in rats
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 303 (3), R301-R310 (2012)
   PUBMED   22647293
  REMARK    GeneRIF: Small conductance Ca(2+)-activated K(+) (SK) channels
            expressed in the hypothalamic paraventricular nucleus play an
            important role in the regulation of sympathetic outflow and
            cardiovascular function.
REFERENCE   6  (bases 1 to 3810)
  AUTHORS   D'hoedt,D., Hirzel,K., Pedarzani,P. and Stocker,M.
  TITLE     Domain analysis of the calcium-activated potassium channel SK1 from
            rat brain. Functional expression and toxin sensitivity
  JOURNAL   J Biol Chem 279 (13), 12088-12092 (2004)
   PUBMED   14761961
  REMARK    GeneRIF: rSK1 subunit is synthesized in cells but does not form
            functional homomeric channels
REFERENCE   7  (bases 1 to 3810)
  AUTHORS   Monaghan,A.S., Benton,D.C., Bahia,P.K., Hosseini,R., Shah,Y.A.,
            Haylett,D.G. and Moss,G.W.
  TITLE     The SK3 subunit of small conductance Ca2+-activated K+ channels
            interacts with both SK1 and SK2 subunits in a heterologous
            expression system
  JOURNAL   J Biol Chem 279 (2), 1003-1009 (2004)
   PUBMED   14559917
REFERENCE   8  (bases 1 to 3810)
  AUTHORS   Shmukler,B.E., Bond,C.T., Wilhelm,S., Bruening-Wright,A.,
            Maylie,J., Adelman,J.P. and Alper,S.L.
  TITLE     Structure and complex transcription pattern of the mouse SK1 K(Ca)
            channel gene, KCNN1
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 36-46 (2001)
   PUBMED   11267657
REFERENCE   9  (bases 1 to 3810)
  AUTHORS   Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K.
  TITLE     hSK4, a member of a novel subfamily of calcium-activated potassium
            channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (20), 11013-11018 (1997)
   PUBMED   9380751
REFERENCE   10 (bases 1 to 3810)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Aug 29, 2022 this sequence version replaced NM_019313.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF000973.1, U69885.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA5760393,
                                    SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-792               JAXUCZ010000016.1  18610769-18611560
            793-906             JAXUCZ010000016.1  18613078-18613191
            907-1377            JAXUCZ010000016.1  18620024-18620494
            1378-1473           JAXUCZ010000016.1  18620784-18620879
            1474-1892           JAXUCZ010000016.1  18622658-18623076
            1893-2034           JAXUCZ010000016.1  18625120-18625261
            2035-2145           JAXUCZ010000016.1  18627070-18627180
            2146-2273           JAXUCZ010000016.1  18628004-18628131
            2274-2282           JAXUCZ010000016.1  18629413-18629421
            2283-2352           JAXUCZ010000016.1  18629636-18629705
            2353-3810           JAXUCZ010000016.1  18631114-18632571
FEATURES             Location/Qualifiers
     source          1..3810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     gene            1..3810
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="potassium calcium-activated channel subfamily N
                     member 1"
                     /db_xref="GeneID:54261"
                     /db_xref="RGD:2962"
     exon            1..792
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..906
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1377
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             988..2598
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /note="potassium channel, calcium activated
                     intermediate/small conductance subfamily N alpha, member
                     1; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 1-like"
                     /codon_start=1
                     /product="small conductance calcium-activated potassium
                     channel protein 1"
                     /protein_id="NP_062186.1"
                     /db_xref="GeneID:54261"
                     /db_xref="RGD:2962"
                     /translation="MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQM
                     MAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRL
                     SDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHARE
                     IQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAA
                     EADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTI
                     CPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVP
                     HTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAA
                     NVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTL
                     ADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPP
                     PWPGPSHLTTAAQSPQSHWLPTTASDCG"
     exon            1378..1473
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1892
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2034
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2145
