LOCUS       NM_053405               1191 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 9 (Kcnk9), mRNA.
ACCESSION   NM_053405
VERSION     NM_053405.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Garcia,G., Noriega-Navarro,R., Martinez-Rojas,V.A.,
            Gutierrez-Lara,E.J., Oviedo,N. and Murbartian,J.
  TITLE     Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain
  JOURNAL   Eur J Pharmacol 862, 172631 (2019)
   PUBMED   31472119
  REMARK    GeneRIF: Study analyzed TASK-1 and TASK-3 expression in ipsilateral
            and contralateral dorsal root ganglia and dorsal and ventral spinal
            cord of naive and formalin-treated or nerve injured rats.
            Pharmacological and molecular data suggest that TASK-1 and TASK-3
            reduce the nociceptive transmission in acute/chronic inflammatory
            and neuropathic pain suggesting antinociceptive role of these
            channels in inflammatory and neuropathic pain.
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Zhang,H., Dong,H., Cilz,N.I., Kurada,L., Hu,B., Wada,E.,
            Bayliss,D.A., Porter,J.E. and Lei,S.
  TITLE     Neurotensinergic Excitation of Dentate Gyrus Granule Cells via
            Galphaq-Coupled Inhibition of TASK-3 Channels
  JOURNAL   Cereb Cortex 26 (3), 977-990 (2016)
   PUBMED   25405940
  REMARK    GeneRIF: results demonstrate that neurotensin (NT) transiently
            increased the neuronal excitability of dentate gyrus granule cells
            (GCs) by inhibiting TASK-3 channels; NT-mediated increases in
            neuronal excitability facilitate long-term potentiation at the
            perforant path-GC synapses
REFERENCE   3  (bases 1 to 1191)
  AUTHORS   Kubota,K., Ohtake,N., Ohbuchi,K., Mase,A., Imamura,S., Sudo,Y.,
            Miyano,K., Yamamoto,M., Kono,T. and Uezono,Y.
  TITLE     Hydroxy-alpha sanshool induces colonic motor activity in rat
            proximal colon: a possible involvement of KCNK9
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 308 (7), G579-G590 (2015)
   PUBMED   25634809
  REMARK    GeneRIF: Hydroxy-alpha sanshool evokes colonic motility via
            blockage of the neural KCNK9 channel in the colonic myenteric
            plexus.
REFERENCE   4  (bases 1 to 1191)
  AUTHORS   Marinc,C., Derst,C., Pruss,H. and Veh,R.W.
  TITLE     Immunocytochemical localization of TASK-3 protein (K2P9.1) in the
            rat brain
  JOURNAL   Cell Mol Neurobiol 34 (1), 61-70 (2014)
   PUBMED   24077856
  REMARK    GeneRIF: the entire rat brain was immunocytochemically analyzed for
            expression of TASK-3 protein.
REFERENCE   5  (bases 1 to 1191)
  AUTHORS   Blankenship,M.L., Coyle,D.E. and Baccei,M.L.
  TITLE     Transcriptional expression of voltage-gated Na and
            voltage-independent K channels in the developing rat superficial
            dorsal horn
  JOURNAL   Neuroscience 231, 305-314 (2013)
   PUBMED   23219908
  REMARK    GeneRIF: In the dorsal horn of the developing rat, TWIK-related
            acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were
            down-regulated during postnatal development
REFERENCE   6  (bases 1 to 1191)
  AUTHORS   Czirjak,G. and Enyedi,P.
  TITLE     TASK-3 dominates the background potassium conductance in rat
            adrenal glomerulosa cells
  JOURNAL   Mol Endocrinol 16 (3), 621-629 (2002)
   PUBMED   11875121
  REMARK    GeneRIF: TASK-3 dominates the resting potassium conductance of zona
            glomerulosa cells
REFERENCE   7  (bases 1 to 1191)
  AUTHORS   Karschin,C., Wischmeyer,E., Preisig-Muller,R., Rajan,S., Derst,C.,
            Grzeschik,K.H., Daut,J. and Karschin,A.
  TITLE     Expression pattern in brain of TASK-1, TASK-3, and a tandem pore
            domain K(+) channel subunit, TASK-5, associated with the central
            auditory nervous system
  JOURNAL   Mol Cell Neurosci 18 (6), 632-648 (2001)
   PUBMED   11749039
REFERENCE   8  (bases 1 to 1191)
  AUTHORS   Vega-Saenz de Miera,E., Lau,D.H., Zhadina,M., Pountney,D.,
            Coetzee,W.A. and Rudy,B.
  TITLE     KT3.2 and KT3.3, two novel human two-pore K(+) channels closely
            related to TASK-1
  JOURNAL   J Neurophysiol 86 (1), 130-142 (2001)
   PUBMED   11431495
REFERENCE   9  (bases 1 to 1191)
  AUTHORS   Chapman,C.G., Meadows,H.J., Godden,R.J., Campbell,D.A.,
            Duckworth,M., Kelsell,R.E., Murdock,P.R., Randall,A.D., Rennie,G.I.
            and Gloger,I.S.
