LOCUS       NM_053804               1756 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 4 (Kcnk4), mRNA.
ACCESSION   NM_053804 XM_008760054
VERSION     NM_053804.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1756)
  AUTHORS   Kanda,H., Noguchi,K. and Dai,Y.
  TITLE     Axonal membrane stretch suppresses neuronal excitability by
            activating mechanosensitive K2P channels at the node of Ranvier
  JOURNAL   Mol Brain 16 (1), 8 (2023)
   PUBMED   36650581
  REMARK    GeneRIF: Axonal membrane stretch suppresses neuronal excitability
            by activating mechanosensitive K2P channels at the node of Ranvier.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1756)
  AUTHORS   Kanda,H., Ling,J., Tonomura,S., Noguchi,K., Matalon,S. and Gu,J.G.
  TITLE     TREK-1 and TRAAK Are Principal K+ Channels at the Nodes of Ranvier
            for Rapid Action Potential Conduction on Mammalian Myelinated
            Afferent Nerves
  JOURNAL   Neuron 104 (5), 960-971 (2019)
   PUBMED   31630908
  REMARK    GeneRIF: we show that TREK-1 and TRAAK are clustered at nodes of
            Ranvier of rat trigeminal Abeta-afferent nerves with a density over
            3,000-fold higher than that on their somas
REFERENCE   3  (bases 1 to 1756)
  AUTHORS   Viatchenko-Karpinski,V., Ling,J. and Gu,J.G.
  TITLE     Characterization of temperature-sensitive leak K+ currents and
            expression of TRAAK, TREK-1, and TREK2 channels in dorsal root
            ganglion neurons of rats
  JOURNAL   Mol Brain 11 (1), 40 (2018)
   PUBMED   29980241
  REMARK    GeneRIF: strong immunoreactivity of TRAAK, TREK-1 and TREK-2
            channels was present mainly in small-sized dorsal root ganglion
            (DRG) neurons of rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1756)
  AUTHORS   Zhang,J., Cao,M., Wu,X., Chen,Y., Liang,W. and Liang,Y.
  TITLE     Enhanced expression of TWIK-related arachidonic acid-activated K+
            channel in the spinal cord of detrusor overactivity rats after
            partial bladder outlet obstruction
  JOURNAL   BMC Urol 15, 100 (2015)
   PUBMED   26444419
  REMARK    GeneRIF: Upregulation of TRAAK was observed in the spinal cord of
            DO rats after chronic PBOO, which may exert a protective effect
            against DO by suppressing the excitability of neurons.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1756)
  AUTHORS   Brohawn,S.G., Campbell,E.B. and MacKinnon,R.
  TITLE     Physical mechanism for gating and mechanosensitivity of the human
            TRAAK K+ channel
  JOURNAL   Nature 516 (7529), 126-130 (2014)
   PUBMED   25471887
REFERENCE   6  (bases 1 to 1756)
  AUTHORS   Pan,Y.P., Xu,X.H. and Wang,X.L.
  TITLE     [mRNA expression alteration of two-pore potassium channels in the
            brain of beta-amyloid peptide25-35-induced memory impaired rats]
  JOURNAL   Yao Xue Xue Bao 38 (10), 721-724 (2003)
   PUBMED   14730890
REFERENCE   7  (bases 1 to 1756)
  AUTHORS   Yamamoto,Y. and Taniguchi,K.
  TITLE     Heterogeneous expression of TASK-3 and TRAAK in rat paraganglionic
            cells
  JOURNAL   Histochem Cell Biol 120 (4), 335-339 (2003)
   PUBMED   14574589
  REMARK    GeneRIF: Localization of the Traak protein was studied.
REFERENCE   8  (bases 1 to 1756)
  AUTHORS   Yamamoto,Y., Kummer,W., Atoji,Y. and Suzuki,Y.
  TITLE     TASK-1, TASK-2, TASK-3 and TRAAK immunoreactivities in the rat
            carotid body
  JOURNAL   Brain Res 950 (1-2), 304-307 (2002)
   PUBMED   12231257
  REMARK    GeneRIF: TRAAK immunoreactivity is detected in type I cells of the
            carotid body and nerve fibers.
REFERENCE   9  (bases 1 to 1756)
  AUTHORS   Ozaita,A. and Vega-Saenz de Miera,E.
  TITLE     Cloning of two transcripts, HKT4.1a and HKT4.1b, from the human
            two-pore K+ channel gene KCNK4. Chromosomal localization, tissue
            distribution and functional expression
  JOURNAL   Brain Res Mol Brain Res 102 (1-2), 18-27 (2002)
   PUBMED   12191490
REFERENCE   10 (bases 1 to 1756)
  AUTHORS   Kim,Y., Bang,H., Gnatenco,C. and Kim,D.
