LOCUS       NM_013192              16473 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 6 (Kcnj6), transcript variant 1, mRNA.
ACCESSION   NM_013192 XM_039088045 XM_346416
VERSION     NM_013192.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 16473)
  AUTHORS   Maslov,L.N., Sementsov,A.S., Naryzhnaya,N.V., Derkachev,I.A.,
            Fu,F., Gusakova,S.V. and Sarybaev,A.
  TITLE     The Role of Mitochondrial KATP Channels in the Infarct-Reducing
            Effect of Normobaric Hypoxia
  JOURNAL   Bull Exp Biol Med 174 (2), 190-193 (2022)
   PUBMED   36602604
  REMARK    GeneRIF: The Role of Mitochondrial KATP Channels in the
            Infarct-Reducing Effect of Normobaric Hypoxia.
REFERENCE   2  (bases 1 to 16473)
  AUTHORS   Yu,L., Li,W., Park,B.M., Lee,G.J. and Kim,S.H.
  TITLE     Hypoxia augments NaHS-induced ANP secretion via KATP channel,
            HIF-1alpha and PPAR-gamma pathway
  JOURNAL   Peptides 121, 170123 (2019)
   PUBMED   31386893
  REMARK    GeneRIF: Hypoxia augments NaHS-induced ANP secretion via KATP
            channel, HIF-1A and PPAR-gamma pathway.
REFERENCE   3  (bases 1 to 16473)
  AUTHORS   Baculis,B.C., Weiss,A.C., Pang,W., Jeong,H.G., Lee,J.H., Liu,D.C.,
            Tsai,N.P. and Chung,H.J.
  TITLE     Prolonged seizure activity causes caspase dependent cleavage and
            dysfunction of G-protein activated inwardly rectifying potassium
            channels
  JOURNAL   Sci Rep 7 (1), 12313 (2017)
   PUBMED   28951616
  REMARK    GeneRIF: Study is first to show direct cleavage of GIRK1 and GIRK2
            subunits by caspase-3, with cleavage sites in GIRK1 (387ECLD390)
            and GIRK2 (349YEVD352) and suggests the possible role of caspase-3
            mediated down-regulation of GIRK channel function and expression in
            hippocampal neuronal injury during prolonged epileptic seizures.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 16473)
  AUTHORS   Liang,W., Chen,M., Zheng,D., Li,J., Song,M., Zhang,W., Feng,J. and
            Lan,J.
  TITLE     The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac
            Cells Against the High Glucose-Induced Injury and Inflammation by
            Inhibiting the ROS-TLR4-Necroptosis Pathway
  JOURNAL   Cell Physiol Biochem 41 (3), 1020-1034 (2017)
   PUBMED   28291959
  REMARK    GeneRIF: The opening of ATP-sensitive K+ channels protects
            cardiomyocytes against the high glucose-induced injury and
            inflammation by inhibiting the ROS-TLR4-necroptosis pathway.
REFERENCE   5  (bases 1 to 16473)
  AUTHORS   Montalbano,A., Corradetti,R. and Mlinar,B.
  TITLE     Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled
            GIRK Channels in Rat Dorsal Raphe 5-HT Neurons
  JOURNAL   PLoS One 10 (10), e0140369 (2015)
   PUBMED   26460748
  REMARK    GeneRIF: inwardly rectifying K+ channels coupled to 5-HT1A
            autoreceptors display pharmacological properties generally expected
            for neuronal GIRK channels, but different from GIRK1-GIRK2
            heteromers
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 16473)
  AUTHORS   Suda,S., Nibuya,M., Suda,H., Takamatsu,K., Miyazaki,T., Nomura,S.
            and Kawai,N.
  TITLE     Potassium channel mRNAs with AU-rich elements and brain-specific
            expression
  JOURNAL   Biochem Biophys Res Commun 291 (5), 1265-1271 (2002)
   PUBMED   11883954
REFERENCE   7  (bases 1 to 16473)
  AUTHORS   Pei,Q., Lewis,L., Grahame-Smith,D.G. and Zetterstrom,T.S.
  TITLE     Alteration in expression of G-protein-activated inward rectifier
            K+-channel subunits GIRK1 and GIRK2 in the rat brain following
            electroconvulsive shock
  JOURNAL   Neuroscience 90 (2), 621-627 (1999)
   PUBMED   10215164
REFERENCE   8  (bases 1 to 16473)
  AUTHORS   Stoffel,M., Tokuyama,Y., Trabb,J.B., German,M.S., Tsaar,M.L.,
            Jan,L.Y., Polonsky,K.S. and Bell,G.I.
