LOCUS       NM_172042               3159 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 2 (Kcnk2), transcript variant 2, mRNA.
ACCESSION   NM_172042
VERSION     NM_172042.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3159)
  AUTHORS   Li,T., Fei,J., Yu,H., Wang,X., Li,D. and Yin,Z.
  TITLE     Prolonged stretching of rat uteri causes hypoxia and inhibits
            contractility via potassium channel TREK1
  JOURNAL   Reproduction 166 (1), 55-64 (2023)
   PUBMED   37184053
  REMARK    GeneRIF: Prolonged stretching of rat uteri causes hypoxia and
            inhibits contractility via potassium channel TREK1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3159)
  AUTHORS   Kanda,H., Noguchi,K. and Dai,Y.
  TITLE     Axonal membrane stretch suppresses neuronal excitability by
            activating mechanosensitive K2P channels at the node of Ranvier
  JOURNAL   Mol Brain 16 (1), 8 (2023)
   PUBMED   36650581
  REMARK    GeneRIF: Axonal membrane stretch suppresses neuronal excitability
            by activating mechanosensitive K2P channels at the node of Ranvier.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3159)
  AUTHORS   Ulkumen,B., Artunc Ulkumen,B., Batir,M.B., Cam,S. and Vatansever,S.
  TITLE     The Role of TREK-1 and AQP5 in Gonadocorticoid-Related Voice
            Disorders
  JOURNAL   J Voice 36 (2), 150-155 (2022)
   PUBMED   32439217
  REMARK    GeneRIF: The Role of TREK-1 and AQP5 in Gonadocorticoid-Related
            Voice Disorders.
REFERENCE   4  (bases 1 to 3159)
  AUTHORS   Garcia,G., Mendez-Resendiz,K.A., Oviedo,N. and Murbartian,J.
  TITLE     PKC- and PKA-dependent phosphorylation modulates TREK-1 function in
            naive and neuropathic rats
  JOURNAL   J Neurochem 157 (6), 2039-2054 (2021)
   PUBMED   33006141
  REMARK    GeneRIF: PKC- and PKA-dependent phosphorylation modulates TREK-1
            function in naive and neuropathic rats.
REFERENCE   5  (bases 1 to 3159)
  AUTHORS   Li,R., Zhao,K., Ruan,Q., Meng,C. and Yin,F.
  TITLE     The transcription factor Foxd3 induces spinal cord
            ischemia-reperfusion injury by potentiating microRNA-214-dependent
            inhibition of Kcnk2
  JOURNAL   Exp Mol Med 52 (1), 118-129 (2020)
   PUBMED   31959866
  REMARK    GeneRIF: The transcription factor Foxd3 induces spinal cord
            ischemia-reperfusion injury by potentiating microRNA-214-dependent
            inhibition of Kcnk2.
REFERENCE   6  (bases 1 to 3159)
  AUTHORS   Koh,S.D., Monaghan,K., Sergeant,G.P., Ro,S., Walker,R.L.,
            Sanders,K.M. and Horowitz,B.
  TITLE     TREK-1 regulation by nitric oxide and cGMP-dependent protein
            kinase. An essential role in smooth muscle inhibitory
            neurotransmission
  JOURNAL   J Biol Chem 276 (47), 44338-44346 (2001)
   PUBMED   11560940
REFERENCE   7  (bases 1 to 3159)
  AUTHORS   Terrenoire,C., Lauritzen,I., Lesage,F., Romey,G. and Lazdunski,M.
  TITLE     A TREK-1-like potassium channel in atrial cells inhibited by
            beta-adrenergic stimulation and activated by volatile anesthetics
  JOURNAL   Circ Res 89 (4), 336-342 (2001)
   PUBMED   11509450
REFERENCE   8  (bases 1 to 3159)
  AUTHORS   Bockenhauer,D., Zilberberg,N. and Goldstein,S.A.
  TITLE     KCNK2: reversible conversion of a hippocampal potassium leak into a
            voltage-dependent channel
  JOURNAL   Nat Neurosci 4 (5), 486-491 (2001)
   PUBMED   11319556
REFERENCE   9  (bases 1 to 3159)
  AUTHORS   Hervieu,G.J., Cluderay,J.E., Gray,C.W., Green,P.J., Ranson,J.L.,
            Randall,A.D. and Meadows,H.J.
