LOCUS       NM_023096               3057 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 10 (Kcnk10), mRNA.
ACCESSION   NM_023096
VERSION     NM_023096.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3057)
  AUTHORS   Messina,D.N., Peralta,E.D. and Acosta,C.G.
  TITLE     Glial-derived neurotrophic factor regulates the expression of TREK2
            in rat primary sensory neurons leading to attenuation of
            axotomy-induced neuropathic pain
  JOURNAL   Exp Neurol 357, 114190 (2022)
   PUBMED   35907583
  REMARK    GeneRIF: Glial-derived neurotrophic factor regulates the expression
            of TREK2 in rat primary sensory neurons leading to attenuation of
            axotomy-induced neuropathic pain.
REFERENCE   2  (bases 1 to 3057)
  AUTHORS   Chang,Y.T., Ling,J. and Gu,J.G.
  TITLE     Effects of GABAB receptor activation on excitability of
            IB4-positive maxillary trigeminal ganglion neurons: Possible
            involvement of TREK2 activation
  JOURNAL   Mol Pain 17, 17448069211042963 (2021)
   PUBMED   34461754
  REMARK    GeneRIF: Effects of GABAB receptor activation on excitability of
            IB4-positive maxillary trigeminal ganglion neurons: Possible
            involvement of TREK2 activation.
REFERENCE   3  (bases 1 to 3057)
  AUTHORS   Viatchenko-Karpinski,V., Ling,J. and Gu,J.G.
  TITLE     Characterization of temperature-sensitive leak K+ currents and
            expression of TRAAK, TREK-1, and TREK2 channels in dorsal root
            ganglion neurons of rats
  JOURNAL   Mol Brain 11 (1), 40 (2018)
   PUBMED   29980241
  REMARK    GeneRIF: strong immunoreactivity of TRAAK, TREK-1 and TREK-2
            channels was present mainly in small-sized dorsal root ganglion
            (DRG) neurons of rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3057)
  AUTHORS   Haenisch,S., von Ruden,E.L., Wahmkow,H., Rettenbeck,M.L.,
            Michler,C., Russmann,V., Bruckmueller,H., Waetzig,V., Cascorbi,I.
            and Potschka,H.
  TITLE     miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium
            Channel in a Rat Epilepsy Model
  JOURNAL   ACS Chem Neurosci 7 (11), 1585-1594 (2016)
   PUBMED   27609046
  REMARK    GeneRIF: Data do not suggest a relevant impact of miRNA expression
            patterns on the pharmacoresponsiveness of temporal lobe epilepsy;
            but confirmed the regulation of the previously described
            miRNA-187-3p and demonstrated that its regulation can exert an
            impact on the expression of the two-pore domain potassium channel
            protein KCNK10/TREK-2.
REFERENCE   5  (bases 1 to 3057)
  AUTHORS   Rivera-Pagan,A.F., Rivera-Aponte,D.E., Melnik-Martinez,K.V.,
            Zayas-Santiago,A., Kucheryavykh,L.Y., Martins,A.H., Cubano,L.A.,
            Skatchkov,S.N. and Eaton,M.J.
  TITLE     Up-regulation of TREK-2 potassium channels in cultured astrocytes
            requires de novo protein synthesis: relevance to localization of
            TREK-2 channels in astrocytes after transient cerebral ischemia
  JOURNAL   PLoS One 10 (4), e0125195 (2015)
   PUBMED   25886567
  REMARK    GeneRIF: Up-regulation of TREK-2 potassium channels in cultured
            astrocytes requires de novo protein synthesis.TREK-2 channels are
            up-regulated in the astrocytic membrane during ischemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3057)
  AUTHORS   Pan,Y.P., Xu,X.H. and Wang,X.L.
  TITLE     [mRNA expression alteration of two-pore potassium channels in the
            brain of beta-amyloid peptide25-35-induced memory impaired rats]
  JOURNAL   Yao Xue Xue Bao 38 (10), 721-724 (2003)
   PUBMED   14730890
REFERENCE   7  (bases 1 to 3057)
  AUTHORS   Han,J., Truell,J., Gnatenco,C. and Kim,D.
  TITLE     Characterization of four types of background potassium channels in
            rat cerebellar granule neurons
  JOURNAL   J Physiol 542 (Pt 2), 431-444 (2002)
   PUBMED   12122143
  REMARK    GeneRIF: Characterization in cerebellar granule neurons
REFERENCE   8  (bases 1 to 3057)
  AUTHORS   Gnatenco,C., Han,J., Snyder,A.K. and Kim,D.
