LOCUS       NM_053870               2656 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus potassium inwardly-rectifying channel, subfamily
            J, member 4 (Kcnj4), mRNA.
ACCESSION   NM_053870
VERSION     NM_053870.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Xu,L., Hao,Y., Wu,X., Yu,P., Zhu,G. and Hong,Z.
  TITLE     Tenidap, an agonist of the inwardly rectifying K+ channel Kir2.3,
            delays the onset of cortical epileptiform activity in a model of
            chronic temporal lobe epilepsy
  JOURNAL   Neurol Res 35 (6), 561-567 (2013)
   PUBMED   23561319
  REMARK    GeneRIF: Down-regulation of the Kir2.3 channel expression
            contributes to the pathogenesis of temporal lobe epilepsy.
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Li,J., Blankenship,M.L. and Baccei,M.L.
  TITLE     Inward-rectifying potassium (Kir) channels regulate pacemaker
            activity in spinal nociceptive circuits during early life
  JOURNAL   J Neurosci 33 (8), 3352-3362 (2013)
   PUBMED   23426663
  REMARK    GeneRIF: Immunohistochemical analysis reveals the expression of
            Kir2.1, Kir2.2, and Kir2.3/Kcnj4 within spontaneously bursting
            neurons that regulate the level of pacemaker activity within the
            developing superficial dorsal horn.
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Wang,G., Zeng,J., Shen,C.Y., Wang,Z.Q. and Chen,S.D.
  TITLE     Overexpression of Kir2.3 in PC12 cells resists rotenone-induced
            neurotoxicity associated with PKC signaling pathway
  JOURNAL   Biochem Biophys Res Commun 374 (2), 204-209 (2008)
   PUBMED   18619942
  REMARK    GeneRIF: These studies provide an entry point for understanding the
            novel roles of Kir2.3 in cell models of PD, and they offer clues
            for the common mechanisms underlying different neurodegenerative
            conditions.
REFERENCE   4  (bases 1 to 2656)
  AUTHORS   Cao,C., Lee-Kwon,W., Payne,K., Edwards,A. and Pallone,T.L.
  TITLE     Descending vasa recta endothelia express inward rectifier potassium
            channels
  JOURNAL   Am J Physiol Renal Physiol 293 (4), F1248-F1255 (2007)
   PUBMED   17670900
  REMARK    GeneRIF: Immunochemical staining verified that both pericytes and
            endothelial cells of descending vasa recta express K(IR)2.1,
            K(IR)2.2, and K(IR)2.3 subunits.
REFERENCE   5  (bases 1 to 2656)
  AUTHORS   Saygili,E., Rana,O.R., Saygili,E., Reuter,H., Frank,K.,
            Schwinger,R.H., Muller-Ehmsen,J. and Zobel,C.
  TITLE     Losartan prevents stretch-induced electrical remodeling in cultured
            atrial neonatal myocytes
  JOURNAL   Am J Physiol Heart Circ Physiol 292 (6), H2898-H2905 (2007)
   PUBMED   17293496
REFERENCE   6  (bases 1 to 2656)
  AUTHORS   Leonoudakis,D., Conti,L.R., Radeke,C.M., McGuire,L.M. and
            Vandenberg,C.A.
  TITLE     A multiprotein trafficking complex composed of SAP97, CASK, Veli,
            and Mint1 is associated with inward rectifier Kir2 potassium
            channels
  JOURNAL   J Biol Chem 279 (18), 19051-19063 (2004)
   PUBMED   14960569
REFERENCE   7  (bases 1 to 2656)
  AUTHORS   Pruss,H., Wenzel,M., Eulitz,D., Thomzig,A., Karschin,A. and
            Veh,R.W.
  TITLE     Kir2 potassium channels in rat striatum are strategically localized
            to control basal ganglia function
  JOURNAL   Brain Res Mol Brain Res 110 (2), 203-219 (2003)
   PUBMED   12591157
REFERENCE   8  (bases 1 to 2656)
  AUTHORS   Bredt,D.S., Wang,T.L., Cohen,N.A., Guggino,W.B. and Snyder,S.H.