  TITLE     Distribution and expression of TREK-1, a two-pore-domain potassium
            channel, in the adult rat CNS
  JOURNAL   Neuroscience 103 (4), 899-919 (2001)
   PUBMED   11301200
REFERENCE   10 (bases 1 to 3159)
  AUTHORS   Bearzatto,B., Lesage,F., Reyes,R., Lazdunski,M. and Laduron,P.M.
  TITLE     Axonal transport of TREK and TRAAK potassium channels in rat
            sciatic nerves
  JOURNAL   Neuroreport 11 (5), 927-930 (2000)
   PUBMED   10790857
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 27, 2020 this sequence version replaced NM_172042.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF325671.1, SRR26360194.2018308.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000013.1  103438554-103438642 c
            90-400              JAXUCZ010000013.1  103435363-103435673 c
            401-518             JAXUCZ010000013.1  103398568-103398685 c
            519-679             JAXUCZ010000013.1  103356876-103357036 c
            680-866             JAXUCZ010000013.1  103353501-103353687 c
            867-1006            JAXUCZ010000013.1  103340810-103340949 c
            1007-3159           JAXUCZ010000013.1  103297393-103299545 c
FEATURES             Location/Qualifiers
     source          1..3159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..3159
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /note="potassium two pore domain channel subfamily K
                     member 2"
                     /db_xref="GeneID:170899"
                     /db_xref="RGD:621448"
     exon            1..89
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1324
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     tandem-pore-domain potassium channel TREK-1; ion transport
                     membrane protein; arachidonic acid sensitive tandem pore
                     domain potassium channel; potassium channel, two pore
                     domain subfamily K, member 2; TREK-1 K(+) channel subunit;
                     two pore potassium channel TPKC1; two pore domain
                     potassium channel TREK-1; stretch-activated potassium
                     channel TREK-1; outward rectifying potassium channel
                     protein TREK-1; potassium channel subfamily K member 2"
                     /codon_start=1
                     /product="potassium channel subfamily K member 2 isoform
                     2"
                     /protein_id="NP_742039.1"
                     /db_xref="GeneID:170899"
                     /db_xref="RGD:621448"
                     /translation="MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSAKPTVL
                     ASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNF
                     IAQHACVNSTELDELIQQIVTAINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGF
                     GNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQ
                     TKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGG
                     SDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTA
                     NVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSE
                     REVLPPLLKAESIYLNGLTPHCAAEDIAVIENMK"
     exon            90..400
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..518
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..679
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..866
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1006
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..3159
                     /gene="Kcnk2"
                     /gene_synonym="rTREK1d; Trek-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgtgtta aaacaaacaa acattttgaa tgctgcatgc ctcatgcttg ccagcgcctc
       61 gcgggagaga cccggctata ccgcaggagt ggcggcccct gacttgctgg atcccaagtc
