LOCUS       NM_053834               2308 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 9 (Kcnj9), mRNA.
ACCESSION   NM_053834
VERSION     NM_053834.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2308)
  AUTHORS   Balana,B., Maslennikov,I., Kwiatkowski,W., Stern,K.M., Bahima,L.,
            Choe,S. and Slesinger,P.A.
  TITLE     Mechanism underlying selective regulation of G protein-gated
            inwardly rectifying potassium channels by the
            psychostimulant-sensitive sorting nexin 27
  JOURNAL   Proc Natl Acad Sci U S A 108 (14), 5831-5836 (2011)
   PUBMED   21422294
REFERENCE   2  (bases 1 to 2308)
  AUTHORS   Kleene,R., Cassens,C., Bahring,R., Theis,T., Xiao,M.F.,
            Dityatev,A., Schafer-Nielsen,C., Doring,F., Wischmeyer,E. and
            Schachner,M.
  TITLE     Functional consequences of the interactions among the neural cell
            adhesion molecule NCAM, the receptor tyrosine kinase TrkB, and the
            inwardly rectifying K+ channel KIR3.3
  JOURNAL   J Biol Chem 285 (37), 28968-28979 (2010)
   PUBMED   20610389
  REMARK    GeneRIF: a decisive role for the neuronal K(+) channel in
            regulating NCAM-dependent neurite outgrowth and attribute a
            physiologically meaningful role to the functional interplay of
            Kir3.3, NCAM, and TrkB in ontogeny
REFERENCE   3  (bases 1 to 2308)
  AUTHORS   Fernandez-Alacid,L., Aguado,C., Ciruela,F., Martin,R., Colon,J.,
            Cabanero,M.J., Gassmann,M., Watanabe,M., Shigemoto,R., Wickman,K.,
            Bettler,B., Sanchez-Prieto,J. and Lujan,R.
  TITLE     Subcellular compartment-specific molecular diversity of pre- and
            post-synaptic GABA-activated GIRK channels in Purkinje cells
  JOURNAL   J Neurochem 110 (4), 1363-1376 (2009)
   PUBMED   19558451
  REMARK    Erratum:[J Neurochem. 2009 Sep;110(5):1715]
REFERENCE   4  (bases 1 to 2308)
  AUTHORS   Pruss,H., Derst,C., Marinc,C., Wenzel,M. and Veh,R.W.
  TITLE     Expression of Kir3.3 potassium channel subunits in supraependymal
            axons
  JOURNAL   Neurosci Lett 445 (1), 89-93 (2008)
   PUBMED   18755244
  REMARK    GeneRIF: The Kir3.3 subunit protein is expressed in raphe-derived
            axons at the light and electron microscopic level.
REFERENCE   5  (bases 1 to 2308)
  AUTHORS   Saenz del Burgo,L., Cortes,R., Mengod,G., Zarate,J., Echevarria,E.
            and Salles,J.
  TITLE     Distribution and neurochemical characterization of neurons
            expressing GIRK channels in the rat brain
  JOURNAL   J Comp Neurol 510 (6), 581-606 (2008)
   PUBMED   18698588
  REMARK    GeneRIF: Data describe localization of GIRK1, GIRK2, and GIRK3
            subunits and 5-HT(1A) receptor in rat brain, and their
            co-expression with markers of glutamatergic, gamma-aminobutyric
            acid (GABA)ergic, cholinergic, and serotonergic neurons.
REFERENCE   6  (bases 1 to 2308)
  AUTHORS   Lunn,M.L., Nassirpour,R., Arrabit,C., Tan,J., McLeod,I.,
            Arias,C.M., Sawchenko,P.E., Yates,J.R. 3rd and Slesinger,P.A.
