LOCUS       NM_053806               1898 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 6 (Kcnk6), mRNA.
ACCESSION   NM_053806 XM_215230
VERSION     NM_053806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1898)
  AUTHORS   Bobak,N., Feliciangeli,S., Chen,C.C., Ben Soussia,I., Bittner,S.,
            Pagnotta,S., Ruck,T., Biel,M., Wahl-Schott,C., Grimm,C., Meuth,S.G.
            and Lesage,F.
  TITLE     Recombinant tandem of pore-domains in a Weakly Inward rectifying K+
            channel 2 (TWIK2) forms active lysosomal channels
  JOURNAL   Sci Rep 7 (1), 649 (2017)
   PUBMED   28381826
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1898)
  AUTHORS   Lloyd,E.E., Pandit,L.M., Crossland,R.F., Marrelli,S.P. and
            Bryan,R.M. Jr.
  TITLE     Endothelium-dependent relaxations in the aorta from K(2p)6.1
            knockout mice
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 305 (1), R60-R67 (2013)
   PUBMED   23637138
REFERENCE   3  (bases 1 to 1898)
  AUTHORS   Buga,A.M., Scholz,C.J., Kumar,S., Herndon,J.G., Alexandru,D.,
            Cojocaru,G.R., Dandekar,T. and Popa-Wagner,A.
  TITLE     Identification of new therapeutic targets by genome-wide analysis
            of gene expression in the ipsilateral cortex of aged rats after
            stroke
  JOURNAL   PLoS One 7 (12), e50985 (2012)
   PUBMED   23251410
REFERENCE   4  (bases 1 to 1898)
  AUTHORS   Lloyd,E.E., Crossland,R.F., Phillips,S.C., Marrelli,S.P.,
            Reddy,A.K., Taffet,G.E., Hartley,C.J. and Bryan,R.M. Jr.
  TITLE     Disruption of K(2P)6.1 produces vascular dysfunction and
            hypertension in mice
  JOURNAL   Hypertension 58 (4), 672-678 (2011)
   PUBMED   21876070
REFERENCE   5  (bases 1 to 1898)
  AUTHORS   Lloyd,E.E., Marrelli,S.P. and Bryan,R.M. Jr.
  TITLE     cGMP does not activate two-pore domain K+ channels in
            cerebrovascular smooth muscle
  JOURNAL   Am J Physiol Heart Circ Physiol 296 (6), H1774-H1780 (2009)
   PUBMED   19363137
  REMARK    GeneRIF: Although K(2P) channels are highly expressed, K(2P)
            currents are not activated via the NO/cGMP pathway in rat middle
            cerebral artery smooth muscle, despite the presence of numerous
            putative PKG phosphorylation sites
REFERENCE   6  (bases 1 to 1898)
  AUTHORS   Popper,P., Winkler,J., Erbe,C.B., Lerch-Gaggl,A., Siebeneich,W. and
            Wackym,P.A.
  TITLE     Distribution of two-pore-domain potassium channels in the adult rat
            vestibular periphery
  JOURNAL   Hear Res 246 (1-2), 1-8 (2008)
   PUBMED   18838117
  REMARK    GeneRIF: K(2P)6.1 (TWIK 2) immunoreactivity was detected in nerve
            terminals, blood vessels hair cells and transitional cells of the
            crista ampullaris and in the somata and neuron fibers of Scarpa's
            ganglia.
REFERENCE   7  (bases 1 to 1898)
  AUTHORS   Patel,A.J., Maingret,F., Magnone,V., Fosset,M., Lazdunski,M. and
            Honore,E.
  TITLE     TWIK-2, an inactivating 2P domain K+ channel
  JOURNAL   J Biol Chem 275 (37), 28722-28730 (2000)
   PUBMED   10887187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF281304.1, JAXUCZ010000001.1 and BF405813.1.