  TITLE     Cloning and expression of two brain-specific inwardly rectifying
            potassium channels
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 6753-6757 (1995)
   PUBMED   7624316
REFERENCE   9  (bases 1 to 2656)
  AUTHORS   Falk,T., Meyerhof,W., Corrette,B.J., Schafer,J., Bauer,C.K.,
            Schwarz,J.R. and Richter,D.
  TITLE     Cloning, functional expression and mRNA distribution of an inwardly
            rectifying potassium channel protein
  JOURNAL   FEBS Lett 367 (2), 127-131 (1995)
   PUBMED   7796907
REFERENCE   10 (bases 1 to 2656)
  AUTHORS   Bond,C.T., Pessia,M., Xia,X.M., Lagrutta,A., Kavanaugh,M.P. and
            Adelman,J.P.
  TITLE     Cloning and expression of a family of inward rectifier potassium
            channels
  JOURNAL   Recept Channels 2 (3), 183-191 (1994)
   PUBMED   7874445
  REMARK    Erratum:[Receptors Channels 1994;2(4):following 350]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053870.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X87635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-555               JAXUCZ010000007.1  112953993-112954547 c
            556-2656            JAXUCZ010000007.1  112927494-112929594 c
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2656
                     /gene="Kcnj4"
                     /gene_synonym="Hirk2"
                     /note="potassium inwardly-rectifying channel, subfamily J,
                     member 4"
                     /db_xref="GeneID:116649"
                     /db_xref="RGD:621436"
     exon            1..555
                     /gene="Kcnj4"
                     /gene_synonym="Hirk2"
                     /inference="alignment:Splign:2.1.0"
     exon            556..2656
                     /gene="Kcnj4"
                     /gene_synonym="Hirk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..1938
                     /gene="Kcnj4"
                     /gene_synonym="Hirk2"
                     /note="IRK3; BIR11; inward rectifier K(+) channel Kir2.3;
                     brain inwardly rectifying K(+) channel 2; potassium
                     channel, inwardly rectifying subfamily J member 4; IRK-3;
                     potassium voltage-gated channel subfamily J member 4"
                     /codon_start=1
                     /product="inward rectifier potassium channel 4"
                     /protein_id="NP_446322.2"
                     /db_xref="GeneID:116649"
                     /db_xref="RGD:621436"
                     /translation="MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMA
                     DIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWCIAFFHGDLEPSPSGPTAGGPGGN
                     GGGAAPTAAKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVG
                     CVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAH
                     VRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGK
                     EELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYS
                     RFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAA
                     AAAAVAAGLGLEAGSKEETGIIRMLEFGSHLDLERMQAATLPLDNISYRRESAI"
ORIGIN      
        1 aggagagaga tcgtggctgg ccaagtgagg ggagccacgc ggccttccgt cctttgtgcg
