LOCUS       NM_023960               1028 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus potassium calcium-activated channel subfamily M
            regulatory beta subunit 4 (Kcnmb4), mRNA.
ACCESSION   NM_023960
VERSION     NM_023960.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1028)
  AUTHORS   Feng,Y., Liu,Y., Cao,P.X., Sun,X., Li,K.X., Li,X.Y., Liu,L.,
            Wang,H.D., Cui,C.P., Xiong,X., Zhang,H.C., Qiao,G.F. and Li,B.Y.
  TITLE     Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex
            Afferent Neuroexcitation via Negative Regulation on KCNMB4 and
            KCa1.1 beta4-subunit Expression
  JOURNAL   Neuroscience 442, 168-182 (2020)
   PUBMED   32653540
  REMARK    GeneRIF: Estrogen-dependent MicroRNA-504 Expression and Related
            Baroreflex Afferent Neuroexcitation via Negative Regulation on
            KCNMB4 and KCa1.1 beta4-subunit Expression.
REFERENCE   2  (bases 1 to 1028)
  AUTHORS   Zhao,H., Xue,Q., Li,C., Wang,Q., Han,S., Zhou,Y., Yang,T., Xie,Y.,
            Fu,H., Lu,C., Meng,F., Zhang,M., Zhang,Y., Wu,X., Wu,S., Zhuo,M.
            and Xu,H.
  TITLE     Upregulation of Beta4 subunit of BKCa channels in the anterior
            cingulate cortex contributes to mechanical allodynia associated
            anxiety-like behaviors
  JOURNAL   Mol Brain 13 (1), 22 (2020)
   PUBMED   32070382
  REMARK    GeneRIF: Upregulation of Beta4 subunit of BKCa channels in the
            anterior cingulate cortex contributes to mechanical allodynia
            associated anxiety-like behaviors.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1028)
  AUTHORS   Noursadeghi,E., Jafari,A., Saghiri,R., Sauve,R. and Eliassi,A.
  TITLE     Impairment of brain mitochondrial charybdotoxin- and
            ATP-insensitive BK channel activities in diabetes
  JOURNAL   Neuromolecular Med 16 (4), 862-871 (2014)
   PUBMED   25344764
  REMARK    GeneRIF: The results demonstrate a modification in the
            mitochondrial BKCa channel gating properties in membrane
            preparations coming from a streptozotocin model of diabetic rats,
            an effect potentially linked to a change in BKCa beta4 and alpha
            subunits expression.
REFERENCE   4  (bases 1 to 1028)
  AUTHORS   Cox,N., Toro,B., Pacheco-Otalora,L.F., Garrido-Sanabria,E.R. and
            Zarei,M.M.
  TITLE     An endoplasmic reticulum trafficking signal regulates surface
            expression of beta4 subunit of a voltage- and Ca(2)-activated K
            channel
  JOURNAL   Brain Res 1553, 12-23 (2014)
   PUBMED   24486049
  REMARK    GeneRIF: Study shows that beta4 subunit of the MaxiK channel has no
            potential endocytic signal and 2 specific amino acids in the
            functional basic motif retention/retrieval trafficking signal at
            the C-terminus may play a role in controlling cellular excitability
REFERENCE   5  (bases 1 to 1028)
  AUTHORS   Petrik,D., Wang,B. and Brenner,R.
  TITLE     Modulation by the BK accessory beta4 subunit of
            phosphorylation-dependent changes in excitability of dentate gyrus
            granule neurons
  JOURNAL   Eur J Neurosci 34 (5), 695-704 (2011)
   PUBMED   21848922
  REMARK    GeneRIF: These results suggest that fast-gating, type I BK channels
            lacking beta4 can increase neuronal excitability in response to
            reduced phosphatase activity and activation of calcium channels.
REFERENCE   6  (bases 1 to 1028)
  AUTHORS   Berkefeld,H., Sailer,C.A., Bildl,W., Rohde,V., Thumfart,J.O.,
            Eble,S., Klugbauer,N., Reisinger,E., Bischofberger,J., Oliver,D.,
            Knaus,H.G., Schulte,U. and Fakler,B.
  TITLE     BKCa-Cav channel complexes mediate rapid and localized
            Ca2+-activated K+ signaling
  JOURNAL   Science 314 (5799), 615-620 (2006)
   PUBMED   17068255
  REMARK    GeneRIF: brain BKCa channels are assembled into complexes with
            calcium channels Cav1.2, Cav2.1 & Cav2.2; complex formation with
            Cav channels enables BKCa-mediated membrane hyperpolarization
            controlling neuronal firing & release of hormones & transmitters
REFERENCE   7  (bases 1 to 1028)
  AUTHORS   Ha,T.S., Heo,M.S. and Park,C.S.
  TITLE     Functional effects of auxiliary beta4-subunit on rat
            large-conductance Ca(2+)-activated K(+) channel
  JOURNAL   Biophys J 86 (5), 2871-2882 (2004)
   PUBMED   15111404
REFERENCE   8  (bases 1 to 1028)
  AUTHORS   Nehrke,K., Quinn,C.C. and Begenisich,T.
