LOCUS       NM_033376               2047 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 3 (Kcnk3), mRNA.
ACCESSION   NM_033376
VERSION     NM_033376.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2047)
  AUTHORS   Teixeira-Fonseca,J.L., Joviano-Santos,J.V., Beserra,S.S., de Lima
            Conceicao,M.R., Leal-Silva,P., Marques,L.P., Souza,D.S. and
            Roman-Campos,D.
  TITLE     Exploring the involvement of TASK-1 in the control of isolated rat
            right atrium function from healthy animals and an experimental
            model of monocrotaline-induced pulmonary hypertension
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 396 (12), 3775-3788 (2023)
   PUBMED   37338577
  REMARK    GeneRIF: Exploring the involvement of TASK-1 in the control of
            isolated rat right atrium function from healthy animals and an
            experimental model of monocrotaline-induced pulmonary hypertension.
REFERENCE   2  (bases 1 to 2047)
  AUTHORS   Yu,Y., He,H., Kang,C. and Hu,K.
  TITLE     TASK-1 regulates mitochondrial function under hypoxia
  JOURNAL   Biochem Biophys Res Commun 578, 163-169 (2021)
   PUBMED   34571371
  REMARK    GeneRIF: TASK-1 regulates mitochondrial function under hypoxia.
REFERENCE   3  (bases 1 to 2047)
  AUTHORS   Lambert,M., Mendes-Ferreira,P., Ghigna,M.R., LeRibeuz,H., Adao,R.,
            Boet,A., Capuano,V., Rucker-Martin,C., Bras-Silva,C., Quarck,R.,
            Domergue,V., Vachiery,J.L., Humbert,M., Perros,F., Montani,D. and
            Antigny,F.
  TITLE     Kcnk3 dysfunction exaggerates the development of pulmonary
            hypertension induced by left ventricular pressure overload
  JOURNAL   Cardiovasc Res 117 (12), 2474-2488 (2021)
   PUBMED   33483721
  REMARK    GeneRIF: Kcnk3 dysfunction exaggerates the development of pulmonary
            hypertension induced by left ventricular pressure overload.
REFERENCE   4  (bases 1 to 2047)
  AUTHORS   Callejo,M., Morales-Cano,D., Mondejar-Parreno,G., Barreira,B.,
            Esquivel-Ruiz,S., Olivencia,M.A., Moreno,L., Cogolludo,A. and
            Perez-Vizcaino,F.
  TITLE     Restoration of Vitamin D Levels Improves Endothelial Function and
            Increases TASK-Like K+ Currents in Pulmonary Arterial Hypertension
            Associated with Vitamin D Deficiency
  JOURNAL   Biomolecules 11 (6), 795 (2021)
   PUBMED   34073580
  REMARK    GeneRIF: Restoration of Vitamin D Levels Improves Endothelial
            Function and Increases TASK-Like K(+) Currents in Pulmonary
            Arterial Hypertension Associated with Vitamin D Deficiency.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2047)
  AUTHORS   Hao,X., Li,H., Zhang,P., Yu,X., Jiang,J. and Chen,S.
  TITLE     Down-regulation of lncRNA Gas5 promotes hypoxia-induced pulmonary
            arterial smooth muscle cell proliferation by regulating KCNK3
            expression
  JOURNAL   Eur J Pharmacol 889, 173618 (2020)
   PUBMED   33010302
  REMARK    GeneRIF: Down-regulation of lncRNA Gas5 promotes hypoxia-induced
            pulmonary arterial smooth muscle cell proliferation by regulating
            KCNK3 expression.
REFERENCE   6  (bases 1 to 2047)
  AUTHORS   Girard,C., Tinel,N., Terrenoire,C., Romey,G., Lazdunski,M. and
            Borsotto,M.
