LOCUS       NM_021688               2530 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Rattus norvegicus potassium two pore domain channel subfamily K
            member 1 (Kcnk1), mRNA.
ACCESSION   NM_021688
VERSION     NM_021688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Jia,S., Wei,G., Bono,J., Pan,Z., Zheng,B., Wang,B., Adaralegbe,A.,
            Tenorio,C., Bekker,A. and Tao,Y.X.
  TITLE     TET1 overexpression attenuates paclitaxel-induced neuropathic pain
            through rescuing K2p1.1 expression in primary sensory neurons of
            male rats
  JOURNAL   Life Sci 297, 120486 (2022)
   PUBMED   35304127
  REMARK    GeneRIF: TET1 overexpression attenuates paclitaxel-induced
            neuropathic pain through rescuing K2p1.1 expression in primary
            sensory neurons of male rats.
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Rhodin,K., Divaris,K., North,K.E., Barros,S.P., Moss,K., Beck,J.D.
            and Offenbacher,S.
  TITLE     Chronic periodontitis genome-wide association studies: gene-centric
            and gene set enrichment analyses
  JOURNAL   J Dent Res 93 (9), 882-890 (2014)
   PUBMED   25056994
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Ma,L., Zhang,X., Zhou,M. and Chen,H.
  TITLE     Acid-sensitive TWIK and TASK two-pore domain potassium channels
            change ion selectivity and become permeable to sodium in
            extracellular acidification
  JOURNAL   J Biol Chem 287 (44), 37145-37153 (2012)
   PUBMED   22948150
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Miller,A.N. and Long,S.B.
  TITLE     Crystal structure of the human two-pore domain potassium channel
            K2P1
  JOURNAL   Science 335 (6067), 432-436 (2012)
   PUBMED   22282804
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Ma,L., Zhang,X. and Chen,H.
  TITLE     TWIK-1 two-pore domain potassium channels change ion selectivity
            and conduct inward leak sodium currents in hypokalemia
  JOURNAL   Sci Signal 4 (176), ra37 (2011)
   PUBMED   21653227
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Washburn,C.P., Bayliss,D.A. and Guyenet,P.G.
  TITLE     Cardiorespiratory neurons of the rat ventrolateral medulla contain
            TASK-1 and TASK-3 channel mRNA
  JOURNAL   Respir Physiol Neurobiol 138 (1), 19-35 (2003)
   PUBMED   14519375
  REMARK    GeneRIF: TASK-1 mRNA is present in ventrolateral medulla neurons
            that regulate respiration or circulation (C1 adrenergic neurons).
            TASK channels are expressed by respiratory cells with putative
            rhythmogenic function and by premotor and motor neurons.
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Nicolas,M.T., Barhanin,J., Reyes,R. and Dememes,D.
  TITLE     Cellular localization of TWIK-1, a two-pore-domain potassium
            channel in the rodent inner ear
  JOURNAL   Hear Res 181 (1-2), 20-26 (2003)
   PUBMED   12855359
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Konu,O., Kane,J.K., Barrett,T., Vawter,M.P., Chang,R., Ma,J.Z.,
            Donovan,D.M., Sharp,B., Becker,K.G. and Li,M.D.
  TITLE     Region-specific transcriptional response to chronic nicotine in rat
            brain
  JOURNAL   Brain Res 909 (1-2), 194-203 (2001)
   PUBMED   11478936
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Cluzeaud,F., Reyes,R., Escoubet,B., Fay,M., Lazdunski,M.,
            Bonvalet,J.P., Lesage,F. and Farman,N.
  TITLE     Expression of TWIK-1, a novel weakly inward rectifying potassium
            channel in rat kidney
  JOURNAL   Am J Physiol 275 (6), C1602-C1609 (1998)
   PUBMED   9843722
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Lesage,F., Lauritzen,I., Duprat,F., Reyes,R., Fink,M., Heurteaux,C.
            and Lazdunski,M.
  TITLE     The structure, function and distribution of the mouse TWIK-1 K+
            channel
  JOURNAL   FEBS Lett 402 (1), 28-32 (1997)
   PUBMED   9013852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC061807.1 and JAXUCZ010000019.1.
