LOCUS       NM_001003820            1329 bp    mRNA    linear   ROD 15-OCT-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 18 (Kcnk18), transcript variant 1, mRNA.
ACCESSION   NM_001003820 XM_579106
VERSION     NM_001003820.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Kim,G.T., Siregar,A.S., Kim,E.J., Lee,E.S., Nyiramana,M.M.,
            Woo,M.S., Hah,Y.S., Han,J. and Kang,D.
  TITLE     Upregulation of TRESK Channels Contributes to Motor and Sensory
            Recovery after Spinal Cord Injury
  JOURNAL   Int J Mol Sci 21 (23), 8997 (2020)
   PUBMED   33256222
  REMARK    GeneRIF: Upregulation of TRESK Channels Contributes to Motor and
            Sensory Recovery after Spinal Cord Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Yang,Y., Li,S., Jin,Z.R., Jing,H.B., Zhao,H.Y., Liu,B.H.,
            Liang,Y.J., Liu,L.Y., Cai,J., Wan,Y. and Xing,G.G.
  TITLE     Decreased abundance of TRESK two-pore domain potassium channels in
            sensory neurons underlies the pain associated with bone metastasis
  JOURNAL   Sci Signal 11 (552) (2018)
   PUBMED   30327410
  REMARK    GeneRIF: reduction of functional TRESK channels in DRG neurons
            contributes to the sensitization of nociceptive sensory neurons and
            cancer pain development through enhancing neuronal excitability
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Liu,P., Xiao,Z., Ren,F., Guo,Z., Chen,Z., Zhao,H. and Cao,Y.Q.
  TITLE     Functional analysis of a migraine-associated TRESK K+ channel
            mutation
  JOURNAL   J Neurosci 33 (31), 12810-12824 (2013)
   PUBMED   23904616
  REMARK    GeneRIF: The endogenous TRESK currents control the onset and the
            frequency of action potential in small-diameter TG neurons and the
            frameshift mutation results in hyperexcitability of these neurons.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Egenberger,B., Polleichtner,G., Wischmeyer,E. and Doring,F.
  TITLE     N-linked glycosylation determines cell surface expression of
            two-pore-domain K+ channel TRESK
  JOURNAL   Biochem Biophys Res Commun 391 (2), 1262-1267 (2010)
   PUBMED   20006580
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Yoo,S., Liu,J., Sabbadini,M., Au,P., Xie,G.X. and Yost,C.S.
  TITLE     Regional expression of the anesthetic-activated potassium channel
            TRESK in the rat nervous system
  JOURNAL   Neurosci Lett 465 (1), 79-84 (2009)
   PUBMED   19716403
  REMARK    GeneRIF: These results provide an anatomic basis for identifying
            functional roles of TRESK in the rat nervous system.
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Kang,D., Mariash,E. and Kim,D.
  TITLE     Functional expression of TRESK-2, a new member of the tandem-pore
            K+ channel family
  JOURNAL   J Biol Chem 279 (27), 28063-28070 (2004)
   PUBMED   15123670
  REMARK    GeneRIF: TRESK-2 is a functional member of the K(2P) channel family
            and contributes to the background K+ conductance in many types of
            cells.
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Czirjak,G., Toth,Z.E. and Enyedi,P.
  TITLE     The two-pore domain K+ channel, TRESK, is activated by the
            cytoplasmic calcium signal through calcineurin
  JOURNAL   J Biol Chem 279 (18), 18550-18558 (2004)
   PUBMED   14981085
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Sano,Y., Inamura,K., Miyake,A., Mochizuki,S., Kitada,C., Yokoi,H.,
            Nozawa,K., Okada,H., Matsushime,H. and Furuichi,K.