  TITLE     p11, an annexin II subunit, an auxiliary protein associated with
            the background K+ channel, TASK-1
  JOURNAL   EMBO J 21 (17), 4439-4448 (2002)
   PUBMED   12198146
REFERENCE   7  (bases 1 to 2047)
  AUTHORS   Han,J., Truell,J., Gnatenco,C. and Kim,D.
  TITLE     Characterization of four types of background potassium channels in
            rat cerebellar granule neurons
  JOURNAL   J Physiol 542 (Pt 2), 431-444 (2002)
   PUBMED   12122143
  REMARK    GeneRIF: Characterization in cerebellar granule neurons
REFERENCE   8  (bases 1 to 2047)
  AUTHORS   Leonoudakis,D., Gray,A.T., Winegar,B.D., Kindler,C.H., Harada,M.,
            Taylor,D.M., Chavez,R.A., Forsayeth,J.R. and Yost,C.S.
  TITLE     An open rectifier potassium channel with two pore domains in tandem
            cloned from rat cerebellum
  JOURNAL   J Neurosci 18 (3), 868-877 (1998)
   PUBMED   9437008
REFERENCE   9  (bases 1 to 2047)
  AUTHORS   Duprat,F., Lesage,F., Fink,M., Reyes,R., Heurteaux,C. and
            Lazdunski,M.
  TITLE     TASK, a human background K+ channel to sense external pH variations
            near physiological pH
  JOURNAL   EMBO J 16 (17), 5464-5471 (1997)
   PUBMED   9312005
REFERENCE   10 (bases 1 to 2047)
  AUTHORS   Wen,D., Suggs,S.V., Karunagaran,D., Liu,N., Cupples,R.L., Luo,Y.,
            Janssen,A.M., Ben-Baruch,N., Trollinger,D.B., Jacobsen,V.L. et al.
  TITLE     Structural and functional aspects of the multiplicity of Neu
            differentiation factors
  JOURNAL   Mol Cell Biol 14 (3), 1909-1919 (1994)
   PUBMED   7509448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000164.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_033376.3.
            
            On Nov 27, 2020 this sequence version replaced NM_033376.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF031384.1, CK602460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-379               JACYVU010000164.1  2086938-2087316     c
            380-2047            JACYVU010000164.1  2051380-2053047     c
FEATURES             Location/Qualifiers
     source          1..2047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..2047
                     /gene="Kcnk3"
                     /gene_synonym="rTASK; Task-1"
                     /note="potassium two pore domain channel subfamily K
                     member 3"
                     /db_xref="GeneID:29553"
                     /db_xref="RGD:61997"
     exon            1..379
                     /gene="Kcnk3"
                     /gene_synonym="rTASK; Task-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1332
                     /gene="Kcnk3"
                     /gene_synonym="rTASK; Task-1"
                     /note="two pore potassium channel KT3.1; TWIK-related
                     acid-sensitive K(+) channel 1; acid-sensitive potassium
                     channel protein TASK-1; two pore K(+) channel KT3.1;
                     TWIK-related acid-sensitive K+ channel; potassium channel,
                     subfamily K, member 3; potassium channel, two pore domain
                     subfamily K, member 3"
                     /codon_start=1
                     /product="potassium channel subfamily K member 3"
                     /protein_id="NP_203694.1"
                     /db_xref="GeneID:29553"
                     /db_xref="RGD:61997"