  TITLE     Cloning of rat KATP-2 channel and decreased expression in
            pancreatic islets of male Zucker diabetic fatty rats
  JOURNAL   Biochem Biophys Res Commun 212 (3), 894-899 (1995)
   PUBMED   7626127
REFERENCE   9  (bases 1 to 16473)
  AUTHORS   Bond,C.T., Ammala,C., Ashfield,R., Blair,T.A., Gribble,F.,
            Khan,R.N., Lee,K., Proks,P., Rowe,I.C., Sakura,H. et al.
  TITLE     Cloning and functional expression of the cDNA encoding an
            inwardly-rectifying potassium channel expressed in pancreatic
            beta-cells and in the brain
  JOURNAL   FEBS Lett 367 (1), 61-66 (1995)
   PUBMED   7601286
REFERENCE   10 (bases 1 to 16473)
  AUTHORS   Lesage,F., Duprat,F., Fink,M., Guillemare,E., Coppola,T.,
            Lazdunski,M. and Hugnot,J.P.
  TITLE     Cloning provides evidence for a family of inward rectifier and
            G-protein coupled K+ channels in the brain
  JOURNAL   FEBS Lett 353 (1), 37-42 (1994)
   PUBMED   7926018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000222.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_013192.4.
            
            On or before Mar 12, 2021 this sequence version replaced
            XM_039088045.1, NM_013192.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN14984031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               JACYVU010000222.1  13618340-13618532   c
            194-242             JACYVU010000222.1  13560120-13560168   c
            243-1163            JACYVU010000222.1  13458404-13459324   c
            1164-16473          JACYVU010000222.1  13371476-13386785   c
FEATURES             Location/Qualifiers
     source          1..16473
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..16473
                     /gene="Kcnj6"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 6"
                     /db_xref="GeneID:25743"
                     /db_xref="RGD:2959"
     exon            1..193
                     /gene="Kcnj6"
                     /inference="alignment:Splign:2.1.0"
     exon            194..242
                     /gene="Kcnj6"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1489
                     /gene="Kcnj6"
                     /note="isoform 1 is encoded by transcript variant 1; g
                     protein-activated inward rectifier potassium channel 2;
                     BIR1; GIRK2; KATP-2; inward rectifier K(+) channel Kir3.2;
                     potassium channel, inwardly rectifying subfamily J member
                     6; GIRK-2; potassium voltage-gated channel subfamily J
                     member 6"
                     /codon_start=1
                     /product="G protein-activated inward rectifier potassium
                     channel 2 isoform 1"
                     /protein_id="NP_037324.1"
                     /db_xref="GeneID:25743"
                     /db_xref="RGD:2959"
                     /translation="MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPR
                     HISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVY
                     TVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYR
                     VITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDG
                     KLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLV
                     SPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILW
                     GYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELANRAELPLSWSVSSKLN
                     QHAELETEEEEKNPEELTERNGDVANLENESKV"
     exon            243..1163
                     /gene="Kcnj6"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..16473
                     /gene="Kcnj6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcagcaga atggagtctc ccgaaagcct gccggggctg atgtgaaatt ggaccatctg
       61 cttccagttg gtctgtttcc tcctcttctt gtattttctt cccttgccat ccaccgtgga
      121 gtgaattact gaatcttgct ccgttccaag agaggcgatg aggatgaagt gaacctaccc
      181 tgtccaccac aaggaaaagc acaaagaaga aatgacaatg gccaagttaa ctgaatccat
      241 gactaatgtc ctggaggggg attccatgga ccaagacgtg gaaagcccag tggccattca
      301 ccagccaaag ttgcctaagc aggccaggga tgacctgcca agacacatca gccgagacag
      361 gaccaaaagg aaaatccaga ggtacgtgag gaaggatggg aaatgtaacg tccaccacgg
      421 caacgtgcgg gagacgtacc gatacctgac ggacatcttc accaccctgg tggacctaaa
      481 gtggagattc aacctattga tctttgtcat ggtctacaca gtgacgtggc ttttctttgg
      541 gatgatctgg tggctaattg catacatccg gggagatatg gaccacatag aggacccctc
      601 gtggactccc tgtgttacca acctcaacgg gtttgtctcc gcttttttat tctcaataga
      661 gacagaaacc accattggtt atggctacag ggtcatcacg gacaagtgcc cagaaggaat
      721 tattctcctc ttaatccagt ccgtgttggg gtccattgtc aacgccttca tggtaggatg
      781 tatgtttgtg aaaatatccc aacccaagaa gagggcagag accctggtct tttccaccca
      841 tgcggtaatc tccatgcggg atgggaaact atgcctgatg ttccgggtag gggacttgag
      901 gaattcccac attgtggagg cctccatcag agccaagttg atcaagtcca aacagacttc
      961 agagggggag ttcattcccc tcaaccagac ggatatcaac gtagggtact acaccgggga
     1021 tgaccgactc tttctcgtgt caccgctgat tattagccat gaaattaacc aacagagtcc
     1081 cttctgggag atctccaaag cccagctgcc taaagaggaa ctggagattg tggtcatcct
     1141 ggagggaatg gtggaagcca caggaatgac gtgccaagct cgaagctcct acatcaccag
     1201 tgagatcctg tggggttacc ggttcacacc agtcctgaca ctggaggacg ggttctatga
     1261 agttgactac aacagcttcc atgagaccta tgagaccagc accccgtccc ttagcgccaa
     1321 agagctagcc gagctggcta accgggcaga gctgcccctg agctggtctg tgtccagcaa
     1381 actgaaccaa catgcagaac tggagacgga agaggaagag aagaacccgg aagaactgac
     1441 agagaggaat ggtgatgtgg caaacctaga gaatgagtcc aaagtgtaga cccagctggg
     1501 tcagcctccc ccactcagac atgacccctc cttgtagacc cagctgggtc aacctcttcc
     1561 actcagatat gacccgccct tgtaggtcca gctgggtcag cctcccccac tcagacatga
     1621 cccctccttg tttcccattt ccttcttttc tgtctctctt actttgacct tgatttattt
     1681 atatttaatt ttggcatttc cagaaaacaa atcttcaagg tgtaaaatac ctacctgccc
     1741 ctctcagacg ttcagatgga caagcagaca gggatttggt taaggtacaa ggtaccttca
     1801 ttgtgcccaa gcctggtctc cactcacaga agagactttt agctacttga tccactttat
     1861 tgtccaatcc aaatcactca aaagagctgt cagagctctg acccagtgtc acaaagagcg
     1921 aggtctgttt accatggcca caggtcagtc ttacagagcc ctgtccatct cacccaacac
     1981 agggcaggta cttaaccata gacactgatg ggaccggacc caggtgaggg aaggatagac
     2041 cactgtacat agatctgccc tgcggaatta ttttctttcg gcaattagaa acaaacccag
     2101 catgcaccag agtaccgtgg agcagaactc ctagtgatgt acatatcatt cctgtagctt
     2161 tagacgtaca ctttagaaat aagaagaaaa aagactccca atgtacagta ggcatttccg
     2221 ttctgatatc tgagtcttct gactattttg atccccttga ctgctggccc tctaaatgca
     2281 tggcctttgt tccaggtccc agactgacag ttgttagagc acctctgtgt tccttgtcat
     2341 ccttatgttg actctaacaa gccataggtg tggggacagt ctggaggtct aacagatggc
     2401 aaaatgctgg cagaccatga cacatttata aaacaggtgt cgttgtttag agataatgag
     2461 ggtctctctc tgagcaccct tgggaggctg taccaggaac aggactctag cacagcccca
     2521 cgtgacattt cccatgaacg tggagtctag cagtttaaga aagctttctg taaaagcatt
