LOCUS       NM_022293               2032 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 13 (Kcnk13), mRNA.
ACCESSION   NM_022293 XM_234380
VERSION     NM_022293.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2032)
  AUTHORS   You,C., Vandegrift,B.J. and Brodie,M.S.
  TITLE     KCNK13 potassium channels in the ventral tegmental area of rats are
            important for excitation of ventral tegmental area neurons by
            ethanol
  JOURNAL   Alcohol Clin Exp Res 45 (7), 1348-1358 (2021)
   PUBMED   33960499
  REMARK    GeneRIF: KCNK13 potassium channels in the ventral tegmental area of
            rats are important for excitation of ventral tegmental area neurons
            by ethanol.
REFERENCE   2  (bases 1 to 2032)
  AUTHORS   Madry,C., Kyrargyri,V., Arancibia-Carcamo,I.L., Jolivet,R.,
            Kohsaka,S., Bryan,R.M. and Attwell,D.
  TITLE     Microglial Ramification, Surveillance, and Interleukin-1beta
            Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1
  JOURNAL   Neuron 97 (2), 299-312 (2018)
   PUBMED   29290552
  REMARK    GeneRIF: Inhibiting THIK-1 function depolarizes microglia. Block of
            THIK-1 function also inhibits release of the pro-inflammatory
            cytokine interleukin-1beta from activated microglia, consistent
            with K(+) loss being needed for inflammasome assembly.
REFERENCE   3  (bases 1 to 2032)
  AUTHORS   Haskins,W., Benitez,S., Mercado,J.M. and Acosta,C.G.
  TITLE     Cutaneous inflammation regulates THIK1 expression in small C-like
            nociceptor dorsal root ganglion neurons
  JOURNAL   Mol Cell Neurosci 83, 13-26 (2017)
   PUBMED   28676376
  REMARK    GeneRIF: DRG neurons of all sizes express THIK1.  Cutaneous
            inflammation downregulates THIK1 expression in only small DRG
            neurons.
REFERENCE   4  (bases 1 to 2032)
  AUTHORS   Theilig,F., Goranova,I., Hirsch,J.R., Wieske,M., Unsal,S.,
            Bachmann,S., Veh,R.W. and Derst,C.
  TITLE     Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1)
            K channels in the mammalian kidney
  JOURNAL   Cell Physiol Biochem 21 (1-3), 63-74 (2008)
   PUBMED   18209473
  REMARK    GeneRIF: THIK-1 and THIK-2 are abundantly expressed in the proximal
            and distal nephron of the mammalian kidney.
REFERENCE   5  (bases 1 to 2032)
  AUTHORS   Hess,A., Wijayanti,N., Neuschafer-Rube,A.P., Katz,N., Kietzmann,T.
            and Immenschuh,S.
  TITLE     Phorbol ester-dependent activation of peroxiredoxin I gene
            expression via a protein kinase C, Ras, p38 mitogen-activated
            protein kinase signaling pathway
  JOURNAL   J Biol Chem 278 (46), 45419-45434 (2003)
   PUBMED   12960165
REFERENCE   6  (bases 1 to 2032)
  AUTHORS   Rajan,S., Wischmeyer,E., Karschin,C., Preisig-Muller,R.,
            Grzeschik,K.H., Daut,J., Karschin,A. and Derst,C.
  TITLE     THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+
            channels
  JOURNAL   J Biol Chem 276 (10), 7302-7311 (2001)
   PUBMED   11060316
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            [WARNING] On Aug 8, 2024 this sequence was replaced by NM_022293.3.