  TITLE     Synergistic interaction and the role of C-terminus in the
            activation of TRAAK K+ channels by pressure, free fatty acids and
            alkali
  JOURNAL   Pflugers Arch 442 (1), 64-72 (2001)
   PUBMED   11374070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 7, 2022 this sequence version replaced
            XM_008760054.3, NM_053804.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.125563.1,
                                           SRR26643298.6861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               JAXUCZ010000001.1  213555656-213555861 c
            207-472             JAXUCZ010000001.1  213553996-213554261 c
            473-599             JAXUCZ010000001.1  213550162-213550288 c
            600-760             JAXUCZ010000001.1  213549876-213550036 c
            761-947             JAXUCZ010000001.1  213549507-213549693 c
            948-1087            JAXUCZ010000001.1  213548986-213549125 c
            1088-1756           JAXUCZ010000001.1  213547577-213548245 c
FEATURES             Location/Qualifiers
     source          1..1756
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1756
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /note="potassium two pore domain channel subfamily K
                     member 4"
                     /db_xref="GeneID:116489"
                     /db_xref="RGD:621449"
     exon            1..206
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     exon            207..472
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1477
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /note="potassium inwardly-rectifying channel, subfamily K,
                     member 4; TWIK-related arachidonic acid-stimulated
                     potassium channel protein; potassium channel subfamily K
                     member 4; potassium channel, two pore domain subfamily K,
                     member 4"
                     /codon_start=1
                     /product="potassium channel subfamily K member 4
                     precursor"
                     /protein_id="NP_446256.3"
                     /db_xref="GeneID:116489"
                     /db_xref="RGD:621449"
                     /translation="MRSTTLLALLALVLLYLVSGALVFQALEQPHEQQVQKDLEDGRD
                     QFLKDHPCVSQKNLEGFIKLVAEALGGGANPETSWTNSSNHSSAWNLGSAFFFSGTII
                     TTIGYGNIALHTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSLRRGIGHIEAVFLK
                     WHVPPGLVRMLSAVLFLLIGCLLFVLTPTFVFSYMESWSKLEAIYFVIVTLTTVGFGD
                     YVPGDGTGQNSPAYQPLVWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQA
                     ASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVAEPAHRPGSPAPAEKVETP
                     PPTASALDYPSENLAFIDESSDTQSERGCALPRAPRGRRRPNPTKKPSRPRGPGRLRD
                     KAVPV"
     exon            473..599
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     exon            600..760
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     exon            761..947
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1087
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1756
                     /gene="Kcnk4"
                     /gene_synonym="KT4.1; TRAAK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccagtaa tagacctaga agattccagg agatgattgt ggcggctgtc ctgagccccg
       61 ggccagctga tgtccaggtt agggcagcac tggggccccg attccagcct ggaaggttgg
      121 actctgcgtc gacccctttc tggctcttct gccactcact ggcctggaca gtacaagatt
      181 ggggagccca gaggctgcag gtgcagtgac cactgctcct caggagctcc ctgctcctcc
      241 ttcccaagct ggaagtggag ctggacctgc ccctggaagg gccatgcgca gcaccacact
      301 cctggccctg ttggcattgg tgctgcttta cttggtatct ggggctctgg tgttccaggc
      361 tctggagcag cctcatgagc agcaggttca gaaggacctg gaagatggcc gagatcagtt
      421 tctgaaggac catccgtgtg tgagccagaa gaacctggag gggttcatca agctcgtggc
      481 tgaagccctg ggagggggcg caaacccaga aaccagttgg accaatagca gcaaccactc
      541 atcagcttgg aacctgggca gcgccttctt tttctcgggg accatcatca ctaccatcgg
      601 ctacggcaat atagccttac acacagatgc tgggcgtctc ttttgtatct tctatgcact
      661 ggtggggatc ccactgttcg ggatgctgct ggctggagtc ggggaccggc tgggctcctc
      721 tctgcgccgg ggcatcggtc acatcgaagc agttttcttg aagtggcatg tgccaccagg
      781 gctggtgaga atgctgtctg cggtgctctt cctgttgatt ggctgcctgc tctttgtcct
      841 cactcctacc ttcgtgttct cctacatgga gagctggagc aagctggaag ccatctactt
      901 tgttatagtg acactcacca ctgtaggctt tggcgattat gtaccaggcg atggcaccgg
      961 gcagaactct ccagcctacc agccgctggt gtggttctgg atcctgtttg gcctagccta
     1021 cttcgcctca gtgctcacca ctatcggcaa ctggttgcga gcggtgtccc gccgaactcg
     1081 cgcagagatg ggtggcctca cggcgcaggc tgctagctgg accggcacag tgacagcacg
     1141 agtgacccag agaactggac ccagcgcccc gccgccagag aaggagcaac cactcctgcc
     1201 ctcttctttg cctgcacctc ctgctgttgc tgagccagcc cacaggcccg gctcccccgc
     1261 acccgcagag aaggtcgaga ctcccccgcc cacggcctca gctctggatt accccagtga
     1321 gaatctggcc ttcatcgacg agtcctcaga cacgcagagt gagcgtggct gtgccctgcc
     1381 tcgtgcgcct cggggtcgcc gccgccccaa cccaacgaag aagccctcca gaccccgggg
     1441 tcctgggcgt cttcgagaca aggccgtgcc ggtgtaggga caggatctct ggcccgcgac
     1501 cctacgccag ggcttcgccc aggcatgctt agcttatttg accaaagagc cctcttttgt
     1561 tccacggaat tgcaacccgg agaggagtcc aatggttgcc aaatgccacc gctcttccct
     1621 ggctggttct tcacatccaa ccatttccaa agcccaccat ccaaggcttt ctgtcttgct
     1681 tccctgccga ttttgccccc acacctcacg actgtgcctc aaaacctgca tcaataaaac
     1741 aaaaagtctg caccaa
//