     2581 gattgctaat ctatgtggtg atgagaaact gcaggctctc cacggagctg tctggtcagc
     2641 agaagacttg ggggtaaagc caagacattc aagagtgccc tgtggaagaa atgacagttt
     2701 cctgccctct cacttcatct ggcacgcctg tccctgggcc ccgcccttac cttttcttac
     2761 attgggattt ttttatcttc tgccatcatt gttgctaccc ttattgtgaa acgaccagaa
     2821 ttcgatacac agagtagaga gcagtctttg tgggaactga caaatctctc ccgggtgtga
     2881 gagtatgccg ctaattgaca atctaacccg tgtctctcaa tcaagagcac aaacatcaac
     2941 aacagccaaa tagctctctc cgtctcattt taatcctcaa ggaaggaaca aaggaaggca
     3001 ggcaacatgt gtaatagtcc aaattcaaaa cgacttgaaa gagaagactg ggaagagaga
     3061 cttaagtgag gtctcagggg caggtggaga tttctcactg taaccgatct ttcttgttgc
     3121 ttttgcattc ataaactgtt cttaaacacc attgtccatc atcaatatgc atcgaataga
     3181 tctgaattta tctcagctcc ttcagatgtg cttagtttga gactccatac cattgaggtc
     3241 aaagagatca aactagctgg tccccatccc cgctgcccct cccccctcac cagaccggtc
     3301 cacacagggt tttgctatag tctcgggacc ttgcttataa gagaggtacc ccaggtctta
     3361 cttatgggaa gtggctcctc caaccaacat ctgggttgtt cctctccctc agcagagatc
     3421 ttaccaccca aagcaaagct attgagcgtg gccctccctt gcctgccagc atttcctttt
     3481 ggcattggtt atttatcgat ggagacactc atccgccctg cactctctaa gcaggaggtg
     3541 atagaggagg gaatcctgaa acaattcccc agaggctgtg ggagtgccca tggcttgacc
     3601 ttgttttagc cttatgaagg ccgccctgct ttggggcacc aatctgcagc agcccaagat
     3661 agggcctgtg tagcacaaag caagatggag aacgcctatg gatgatctgc cgacttagct
     3721 cctgaagatt cgttgggcct tttaaaatct attactgagg tctgaaggac aaaggatcct
     3781 cactgatggg ttgaaagagc agctctgagg ttgatggctt tttgtaggat gacacaataa
     3841 ggcctgggca acaccagtgt cacttcctca gccgtgctgt gaccacagca ggcactctga
     3901 tggttctttc ctgactctca tcttcttgct gtcactgtgc tgggtgatgc aagtggagcc
     3961 tgtttgtaac atgagctcaa aatcttcaca gggagcgtcc ctaaaggacc ttttattaga
     4021 ctgtccttag caaacgtgtc tatttttcta cggtcactga gaaaaaggtt taacagtgta
     4081 ttttgtgtca actgttaaaa tttgaaatgt cattatgact gaattttcta agcagcaagt
     4141 agccggtggg gtttttcatt aagatgattc aacaaaaggg accctaatgc ctcccctttc
     4201 ctgtccacaa tccccagtca ctatccccac agtatctcct ccagcaaatc aaatgctaca
     4261 aaaatgatac acctatccag gcaccaagac ccataaccat tggagagtac actctctttc
     4321 tctctatatc tccccctccc cctctcctcc ctccttcttc ctctctctac ccttctccct
     4381 ttctccctcc ccctcctttt ctccctcccc tccccctcct cctcctccct ctctctcccc
     4441 tcctcttccc cctccccctc ctcctttccc ctctctcccc ctctcccttt tggggctgct
     4501 tggttgttat cgctgagtca tttccccccc ccaataaagc acagtgaaat ccctagacca
     4561 gataagtacc ttgaactcaa gggtaacagt cactacagtt gagtccagtc tacggtcagg
     4621 ttagctcctt gaggaaagag aaggtttgtc tggaaggatg gagcagaaga gacctctgtt
     4681 ctactgacac cccctctccc attagctctc ctatatatag gagatgaaat cagtattgtg
     4741 tttgtctgcg gtggtccctg ggcacgcagc atgcctgtgt tgacacatta gaacggccac
     4801 gttacatcat tggctcatcc ctttcaagtc cttcatgttg ggtatggttg tgactccatg
     4861 aggtagaacc ctctcttcct gcaccttcct gtccgtccct ctcttttgtc tctctttagt
     4921 tccagaccca ctgatttaat ttagtacccg agtcccctaa cagaaaccta gctactgtat
     4981 caagatgtgg acctatttct taagcacaac ttttacgggt ttaaccaaag taggactctg
     5041 acatgcctgg ttttctcatt atactctaat ttataattta attatgacta cactttaaag
     5101 cccggacgtt caagtttctt tctttctttc ttcccctacc tgttgctttt ctggttgaac
     5161 ttctggtgtc ttggagtgtt tgggactgac caagggtgca ggagggagta cacagatgcc
     5221 ctggaagacc ccatgagcac acttcgaagt gccagatcct tagctgagag aaactgtgaa
     5281 agcctagaca ctcgctacca gcacgactta gcaagagtca cctggtcatt tctttccctg
     5341 acttcagaca tgttctaaat gacacagaag cctagacggc agcttcagaa gaaatggcct