            
            On Nov 26, 2020 this sequence version replaced NM_022293.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287301.1, SRR26643290.23799.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               JAXUCZ010000006.1  124971809-124972238
            431-2032            JAXUCZ010000006.1  125073272-125074873
FEATURES             Location/Qualifiers
     source          1..2032
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2032
                     /gene="Kcnk13"
                     /gene_synonym="prdx1; THIK-1"
                     /note="potassium two pore domain channel subfamily K
                     member 13"
                     /db_xref="GeneID:64120"
                     /db_xref="RGD:68941"
     exon            1..430
                     /gene="Kcnk13"
                     /gene_synonym="prdx1; THIK-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1314
                     /gene="Kcnk13"
                     /gene_synonym="prdx1; THIK-1"
                     /note="tandem pore domain halothane-inhibited potassium
                     channel 1; tandem pore domain potassium channel THIK-1;
                     potassium channel, subfamily K, member 13; potassium
                     channel, two pore domain subfamily K, member 13"
                     /codon_start=1
                     /product="potassium channel subfamily K member 13"
                     /protein_id="NP_071629.2"
                     /db_xref="GeneID:64120"
                     /db_xref="RGD:68941"
                     /translation="MAGRGCSCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELA
                     QELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATKAGIRMDSVRPRWDFTGAFY
                     FVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITVIAYVMRTC
                     HHQQLRRRGTVARDNGKAPRKGEADSLAGWKPSVYYVMLILCLASVAISCGASALYTT
                     MEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYENEGLYRFVNFFFILMGVCCIYSMF
                     NVISILIKQTVNWILRKLDSGCFPQCQRGLLRSRRNVVMPGNIRNRCNISIETDGVME
                     SDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQTSTSSRDDEFSGGVGAFA
                     VMNNRLAETSGDR"
     exon            431..2032
                     /gene="Kcnk13"
                     /gene_synonym="prdx1; THIK-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagagcg ggctaagatc cgcagagccg gatcttacca ggggcgtggg cacaagtccg
       61 cgggcagcga ccctcgcggg gttgtcctcc agtgccatgg ctggccgcgg ttgcagctgc
      121 agccccggcc acctgaacga ggacaacgcg cgcttcctgc tgctcgcggg gctcatcctg
      181 ctttacctgc tgggcggcgc cgcagtcttc tccgcgctgg agctagcgca ggagctgcag
      241 gccaagcagc gctgggaaga gcgcctggcc aacttcagca ggggccacaa cctgagccgc
      301 gaagagctgc gaggcttcct ccgccactac gaggaagcca ccaaggcggg catccgcatg
      361 gacagcgtgc gccctcgctg ggacttcacg ggcgccttct acttcgtggg cacagtggta
      421 actaccatag ggttcgggat gacgacccca gccacaacgg gagggaaggt ttttctgatc
      481 ttttatggtc tcattggatg tgcgagtacc atcctcttct tcaacctctt tctggagcgg
      541 ctgatcaccg tcatcgccta cgtcatgaga acctgccacc accagcagct gcgcagacgt
      601 gggacggtag cccgggacaa cgggaaggcc cctagaaagg gcgaggcaga cagcctggct
      661 ggctggaagc cctccgtgta ctacgtcatg ctgatcctgt gcttggcatc agtagccatc
      721 tcctgtggag cctcggctct gtacaccacc atggaaggct ggagctactt tgactccgtc
      781 tacttctgtt ttgtggcttt cagcaccatt ggcttcgggg acctggtgag cagccagaac
      841 gctcagtatg agaacgaagg gctctaccgc tttgtcaatt tcttcttcat cctcatgggt
      901 gtctgctgca tctactccat gtttaacgtc atctccatcc tgatcaaaca gacagtgaac
      961 tggatcctga ggaaactgga tagcgggtgc ttcccacaat gccaaagagg actcctgcgg
     1021 tccaggagga acgtggtgat gccgggcaac atccggaaca ggtgcaacat ctccatagag
     1081 acggacgggg tgatggaaag tgacactgat gggcgacgtc tctcggggga gatgatctcc
     1141 atgaaggaca ccaacaaggt ctccctggcc atcctgcaga agcagttgtc cgagatggcc
     1201 aatggtggac cccaccagac cagcacatcc tcccgggatg atgagttctc agggggcgtg
     1261 ggagcctttg cagtaatgaa taacaggttg gcagagacca gtggggacag gtagggacca
     1321 gaagtagctg ccacatgaag aaacccaggg caagtggggg ataggtcact gccacacccc
     1381 cagggacctc agctgtgtct ctggctgttg gaattagcat ctccagtcca gcttttgaaa
     1441 tctgaccttg gccctgggca gcagtaacct ctcaaggttg gggactggag ccatcttccc
     1501 tgactcttac tttacccttg aattcccaat ttcgcgtttg gaattgtctg ggggagatgg
     1561 gtttccgtcc agctttgatc ccctacccca acccggtcat gatccatccc tagggaggga
     1621 aagccccgaa aagcctgact ctgtcatgta gtgtgaatgg cggctgaact tcacccagcc
     1681 cctcaagaaa aggcagcgaa cattcccgaa tgcctctggg ccttgttcta ttattggttc
     1741 cactaatagg gaaaacatct aactttctct ttatatctgc ttctctgttt gggagtcttg
     1801 gtttcgtttt gttttgtttc ctatctgact agtgtatctt tttggatctc agatgataag
     1861 gaaaccaagt ctaccttcaa acctctaagt tgtagcaaga tgaaggcagt gagtcaaaga
     1921 ggaggaaagc tcccatcttg taactaaagc ctaccgctta ctgtgttctt tctgaatggt
     1981 tacacggatt atgtcatttt accagggcct ggagcctgct gtaaaggcaa cc
//