       61 ggcatccgac aaactccact cccactcatc ccagcctcag tgtggccatc agctgcggct
      121 ggataccttc ctgggcatac cttctctggt ttcaaggtgg ggagatggag ggctaggcag
      181 tgtcccagta ccactgggtg aagtgggcaa agccaggccc tgacttcggt ggctgacatt
      241 ctgacagaga actgtgcaga caagtggaag acaggccaca ggcaccttct ctgaagtccc
      301 cactcttttc caagtctggg aaatgggaca gtaccaccaa tgtctcagag tagctttcac
      361 caagtgtgtg aagtagtcac caactttaaa agaagctgcc aaactacaaa gtgccttgca
      421 catgccaagg gccataccca tctctgttct ggtcctatcc ctcactccag ccccaagggc
      481 agcctttgtg acagccagct gcaccgggaa gcttggtctc agaaccttcc atgcctagag
      541 gtttcaaccc tgcaggccct gcatctcccc aggtgaccac gacgacggcc tcaggtcatg
      601 cacggacaca gccgcaacgg gcaggcccac gtgcccaggc ggaaacgccg caaccgcttc
      661 gtcaagaaga acggccagtg caacgtgtac ttcgccaacc tgagcaacaa gtcccagcgc
      721 tacatggcgg acatcttcac gacgtgcgtg gacacgcgct ggcgctacat gctcatgatc
      781 ttctccgcgg ccttcctcgt ttcctggctc tttttcggcc tccttttctg gtgcattgcc
      841 tttttccacg gtgacctgga gcctagtccc tccgggccca cggcgggagg cccggggggc
      901 aatggcggcg gggcagcccc gacagcggcc aaaccgtgta tcatgcatgt aaacggcttt
      961 ttgggagcct tcctcttctc ggtggagaca cagacgacca tcggttatgg gttccggtgt
     1021 gtgacagagg agtgcccgtt ggcggtcatc gcagtggttg tccagtccat tgtgggctgt
     1081 gtcatcgact ccttcatgat tggtactatc atggccaaga tggcacggcc caagaagcgg
     1141 gcgcagaccc tgctgttcag ccaccacgct gtcatctccg tgcgggacgg caagctctgc
     1201 ctgatgtggc gcgtgggcaa cctgcgcaag agccacatcg tggaggccca cgtccgggcc
     1261 cagctcatca agccctacat gacacaggag ggtgagtacc tgccactgga ccagcgggac
     1321 ctcaacgtgg gctatgacat tggcctggac cgcatcttct tggtgtcacc catcatcata
     1381 gtgcatgaga ttgatgagga cagtccactc tacggcatgg gcaaggagga actggagtcg
     1441 gaggactttg agattgtggt catcctggag ggcatggtag aggccacggc tatgaccaca
     1501 caggcccgca gctcctacct ggccagtgag atcctgtggg gccaccggtt cgagcctgtg
     1561 gtcttcgagg agaagagtca ctacaaggtg gactactcac ggttccacaa gacctacgag
     1621 gtggctggca ccccttgctg ctctgcccgt gagcttcaag agagcaagat cacggtgctg
     1681 cccgccccac cgccccctcc cagtgccttc tgctatgaga acgagttggc cctcatgagc
     1741 caggaggaag aagaaatgga agaggaggct gctgccgcag cagccgtggc tgccggcctg
     1801 ggcctggagg ctggctccaa agaggagaca ggcattatcc ggatgcttga gtttggcagc
     1861 cacctggatc tggagcgcat gcaagccgct acccttcctc tggacaacat ttcttaccgc
     1921 agggagtctg ccatctgacc tccaggccct gccctcctct atccctgcaa gagcctctgc
     1981 caggggtggg acatcaggac aagccttcca ctcttaggac agagttgttc atggctctgt
     2041 ggacctggag gaatgtgggg gcttcaaaga ctgggagatc ccctcctgtt gactgcaggg
     2101 cccaggactg ggaaggaccc aggtactcag tcctgatggc ctgggccccc tggcatctcc
     2161 ccacggtggc tctgggcccc cagatcttcc acccttttcc cactgaccct tcaaggatgt
     2221 accccttcta ctctcaggac cttggggaag gcggctggac tgctgggggg tgggcatcat
     2281 ggggttctgg gtgggcaggg tgggtctggg ggagggggaa gggtgtgttt cttttgcatg
     2341 actgtggtct gtgctcttga ctctcttttg taaatatcta taaatggaag agatggagac
     2401 acaagtccac ctctgcccat ttctacctgt gagacagaga gaggccgcca cccctctctg
     2461 tgcacccccg tccagcctca gccctaccca cctacccagc tggctgggcc tctgagacct
     2521 ttgaagccag ctgtgtatgg tgttggtttg ggtagagagg ggactcagac gtgggatgag
     2581 taccccctcc ctccttgcag tccccagatt gatgatggcg tttgtaacta tttttaataa
     2641 agcatatggt ccacta
//
