LOCUS       NP_062186                536 aa            linear   ROD 01-MAY-2025
DEFINITION  small conductance calcium-activated potassium channel protein 1
            [Rattus norvegicus].
ACCESSION   NP_062186
VERSION     NP_062186.1
DBSOURCE    REFSEQ: accession NM_019313.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 536)
  AUTHORS   Deng,S., Zhou,X., Ge,Z., Song,Y., Wang,H., Liu,X. and Zhang,D.
  TITLE     Exosomes from adipose-derived mesenchymal stem cells ameliorate
            cardiac damage after myocardial infarction by activating
            S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization
  JOURNAL   Int J Biochem Cell Biol 114, 105564 (2019)
   PUBMED   31276786
  REMARK    GeneRIF: these results indicate that ADSC-derived exosomes
            ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1
            signaling and promoting macrophage M2 polarization.
REFERENCE   2  (residues 1 to 536)
  AUTHORS   Autuori,E., Sedlak,P., Xu,L., C Ridder,M., Tedoldi,A. and Sah,P.
  TITLE     rSK1 in Rat Neurons: A Controller of Membrane rSK2?
  JOURNAL   Front Neural Circuits 13, 21 (2019)
   PUBMED   31001092
  REMARK    GeneRIF: rSK1 appears to act as chaperone for rSK2 channels and
            expression of rSK1 may control the level of functional SK current
            in rat neurons.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 536)
  AUTHORS   Wang,Y., Qu,L., Wang,X.L., Gao,L., Li,Z.Z., Gao,G.D. and Yang,Q.
  TITLE     Firing pattern modulation through SK channel current increase
            underlies neuronal survival in an organotypic slice model of
            Parkinson's disease
  JOURNAL   Mol Neurobiol 51 (1), 424-436 (2015)
   PUBMED   24841382
  REMARK    GeneRIF: SK channel current is a substantial element in sustaining
            the substantia nigra pars compacta dopaminergic neuroal rhythmic
            pacemaking.
REFERENCE   4  (residues 1 to 536)
  AUTHORS   Gymnopoulos,M., Cingolani,L.A., Pedarzani,P. and Stocker,M.
  TITLE     Developmental mapping of small-conductance calcium-activated
            potassium channel expression in the rat nervous system
  JOURNAL   J Comp Neurol 522 (5), 1072-1101 (2014)
   PUBMED   24096910
  REMARK    GeneRIF: This study demonistrated that SK1 and SK2 transcripts
            showed strong expression starting from E15 in the striatum and
            decreased throughout pre- and postnatal development.
REFERENCE   5  (residues 1 to 536)
  AUTHORS   Gui,L., LaGrange,L.P., Larson,R.A., Gu,M., Zhu,J. and Chen,Q.H.
  TITLE     Role of small conductance calcium-activated potassium channels
            expressed in PVN in regulating sympathetic nerve activity and
            arterial blood pressure in rats
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 303 (3), R301-R310 (2012)
   PUBMED   22647293
  REMARK    GeneRIF: Small conductance Ca(2+)-activated K(+) (SK) channels
            expressed in the hypothalamic paraventricular nucleus play an
            important role in the regulation of sympathetic outflow and
            cardiovascular function.
REFERENCE   6  (residues 1 to 536)
  AUTHORS   D'hoedt,D., Hirzel,K., Pedarzani,P. and Stocker,M.
  TITLE     Domain analysis of the calcium-activated potassium channel SK1 from
            rat brain. Functional expression and toxin sensitivity
  JOURNAL   J Biol Chem 279 (13), 12088-12092 (2004)
   PUBMED   14761961
  REMARK    GeneRIF: rSK1 subunit is synthesized in cells but does not form
            functional homomeric channels
REFERENCE   7  (residues 1 to 536)
  AUTHORS   Monaghan,A.S., Benton,D.C., Bahia,P.K., Hosseini,R., Shah,Y.A.,
            Haylett,D.G. and Moss,G.W.