      121 tgctgctcag aactccaaac cgaggctctc gttctccgca aaacccaccg tgcttgcttc
      181 ccgggtggag agtgactcgg ccattaatgt tatgaaatgg aagacggtct ccacgatttt
      241 cctggtggtc gtcctctacc tgatcatcgg agccacggtg ttcaaggcgt tggagcagcc
      301 tcaggagatt tctcagagga ccaccattgt gatccagaaa cagaacttca tagcccagca
      361 tgcctgcgtc aactccaccg agctggatga actcatccag caaatagtga cggccataaa
      421 tgcagggatt atccccttag gaaacaactc caatcaagtt agtcactggg acctcggaag
      481 ctctttcttc tttgccggca ctgttatcac aaccatagga tttggaaaca tctccccacg
      541 aactgaaggt ggaaaaatat tctgtatcat ctatgccttg ctgggaattc ccctctttgg
      601 ttttctactg gctggggttg gggatcagct tggaaccata tttggaaaag gaattgccaa
      661 agtggaggac acatttatta agtggaatgt tagtcagacc aagattcgta tcatctcgac
      721 catcatcttc atcctgtttg gctgtgtcct cttcgtggct ctccccgccg tcatattcaa
      781 gcacatagaa ggctggagtg ccctggacgc catctacttt gtggtcatca ctctgaccac
      841 cattggattt ggcgattatg tggcaggtgg gtcggacatt gaatatctgg acttctacaa
      901 gcccgttgtg tggttctgga tcctcgttgg gctggcctac tttgcggctg ttctgagcat
      961 gattggagac tggctacggg tgatatctaa gaagacgaag gaagaggtgg gagagttcag
     1021 agcgcatgcc gctgagtgga cagccaatgt cacagccgag ttcaaggaaa caaggaggcg
     1081 gctgagtgtg gagatctatg acaagttcca gcgtgccacg tccgtgaagc ggaagctctc
     1141 tgcagagctg gcgggtaacc ataaccagga actgactcca tgtaggagga ccctgtcggt
     1201 gaaccacctg accagcgaga gggaagtcct gcctcccttg ctgaaggctg agagcatcta
     1261 tctgaacggt ctgacaccac actgtgctgc tgaagacatc gctgtcattg agaacatgaa
     1321 gtagctctct cttggaagtc tgaggtggag ccatagggaa gggcttctct aggctcctgg
     1381 taactgttgc tggtagcatc taaacgttgt gcatgatgag ctcaaaggaa aagcagatag
     1441 attcacccat ctggtcacct tacatccagg gagtgtggag tcctgaggcg gcactcatga
     1501 ggaggctcct gagctgtccc actgagtggc gagtgacgga cgggcaatgt ctgatacctt
     1561 ttttgtgccc agactgtttc ccttcccctc tctcctaatg tgccataagg cctctgaatg
     1621 aatcagaatg ctttgctagt cgtggagttt ggagggatca gcccttggtc cttcagggtt
     1681 cgcctaactg agcctggata cctgaccact taggaatgac aacatttctt tttgtaaatg
     1741 gcaagaaatt cttacgcagc cttttaccta agaaattttc tgccagtgcc ttatcttatg
     1801 aagaaacaag accctgtctg gtgggcttgt ggttccccct ccccaccctc accctgggct
     1861 cacctctgct gactctcact gcccccctcc cctttgctta ccatgctgga agcgaggcat
     1921 agcttgacag aagaaacaga tgccaaccat gggcacagaa gcaacacggg agctctggtg
     1981 tcctgggcac tgcagagaag ggaggtcaga gaaggcccct ctgagtattt atttgactgg
     2041 cgtaccagtg gtacagctct atatatgtac agagtaataa ttcccagcca ggtaaccttg
     2101 gctgcttcca cacagcaccc ccttcctttt ttctggcagt atttgaagtt tatcatttat
     2161 taatagctag tcatttttaa aggcagaaga ggtaagcaca tacatctgca gtctaagcgg
     2221 tgtaatgagg aaaactgttc agactggtat tccaaggtga cctcagacag tcggtatgga
     2281 ttcattctga tgggaagaaa gcacagagac cacatgtgtg tgcgttgact cacacgctgc
     2341 tcaccgtcgg cttggactag cccacgaggt atagcaggct tgcacacttt tcctaagtgg
     2401 ttcttgccaa actggagggt gaggcgatgc ccttcagaag ggggcacagc cccagccggc
     2461 ccagggtccc tctgtggtca tgactgggtg tgagcacaga ggctggactt gggatcactg
     2521 tgagttttgc acacggaaag atacaggctg ctggcctaca tcatctctaa cactagagaa
     2581 aacgctgagt agcacaatct aaaccccctg agttactttt taagagaagg ctgataactc
     2641 gttataattt aagtttatat cctgtaattc tttttggatg tttcaagatt cagaaaaaaa
     2701 aatcagtacc tgcatctagt aaaccaccac cattccctcc gtgtctgtac tcacacctgc
     2761 tgaacactgt ctgtgtaatt tttaaagccc agaaggaaaa ggagtcctct acctgcaatc
     2821 gcaaaaccga tttcttttcc ttctggggga ggagggatgg gcttacgtga gcacgtggca
     2881 ttcagatgaa agtcttaaga agtaaaccca ggatgtttaa aaacacgaaa agattcatat
     2941 tttccgaaat ttgaatttaa gctgtaaatg taaatatatc cagttcgctt gcagagagta
     3001 cttttataaa cctatgaaga ttctaaccaa aattttagag tgtggggctc tcttacagag
     3061 aaagctatac ccatctcctg aatagccctt cttgaaggct gatgtggtgg gatgtaccac
     3121 gcataaactg tgaactggat ggacaaataa agtttgtaa
//