     5401 ctatgtgtga ccagtattac tacgctgcac tcattttttt tccggcttca tcccaatgga
     5461 tagctgtaaa actgaaaaag atgaacaaaa tttgtataat tgattgatat tacaacacgg
     5521 cttaaaaaaa acactgtctt aagttagact tgatgtcaaa ctgtatttta aaacatgttc
     5581 cctttcacgt tagaatagag taacgactcc ctcttcccag tctgtgtacc ctggcgtctc
     5641 cgaggggact caggactcaa catgtcatgt agatgtggag actgtgagaa ggtctgtcag
     5701 gaacaagggc agtatgtaca gttttgactg tgcataccta acaacaggac aatattttac
     5761 ctgacattgt aaaggcagga cactcccaca aattatccct tggaactctc acccgccaca
     5821 cgaggtcagg tactgtcgtc tttgtaattg gagtttgggc aaattgacaa acttatcaaa
     5881 ggtccaggcc agttaacaat agaccctggc ctcaaaccca ggtcacaagg gtgtgagcga
     5941 gcacggggtg atttttatta tgaaaacatt tggcacacca agctgctaag acggctttac
     6001 tgttactaca taccctcttt ctagctgatg ccaatgctca tgtttataaa tggttgggag
     6061 gaaaacaagc caagaatact tgggggacac aggagtcaga tctcaggggc cagggatgga
     6121 gcttggttag gagtgtgctt gcctaattca tgaaatgacc catgtttggt tcctatcatc
     6181 gctgagtaaa taaagcatgt tagcacccca cccccaccct gtccattata gcattttgga
     6241 agtggaggca ggaaggtgaa ctcaagttca tcctcggtca tatggggagt ttgtgattag
     6301 cctgagctac ctgggaccct caaaagaaaa tgatgattca aatttcggtc cataagtggt
     6361 tccattggaa aacagggtat gaaatctgtg cgtggattgc ctggggctgc tcagactctg
     6421 ttctaggaga cctgagtaac tgcaagaggt cgtgtggcgg gcaacacctg tactactatt
     6481 actaactaat agtaaccatt gcatgtgtgt cagttaagaa ttaaactagt taagaattaa
     6541 actagtccca cgggcgtctg ggaatgtcag agtacgacct ctttccccac cccagatctc
     6601 ctggggttgc taatagttct gttacagcac aacacgttat ggttttcagg gctcacagag
     6661 aaaaggcttg cctttccaac ccagcctttc cgggattcag tgtctaccta ggaagtcgct
     6721 agaatagaac tgctccttaa tgcgcaataa agacatgaga cgtcctggcc catcagctga
     6781 gtacagcttc tctgtgtccg tgggctttca gttctacaga ctgtccagcc cgctggtgtc
     6841 tgctcgagtg aggctagcag tgtgaaggag aagggtcagg ggctgaggct aatcccacat
     6901 tcttgctgct tcctctagtc tggaactcgg gattggtccg tggtgtaaag gatccaggaa
     6961 cctcggtcac tgtttcttta cattggccct ggctctctct ggccccttgg atagaagttc
     7021 agcatgagga tgaccaactg ctcttccagg gaacctcaga ggcttttgga agccttgggg
     7081 gctagagcaa ggttactata tcattggaga ctgcaaagca gaccaatccc agtgatagga
     7141 accttagatg aggctatatt aagtggcatt gtctagactc ataaatttga tttacttttg
     7201 gtctaaggaa gcatttctca tcctggtcag ctaaacttgg cattttatct tttatattat
     7261 atttgagaca gaggggggag agggagagag agatagagag agagagagag agagagagag
     7321 agagagagag agagagagag agagcacaaa cacatcaggt tctcttatga gtgatttcga
     7381 ggaaattaga tggaaaagaa aatattttgc aacaaattgt tgtatgttgt gctgttgatc
     7441 ccacatctct aactaagtgg gtgacaatgt cctatccatc acagaaacca tgcagaactc
     7501 ctataactac tcaaccactt agaagaaaca gccaggttac ccaccttcaa agtccaacac
     7561 cacaaaactt aatcaatgta aaaggagcca aacttctact tggcctcatg ccttagcaaa
     7621 agaaagcttc acacacccac ctactcacac gggacagccc cagggaaagg aaggcaatgc
     7681 ttcaatatac aagatgagtt cagggacgtg ctcatgctga tggagagcaa gagggttagt
     7741 cggttggccg gtcgttgtca aaactctata atgttctttt ctacactctt ccccttggct
     7801 tggatgctga tgtgtgtgag gttggcagac aacaatgacc acagagtcaa gaggtctcag
     7861 tccgaggtag acgggttcct tcacggaccc gaccaatcac aagatcaagg ctcagcgccc
     7921 actgtacgaa cactcaccat taaaactgtg acatcaatgt agccaatcta tacgatgggc
     7981 tgttcttctc aggcaatgta aataaattat ccgctaccaa caagcactag tgaacctaac
     8041 attgccagtc atcagggttt ctaaatttta aacaaagctc atcgtgtatt catcaagagc
     8101 cccacaggaa gtcccgggag tctaagatca gacccaggtt gaggctggac acccttcaga
