LOCUS       NM_001039516            3489 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 5 (Kcnk5), mRNA.
ACCESSION   NM_001039516 XM_001055785
VERSION     NM_001039516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3489)
  AUTHORS   Kim GT, Cho YW, Tak HM, Lee JS, Kim EJ, Han J and Kang D.
  TITLE     Age-related changes in two-pore domain acid-sensitive K channel
            expression in rat dorsal root ganglion neurons
  JOURNAL   Clin Exp Pharmacol Physiol 39 (1), 43-48 (2012)
   PUBMED   22017174
  REMARK    GeneRIF: Results suggest that expression of TASK-2 and TASK-3 (but
            not TASK-1) undergoes age-related changes in dorsal root ganglion
            (DRG) neurons; TASK-2 and TASK-3 are likely to contribute to
            resting membrane potential in DRG neurons in neonates and adults.
REFERENCE   2  (bases 1 to 3489)
  AUTHORS   Ruminot I, Gutierrez R, Pena-Munzenmayer G, Anazco C,
            Sotelo-Hitschfeld T, Lerchundi R, Niemeyer MI, Shull GE and Barros
            LF.
  TITLE     NBCe1 mediates the acute stimulation of astrocytic glycolysis by
            extracellular K+
  JOURNAL   J Neurosci 31 (40), 14264-14271 (2011)
   PUBMED   21976511
REFERENCE   3  (bases 1 to 3489)
  AUTHORS   Niemeyer MI, Cid LP, Pena-Munzenmayer G and Sepulveda FV.
  TITLE     Separate gating mechanisms mediate the regulation of K2P potassium
            channel TASK-2 by intra- and extracellular pH
  JOURNAL   J Biol Chem 285 (22), 16467-16475 (2010)
   PUBMED   20351106
REFERENCE   4  (bases 1 to 3489)
  AUTHORS   Zhang XM, Zhong YM and Yang XL.
  TITLE     TASK-2 is expressed in proximal neurons in the rat retina
  JOURNAL   Neuroreport 20 (10), 946-950 (2009)
   PUBMED   19424094
  REMARK    GeneRIF: In contrast to weak expression in the outer retina, TASK-2
            is strongly expressed in the inner retina. TASK-2 immunoreactivity
            was diffusely distributed throughout the inner plexiform
            layer.(TASK-2)
REFERENCE   5  (bases 1 to 3489)
  AUTHORS   Gabriel A, Abdallah M, Yost CS, Winegar BD and Kindler CH.
  TITLE     Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in
            the rat central nervous system
  JOURNAL   Brain Res Mol Brain Res 98 (1-2), 153-163 (2002)
   PUBMED   11834308
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129068.1.
            
            On or before Jan 11, 2007 this sequence version replaced
            XM_001055785.1, NM_001039516.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129068.1, AM229406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p16"
     gene            1..3489
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /note="potassium two pore domain channel subfamily K
                     member 5"
                     /db_xref="GeneID:364241"
                     /db_xref="RGD:1564985"
     exon            1..531
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1857
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /note="potassium channel, subfamily K, member 5; potassium
                     channel, two pore domain subfamily K, member 5"
                     /codon_start=1
                     /product="potassium channel subfamily K member 5"
                     /protein_id="NP_001034605.1"
                     /db_xref="GeneID:364241"
                     /db_xref="RGD:1564985"
                     /translation="MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLH
                     LLKEFPCLSQEGLDKILQVVSDAADQGVAITGNQTFNNWNWPNAMIFAATVITTIGYG
                     NVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTRRGVSLRKAQI
                     TCTAIFIVWGVLVHLVIPPFVFMVTEEWNYIEGLYYSFITISTIGFGDFVAGVNPSAN
                     YHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKA
                     LQMAGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGERVPGPGHGLGAQGG
                     DGLPSIPASLAPLVVYSKNRVPSLEEVSQTLRNKGHVSRPLGEDAAAQTPKEGYPTSE
                     VFINQLDRISEEGEPWEALDYHPLIFQNANITFENEETGLSDEETSKSSVEDNLTSKE
                     QPQPGPMTEVPSSSTGEFPSSDESTFTSTESELSVPYEKLMNEYNKADSPRGT"
     exon            532..643
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            644..810
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..979
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..3464
                     /gene="Kcnk5"
