LOCUS       NM_022292               1891 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 12 (Kcnk12), mRNA.
ACCESSION   NM_022292
VERSION     NM_022292.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1891)
  AUTHORS   Renigunta,V., Zou,X., Kling,S., Schlichthorl,G. and Daut,J.
  TITLE     Breaking the silence: functional expression of the two-pore-domain
            potassium channel THIK-2
  JOURNAL   Pflugers Arch 466 (9), 1735-1745 (2014)
   PUBMED   24297522
  REMARK    GeneRIF: the characteristics of THIK-2 channels can be analysed in
            heterologous expression systems by using trafficking and/or gating
            mutants
REFERENCE   2  (bases 1 to 1891)
  AUTHORS   Theilig,F., Goranova,I., Hirsch,J.R., Wieske,M., Unsal,S.,
            Bachmann,S., Veh,R.W. and Derst,C.
  TITLE     Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1)
            K channels in the mammalian kidney
  JOURNAL   Cell Physiol Biochem 21 (1-3), 63-74 (2008)
   PUBMED   18209473
  REMARK    GeneRIF: THIK-1 and THIK-2 are abundantly expressed in the proximal
            and distal nephron of the mammalian kidney.
REFERENCE   3  (bases 1 to 1891)
  AUTHORS   Rajan,S., Wischmeyer,E., Karschin,C., Preisig-Muller,R.,
            Grzeschik,K.H., Daut,J., Karschin,A. and Derst,C.
  TITLE     THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+
            channels
  JOURNAL   J Biol Chem 276 (10), 7302-7311 (2001)
   PUBMED   11060316
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022292.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF287300.1, SRR26643298.33907.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-879               JAXUCZ010000006.1  12494850-12495728
            880-1891            JAXUCZ010000006.1  12543210-12544221
FEATURES             Location/Qualifiers
     source          1..1891
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..1891
                     /gene="Kcnk12"
                     /gene_synonym="THIK-2"
                     /note="potassium two pore domain channel subfamily K
                     member 12"
                     /db_xref="GeneID:64119"
                     /db_xref="RGD:68940"
     exon            1..879
                     /gene="Kcnk12"
                     /gene_synonym="THIK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             489..1781
                     /gene="Kcnk12"
                     /gene_synonym="THIK-2"
                     /note="tandem pore domain halothane-inhibited potassium
                     channel 2; tandem pore domain potassium channel THIK-2;
                     potassium channel, subfamily K, member 12; potassium
                     channel, two pore domain subfamily K, member 12"
                     /codon_start=1
                     /product="potassium channel subfamily K member 12"
                     /protein_id="NP_071628.1"
                     /db_xref="GeneID:64119"
                     /db_xref="RGD:68940"
                     /translation="MSSRSPRPPPRRCRRRLPRPSCCCCCCRRSHLNEDTGRFVLLAA
                     LIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALA
                     AGVRADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILF
                     FNLFLERIISLLAFIMRACRERQLRRSGLLPATFRRGSALSEADSLAGWKPSVYHVLL
                     ILGLFAVLLACCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYRNQGLY
                     RLGNFLFILLGVCCIYSLFNVISILIKQVLNWMLRKLSCRCCTRCCPAPGAPLSRRNA
                     ITPGSRLRRRLAALGTDPAARDSDAEGRRLSGELISMRDLTASNKVSLALLQKQLSET
                     ANGYPRSVCVNTRQNGFSGGVGALGIMNNRLAETSASR"
     exon            880..1891
                     /gene="Kcnk12"
                     /gene_synonym="THIK-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctaggcg cgaccgatcc ccagtagcct catgggacgc tccagaggac tctctctgtg
       61 ccctgccacc gtgttccgat cctaggcgtc cggactccac ggttcaccct gaccgcaacc
      121 cgcggcctgt ccagagtgga gtatgcggcc cggagccccg tggactccgg ccaccgggcg
      181 gcgctggcct agcttcggag cccagagccc gagggcagca agtgaggagc cgcgagaggc
      241 agtaaggcgt cggggcgcgg agagaagcgc tccagcccgg gtgtccactg ggccgggtga
      301 ccggtgggtg gcctgaacgc cgggcaggag gcggatcgcc ctgccgtccc ggttccgggg
      361 agactgcaga ggggctccgc cgcagcccct gtcttctggc caccatcctc acgctcctgc
      421 tcctgcggcg gggatgtcac ggccccggct ccgagcgccg tcccagcccc ggggctgagc
      481 tgcggaccat gtcctcccgc agcccccggc ccccgccccg ccgctgccgc cgccgcctgc
      541 cgcgcccctc ctgctgctgc tgctgctgcc gccgctcgca cctcaacgag gacaccggac
      601 gcttcgtgct gctggccgcg ctcattggcc tctacctggt ggcgggcgcc accgtcttct
      661 ccgcgctcga gagcccgggc gaggcggagg cgcgggcgcg ctggggcgcc acgctgcgca
      721 acttcagcgc tgcgcacggc gtcgcggagc cggagctgcg cgccttcctc cggcactacg
      781 aggccgcgct ggccgccggg gtccgcgccg acgcgctgcg cccgcgctgg gacttccctg
      841 gagccttcta cttcgtgggc accgtggtgt cgaccatagg tttcggcatg accaccccag
      901 ccacagtggg cgggaaggcc ttcctcatcg cctacggact gttcggctgc gcggggacca
      961 tcctgttctt caacctcttt ctggagcgca tcatctcgct gctggccttc atcatgcgcg
     1021 cctgccggga gcgtcagctg cgccgcagtg gcctgctgcc cgccaccttc cgccgcggct
     1081 cggcgctgtc ggaggccgac agcctggcgg gctggaagcc ctcggtgtat cacgtgctgc
     1141 tcatcctggg cctgttcgcc gtgctgctgg cctgctgcgc ctcggccatg tacaccagcg
     1201 tggagggctg ggactacgtg gactcgctct acttctgctt cgtcaccttc agcaccatcg
     1261 gcttcgggga cctggtgagc agccagcacg ccgcctaccg gaaccagggg ctctaccgtc
     1321 tgggcaactt cctcttcatc ctgctcggcg tgtgctgcat ctactcgctc ttcaacgtca
     1381 tctccatcct catcaagcag gtgctcaact ggatgctgcg caagctgagc tgccgctgct
     1441 gcacgcgctg ctgcccggct cccggcgcgc ccctgtcccg gcgcaacgcc atcaccccgg
     1501 gctcccggct gcgccgtcgc ctggccgcgc tgggtaccga ccccgcggct cgcgacagcg
     1561 acgccgaggg ccgccgcctg tcgggagagc tcatctcaat gcgcgacctc acggcgtcca
     1621 acaaggtgtc gctggcactg ctgcagaagc agctttccga gacggccaac ggctacccgc
     1681 gcagcgtgtg cgtcaacacg cgccagaacg gcttctcggg cggcgtgggc gcgctgggca
     1741 tcatgaacaa ccggctggca gagaccagcg cctccaggta gagcggccgc ccgcccccag
     1801 cgccgcggac ctggccgggg ctgcgcgccg ccgggcgggt ttgcttcact tctctccgag
     1861 atggcgcttt cttaatcttt atccaataaa a
//