  TITLE     Functional expression of TREK-2 K+ channel in cultured rat brain
            astrocytes
  JOURNAL   Brain Res 931 (1), 56-67 (2002)
   PUBMED   11897089
  REMARK    GeneRIF: is functionally expressed in cortical astrocytes in
            culture, and may be involved in K+ homeostasis of astrocytes during
            pathological states
REFERENCE   9  (bases 1 to 3057)
  AUTHORS   Gu,W., Schlichthorl,G., Hirsch,J.R., Engels,H., Karschin,C.,
            Karschin,A., Derst,C., Steinlein,O.K. and Daut,J.
  TITLE     Expression pattern and functional characteristics of two novel
            splice variants of the two-pore-domain potassium channel TREK-2
  JOURNAL   J Physiol 539 (Pt 3), 657-668 (2002)
   PUBMED   11897838
REFERENCE   10 (bases 1 to 3057)
  AUTHORS   Bang,H., Kim,Y. and Kim,D.
  TITLE     TREK-2, a new member of the mechanosensitive tandem-pore K+ channel
            family
  JOURNAL   J Biol Chem 275 (23), 17412-17419 (2000)
   PUBMED   10747911
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_023096.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF385401.1, AF196965.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               JAXUCZ010000006.1  123551768-123552184 c
            418-752             JAXUCZ010000006.1  123496259-123496593 c
            753-870             JAXUCZ010000006.1  123476787-123476904 c
            871-1031            JAXUCZ010000006.1  123468168-123468328 c
            1032-1218           JAXUCZ010000006.1  123430676-123430862 c
            1219-1361           JAXUCZ010000006.1  123428082-123428224 c
            1362-3057           JAXUCZ010000006.1  123423950-123425645 c
FEATURES             Location/Qualifiers
     source          1..3057
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..3057
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /note="potassium two pore domain channel subfamily K
                     member 10"
                     /db_xref="GeneID:65272"
                     /db_xref="RGD:619732"
     exon            1..417
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..1982
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /note="TREK-2 K(+) channel subunit; outward rectifying
                     potassium channel protein TREK-2; potassium channel
                     TREK-2; potassium channel, subfamily K, member 10;
                     potassium channel, two pore domain subfamily K, member 10"
                     /codon_start=1
                     /product="potassium channel subfamily K member 10"
                     /protein_id="NP_075584.1"
                     /db_xref="GeneID:65272"
                     /db_xref="RGD:619732"
                     /translation="MKFPIETPRKQVNWDPKVAVPAAAPPVCQPKSATNGHHPVPRLS
                     ISSRATVVARMEGASQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQK
                     NTIALEKAEFLRDHICVSPQELETLIQHALDADNAGVSPVGNSSNSSSHWDLGSAFFF
                     AGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
                     KVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
                     VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVG
                     EIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDML
                     SPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGST
                     SKLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEDETEKMCNSDNSSTAMLTECI
                     QQQAEMENGMVPMDTKDQGLENNSLLEDRN"
     exon            418..752
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..870
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1031
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1218
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1361
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..3057
                     /gene="Kcnk10"
