LOCUS       NM_017099               1577 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 8 (Kcnj8), mRNA.
ACCESSION   NM_017099
VERSION     NM_017099.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1577)
  AUTHORS   Brennan,S., Chen,S., Makwana,S., Esposito,S., McGuinness,L.R.,
            Alnaimi,A.I.M., Sims,M.W., Patel,M., Aziz,Q., Ojake,L.,
            Roberts,J.A., Sharma,P., Lodwick,D., Tinker,A., Barrett-Jolley,R.,
            Dart,C. and Rainbow,R.D.
  TITLE     Identification and characterisation of functional Kir6.1-containing
            ATP-sensitive potassium channels in the cardiac ventricular
            sarcolemmal membrane
  JOURNAL   Br J Pharmacol 181 (18), 3380-3400 (2024)
   PUBMED   38763521
  REMARK    GeneRIF: Identification and characterisation of functional
            Kir6.1-containing ATP-sensitive potassium channels in the cardiac
            ventricular sarcolemmal membrane.
REFERENCE   2  (bases 1 to 1577)
  AUTHORS   Li,H., Chen,D., Sun,W., Chen,J., Luo,C., Xu,H., Ma,J.H. and Tang,S.
  TITLE     KATP Opener Attenuates Diabetic-Induced Muller Gliosis and
            Inflammation by Modulating Kir6.1 in Microglia
  JOURNAL   Invest Ophthalmol Vis Sci 62 (2), 3 (2021)
   PUBMED   33523201
  REMARK    GeneRIF: KATP Opener Attenuates Diabetic-Induced Muller Gliosis and
            Inflammation by Modulating Kir6.1 in Microglia.
REFERENCE   3  (bases 1 to 1577)
  AUTHORS   Peng,K., Hu,J., Xiao,J., Dan,G., Yang,L., Ye,F., Zou,Z., Cao,J. and
            Sai,Y.
  TITLE     Mitochondrial ATP-sensitive potassium channel regulates
            mitochondrial dynamics to participate in neurodegeneration of
            Parkinson's disease
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (4 Pt A), 1086-1103 (2018)
   PUBMED   29353068
  REMARK    GeneRIF: it can be concluded that mitoKATP channels regulate
            mitochondrial dynamics to participate in rotenone-induced
            Parkinson's disease mainly attributes to the pore subunits of
            Kir6.1.
REFERENCE   4  (bases 1 to 1577)
  AUTHORS   Cooper,P.E., McClenaghan,C., Chen,X., Stary-Weinzinger,A. and
            Nichols,C.G.
  TITLE     Conserved functional consequences of disease-associated mutations
            in the slide helix of Kir6.1 and Kir6.2 subunits of the
            ATP-sensitive potassium channel
  JOURNAL   J Biol Chem 292 (42), 17387-17398 (2017)
   PUBMED   28842488
  REMARK    GeneRIF: both Kir6.1(V65M) and Kir6.2(V64M) mutations essentially
            abolish high-affinity sensitivity to the KATP blocker glibenclamide
            in both intact cells and excised patches. This raises the
            possibility that, at least for some CS mutations, sulfonylurea
            therapy may not prove to be successful and highlights the need for
            detailed pharmacogenomic analyses of CS mutations.
REFERENCE   5  (bases 1 to 1577)
  AUTHORS   Liu,X., Duan,P., Hu,X., Li,R. and Zhu,Q.
  TITLE     Altered KATP Channel Subunits Expression and Vascular Reactivity in
            Spontaneously Hypertensive Rats With Age
  JOURNAL   J Cardiovasc Pharmacol 68 (2), 143-149 (2016)
   PUBMED   27035370
  REMARK    GeneRIF: In vascular smooth muscle KATP channel subunits Kir6.1 and
            SUR2B contribute to modify the functionality of this channel in
            hypertension with age.