  TITLE     A novel two-pore domain K+ channel, TRESK, is localized in the
            spinal cord
  JOURNAL   J Biol Chem 278 (30), 27406-27412 (2003)
   PUBMED   12754259
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 17, 2022 this sequence version replaced NM_001003820.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY567970.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               JAXUCZ010000001.1  268360738-268361060
            324-452             JAXUCZ010000001.1  268364215-268364343
            453-1329            JAXUCZ010000001.1  268374136-268375012
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1329
                     /gene="Kcnk18"
                     /gene_synonym="Tresk-2"
                     /note="potassium two pore domain channel subfamily K
                     member 18"
                     /db_xref="GeneID:445371"
                     /db_xref="RGD:1303091"
     exon            1..323
                     /gene="Kcnk18"
                     /gene_synonym="Tresk-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1252
                     /gene="Kcnk18"
                     /gene_synonym="Tresk-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tandem-pore K+ (K(2P)) channel; two-pore-domain potassium
                     channel TRESK; potassium channel, subfamily K, member 18;
                     potassium channel, two pore domain subfamily K, member 18"
                     /codon_start=1
                     /product="potassium channel subfamily K member 18 isoform
                     1"
                     /protein_id="NP_001003820.1"
                     /db_xref="GeneID:445371"
                     /db_xref="RGD:1303091"
                     /translation="MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLP
                     GLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDKLCNILKCNLTVVEGSR
                     KDLCEHLQQLKPQWFKAPEDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYAL
                     FGIPLMFLVLTDIGDILAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKPADE
                     AIPQIVIDAGADELLDPQPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSC
                     PELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCAAAILPFWETDLGFE
                     DAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTL
                     MLFVCQREVSLPC"
     exon            324..452
                     /gene="Kcnk18"
                     /gene_synonym="Tresk-2"
                     /inference="alignment:Splign:2.1.0"
     exon            453..1329
                     /gene="Kcnk18"
                     /gene_synonym="Tresk-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctcccat cctatcctca gatgcatcaa gaggatggag gctgaggagc cacctgaagc
       61 tagaagacgc tgtcccgagg ccctggggaa ggccagcgga tgctgccctg aggccccggg
      121 gaaggccaga ggatgctgtc ctgaggccct gggcaagctt ctgcccggcc tctgcttcct
      181 ttgctgcctg gtaacctatg cgctggtggg tgctgctctc ttctccgctg tcgagggccg
      241 ccctgaccca gaagcagagg agaaccctga gttgaagaag ttcctggaca agctgtgcaa
      301 catcctgaaa tgcaacctga cagtggttga aggtagcagg aaagacctgt gtgagcatct
      361 acagcagctc aagccccagt ggttcaaggc gcctgaggac tggtccttct tgagtgctct
      421 tttcttctgc tgcacagtgt tcagcacagt gggttatggc cacatgtacc ccgtcaccag
      481 gctgggtaag ttcctgtgca tgctatatgc actctttgga atccctttaa tgttcctggt
      541 cctcacagac atcggggaca tcctggccgc catcttatct agggcttaca gccggttcca
      601 ggctctcctt tgcctccccc gagatatctc caagtggcgc ccccttctgc tatgccggaa
      661 gcagactgac agcaaacccg cagatgaagc catccctcag attgtcattg atgctggtgc
      721 agacgagctc ctagacccac agcccagcag ggagcctgca tctcctagct gcaatgtgga
      781 gctgtttgag agattggttg ctcgagagaa acagaacgag ctacaaccac ccatgcggcc
      841 ggtcgagagg agcaactcgt gtcccgagct ggtgctgggg cggctgtcct gttctattct
      901 tagcaatctg gatgaagtgg gccagcaagt ggagaggctg gacatccctc tccccgtcat
      961 cgcgctggtc atcttcgcgt acatctcctg tgcagctgct atcctgccct tctgggagac
     1021 cgacctaggc ttcgaggatg ccttctactt ctgctttgtg acactgacca ccattgggtt
     1081 cggggacatc gtgttagtgc accctcactt cttcctcttc ttctccatct acatcatcgt
     1141 gggcatggag atcctgttca tcgccttcaa actgatgcag aaccggctcc tgcacaccta
     1201 caaaaccctc atgctgtttg tttgccaaag agaggtttcg ctaccttgct aaaaaacaaa
     1261 caaacaaaca aacaaacaaa caacaacaac aacaacaaaa cccccgaggg ttctggtgtc
     1321 tctgtgaca
//