     8161 gtattccagt gctagattta cagtcataaa tgcaagcaac aggccaccca gagccagagc
     8221 ctcagattcc agctgcgacc catgggaacc tctgggtcct tcagccagag tcctcagagg
     8281 aggaagagca ctgccctcag atccactctg ccatcgtctc tcagtccctc tgtctgtgag
     8341 agcaacccca gcagccccct cccctgctca gtttagccag tgacaaggct cactgaggcc
     8401 tctcagaact gccacacagg gtctgtttct tgcacaacca gacaacgaca gacgtgtctt
     8461 ctgaggtctt tgaactctta agaataccta gaaggggggt tggggattta gctcagtggt
     8521 agagcgcttg cctagcaagt gcaaggccct gggttcaatc cccagctccg aaaaaaaaaa
     8581 aaaaaagaaa aagaaaaaag aatacctaga aggcattttt cttttgtttg tctgtttgtt
     8641 tgtttattta tctatttatt tttgttctag aaatgcccac catcccctgc cctctctcca
     8701 gccccctctc tccccctaca ccagatcctg ccccaccctc actgttgttc ctctcccacc
     8761 cagttccctc cctccaccca cctcctgact attttgttta cccttctgag aaaggttcaa
     8821 acatctcccc ttgggccctc cttgttactt agctatggag tgtgtcgtgg ttaatatcta
     8881 cttcatcatc agtgagcgca caccacgcat gtcctttgga gtctgcgtta cctcactcag
     8941 gatgatattt tctaattcca tccttttgcc tactaatttc ctaatgtcct tgtttttaat
     9001 agctgaatct gggaggtatt cttaacttca cagagcacct tctgggtcag gaatgaattt
     9061 aggcctttaa agtctgttag gtgccagcca tatgtaaacc caataaaata ctaaagttaa
     9121 aaggacatgt ataaggcaga cgctacgact tcaccccaag gattatctcg gtgatgattt
     9181 tgtgtgcgtg tttattttct cattagatac aaattcttcc tgcctgagaa attgtcactt
     9241 tggggtctcc cagtggtgtg aggacaggaa gccagtcact tgggggtatc acagtgacct
     9301 ttctggatag tcgaacctgc ccctcagtct aagcaagtct cagagctgac ctgttggaac
     9361 ccaccttaca accaatatga ctcccaccta ggcctcagat acatgcccag gcccgcccat
     9421 ctcagcacca gggctcacct ggtgtgcgtg ctggatcttc agggacgctg gaggagaaat
     9481 gagaattttc cacaccccaa acatcacact gtaggacttg ctcccatcta ccaggcatcg
     9541 tgactctcct ttttccccac actccctgtg gtttacaact ctccctctgc tagcggctgc
     9601 cctacaggaa caaaggatcc tctggatgct acacaatgtg gtgggggtgg gttgttccca
     9661 ggccttcgta tctaacactc agactgggaa atataaaata gacactcaca aacatgtgtg
     9721 cacagacaca taaacacagg ccacattctt agaccctcca aatgggtatg accaaatccg
     9781 caacgttttc agaagattgg ggttggagag agctcggcag ctaagagcac ttaccgctct
     9841 tgcagagacg ccatgtttgg ctccagacac ccaagtcagg catctcacaa cctcctgtaa
     9901 ctccagctcc aggcgaacac gacagttctg acctctgcag gcaactgcag ctctgttcac
     9961 atagttacac acacacacac acacacacac acacacactt aaaacaatag aagtaaaatc
    10021 taaaagaaaa ggtttctgga agtctaaacg tgagtgagga ccgccctctc ctactattac
    10081 agtggcatta gctttcaaat gctcttacag atcaatgatc acacccccga ccggacccgc
    10141 ccccgccccg ctctgcccca ccccggcccc acccccgcaa acataaccct tcttcctgga
    10201 gtgaatgaga actctgcttg ctccccacac cccggtcccc gcgtttggtg gtgtcattgt
    10261 ttcagatttg taagacgtgt agcatggtat gttacggctg tgtgccgttc agttcactgc
    10321 gggattaaac gccttctcag ctacttcctg tctgtctgta gattgtcacg ttggagtggc
    10381 tctgctcaga tcttgtgttc actctgtagg tgggttgttc gttttcctat tcttgaactg
    10441 aaaaggctct ttgtatattt tggatacctg ttcttcttca ttagctgcat ctttcggaaa
    10501 tgcttcccct tgctggccgt tcctctttgc tctgcagaag tttcttattt cagcgaagtc
    10561 cagcctggca atcagccctc acagaccgtg cctttggagc cgtatctaag acaccatcat
    10621 aaaccccagt ttggccggga cttcctcccg tgtcctggga gctttgacat tttagctgtt
    10681 ccccaggtct cggatgatgc cttgggactg gtatgaagct tgtgttcaaa tctgttttta
    10741 tcttaccgtg tctaagctgt ttgctgaaac agcagccttt gccagtttgt cagaaagcag
    10801 cctcttcccg gcacaggctg atcgctgaga tacgtggcct gtgtccgcgc tctctagtcg
    10861 gattcttctt ctgtctgtct actctgttac caatactaca gagtctccac agatagacta