  TITLE     Molecular identification of Ca2+-activated K+ channels in parotid
            acinar cells
  JOURNAL   Am J Physiol Cell Physiol 284 (2), C535-C546 (2003)
   PUBMED   12388098
REFERENCE   9  (bases 1 to 1028)
  AUTHORS   Weiger,T.M., Holmqvist,M.H., Levitan,I.B., Clark,F.T., Sprague,S.,
            Huang,W.J., Ge,P., Wang,C., Lawson,D., Jurman,M.E.,
            Glucksmann,M.A., Silos-Santiago,I., DiStefano,P.S. and Curtis,R.
  TITLE     A novel nervous system beta subunit that downregulates human large
            conductance calcium-dependent potassium channels
  JOURNAL   J Neurosci 20 (10), 3563-3570 (2000)
   PUBMED   10804197
REFERENCE   10 (bases 1 to 1028)
  AUTHORS   Brenner,R., Jegla,T.J., Wickenden,A., Liu,Y. and Aldrich,R.W.
  TITLE     Cloning and functional characterization of novel large conductance
            calcium-activated potassium channel beta subunits, hKCNMB3 and
            hKCNMB4
  JOURNAL   J Biol Chem 275 (9), 6453-6461 (2000)
   PUBMED   10692449
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY028605.1.
            
            On Jun 9, 2003 this sequence version replaced NM_023960.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY028605.1, BC161829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1028
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1028
                     /gene="Kcnmb4"
                     /note="potassium calcium-activated channel subfamily M
                     regulatory beta subunit 4"
                     /db_xref="GeneID:66016"
                     /db_xref="RGD:620728"
     exon            1..354
                     /gene="Kcnmb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..651
                     /gene="Kcnmb4"
                     /note="BKbeta4; slo-beta-4; k(VCA)beta-4; potassium large
                     conductance calcium-activated channel, subfamily M, beta
                     member 4; BK channel subunit beta-4; maxi K channel
                     subunit beta-4; charybdotoxin receptor subunit beta-4;
                     calcium-activated potassium channel, subfamily M subunit
                     beta-4; calcium activated potassium channel beta 4
                     subunit; potassium channel subfamily M regulatory beta
                     subunit 4"
                     /codon_start=1
                     /product="calcium-activated potassium channel subunit
                     beta-4"
                     /protein_id="NP_076450.1"
                     /db_xref="GeneID:66016"
                     /db_xref="RGD:620728"
                     /translation="MAKLRVSYEYTEAEDKSIRLGLFLIVSGILSLFIFGFCWLSPAL
                     QDLQATAANCTVLSVQQIGEVFECTFTCGTDCRGTSQYPCVQVYVNNSESNSRALLHS
                     DQHQLLTNPKCSYIPPCKRENQKNSESVMNWQQYWKDEIGSQPFTCYFNQHQRPEDVL
                     LQRTHDEIVLLHCFLWPVVAFVVGVLIVVLTICAKSLAVKAEAMKKRKFS"
     exon            355..482
                     /gene="Kcnmb4"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1012
                     /gene="Kcnmb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggagagt ggggggcgat ggcgaagctc agggtgtctt acgagtacac ggaagccgaa
       61 gacaagagca tccggctcgg cttgttcctc atcgtctctg gcatcctgtc gctcttcatc
      121 ttcggcttct gctggctcag tcccgccttg caggatctgc aagccacggc ggccaactgc
      181 acggtgctgt cggtgcagca gatcggcgag gtgttcgagt gcaccttcac ctgtggcacc
      241 gactgcaggg gcacctcgca gtatccctgc gtccaggtgt acgtgaacaa ctccgagtcc
      301 aactccaggg cgctgctaca cagcgaccag caccagctcc tgactaaccc caagtgctcc
      361 tatatcccgc cctgtaagag agaaaaccag aagaactcgg aaagtgtcat gaactggcaa
      421 cagtattgga aagatgagat cggttcccag ccattcactt gctattttaa tcaacatcaa
      481 agaccagagg acgttctcct gcagcgcaca catgacgaga ttgtcctcct gcactgcttc
      541 ctctggccgg tggtggcgtt tgtggtgggt gtcctcatcg tggtcctcac catctgtgcc
      601 aagagcctgg cagtcaaggc agaagccatg aagaaacgca agttctctta acggggagga
      661 ggattgtggg aagccaagac cagaggctgc ctcatgggca ctcgcctacc ctgcagagcc
      721 cacatttggt ggcgcaggag atggaagggg ccacaaaagg cctccaagag gcccctccct
      781 caacggcagc agaagcaggc acagctggaa gactggggaa cttgttgctt gtatcccgtg
      841 tgctgtagca atggctaaag ggtcaagctc ttagctctat ggagtgactg tttgggaaac
      901 cctctaagaa gtcggtttcc cttggaaagt tacagtctat tatttgtata gtgtagtata
      961 caaaccatta tgacttatgc tcctcacaaa tattaaaaga cagtgttctg tgaaaaaaaa
     1021 aaaaaaaa
//