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2273
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2282
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2352
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..3810
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttagagga caaagcagga cagaaccagc agcccacatt tcagttttgg agagccaccc
       61 cagagtgggc tgggggaact gagtcttggg tctagcccaa gtccgggctc cagactctgc
      121 ttttcggctc cttgagctct ccagacccca ggaggctcat tgttctggct gggtagtttg
      181 accttcacgg tcccgccacc ccggcattcg ccgttagggg cgcagggggg accccatctg
      241 cgtgagcagc accttacaac cagacaccgg gacagagaag ttttctcttc ctgccgctct
      301 ggtcacttag gcaccccacc ccccaacccc aaccaggacc ttccagtctg ggccgcgtca
      361 tcagctgctc gagtctcccg gcgtctctcc ctctcgaccc tcccctgccc caggctcagc
      421 ttcccgcagg agtgcagttc tctgtgggag gcgacagctg ctgcgcctga ctgggttgaa
      481 gggcaagggt tcccggtcct ggtcgcagcc tcagtttacc cgtctgtaaa ctgtgtgtgt
      541 aaagccagcg gataccaagg ttcaccccag cccttggcgt gtcctcggtc actgtcagcc
      601 tcggcggggt gcacgctggg agccgccgcg gaagggacac ctgaccgtcc ccagcgggcc
      661 gcgagggtgg gggtccgcgc tgcagcggcg cgcgcacctc tgttcccacg cccttgcccg
      721 gctgcttgtt cacttggttt tgctctcgga ccaggacgca gggactccag cagctgaagc
      781 tgaagactgc tggtgtggag aagaaaagag ccacgggcag agccatccca cctctgaggg
      841 caacttcaag gcaccaagta acacggacct caggttggtg gtttccagag ccctttacag
      901 cccagggtct gttcggaagc ccttctgctg aaccatgctg ggccccaacg ggcctgctgc
      961 aagtccagcc cacggaggca ggtggccatg agtagccgca gccacaatgg cagtgtgggg
     1021 cggcctctgg gcagtgggcc tggattcctg ggctgggaac ctgtggaccc cgaggcaggc
     1081 cgcccccgac agcccaccca aggccccggc ctgcagatga tggccaaggg tcagcctgct
     1141 gggctgtcac ccagtggccc caggggccac tcccaggcgc aggaggagga agaggaagag
     1201 gaggatgagg acaggccagg ctcagggaag cccccgaccg tcagtcaccg cctgggccac
     1261 cgtagggccc tcttcgagaa gcgtaaacga ctcagtgact atgcactcat ctttggcatg
     1321 ttcgggattg tcgtcatggt gacagaaaca gagctgtcct ggggtgtgta caccaaggag
     1381 tctctgtgct cattcgccct gaaatgccta atcagcctct ccactgtcat cctgcttggc
     1441 cttgtcatcc tctaccacgc ccgagagatc cagctgttcc tggtggacaa tggtgccgat
     1501 gactggcgca ttgccatgac gtgggagcga gtgtccctga tctcgctgga gttggctgtg
     1561 tgtgccatcc acccagtgcc tggccactac cgcttcacat ggacggcgcg gctggccttc
     1621 tccctggtgc cgtcagcagc cgaggcggat gtggatgtgc ttctgtccat ccccatgttt
     1681 ctgcgcctct atctgctggc tcgggtcatg ctcctgcaca gccgcatctt cacggacgca
     1741 tccagtcgca gcatcggagc cctgaaccgt gtcaccttca acacacgctt tgtcaccaag
     1801 acactcatga ccatctgccc tggcactgtg ctgttggtct tcagcatctc ctcctggatc
     1861 gtcgctgcat ggacagtgcg cgtgtgtgag aggtaccatg ataaacagga agtgaccagc
     1921 aacttcctgg gggccatgtg gctcatctcc attaccttcc tgtccatcgg ctacggggac
     1981 atggtgccgc acacctactg tgggaagggc gtgtgtctgc tcaccggcat catgggagca
     2041 ggctgcactg cactcgtggt ggccgtcgtg gcccggaagt tggaactcac caaggctgag
     2101 aaacacgtgc acaacttcat gatggacaca cagctcacca agcgggttaa aaacgccgct
     2161 gcaaacgttc tcagggagac atggctcatc tacaaacaca ccaggctagt gaagaagcca
     2221 gaccaaagcc gggttcggaa acaccagcgt aagttccttc aggccatcca tcaggcgcag
     2281 aagctccgga ctgtgaagat tgaacaaggg aaggtgaatg atcaggccaa cacgctggct
     2341 gacctggcca aggcacagag catcgcatat gaggtggtgt cggagctgca ggcccagcag
     2401 gaggagttgg aggcccgtct ggctgccctg gagagccgcc tggatgtcct aggcgcctcc
     2461 ctgcaggccc taccaagtct catagcccaa gccatatgcc ctctaccacc accctggccc
     2521 gggcccagtc acctgaccac agccgcccag agcccacaaa gccactggct gcccaccacg
     2581 gcatcagact gtgggtgagg gcctgctggt cactagactg cttaatcttg gccattgtgt
     2641 ggccacagct agctcctcac tgttctggac ctccggacga ctgagtttgc aagcttgggt
     2701 ggaactgaac tgactggact ggcattcatt cctctgaggc tggaccatga gatccatggc
     2761 cccttagctg tcccaagccc caggagggca aggagtagta gaaggggggc ctcgacattt
     2821 ctaagtaaat cagaagcctc cagcccactt cctgtttaca tggcaggggg gccatgacca
     2881 tctccccaga ggaggtggat gacccagcct gtgggttcct gaatgggcaa ggacaggggt
     2941 ggaaagtcac tgcccatgca ttgagtactt gctgtataca gggactgata caatgacttt
     3001 tcttcaggat ctaattggag taaggtacaa acaaatgaaa gttgagagag gtgaggccac
     3061 ttgcctgcag tcacacagca atggtctgag gcagacacac ttgtcaaaca gcacaggtgg
     3121 atagattcta cttggggatc ctcatgtcaa agtaagggca cacgggaggg tatgggggca
     3181 gatgtgagag ggtgagaggc cagggttaca gacaagcaaa atcaccacgg tcccttcaga
     3241 cctcaggttc catccagact ttgggtactt ggggaacacc gagacacctc acaggggtag
     3301 gtggcttgtc acaatcaacc atggagccta agtcatggca gcccctgata tggacgttag
     3361 ccacctgtct caggagatag tagacctgaa ctgaatccca ggggcccagc ttggactcta
     3421 caagtttgtg ggcaggagct gtggggtgga gcggggggtg gggctggttt tatttccctg
     3481 ctgctatggg gcaagtctct aaggggaaac aggccaaacc taacccccac aggggtcaga
     3541 cagtaggtgc tcaataaatg ctccctcttc ctgagactgc ccatgaaggc ttgggaaaca
     3601 tagcctcatc cagtcccctc tgagtccagt gttagctcct gtccatgagg aggggactgg
     3661 gatcaaaaca ggaccggaag aagtaaggca ggtcaatgtg acacatgcct ttattcctaa
     3721 cacttgggag gccaaggcag gaggcttgca atgtatgcac agtaagacct gggggtggca
     3781 cagaaataaa caaggctgga ggtgacttga
//