                     /translation="MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELR
                     QLELRARYNLSEGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPS
                     TDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKRGLGMRHAEVSMANMV
                     LIGFVSCISTLCIGAAAFSYYERWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQP
                     QYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGQAGGLGGL
                     SCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGGSGFRNVYAEMLHFQSMCSCLWYKS
                     REKLQYSIPMIIPRDLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSVS
                     TGLHSLATFRGLMKRRSSV"
     exon            380..2047
                     /gene="Kcnk3"
                     /gene_synonym="rTASK; Task-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccaggcc gcctccgggg cagcagcagc ggcggcggcc ggggccgggg cgcgggccgg
       61 agacgccgga gggccggcga ggacccggga gggacgatga agcggcagaa tgtgcgcacg
      121 ttggctctca tcgtgtgcac cttcacctac ctgctggtgg gcgccgcggt gttcgacgcg
      181 ctggagtcgg agccggagat gatcgagcgg cagcggctgg agctgcggca gctggagctg
      241 cgggcgcgct acaacctcag cgagggcggc tacgaggagc tggagcgcgt cgtgctgcgc
      301 ctcaagccgc acaaggccgg cgtgcagtgg cgcttcgccg gctccttcta cttcgccatc
      361 accgtcatca ccacaatcgg ctatggtcat gcggctccca gcacggacgg aggcaaggtg
      421 ttctgcatgt tctacgcgct gctgggcatc ccgctcacac tagtcatgtt ccagagcctg
      481 ggtgaacgca tcaacacctt cgtgaggtac ctgctgcacc gtgcgaagag ggggctgggc
      541 atgcggcacg ccgaggtgtc catggccaac atggtgctca tcggtttcgt gtcgtgcatc
      601 agcacgctgt gtatcggcgc cgctgccttc tcctactatg agcgctggac tttcttccag
      661 gcctattact actgcttcat caccctcacc accatcggct tcggcgacta cgtggcgctg
      721 cagaaggacc aggcgctgca aacgcagcct cagtacgtgg ccttcagctt cgtatacatc
      781 ctcaccggcc tcacggtcat cggcgccttc ctcaacctcg tggtgctgcg attcatgacc
      841 atgaacgccg aggacgagaa gcgtgatgca gagcaccgtg cgctgctcac gcacaatggc
      901 caggctggcg gcctgggtgg cctgagctgc ctaagcggta gcctgggcga tggcgtgcgt
      961 ccccgcgacc cagtcacttg cgcagcggct gcaggcggca tgggcgtggg cgtgggcgtc
     1021 ggtggcagcg gcttccgcaa cgtctatgct gaaatgctgc actttcagtc catgtgctcg
     1081 tgcctctggt acaagagccg cgagaagctg cagtactcca tccccatgat catcccgcgg
     1141 gacctctcca catccgacac gtgcgtggag cacagccact cgtcgccagg aggcggcggc
     1201 cgctacagcg acacgccctc acacccttgc ctgtgcagcg ggacgcaacg ctcggccatc
     1261 agctccgtgt ccacgggcct gcacagcctg gctaccttcc gcggcctcat gaagcgcagg
     1321 agctcagtgt gaaccacagc caagcctgga gcacctgtga gccagcgggg gtgggggacc
     1381 tgcctgcaga agccgcagga gttggccagg aggcccccca aagacgcctt cgggccccat
     1441 gggaagtccc cagcccatca ccaccgccac ctctactcct ccccagcccc taaatctcca
     1501 actgtgcggg ctttcaccag ccagcaggag gccgggctct gaggacccct ggagccccca
     1561 tcagagcccg aagaattctg agaaatgtga aacttagggg gtggggagac ggggaagcag
     1621 ccacggggag ctgctgagaa gccccccagt cctcagaggc cctgctgggc cccagacccc
     1681 ttgcctccca agggaactaa tgttctaggt ttttgttttc tgttttggtt tggttctcgt
     1741 gtctctctct ctctctctct ctctctctct ctctctctct ctctctctct ctctctctct
     1801 ctctctctca tatctctact tatacctccc ctgggctctc caaagcccaa ggtgtctttg
     1861 tccaggtcac cccccactca gtccctcccg gctctctcat ccccagccat gtctcccagc
     1921 cttccactac cttaatgtgt ccactcccct tctgtttttt gcatggctat gcagttatgg
     1981 aagaaaaaaa aaggaaaccc cagcagtccc taaagctagt ccccagaggg caagatagaa
     2041 gaaaaaa
//