  TITLE     Cloning, localisation and functional expression of a novel human,
            cerebellum specific, two pore domain potassium channel
  JOURNAL   Brain Res Mol Brain Res 82 (1-2), 74-83 (2000)
   PUBMED   11042359
REFERENCE   10 (bases 1 to 1191)
  AUTHORS   Kim,Y., Bang,H. and Kim,D.
  TITLE     TASK-3, a new member of the tandem pore K(+) channel family
  JOURNAL   J Biol Chem 275 (13), 9340-9347 (2000)
   PUBMED   10734076
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF391084.1.
            
            On Dec 5, 2007 this sequence version replaced NM_053405.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF391084.1, AF192366.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="potassium two pore domain channel subfamily K
                     member 9"
                     /db_xref="GeneID:84429"
                     /db_xref="RGD:621451"
     CDS             1..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /note="two pore potassium channel KT3.2; TWIK-related
                     acid-sensitive K(+) channel 3; acid-sensitive potassium
                     channel protein TASK-3; two pore K(+) channel KT3.2;
                     potassium channel, subfamily K, member 9 (Task-3);
                     potassium channel, two pore domain subfamily K, member 9;
                     potassium channel subfamily K member 9"
                     /codon_start=1
                     /product="potassium channel subfamily K member 9
                     precursor"
                     /protein_id="NP_445857.2"
                     /db_xref="GeneID:84429"
                     /db_xref="RGD:621451"
                     /translation="MKRQNVRTLSLIACTFTYLLVGAAVFDALESDHEMREEEKLKAE
                     EVRLRGKYNISSDDYQQLELVILQSEPHRAGVQWKFAGSFYFAITVITTIGYGHAAPG
                     TDAGKAFCMFYAVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTEVSMENMV
                     TVGFFSCMGTLCLGAAAFSQCEDWSFFHAYYYCFITLTTIGFGDFVALQSKGALQRKP
                     FYVAFSFMYILVGLTVIGAFLNLVVLRFLTMNTDEDLLEGEVAQILAGNPRRVVVRVP
                     QSRKRHHPMYFLRKYGRTLCYLCFPGANWGDDDDDDDDAVENVVVTTPVPPAVAAAAA
                     AATPGPSTRNVRATVHSVSCRVEEIPPDVLRNTYFRSPFGAIPPGMHTCGENHRLHIR
                     RKSI"
     exon            1..283
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /inference="alignment:Splign:2.1.0"
     exon            284..1191
                     /gene="Kcnk9"
                     /gene_synonym="Task-3; Task3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaagcggc agaacgtgcg taccctgtcc ttgatcgcct gtaccttcac ctacctgctg
       61 gtgggtgccg cggtgttcga cgccctcgag tcggaccatg agatgcgcga ggaggagaaa
      121 cttaaagcag aagaggtccg cctcagaggc aagtacaaca tcagctccga tgactaccag
      181 cagctggagc tggtaatcct gcagtctgag ccccaccgcg ctggtgtcca gtggaagttc
      241 gccgggtcct tctacttcgc tatcactgtc atcacaacta tcggatatgg acatgctgca
      301 cctggaaccg atgctggcaa ggccttctgt atgttctatg ctgtgctggg tatccctctg
      361 acgctggtta tgttccagag cctgggcgag cgcatgaaca ccttcgtgcg ctacctgctg
      421 aaacggatca agaagtgctg tggcatgcgc aacactgaag tttctatgga gaacatggtg
      481 accgtcggct tcttttcttg catgggcacc ctgtgccttg gggcggctgc cttttcccag
      541 tgcgaagatt ggagcttctt ccacgcttac tactactgct tcattacact gactactata
      601 gggttcggcg actttgtggc cctgcaatcc aagggtgccc tgcagaggaa gccattctac
      661 gtggccttca gcttcatgta tatcctggtg ggcctgaccg tcatcggtgc cttcctcaat
      721 cttgtggtcc tgcgattcct gaccatgaat accgatgaag atcttctgga gggagaagtt
      781 gcgcagatac ttgctggaaa cccaagacgg gtggttgtcc gtgtgcctca gagtcgcaag
      841 aggcaccacc ccatgtactt cctcaggaaa tacggccgaa ccctgtgcta tctctgcttc
      901 cctggtgcca actggggtga tgatgatgac gatgatgatg acgccgtcga gaatgtcgta
      961 gttactactc ctgttcctcc tgctgttgct gctgctgctg ctgctgctac tcctggtccc
     1021 agtaccagga atgtccgggc tacagtccac tcggtttcct gcagggttga agagatccct
     1081 ccggacgtgc tgaggaacac ctacttccgg tccccattcg gcgccatccc tcctggaatg
     1141 cacacctgcg gggaaaacca caggctgcac atccgtcgca agtccatcta a
//