            
            On Oct 25, 2007 this sequence version replaced NM_021688.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.59977.1,
                                           SRR26643297.52114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1325              BC061807.1         1-1325
            1326-2530           JAXUCZ010000019.1  70893849-70895053
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..2530
                     /gene="Kcnk1"
                     /gene_synonym="Twik"
                     /note="potassium two pore domain channel subfamily K
                     member 1"
                     /db_xref="GeneID:59324"
                     /db_xref="RGD:621447"
     exon            1..378
                     /gene="Kcnk1"
                     /gene_synonym="Twik"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1034
                     /gene="Kcnk1"
                     /gene_synonym="Twik"
                     /note="rTWIK; inward rectifying potassium channel protein
                     TWIK-1; putative potassium channel TWIK; potassium
                     channel, subfamily K, member 1; potassium channel K2P1;
                     potassium channel, two pore domain subfamily K, member 1"
                     /codon_start=1
                     /product="potassium channel subfamily K member 1"
                     /protein_id="NP_067720.1"
                     /db_xref="GeneID:59324"
                     /db_xref="RGD:621447"
                     /translation="MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSV
                     ELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGVSVLSNASGNWNW
                     DFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHV
                     TRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYF
                     CFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKF
                     RKMFYVKKDKDEDQVHIMEHDQLSFSSITEQAAGLKEEQKQNEPFVASQSPPYEDGSA
                     NH"
     exon            379..774
                     /gene="Kcnk1"
                     /gene_synonym="Twik"
                     /inference="alignment:Splign:2.1.0"
     exon            775..2530
                     /gene="Kcnk1"
                     /gene_synonym="Twik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggagcgc gggcgccggg aagatgctgc agtccctggc cggcagctcg tgcgtgcgcc
       61 tggtggagcg gcaccgctcg gcctggtgct tcggcttcct ggtgctgggc tacctgctct
      121 acctggtgtt cggcgccgtg gtcttctcgt ccgtggagct gccttatgag gacctgctgc
      181 gccaggagct gcgcaagctg aagcggcgct tcctggagga gcacgagtgc ctgtcggagc
      241 cccagctgga gcagttcctg ggccgcgtgc tggaggccag caattatgga gtgtcggtgc
      301 tcagcaacgc ctcggggaat tggaattggg acttcacctc ggcgctcttc ttcgccagca
      361 cggtgctctc caccacaggc tatggccaca cggtgccctt gtcagatggg ggcaaggcct
      421 tctgcatcat ctactctgtc attggcatcc cgttcaccct cctcttcctg acggccgtgg
      481 tccagcgtgt caccgtgcat gtcacccgca gaccggtcct ctacttccac atacgctggg
      541 gcttctccaa gcaggtggtg gccatcgtcc atgccgttct gctgggattc gtcaccgtgt
      601 cctgcttctt cttcatcccg gccgccgtgt tctccgtgct ggaggatgac tggaacttcc
      661 tcgaatcttt ttacttctgt ttcatctccc tgagcaccat cggcctgggg gactacgttc
      721 caggggaagg ctacaaccag aagttccggg agctgtacaa gatcgggatc acgtgttacc
      781 tgctcctggg actcatagcc atgctggttg tcctggaaac cttctgtgag ctccacgagc
      841 tgaagaaatt caggaaaatg ttctatgtga agaaagacaa ggatgaagac caagttcaca
      901 tcatggagca tgaccaactg tccttttcct ccatcactga gcaggcggcc ggcctgaagg
      961 aggagcagaa gcaaaacgag ccttttgtgg cctcccagtc accaccctat gaggatggct
     1021 ctgcaaacca ttgagcatgg gtcaccagac cccggacatg aggcagagcc tagactgtgt
     1081 tcatttttac gagaaagtca aagctaagat gatgttattt taagaaatat ctactgttaa
     1141 caatatttta aaaacacgga actttggatc ctgggggagt gggttttaat ctctgggcaa
     1201 atgaggtgtg cacccataac tcacaggcaa tgtgatcacc tgacatcatg cagctgtaac
     1261 tcacaggcga tgtcatcacc tggcatcctg cacctgtaac tcacaggtga tgtcatcgcc
     1321 tggcaccctg cacctgtaac tcacaggtga tattatcacc tggcatcctg cacctgtaac
     1381 tcacaggtga tgtcatcacc tggcatcctg cacttgtaac tcacaggtga tgtcatcatc
     1441 tggcatcctg cacctgtaac tcacaggtga tgtcatcacc tgggatcccg cacctgtaac
     1501 tcacaggtga tgtcatcgcc tggcaccctg cacctgtaac tcacaggtga tattatcacc
     1561 tggcatcctg cacctgtaac tcacaggtga tgtcatcacc tggcatcctg cacttgtaac
     1621 tcacaggtga tgtcatcatc tggcatcctg cacctgtaac tcacaggtga tgtcatcacc
     1681 tgggatcccg cacctgtaac tcacaggtga tgtcatcgcc tggcatcctg cacctgtaac
     1741 tcacaggtga tgtcatcgcc tggcatcctg cacctgtaac tcacaggtga tgtcatcacc
     1801 tggcattaca cactggggat gaatacttga aacagtgtac tgcagtggat ggaggcaggt
     1861 tttctttgta actggggact ctgggtttgc attccaatca ttttgccgac agctaggtag
     1921 caacatttat atttaaaaac aaaacaaaaa aatctataga gatgtatttt ataaataggc
     1981 ttaagtgtcc cggcttgcat gtgcctatcc aaaatgatta tttttgtaga agtctaaatt
     2041 aactctattt ataatgaata ggtcaccatc cactgtgtac atagaacata taaatatgtt
     2101 tatattctgt gcatatgtgt aggctaccag atatccctgg acttcttaag ccaagataag
     2161 agtttttttt tcctttttga tttctcttta tactaaagaa cccagaattg ccacaacaag
     2221 ctaggaagca taacaaactc aagagaaaat caggatgatt ttctgttcct atatacattt
     2281 ctactctctt gcgacggcgt aggaccagac aagtgaggaa gagggttggt gagaaggtga
     2341 atctatttgg tatggaaggc atgctaccag gtctacccac ctcacaggcc cggagggcac
     2401 accaccggtt ctacccacct cacactaaag cacaatggca gtgtccctct ctcccgaaca
     2461 aattatgtca ggttaatctg agaattctac gtttagaagc tgaaatcaat aaaatcatgg
     2521 cagattgcaa
//