  TITLE     The SK3 subunit of small conductance Ca2+-activated K+ channels
            interacts with both SK1 and SK2 subunits in a heterologous
            expression system
  JOURNAL   J Biol Chem 279 (2), 1003-1009 (2004)
   PUBMED   14559917
REFERENCE   8  (residues 1 to 536)
  AUTHORS   Shmukler,B.E., Bond,C.T., Wilhelm,S., Bruening-Wright,A.,
            Maylie,J., Adelman,J.P. and Alper,S.L.
  TITLE     Structure and complex transcription pattern of the mouse SK1 K(Ca)
            channel gene, KCNN1
  JOURNAL   Biochim Biophys Acta 1518 (1-2), 36-46 (2001)
   PUBMED   11267657
REFERENCE   9  (residues 1 to 536)
  AUTHORS   Joiner,W.J., Wang,L.Y., Tang,M.D. and Kaczmarek,L.K.
  TITLE     hSK4, a member of a novel subfamily of calcium-activated potassium
            channels
  JOURNAL   Proc Natl Acad Sci U S A 94 (20), 11013-11018 (1997)
   PUBMED   9380751
REFERENCE   10 (residues 1 to 536)
  AUTHORS   Kohler,M., Hirschberg,B., Bond,C.T., Kinzie,J.M., Marrion,N.V.,
            Maylie,J. and Adelman,J.P.
  TITLE     Small-conductance, calcium-activated potassium channels from
            mammalian brain
  JOURNAL   Science 273 (5282), 1709-1714 (1996)
   PUBMED   8781233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF000973.1, U69885.1 [ECO:0000331]
            RNAseq introns       :: partial sample support SAMEA5760393,
                                    SAMN12840105 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..536
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p14"
     Protein         1..536
                     /product="small conductance calcium-activated potassium
                     channel protein 1"
                     /note="potassium channel, calcium activated
                     intermediate/small conductance subfamily N alpha, member
                     1; potassium intermediate/small conductance
                     calcium-activated channel, subfamily N, member 1-like"
                     /calculated_mol_wt=59084
     Region          1..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Region          89..198
                     /region_name="SK_channel"
                     /note="Calcium-activated SK potassium channel; pfam03530"
                     /db_xref="CDD:460958"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Site            136..156
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Site            224..244
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Site            273..293
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Region          287..366
                     /region_name="Ion_trans_2"
                     /note="Ion channel; pfam07885"
                     /db_xref="CDD:462301"
     Site            313..333
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Region          380..459
                     /region_name="Calmodulin-binding. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Region          380..457
                     /region_name="CaMBD"
                     /note="Calmodulin binding domain; pfam02888"
                     /db_xref="CDD:460739"
     Region          413..>503
                     /region_name="EnvC"
                     /note="Septal ring factor EnvC, activator of murein
                     hydrolases AmiA and AmiB [Cell cycle control, cell
                     division, chromosome partitioning]; COG4942"
                     /db_xref="CDD:443969"
     Site            487..507
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     Region          514..536
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70606.2)"
     CDS             1..536
                     /gene="Kcnn1"
                     /gene_synonym="KCa2.1; SK1; SKCa1"
                     /coded_by="NM_019313.2:988..2598"
                     /db_xref="GeneID:54261"
                     /db_xref="RGD:2962"
ORIGIN      
        1 mssrshngsv grplgsgpgf lgwepvdpea grprqptqgp glqmmakgqp aglspsgprg
       61 hsqaqeeeee eededrpgsg kpptvshrlg hrralfekrk rlsdyalifg mfgivvmvte
      121 telswgvytk eslcsfalkc lislstvill glvilyhare iqlflvdnga ddwriamtwe
      181 rvslislela vcaihpvpgh yrftwtarla fslvpsaaea dvdvllsipm flrlyllarv
      241 mllhsriftd assrsigaln rvtfntrfvt ktlmticpgt vllvfsissw ivaawtvrvc
      301 eryhdkqevt snflgamwli sitflsigyg dmvphtycgk gvclltgimg agctalvvav
      361 varkleltka ekhvhnfmmd tqltkrvkna aanvlretwl iykhtrlvkk pdqsrvrkhq
      421 rkflqaihqa qklrtvkieq gkvndqantl adlakaqsia yevvselqaq qeelearlaa
      481 lesrldvlga slqalpslia qaicplpppw pgpshlttaa qspqshwlpt tasdcg
//