REFERENCE   6  (bases 1 to 1577)
  AUTHORS   Vanoye,C.G., MacGregor,G.G., Dong,K., Tang,L., Buschmann,A.S.,
            Hall,A.E., Lu,M., Giebisch,G. and Hebert,S.C.
  TITLE     The carboxyl termini of K(ATP) channels bind nucleotides
  JOURNAL   J Biol Chem 277 (26), 23260-23270 (2002)
   PUBMED   11956191
REFERENCE   7  (bases 1 to 1577)
  AUTHORS   Light,P.E., Kanji,H.D., Fox,J.E. and French,R.J.
  TITLE     Distinct myoprotective roles of cardiac sarcolemmal and
            mitochondrial KATP channels during metabolic inhibition and
            recovery
  JOURNAL   FASEB J 15 (14), 2586-2594 (2001)
   PUBMED   11726534
  REMARK    GeneRIF: Data suggest that sarc and mitoKATP channel populations
            play distinct protective roles, triggered by PKC and/or adenosine,
            during chemically induced hypoxia/reoxygenation.
REFERENCE   8  (bases 1 to 1577)
  AUTHORS   Sgard,F., Faure,C., Drieu la Rochelle,C., Graham,D., O'Connor,S.E.,
            Janiak,P. and Besnard,F.
  TITLE     Regulation of ATP-sensitive potassium channel mRNA expression in
            rat kidney following ischemic injury
  JOURNAL   Biochem Biophys Res Commun 269 (2), 618-622 (2000)
   PUBMED   10708603
REFERENCE   9  (bases 1 to 1577)
  AUTHORS   Akao,M., Otani,H., Horie,M., Takano,M., Kuniyasu,A., Nakayama,H.,
            Kouchi,I., Murakami,T. and Sasayama,S.
  TITLE     Myocardial ischemia induces differential regulation of KATP channel
            gene expression in rat hearts
  JOURNAL   J Clin Invest 100 (12), 3053-3059 (1997)
   PUBMED   9399952
  REMARK    Erratum:[J Clin Invest 1998 Feb 15;101(4):915]
REFERENCE   10 (bases 1 to 1577)
  AUTHORS   Inagaki,N., Tsuura,Y., Namba,N., Masuda,K., Gonoi,T., Horie,M.,
            Seino,Y., Mizuta,M. and Seino,S.
  TITLE     Cloning and functional characterization of a novel ATP-sensitive
            potassium channel ubiquitously expressed in rat tissues, including
            pancreatic islets, pituitary, skeletal muscle, and heart
  JOURNAL   J Biol Chem 270 (11), 5691-5694 (1995)
   PUBMED   7890693
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D42145.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017099.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D42145.1, BC078863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093047, SAMN16676786
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1577              D42145.1           4-1580
FEATURES             Location/Qualifiers
     source          1..1577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q44"
     gene            1..1577
                     /gene="Kcnj8"
                     /gene_synonym="Kir6.1; uKATP-1; UKATP1"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 8"
                     /db_xref="GeneID:25472"
                     /db_xref="RGD:2960"
     exon            1..114
                     /gene="Kcnj8"
                     /gene_synonym="Kir6.1; uKATP-1; UKATP1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..550
                     /gene="Kcnj8"
                     /gene_synonym="Kir6.1; uKATP-1; UKATP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1451
                     /gene="Kcnj8"
                     /gene_synonym="Kir6.1; uKATP-1; UKATP1"
                     /note="inwardly rectifier K(+) channel Kir6.1; potassium
                     channel, inwardly rectifying subfamily J member 8; inward