    10921 gcattgagtc tcggcaatgg caggcaggca gtcctctgtt ttctcactat ttcttcaaca
    10981 gtgaatagtt gatttcgtct attctgggtc ttttgcttct cttacaaact atttagagag
    11041 ccgatatcca cacagaaatc tgttcgactt tggattggta tcgtcttgcc tccaaagatt
    11101 aagtggagaa gagacaacac ctctgttttt tctgtcccgc agaccccagg atgttgttta
    11161 tttattcttt ggatcgttca ccttttatag ttttccacac agagatcttt cacatacttt
    11221 aatagactta cacccaagaa tttcatttca ggggggtgct aacttaaatg ttcatttttt
    11281 taaaatttca gattccaatt gctcattgct ggtatttaag gaagcaattg gcatttgtat
    11341 actaatttgt gtctaaaata tttatgtaaa tttttaatct tggtcttgcc aagcgtggtg
    11401 gcacatgcct tcagtcccag ccctcaagag gcaggggcag ggggatctac atgagttcaa
    11461 ggccagtctg gtttacaaaa caagttccag gacagcccaa ggtgccaggg ttacacagag
    11521 aaaccctatc aaaaaaaaaa aaaaaagagc tttttgtcaa ttcttcaaga ttagaggtga
    11581 gcacgtcatc tgtaaatgat agctttttct tcccttctga tctgtagatt tttagttaac
    11641 ttttcttgtc atattgtatc ctctgacctt tagaatcatg tttaaatagt agtagttcct
    11701 ctgataggtc tgaacaggaa acaagctctg acggttaagt gaagtgaacc aaaatgaagt
    11761 tctgagtgct gctccccgtc taggaaatgt ccctctactc acactttatg gagaaccttt
    11821 tgttgtctgt aacagtttta taaataactg tatatggctc agagccccaa gatgtgatct
    11881 ccagacaaaa gaataaaagg tataaacata aacaatgagg cattacatgg ttgaaaagtg
    11941 atcaataatc tcacagaatg acatagaata gccttaagtg cagattatta agtttaaaat
    12001 tttctaaaaa agaccacagt gctgcccgct tttgactgta tgctgcttgt ggaggatttt
    12061 gtgctgaatg gctctttggg ttttatcagt tctctttcta tagcttttga tattatcaca
    12121 tataattttt atcactctgc ccactaatct ggattatggg aatttgcctt taaatgttga
    12181 actgccttcc ttatctggca caaggcccgc tcggtcgtgg tatagttttc cttttatgca
    12241 ttgttcggtt cggtttgcga gtggcttgtc gttgaggctg tctgcatctg tgttcgtggg
    12301 agctgtgggc gtgttgcttt catttactga agtatcttct cctcgtttgt ccttagggtg
    12361 atgctgggct cctagtgtgg accgagaagt atttctccta attccatcct ctgaaagaca
    12421 ttacagagaa ctgatatatt ttcctcccta actgcttgga agaattcacc cagaatgaac
    12481 ccatctggac ctagtgcttt ctggttggga aggtcatcaa taatttactt aaagtcgggg
    12541 ctggagagat gaggcggcgg ttaagatggc ttattgttct tacagacagc ctgggttcag
    12601 ttcccagtgc acacacggtg gctcacaatc acctagaact ccagttccaa gggacctggc
    12661 accttcttct ggcttccatg ggctactgca tgcgtgggat gcacgtaagc tcacacagga
    12721 atccagactc gtgcgcataa ataaaagtaa acgaaacttt gaagtctcta atgtatagac
    12781 cttttgggct atgtttttct aatgtgagtt ttggtagact gtatgtttct agtaacgatt
    12841 gtacttcagc catgcagaga tgtgtggaca ggccctttgg ggttctttct acgaccacgg
    12901 ggtctgtcgt tgtgttccct gatatttcat cagttctctc tctctctctc tctctctctc
    12961 tctctctctc tctctctctc tctctctctc tctctctctc tccctgcaca aatagaaatg
    13021 taattatttt atttcaaaaa actggttctt gactccactg atctctttag tcactttcct
    13081 gtctttagtt ctgtcagttt gtccttgctt actttggatt taactcgctc atttaattac
    13141 gtgactgatc tcagatttct ttctgctcgc tgcatccgat gctacggatt gtcactccgg
    13201 ccgcttctac ttcgtgtctg attgtggttt ctcatcctct ccgagttcaa tgtctatttt
    13261 taaaatttct cctgagattt cttctacgtt ctgagaattg tgatgtttaa tcctaaagtg
    13321 tttagagatg ccccaggtct ctctctgtgg ctgatttcta gcttcactcc actgtgttct
    13381 gcaggggaac actgtagaat ttgtatagtt ttaatgtggt acggtgtgtc taatggccct
    13441 gaatgaagca tcctagtgaa tgctctctgt gactttgaga agaattggtc accagatgtt
    13501 cggttcctca tttttccagc aagcgtttga cgccaccatg cctgtctctc tgattccact
    13561 gtccgtctct gtttgatccc actgcgcatg tctctatgtt tgaccgcccc ccccccccaa
    13621 cgcgcatgtc tctatgtttg actccaccgc gcatgtctct atgtttgacc ctaccgcgcc