  TITLE     A unique sorting nexin regulates trafficking of potassium channels
            via a PDZ domain interaction
  JOURNAL   Nat Neurosci 10 (10), 1249-1259 (2007)
   PUBMED   17828261
REFERENCE   7  (bases 1 to 2308)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   8  (bases 1 to 2308)
  AUTHORS   Grosse,G., Eulitz,D., Thiele,T., Pahner,I., Schroter,S.,
            Takamori,S., Grosse,J., Wickman,K., Tapp,R., Veh,R.W.,
            Ottersen,O.P. and Ahnert-Hilger,G.
  TITLE     Axonal sorting of Kir3.3 defines a GABA-containing neuron in the
            CA3 region of rodent hippocampus
  JOURNAL   Mol Cell Neurosci 24 (3), 709-724 (2003)
   PUBMED   14664820
REFERENCE   9  (bases 1 to 2308)
  AUTHORS   Wischmeyer,E., Doring,F., Wischmeyer,E., Spauschus,A., Thomzig,A.,
            Veh,R. and Karschin,A.
  TITLE     Subunit interactions in the assembly of neuronal Kir3.0 inwardly
            rectifying K+ channels
  JOURNAL   Mol Cell Neurosci 9 (3), 194-206 (1997)
   PUBMED   9245502
REFERENCE   10 (bases 1 to 2308)
  AUTHORS   Dissmann,E., Wischmeyer,E., Spauschus,A., Pfeil,D.V., Karschin,C.
            and Karschin,A.
  TITLE     Functional expression and cellular mRNA localization of a G
            protein-activated K+ inward rectifier isolated from rat brain
  JOURNAL   Biochem Biophys Res Commun 223 (2), 474-479 (1996)
   PUBMED   8670306
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_053834.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L77929.1, SRR26643298.52469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               JAXUCZ010000013.1  87320180-87320293   c
            115-215             JAXUCZ010000013.1  87319028-87319128   c
            216-1093            JAXUCZ010000013.1  87316959-87317836   c
            1094-2308           JAXUCZ010000013.1  87313191-87314405   c
FEATURES             Location/Qualifiers
     source          1..2308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..2308
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 9"
                     /db_xref="GeneID:116560"
                     /db_xref="RGD:621440"
     exon            1..114
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            115..215
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /inference="alignment:Splign:2.1.0"
     exon            216..1093
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..1425
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /note="potassium voltage-gated channel subfamily J member
                     9; inwardly rectifier K(+) channel Kir3.3; potassium
                     channel, inwardly rectifying subfamily J member 9; GIRK-3;
                     inward rectifier K(+) channel Kir3.3"
                     /codon_start=1
                     /product="G protein-activated inward rectifier potassium
                     channel 3"
                     /protein_id="NP_446286.1"
                     /db_xref="GeneID:116560"
                     /db_xref="RGD:621440"
                     /translation="MAQENAAFSPGSEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRY
                     LTDLFTTLVDLQWRLSLLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVN
                     NLNGFVAAFLFSIETETTIGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVK
                     ISQPNKRAATLVFSSHAVVSLRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEG
                     EFIPLHQTDLSVGFDTGDDRLFLVSPLVISHEIDAASPFWEASRRALERDDFEIVVIL
                     EGMVEATGMTCQARSSYLVDEVLWGHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCS
                     ARELAEAAARLDAHLYWSIPSRLDEKVEEEGAGEGAGAGDGADKEQNGCLPPPESESK
                     V"
     exon            1094..2308
                     /gene="Kcnj9"
                     /gene_synonym="Girk3; Kir3.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgcggct cccactctca gaggggacct agggtattgg gggagatggt gtcagggaca
       61 tggactccaa cccccaaggg tctctgctgc tggctactct cctcttcagg ctctggggcc
      121 gtgagagcct agggaaggac cctggacatc ccgtctctcc gggaagattt taacacagag
      181 tgcttctcag ggggaagaat tcgaagcaaa accagacccc gcaggatccc cgctgcggcc
      241 gccatggcgc aggagaacgc cgctttctct cccgggtcgg aggagccacc gcggcgccgc
      301 ggtcgccagc gctacgtgga gaaggacggg cgctgcaacg tgcagcaggg caacgtccgc
      361 gagacctacc gctacctgac cgacctgttc accacgctgg tagatctgca gtggcgcctc
      421 agcctgctct tcttcgtgct cgcctacgcg ctcacctggc tcttcttcgg cgccatctgg
      481 tggctcatcg cctacggccg cggcgacctg gagcacctgg aggacaccgc gtggacaccg
      541 tgcgtcaaca acctcaacgg cttcgtggcc gccttcctct tctccatcga gacagaaacc
      601 accatcggct atgggcaccg tgtcatcacc gaccagtgcc ccgagggcat cgtgctgctg
      661 ctgttgcaag ccatcctggg ctccatggtg aacgctttca tggtgggctg catgttcgtc
      721 aagatctcgc agcccaacaa gcgcgccgcc acgctcgtct tctcctcgca cgccgtggtg
      781 tctctgcgcg acgggcgcct ctgtctcatg tttcgcgtgg gggacctgcg atcctcgcac
      841 atcgtcgagg cctccatccg cgccaagctc atccgctcgc gccagacgct cgagggcgag
      901 ttcatccctc tgcaccagac cgacctcagc gtgggcttcg acacggggga cgaccgcctc
      961 ttcctcgtct cacctctcgt catcagccat gagatcgacg ccgccagccc cttctgggag
     1021 gcatcgcgcc gcgccctcga gagggacgac ttcgagatcg tagtcattct cgagggcatg
     1081 gtggaagcca cgggaatgac gtgccaagct cgaagctcgt acctggtaga cgaagtgttg
     1141 tggggccacc gattcacatc cgtgctcacc ctggaggacg gtttctatga ggtggactac
     1201 gctagcttcc atgaaacctt tgaggtgccc acaccctcat gcagtgctcg ggaactggca
     1261 gaagctgcag cccgccttga cgcccatctc tactggtcca tccccagcag gctggatgag
     1321 aaggtggagg aagaaggggc tggggagggg gcaggcgcag gagatggagc tgacaaggag
     1381 caaaatggct gcctgccacc cccggagagt gagtccaagg tgtgactggt tttctacaac
     1441 cccctgtggc agaccagggg gccagacaca ggtccatgga ggctgcagaa tggagatgga
     1501 agtagaggag gcaggcagtg tcccaaggaa tggttaacgt tgggagaggc ccactgagtc
     1561 caggatccag tggggaaggc ccaaggtcct ggtttgagga aaatagaggg tgggggtgga
     1621 gagagatcat atcggtctgt ctgtgtttga ctttgacatc tgttcatggg tggatggata
     1681 gacagaagga tgggcttatg ggggttgaat gggaaggtgg gcagaaagag acagtcaatg
     1741 gatagcttgg gtggattgac agttggtgaa cggccggtgc agcactcctt tgtgcaaaat
     1801 ctacaggcac ccttttcttc caggcatggg tagccttgaa ccagggtcca tggcttaggg
     1861 agcagattgt caggtagact gcagtcccca ctcaccaccc cccaactggc ctccctatgt
     1921 gtggcatgcc tgcccaacta gacaaagtgg ccacagagaa gaaagcactg ggtggaggtg
     1981 ggcacagatg tgggtgccct ccccaccttc actgtcccat accgatgggt cagaaaggtg
     2041 ccaatggcct taatcctcag gttacaggca aacaagcggt ggaggtaaac ccggagcagg
     2101 ggccctggag agggacctga ggagacccaa ggacaactat ttttcgagag agaggaatga
     2161 aaccttgcag gtactgccgg agaagcaaga aggcagagag agattccgaa ggaaaagaaa
     2221 ggccatggga ggggttgggg atttagctca gcggcttgcc tagcgagcgc aaggccctgg
     2281 gttcggtccc cagctccgga aaaaaaaa
//