                     rectifier K(+) channel Kir6.1; Inwardly rectifying
                     potassium channel gene, subfamily J-8 (ATP sensitive);
                     potassium voltage-gated channel subfamily J member 8"
                     /codon_start=1
                     /product="ATP-sensitive inward rectifier potassium channel
                     8"
                     /protein_id="NP_058795.3"
                     /db_xref="GeneID:25472"
                     /db_xref="RGD:2960"
                     /translation="MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACN
                     LAHKNIREQGRFLQDIFTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIY
                     AYMEKGITEKSGLESAVCVTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLI
                     LQNIVGLIINAVMLGCIFMKTAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKS
                     MIISASVRIQVVKKTTTPEGEVVPIHQQDIPVDNPIESNNIFLVAPLIICHVIDKRSP
                     LYDISATDLVNQDLEVIVILEGVVETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGV
                     YSVDYSKFGNTVRVAAPRCSARELDEKPSILIQTLQKSELSHQNSLRKRNSMRRNNSM
                     RRSNSIRRNNSSLMVPKVQFMTPEGNQCPSES"
     exon            551..1577
                     /gene="Kcnj8"
                     /gene_synonym="Kir6.1; uKATP-1; UKATP1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgacatcccc cggatatgca cttcgggagg cccctgctcc cgggatgcga gagctaggga
       61 cctgtccgcc ctgtgcggag ctccagccgc cgccgggcgc gcaaccctga gtctaggacg
      121 cgttgtggag gaaaggagtc agggcaggtg cctaggcggg ctatgctgaa aggaagatgc
      181 tggccaggaa gagcatcatc ccggaggagt atgtgctggc ccgcatcgcg gcggagaacc
      241 tgcgcaaacc gcgcatccgc gaccgcctcc ccaaagcccg cttcatcgcc aagagcggag
      301 cctgcaacct ggctcacaag aacatccgag agcaaggtcg cttcctgcag gacatcttca
      361 ccaccttggt agacctgaag tggcgtcaca cgctggtcat cttcaccatg tccttcctct
      421 gcagctggct gctcttcgct atcatgtggt ggctggtggc cttcgcccac ggggacatct
      481 atgcttacat ggagaaaggc atcacggaga agagtggcct ggagtctgcc gtctgtgtga
      541 ccaatgtcag gtcattcact tctgcgtttc tcttctccat cgaggttcaa gtgaccattg
      601 ggtttggagg gagaatgatg actgaggagt gccctctggc catcacggtt ttgattctgc
      661 agaacattgt gggtctgatc atcaacgcgg tcatgttggg ctgcatcttc atgaagacgg
      721 cccaggccca cagaagggca gagacgctga ttttcagccg ccatgctgta attgcggtcc
      781 gtaatggcaa gctgtgcttc atgttccggg tgggtgacct gaggaaaagc atgatcatta
      841 gcgcctcggt gcgcatccag gtggtcaaga aaaccacgac gccagaagga gaggtggtgc
      901 ctattcacca gcaggacatc cctgtggata atcccatcga gagcaataac atcttcctag
      961 tggccccttt gatcatctgc catgtgattg ataagcgtag ccccctgtac gatatctcag
     1021 ccactgacct tgtcaaccaa gacctggagg tcatagtgat tctcgagggc gtggtggaaa
     1081 ccacgggcat caccacgcaa gcgcggacct cctacattgc agaggagatc cagtggggac
     1141 accgcttcgt gtcgattgtg actgaggagg agggagtgta ctctgtggac tattctaaat
     1201 ttggtaatac tgtgagagtg gcggcgccaa gatgcagtgc ccgggagctg gacgagaaac
     1261 cttccatctt gattcagacc ctccaaaaga gtgaactgtc gcaccagaat tctctgagga
     1321 agcgcaactc tatgagaaga aacaactcca tgaggaggag caactccatc cggaggaata
     1381 actcttccct catggtgccc aaggtgcaat tcatgactcc agaaggaaac cagtgcccat
     1441 cagaatcatg agggcaggac gaccctagac agccactcac tgagtcccga tgactgacag
     1501 accatcctga gacagtttgc tgagttctgg tgatcgaagt atcggacctg tcgccaattc
     1561 agggcaggaa cacaaca
//