                     /gene_synonym="TASK2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcgctgg gcgtactgtc gcgcgcagag aggcggcaca cgtgtctccc ggtgtgggtt
       61 ctgagtttca ccctaccctt caggatcgag agattggcgt ggcccccaga ccccttttgg
      121 tgtacgctca ccctggcctg tgtgaacgtg atcctcgcag ttccctgcgc tcagggagcc
      181 aacttggtca agcaactgtc ccgggagcgg cgcgcggggg ggtaccgggc actgcgcatg
      241 cggagctcca aattcaaaca gctgtgtcca gggctgcagg acgggtgaac ccggagctgc
      301 tggaattagg ggactctttc tcctggaggt ggcctttcca gagccatggt ggaccggggt
      361 cccttactca cctcggccat catattctac ctggccatcg gggcggcgat cttcgaagtg
      421 ctggaggagc cacactggaa ggaggccaag aaaaactact atacacagaa actgcatcta
      481 ctcaaggagt ttccgtgcct gagtcaggag ggcctggaca agatcctaca ggtggtgtct
      541 gatgctgcgg atcagggcgt ggccatcacc gggaaccaga ctttcaacaa ctggaactgg
      601 cccaatgcga tgattttcgc agccacagtc atcaccacca tcggttatgg taatgtggct
      661 cccaagaccc cagctgggcg cctcttctgt gtcttctatg gcctgttcgg ggtgccactg
      721 tgcctgacat ggatcagtgc cctgggcaag ttcttcgggg gacgtgccaa gaggctgggc
      781 cagtttctta caaggagagg agtgagcctg aggaaggctc agatcacatg tacggccatc
      841 ttcatcgtgt ggggcgtcct ggtccacctg gtgatcccgc ccttcgtgtt catggtgacg
      901 gaagagtgga actacattga gggcctctac tattccttca tcaccatctc caccattggc
      961 tttggggact ttgtggccgg tgtgaacccc agtgccaact accacgccct ctaccgctac
     1021 tttgtagagc tttggatcta cctggggctg gcttggctgt ccctctttgt caactggaag
     1081 gtgagcatgt ttgtggaagt acacaaagcc atcaagaaga ggaggaggcg gcggaaggaa
     1141 tccttcgaga gctccccaca ctcccggaag gccctgcaga tggccggaag tacggcttcc
     1201 aaggacgtca acatcttcag cttcctatcc aaaaaggagg agacctataa tgacctcatc
     1261 aaacagattg ggaagaaggc aatgaaaaca agtgggggtg gggagagggt cccaggaccc
     1321 ggacacgggc tgggagctca aggcggggat ggcttaccca gcatccctgc atccctggca
     1381 cctttggtgg tctattccaa gaatcgagtg cccagtttgg aagaggtatc tcagactcta
     1441 agaaacaaag gacacgtgtc aaggccactt ggtgaggacg ctgcggcaca gacccccaag
     1501 gaaggttacc caacctccga agtgtttatt aaccaactgg accgtatcag cgaggagggt
     1561 gagccgtggg aagccctgga ctaccacccg ctcattttcc aaaacgccaa catcaccttt
     1621 gagaacgaag aaaccggcct ctctgatgag gagacctcta agtcttccgt ggaggacaac
     1681 ctgacctcaa aggagcagcc tcagccgggg cccatgactg aggtgccctc gagcagcacg
     1741 ggtgaattcc cttcatcgga tgagtccacc ttcaccagca ctgagtcaga gctctctgtg
     1801 ccttatgaga agctgatgaa cgagtacaac aaggcagaca gccccagggg cacgtgaggc
     1861 gggcctggct cccagctgct ttccagtggc ttcctctcac aagggatgtc ctacgatggc
     1921 cagaccctgg ggagaaggct ctggaaatga gatgaggagc cagggacctg cctttccttc
     1981 tgtcctctcc agttggttgc ttccatggga tgcagtgttg gcccaggaca ggcctccatt
     2041 ctgtggccca gtgaggaggc tgctgtcctg ggccttcccg gctggagtat ctgctgactc
     2101 agaggcctac atgtagacct caacactcac cctggaggtc ctgtgtttgc tgctgaagcc
     2161 ttcccccatc gttcggttga ctgtcttacg gttctctgag gccaagagcc tcagctgagt
     2221 tcaccagtgt taatgggcaa agcccttgtg cccggcacta aactagacat ctggaaggag
     2281 gaggaggagg agcttgtaag acccaagggg ttagcatgcg gttctcgggt gttctgggaa
     2341 ggcacagaca tgatgggggt ttggggcacc ttagtacccc agcagtagca gggcctactt
     2401 gcccacctgt tcatcacctc ccagcaagcc ccttactgca aacctcaggg caggggccgt
     2461 gggagagggg acatgtgtat ctcgtatgtg gagccacgct cacctcggat cccctctgaa
     2521 gagcaacagc aggccaaagg tctcctaggc cctgaaagtg caggagaaag atagaagctc
     2581 cgggtgtggt cagagagctc agtaatgagg tgcaggcccc tccgccccag cctaggcgcc
     2641 cacactccca gcccaccgtc tcattttgta gagatccctc actgcccccc ccccccgccc
     2701 ctccacttta acggggcctg tagagtgagg ccaaactgct ctcggctcac ggaactgtga
     2761 attgagcccc tcccctgcct ccagccactg tgtggtgtga gcatgcgcag gtgccagtgg
     2821 gcatgtgtgc gtgcgcatcc tggctgggga gaaaggaaaa tgtgaatctt actggtccag
     2881 ctcctagcgg ctgggaacta gctgccgtat aagtgcttga tgctcagcct tcaaccagcc
     2941 cactctggcc taaatgcttt ttttgttatt aatatttttt taacgaactg tctttttttt
     3001 ttttttatac ccagagccag taaagaacag ggtccctgcc gttgggatgg aggtctgtct
     3061 gtcgggcact ctgttgtcct cccaactcag cttgtccttt gtctagcgag ggagagagag
     3121 acagccgcag gtctcaggtg tggggcagga gatatggagt tcccagctca gctgattacc
     3181 tgcctcagcc cctccccttg ccctgttcgt ttgccaaggg gcgtaatagg gccagagccc
     3241 ccacgttatg acagtgagag gtgtgtgtcc atacgtccgc catcctcaaa gcggttgcat
     3301 aggccacacc ggcctcgggg tgggagaaag agcctggctc ctgtgagatg tcctaagctg
     3361 aatgtcccgg agccatagta accacactgt atgcatgtac tggtggtgaa gacaggtgta
     3421 atttatttta acattttttt ttacaataaa acacatgaac aagcaaaaaa aaaaaaaaaa
     3481 aaaaaaaaa
//