    13681 tgtctgtgtg attctgacta gcgcccctaa ttacatctca tcagttcacc tctatgtcac
    13741 ttttaaactt atggtcccta attgagtcag ctttttaact ttcaactttt aaaatccttt
    13801 gtttgtaaaa gtgaaattta actaccacaa acactcttgt gtccagcaat cctttaccaa
    13861 ccacactcct ctcccacctc ctaccacact aaagcaggtg gcagccaggc aggttggggg
    13921 gtaggcactg tgttaagaca tagtgacctt ctccacagta gaacacttca cggaaggtta
    13981 gcaacatgga tgtagaataa acacactgct acatattaaa tgaaaaagtc atccggggaa
    14041 tggaggagat gattcaggtt ttaagggcat tcactgctct tgcaaaggac cagagtttga
    14101 ttcctggcgc ccatgtcagg aagctcacag ccacctgtaa ctccagctac attgtatcca
    14161 ctgcaccggg atacatgtgt ccattctacc acaaacagat acccaggaat gaaaatattt
    14221 ttttataagt aatcgaatgc tagcatggta ttagcaagct gcatccagta caccaccagc
    14281 tctgcccctc tggaaacgtg caggcagggg ttcgccgaaa ctatgttggt tctaaaccaa
    14341 acaaaccgta aaggagatgc tatggccctt ctgtctttta gctgtaacac atgttaacgg
    14401 aatcacttta tttattttct gccctgtttt agttattggc ccaaaacgca aaaaggaaat
    14461 ccttctcatt attagtttaa aataatgact gtatcttctt ctcccagtaa ggggccagat
    14521 tcttgctgcg gctgagtaag gactcttgcc cttgaactat ttcctagggc agaaaaataa
    14581 tgtattctgg agaaatccac taattcaaag tccactatca gtaccaagtt ttcacacccc
    14641 ctaatcatgg ttctaggaaa cacgggttaa gactgagtct agtctggcgg aacttgctta
    14701 cctgtgctgt gccatgaagg tctcaccaaa ctgtcacaga gacctgccaa ggaggactcc
    14761 cagaaagctc tggaactgta ttataaaggt tgaggtatca tgaggtcctc accagcatcc
    14821 agagaacgcc aagcgtacga gcaatgcctg ctgctcttcc aggctcccag catccacgct
    14881 gggcagctca caagcaaccc cagccccaga gaacgaacac cctcttctga cattttcaaa
    14941 cacccaaagt ggcataaact cacacagaca tgcacacata catgtaaatt aaagttaaat
    15001 gttaatttta aaatgtttcg aacaaacata acaccccccc aatggaagca caaatagatt
    15061 taatcttcaa ttctgtgcgc atcaattttc ccaagaactt gagattttaa taaaatgctt
    15121 atgtccttca gagaaataag gttttcatgt tcagggctaa gggaggcctc aggttcaagg
    15181 ctgaaagggt gacaaagctt atttgtgtca taaacaatcc aaacagcttg ctaaaactcc
    15241 atgcaaggct ttcttggagg ttcgtgtgtg ttggttacac tcagtgagta actgctgccc
    15301 agtgaccaag gccttaatta agcaaggatc tctgaggaca ctaatacata gtaatatctt
    15361 ctgttgttct caacgggcta ccaccctgga gctgtccact cttactgagt gagaaacccc
    15421 tatgagcaaa agctaactcc cacgttactc atgaaaaaag tcagttttag ggacaaggct
    15481 agttaatccc gagagacagc tagaaccagt tgcctgggat ttaacaacag caaggcgggc
    15541 tctgtgtgga cagcaggcaa tagtgtggtg tggcaggaag aggtatacct tgatgttttt
    15601 tgaggcctgg gtgggctttg gaaggagaaa gagaagccag aataaaacac ggccgtagag
    15661 gaccagggga cagtgcctgg ctagtctaca aaggataggt ggcttcccag gagatttggt
    15721 aaaaatactt tgtgaagact ggtgctaagt catagaagtc tctgagctaa aggtggagga
    15781 acacagtctg cagtttctta aagccatcat ggtgtcaaaa tagctcctaa ctcttaagat
    15841 tggacaaaag aacggcctcc actgaccaag atgtcctcga cacaacatgt caagcactcc
    15901 aaaacaattc agtgagtctg ggaaaaaaat tttttagaaa gtggaaaagt agaatttcag
    15961 taagagttga ctataaacct ggctaattca tatgctgaga atgctggagc gttcactgta
    16021 gctttcttta agcaaagcca atactcttct agagatgcca agaaaacaca gggagaaaca
    16081 tcttccccca aaaacctctc ctgtgaaggc ttcaagtttc ttcgcagtta agtagctgat
    16141 gcctgcttct gaggtcattg ctgccaacct ccccatcaag ctttttaaaa acgaaagcca
    16201 ggcagagccc cagtcctggt ttggctcctg acccaccttc caatcctttt gtaactccct
    16261 tgactcaatc caagtatgtc tgcgcacgga caaggcgaaa gcatgcttga tgcgaaagca
    16321 caaattatgt attgaggaat ctctacaatg ccaaattttt ttagaataaa aaatatatat
    16381 atatttaaga actcgctgtg ttagggaaac tgtttacata ttgaggcgtt cctctttttt
    16441 tgactggaac aataaaagaa taatttgata tgg
//