                     /gene_synonym="TREK2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccggctccgc ctggccgctg ctcagcctcg catctgtcta ccgcgctgct gcagaagcag
       61 cccggctctt tcacggaacc accctcagca tcccatctta ctttttcttt cacccacaag
      121 ggcagcagct ggccaccccc ttaaccggtg caaacaccca accaagccag tgctcgttcg
      181 gtgcttccct cagctagtat tttcccgctt atctttctcc cgggctcccc acgagccact
      241 tcaaggctcg tccatcgtcc caaattcttc cgttggtctg tttaaccggc gagttgtaaa
      301 tcttgaagac tttattattt tattttgatt cttttcattt catcccccct gtgggcaacg
      361 gagcaatgaa atttccaatc gagacgccaa gaaagcaggt gaactgggat cctaaagtgg
      421 ccgtgcctgc agcagcccca ccagtgtgcc agcccaagag tgccactaac gggcaccatc
      481 ctgttcctcg actctccatt tcctccagag ccacggtggt agccaggatg gaaggcgcct
      541 cccagggagg cctgcaaaca gttatgaaat ggaaaacagt ggttgccatc tttgtggtgg
      601 tcgtggtcta cctcgtcacc ggtggccttg tcttccgggc attggaacag ccctttgaga
      661 gcagtcagaa gaacacaatt gccttggaga aggcagaatt cttgagagat catatctgtg
      721 tgagccccca ggaactggag acactgatcc agcacgcact tgatgctgat aatgcagggg
      781 tcagcccggt aggaaactcc tccaacagca gcagtcactg ggacctcgga agtgccttct
      841 tctttgctgg gacggtcatc acgaccatag ggtatgggaa tattgctccg agtactgaag
      901 gaggcaaaat cttttgtatt ttatacgcca tctttgggat cccgctcttc ggtttcttat
      961 tggctggaat tggagaccaa cttggaacca tctttggcaa aagcattgca agagtggaaa
     1021 aggttttccg aaaaaagcaa gtgagtcaga ccaagatccg ggtcatctca actattcttt
     1081 tcatcttggc tggctgcatc gtgtttgtga cgatccctgc tgtcatcttt aaatacatag
     1141 agggctggac cgccttggag tccatctact ttgtggtagt cactctgacc acagtgggct
     1201 ttggtgattt tgtggcaggg ggaaatgctg gcatcaatta ccgagaatgg tacaagccgc
     1261 tggtgtggtt ttggatcctt gttggccttg cctactttgc agctgtcctc agtatgattg
     1321 gagactggct gcgagtttta tccaaaaaga caaaagaaga ggtgggtgag atcaaagccc
     1381 atgcagctga atggaaggct aatgtcactg ctgagttccg ggagacgaga cgacggctca
     1441 gcgttgagat ccatgacaag ctgcaacggg cagccaccat ccgaagtatg gagcgccgga
     1501 gactgggatt ggaccagagg gcccactcac tggacatgct ttcccccgag aagcgctctg
     1561 tctttgcagc cctggacaca ggccgtttca aggcctcatc ccaggagagt atcaacaaca
     1621 gacccaataa cctacgcctt aaggggccag aacagctcaa caaacacggg cagggcgctt
     1681 ctgaggacaa catcatcaac aagtttgggt ccacctccaa actcacaaag aggaaaaaca
     1741 aagatctcaa aaagacctta cctgaggatg ttcagaaaat ctacaaaacc ttccggaatt
     1801 actctctgga tgaagagaag aaagaggacg agacagagaa gatgtgtaac tcagacaact
     1861 ccagcacagc catgctgaca gagtgcatac agcagcaagc tgagatggag aatggaatgg
     1921 tacccatgga caccaaagac caggggctgg agaacaattc tttacttgaa gacagaaact
     1981 aaatgttaaa gacactggag ctggactaag tgttgtcttg tttttgtttg ttcttgtttt
     2041 gttttgtttt ctgtcttgtt tttgttttaa tattcacact gagacacgtg ccttaaatag
     2101 acttgttagt ccaaaattac atagcattga atatatttca ctgtgccata cacaactgaa
     2161 agcttgctct gccaaaatga gtcaaacaag acctttgttt caaatagtgg tggcaggacc
     2221 catgggagca tttgcacagg tagcaggtgt cggctattcc tgtgagggga gttccaatgg
     2281 cagtgctata gtctcctcac acagtgccac cctggcatgg tacacaggca aggcagcttt
     2341 ccctcagacc agcctctgag aggacaggtt tgacttttga attgagtctc ctttccccaa
     2401 ccaaccctta gtgataggtt gtgcacagaa ggggtggctg tttgcgaggg acctggtgac
     2461 tctagcaagg gtttgagtgg acattttgac aggccacgtg cagaacacct actccgaaat
     2521 gaatgtcctt gggacccaag agtacctggg aaactgttca gagcacacat attttataag
     2581 gtgcaattgc ttttctcatt aaaaaaaaaa tcacagacac atcccactgt ggatatctcc
     2641 ttaaccaatg acagacgtcc actgaacttt atcctcacgg gatatgtaat gcaggcgggc
     2701 tcgcaagctt tggtgaacac accgcctcag cctctgcctc gtttggaagg cagatcatgc
     2761 attttcttca gtgggtgtga aggtaaaaaa ataaactgat tttggaacat tcatactcac
     2821 ttttctatgg gaactttaat tataactcgt tttgatagga gggcggaaat accaaaatta
     2881 ttgcctttgc atgataccag tggcttgctg ttctgtctag ctgctcctaa ttttttttta
     2941 aataaagata aaagtagaca tcttgcattt gtgagacaca ccgaggagga ccatggcatc
     3001 tttccatctc agggcttcct gtccttttgg gtgtcttaga gtagacttag ctatggg
//