            
            On Oct 11, 2007 this sequence version replaced NM_053806.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.436353.1, AF281304.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840110,
                                           SAMN16676789 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AF281304.1         1-318
            319-764             JAXUCZ010000001.1  93653501-93653946   c
            765-1627            AF281304.1         320-1182
            1628-2073           JAXUCZ010000001.1  93653501-93653946   c
            2074-2343           BF405813.1         1-270               c
FEATURES             Location/Qualifiers
     source          1..1898
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1898
                     /gene="Kcnk6"
                     /gene_synonym="Twik-2; Twik2"
                     /note="potassium two pore domain channel subfamily K
                     member 6"
                     /db_xref="GeneID:116491"
                     /db_xref="RGD:621450"
     CDS             1..942
                     /gene="Kcnk6"
                     /gene_synonym="Twik-2; Twik2"
                     /note="potassium inwardly-rectifying channel, subfamily K,
                     member 6; potassium channel, two pore domain subfamily K,
                     member 6; potassium channel, subfamily K, member 6;
                     potassium channel subfamily K member 6-like"
                     /codon_start=1
                     /product="potassium channel subfamily K member 6"
                     /protein_id="NP_446258.2"
                     /db_xref="GeneID:116491"
                     /db_xref="RGD:621450"
                     /translation="MRRGALLASALVAYAGYLALGALLVARLERPHEARLRAELGTLR
                     EQLLRHSPCVAAHALDAFVERVLAAGRLGRAVLANASGPANASDPAWDFASALFFAST
                     LVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWLSLR
                     WGWHPQRAARWHLVALLMVIVAIFFLIPAAVFAYLEEAWSFLDAFYFCFISLSTIGLG
                     DYVPGEAPGQPYRSLYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDP
                     ARLHQDEDDQVDILDARTDLHQHLSAASHANYASIPR"
     exon            1..322
                     /gene="Kcnk6"
                     /gene_synonym="Twik-2; Twik2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..718
                     /gene="Kcnk6"
                     /gene_synonym="Twik-2; Twik2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1882
                     /gene="Kcnk6"
                     /gene_synonym="Twik-2; Twik2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcggcggg gcgcgctcct ggctagcgcc ctggtcgcct acgccgggta cctggcgctc
       61 ggcgcgctgc ttgtggcgcg gctggagcgg ccgcacgaag cccggctgcg ggcagagctg
      121 gggacgctgc gggagcagct gctgcggcac agcccgtgcg tggcggctca cgccctggac
      181 gccttcgtgg agcgggtgct ggcggcagga cggctggggc gcgcagtgct ggccaacgca
      241 tcgggacccg ccaacgcttc ggaccccgcg tgggactttg cctcggcgct cttcttcgcc
      301 agcacgctag tcaccaccgt gggctatggc tacacgaccc cactgacgga tgcaggcaaa
      361 gccttctcca tcgtttttgc actcctgggc gtgcctatca ccatgctact tctgactgcc
      421 tcagcccagc gcctgtcact gctgctcacc cacgcacccc tgtcctggct gagcctgcgc
      481 tggggctggc acccgcagcg ggcagcccgc tggcacctgg tggccctact gatggtcata
      541 gtggctatat ttttcctgat cccggctgcg gtcttcgcct accttgagga ggcctggagc
      601 tttctggatg ctttctattt ctgcttcatc tctctgtcca ccattggcct gggggactat
      661 gtgcctgggg aagccccggg ccagccttac cgatccctct acaaggtgct tgtcacagca
      721 tacctcttcc tcggccttgt tgccatggtg ctggtgttgc agactttccg ccgtgtttct
      781 gacctccatg gcctcactga actcatcttg ctgccggatc ccgaccctgc caggctccac
      841 caggatgagg atgaccaggt ggacattctg gatgcccgga cagatctgca tcagcatctc
      901 tctgctgcct cccacgctaa ttacgcctcc atccccaggt agctgtcgac ctggacacac
      961 ctggcctggg ctttgggccc catgtgatta gatcaactag aaagcccact cacactctcc
     1021 actgggaggt gaggagtagc cgctttgctc ctgtgtcctc cgctcctcag ggccctgaca
     1081 cagtcatttt ctcctcctat cttttctccc atttcttctc agactctgac cgtttgggct
     1141 ttctgacttt gtgagagtgg tggtttctat gcctttttgt tttgttttgt tcttgttctt
     1201 ctgtatctca ctctcttgca tagtacatct ggcacatcca gttcttctgg gctccaaccc
     1261 tgggctccat ttcagccagt gaggtaaact gaccgactgg tcccttgaca gtgacaagct
     1321 ccagtgggca ccagaagagg caagagtagc caggactgag gagtgaacct gatatgttca
     1381 gggttatctt tcctggggac aggaactaac ccaagacctg ctagtcaaga gaaaaaatag
     1441 tcccttctcc tcaggtgtct atgggccata gtacctgtgg gaagaggcct gcaatgggcc
     1501 agcatctccc tcagtgactt aacaggcaag gaactgaccc aggatatgag ccgagatcca
     1561 agtggcatga gacaagcagc ttagcgtagt tcctgtggtg ataccatgtc ttttactggg
     1621 cattgatggc cgtgggctct ggagccagtc ttcctgggcg tgccctgtga ctgggccatg
     1681 tttcaccaat gcatttggac ggtcactcta cctttcagac tctgtctcct aaatggtgac
     1741 cataataacg cttactctaa aaggcgaact caaccagtag cacatgcctg taacctgagc
     1801 tgaagcagga ggcttgagag ttcaaaggca ggagccaggc aataaaacaa tgtaagcaat
     1861 aaaataataa taatgatgat gaaaaaaaaa aaaaaaaa
//
